CN113226302B - 用于治疗或预防痛风或高尿酸血症的化合物的晶型 - Google Patents

用于治疗或预防痛风或高尿酸血症的化合物的晶型 Download PDF

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Publication number
CN113226302B
CN113226302B CN201980080515.8A CN201980080515A CN113226302B CN 113226302 B CN113226302 B CN 113226302B CN 201980080515 A CN201980080515 A CN 201980080515A CN 113226302 B CN113226302 B CN 113226302B
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compound
crystal form
crystalline
dibromo
benzofuran
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CN113226302A (zh
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颜顺启
叶立天
李征
王瑞平
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Guangzhou Ruianbo Pharmaceutical Technology Co ltd
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Guangzhou Ruianbo Pharmaceutical Technology Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980080515.8A 2018-12-06 2019-12-05 用于治疗或预防痛风或高尿酸血症的化合物的晶型 Active CN113226302B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018119567 2018-12-06
CNPCT/CN2018/119567 2018-12-06
PCT/US2019/064784 WO2020118113A1 (en) 2018-12-06 2019-12-05 Crystalline forms of a compound for treating or preventing gout or hyperuricemia

Publications (2)

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CN113226302A CN113226302A (zh) 2021-08-06
CN113226302B true CN113226302B (zh) 2023-08-18

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Country Status (12)

Country Link
US (2) US12145917B2 (https=)
EP (1) EP3890723A4 (https=)
JP (2) JP2022511800A (https=)
KR (1) KR102946486B1 (https=)
CN (1) CN113226302B (https=)
AU (1) AU2019394974B2 (https=)
BR (1) BR112021010708A2 (https=)
EA (1) EA202191545A1 (https=)
IL (1) IL283663B2 (https=)
SG (1) SG11202105745UA (https=)
TW (1) TWI828817B (https=)
WO (1) WO2020118113A1 (https=)

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US12145917B2 (en) 2018-12-06 2024-11-19 Arthrosi Therapeutics, Inc. Crystalline forms of a compound for treating or preventing gout or hyperuricemia
EP3968989A4 (en) * 2019-05-14 2022-12-28 Arthrosi Therapeutics, Inc. COMPOUND FOR TREATMENT OF GOUT OR HYPERURICEMIA
WO2021252630A1 (en) * 2020-06-10 2021-12-16 Arthrosi Therapeutics, Inc. Methods for treating or preventing chronic kidney disease
US20250066316A1 (en) * 2021-12-02 2025-02-27 Arthrosi Therapeutics, Inc. Crystalline forms of a compound for treating or preventing gout or hyperuricemia
CN118974028A (zh) * 2021-12-30 2024-11-15 广州瑞安博医药科技有限公司 用于治疗痛风或高尿酸血症的化合物的制备

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US20250059150A1 (en) 2025-02-20
IL283663B2 (en) 2025-12-01
US20220024889A1 (en) 2022-01-27
TW202039453A (zh) 2020-11-01
BR112021010708A2 (pt) 2021-08-24
KR20210100677A (ko) 2021-08-17
CN113226302A (zh) 2021-08-06
EA202191545A1 (ru) 2021-10-28
TWI828817B (zh) 2024-01-11
AU2019394974B2 (en) 2025-08-28
IL283663A (en) 2021-07-29
IL283663B1 (en) 2025-08-01
EP3890723A4 (en) 2022-08-03
CA3121913A1 (en) 2020-06-11
JP2025026857A (ja) 2025-02-26
US12145917B2 (en) 2024-11-19
AU2019394974A1 (en) 2021-07-15
JP2022511800A (ja) 2022-02-01
WO2020118113A1 (en) 2020-06-11
SG11202105745UA (en) 2021-06-29
KR102946486B1 (ko) 2026-03-31
EP3890723A1 (en) 2021-10-13

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