TWI805577B - 靶向組合物 - Google Patents

靶向組合物 Download PDF

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Publication number
TWI805577B
TWI805577B TW107112376A TW107112376A TWI805577B TW I805577 B TWI805577 B TW I805577B TW 107112376 A TW107112376 A TW 107112376A TW 107112376 A TW107112376 A TW 107112376A TW I805577 B TWI805577 B TW I805577B
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compound
mmol
preparation
solution
seq
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TW107112376A
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TW201842183A (zh
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詹姆士 赫耶斯
瑞察德 Ｊ 霍蘭登
亞當 喬吉
艾咪 C H 理
艾倫 D 馬汀
妮可拉斯 M 思妮德
愛蜜莉 P 西
馬克 烏德
葉欣
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加拿大商艾爾布圖斯生技公司
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
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TW107112376A 2017-04-11 2018-04-11 靶向組合物 TWI805577B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762484247P 2017-04-11 2017-04-11
US62/484,247 2017-04-11
US201762525071P 2017-06-26 2017-06-26
US62/525,071 2017-06-26

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TW201842183A TW201842183A (zh) 2018-12-01
TWI805577B true TWI805577B (zh) 2023-06-21

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TW112118993A TW202413641A (zh) 2017-04-11 2018-04-11 靶向組合物

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US (3) US11427823B2 (cg-RX-API-DMAC7.html)
EP (2) EP3950004A1 (cg-RX-API-DMAC7.html)
JP (3) JP2020516296A (cg-RX-API-DMAC7.html)
KR (3) KR102656438B1 (cg-RX-API-DMAC7.html)
CN (2) CN118460536A (cg-RX-API-DMAC7.html)
AU (2) AU2018250553B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019021359A2 (cg-RX-API-DMAC7.html)
CA (1) CA3059426A1 (cg-RX-API-DMAC7.html)
MA (1) MA52546A (cg-RX-API-DMAC7.html)
MX (3) MX2019012280A (cg-RX-API-DMAC7.html)
NZ (1) NZ757927A (cg-RX-API-DMAC7.html)
PH (1) PH12019502333A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201909433XA (cg-RX-API-DMAC7.html)
TW (2) TWI805577B (cg-RX-API-DMAC7.html)
WO (1) WO2018191278A2 (cg-RX-API-DMAC7.html)

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MA45478A (fr) * 2016-04-11 2019-02-20 Arbutus Biopharma Corp Compositions de conjugués d'acides nucléiques ciblés
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CN110997917B (zh) 2017-12-01 2024-04-09 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
EP4455285A3 (en) 2017-12-01 2025-02-26 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof
EP3718572B1 (en) 2017-12-01 2024-07-31 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method and use
CN118291457A (zh) 2017-12-01 2024-07-05 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
AU2018374219C1 (en) 2017-12-01 2023-05-11 Suzhou Ribo Life Science Co., Ltd. Double-stranded oligonucleotide, composition and conjugate comprising double-stranded oligonucleotide, preparation method therefor and use thereof
KR102617947B1 (ko) 2017-12-29 2023-12-27 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 접합체와 제조 및 그 용도
WO2020038377A1 (zh) 2018-08-21 2020-02-27 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
CN111655297A (zh) 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
JP7588855B2 (ja) * 2018-11-02 2024-11-25 ジェネヴァント サイエンシズ ゲーエムベーハー 治療方法
CN113226332B (zh) * 2018-11-02 2025-05-09 阿布特斯生物制药公司 二价靶向缀合物
EP3903830A4 (en) 2018-12-28 2023-04-26 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH NUCLEIC ACID, PROCESS FOR THEIR PREPARATION AND ITS USE
EP3941921A4 (en) * 2019-03-20 2023-05-03 Arbutus Biopharma Corporation Therapeutic methods for treating hepatitis b
CN113227376B (zh) 2019-05-22 2024-04-09 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
JP7610268B2 (ja) * 2019-05-22 2025-01-08 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、薬物組成物及び複合体ならびに調製方法と使用
US20220305107A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
CN115884984A (zh) * 2019-12-06 2023-03-31 盖纳万科学有限公司 用于治疗肝纤维化的结合物和方法
AU2020408039A1 (en) 2019-12-20 2022-08-18 Arbutus Biopharma Corporation Synthetic processes and intermediates
MX2023005138A (es) * 2020-11-06 2023-06-23 Arbutus Biopharma Corp Conjugados dirigidos que comprenden arnpi modificado.
CN114853829A (zh) * 2021-02-05 2022-08-05 上海拓界生物医药科技有限公司 一种核酸配体、其缀合物、制备方法及用途
WO2022199685A1 (zh) * 2021-03-25 2022-09-29 安沛治疗有限公司 具有延长的体内半衰期的核酸分子缀合物
TW202340466A (zh) * 2021-12-16 2023-10-16 大陸商上海拓界生物醫藥科技有限公司 一種ｄｓｒｎａ、其製備方法及應用
KR20240136985A (ko) * 2022-01-20 2024-09-19 청두 신정허 파마슈티컬 테크놀로지 컴퍼니 리미티드 표적화 리간드 및 이의 용도
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