KR102946486B1 - 통풍 또는 고뇨산혈증의 치료 또는 예방을 위한 화합물의 결정형 - Google Patents

통풍 또는 고뇨산혈증의 치료 또는 예방을 위한 화합물의 결정형

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Publication number
KR102946486B1
KR102946486B1 KR1020217021172A KR20217021172A KR102946486B1 KR 102946486 B1 KR102946486 B1 KR 102946486B1 KR 1020217021172 A KR1020217021172 A KR 1020217021172A KR 20217021172 A KR20217021172 A KR 20217021172A KR 102946486 B1 KR102946486 B1 KR 102946486B1
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South Korea
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compound
theta
crystalline
dibromo
benzofuran
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KR1020217021172A
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Korean (ko)
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KR20210100677A (ko
Inventor
슌키 얀
šœ키 얀
리테인 예
젱 제인 리
루이핑 왕
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아쓰로시 테라퓨틱스, 인크.
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Publication of KR20210100677A publication Critical patent/KR20210100677A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020217021172A 2018-12-06 2019-12-05 통풍 또는 고뇨산혈증의 치료 또는 예방을 위한 화합물의 결정형 Active KR102946486B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018119567 2018-12-06
CNPCT/CN2018/119567 2018-12-06
PCT/US2019/064784 WO2020118113A1 (en) 2018-12-06 2019-12-05 Crystalline forms of a compound for treating or preventing gout or hyperuricemia

Publications (2)

Publication Number Publication Date
KR20210100677A KR20210100677A (ko) 2021-08-17
KR102946486B1 true KR102946486B1 (ko) 2026-03-31

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Country Status (12)

Country Link
US (2) US12145917B2 (https=)
EP (1) EP3890723A4 (https=)
JP (2) JP2022511800A (https=)
KR (1) KR102946486B1 (https=)
CN (1) CN113226302B (https=)
AU (1) AU2019394974B2 (https=)
BR (1) BR112021010708A2 (https=)
EA (1) EA202191545A1 (https=)
IL (1) IL283663B2 (https=)
SG (1) SG11202105745UA (https=)
TW (1) TWI828817B (https=)
WO (1) WO2020118113A1 (https=)

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EP4349414B1 (en) 2014-12-23 2025-10-15 Dyve Biosciences, Inc. Formulations for transdermal administration
EP3484862B1 (en) 2016-07-18 2021-09-01 Arthrosi Therapeutics, Inc. Compounds, compositions and methods for treating or preventing a symptom associated with gout or hyperuricemia
EP3681479B1 (en) 2017-09-15 2024-01-31 Dyve Biosciences, Inc. Sodium bicarbonate for use in the treatment of gout and related disorders
SG11202105743RA (en) 2018-12-06 2021-06-29 Arthrosi Therapeutics Inc Methods for treating or preventing gout or hyperuricemia
KR102946486B1 (ko) 2018-12-06 2026-03-31 아쓰로시 테라퓨틱스, 인크. 통풍 또는 고뇨산혈증의 치료 또는 예방을 위한 화합물의 결정형
WO2020232156A1 (en) * 2019-05-14 2020-11-19 Arthrosi Therapeutics, Inc. Compound for treating gout or hyperuricemia
KR20230024354A (ko) * 2020-06-10 2023-02-20 아쓰로시 테라퓨틱스, 인크. 만성 신장 질환을 치료 또는 예방하는 방법
TW202330485A (zh) * 2021-12-02 2023-08-01 美商安索治療公司 用於治療或預防痛風或高尿酸血症之化合物的結晶形式
WO2023125667A1 (en) * 2021-12-30 2023-07-06 Arthrosi Therapeutics, Inc. Preparation of a compound for the treatment of gout or hyperuricemia

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CA3121913A1 (en) 2020-06-11
IL283663B1 (en) 2025-08-01
CN113226302B (zh) 2023-08-18
CN113226302A (zh) 2021-08-06
JP2025026857A (ja) 2025-02-26
EA202191545A1 (ru) 2021-10-28
KR20210100677A (ko) 2021-08-17
TW202039453A (zh) 2020-11-01
AU2019394974A1 (en) 2021-07-15
SG11202105745UA (en) 2021-06-29
JP2022511800A (ja) 2022-02-01
EP3890723A4 (en) 2022-08-03
WO2020118113A1 (en) 2020-06-11
IL283663B2 (en) 2025-12-01
EP3890723A1 (en) 2021-10-13
US20250059150A1 (en) 2025-02-20
BR112021010708A2 (pt) 2021-08-24
AU2019394974B2 (en) 2025-08-28
IL283663A (en) 2021-07-29
US20220024889A1 (en) 2022-01-27
US12145917B2 (en) 2024-11-19
TWI828817B (zh) 2024-01-11

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