TWI767976B - 用抗pd-1抗體治療癌症之方法 - Google Patents

用抗pd-1抗體治療癌症之方法 Download PDF

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TWI767976B
TWI767976B TW107100822A TW107100822A TWI767976B TW I767976 B TWI767976 B TW I767976B TW 107100822 A TW107100822 A TW 107100822A TW 107100822 A TW107100822 A TW 107100822A TW I767976 B TWI767976 B TW I767976B
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cancer
specific example
binding agent
dose
antibody
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TW107100822A
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TW201831200A (zh
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大衛 顏金斯
哈雷 拉肯
嚴艾莉
艾倫 狄亞茲
魯賢丹
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美商提薩羅有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW107100822A 2017-01-09 2018-01-09 用抗pd-1抗體治療癌症之方法 TWI767976B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201762444336P 2017-01-09 2017-01-09
US62/444,336 2017-01-09
US201762477423P 2017-03-27 2017-03-27
US62/477,423 2017-03-27
US201762491220P 2017-04-27 2017-04-27
US62/491,220 2017-04-27
US201762556386P 2017-09-09 2017-09-09
US62/556,386 2017-09-09

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TW201831200A TW201831200A (zh) 2018-09-01
TWI767976B true TWI767976B (zh) 2022-06-21

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US (2) US11407830B2 (https=)
EP (2) EP3565844B8 (https=)
JP (2) JP7110206B6 (https=)
KR (1) KR102606252B1 (https=)
CN (1) CN110382545A (https=)
AU (2) AU2018206481B2 (https=)
BR (1) BR112019014187A2 (https=)
CA (1) CA3049440A1 (https=)
DK (1) DK3565844T5 (https=)
ES (1) ES2945745T3 (https=)
FI (1) FI3565844T3 (https=)
HU (1) HUE061842T2 (https=)
IL (1) IL267804B2 (https=)
MA (1) MA47208A (https=)
MX (1) MX2019008207A (https=)
PL (1) PL3565844T3 (https=)
PT (1) PT3565844T (https=)
SG (2) SG10201913075RA (https=)
TW (1) TWI767976B (https=)
WO (1) WO2018129559A1 (https=)
ZA (1) ZA201904316B (https=)

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