TWI765002B - 受體拮抗劑之皮下投藥 - Google Patents

受體拮抗劑之皮下投藥 Download PDF

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Publication number
TWI765002B
TWI765002B TW107108546A TW107108546A TWI765002B TW I765002 B TWI765002 B TW I765002B TW 107108546 A TW107108546 A TW 107108546A TW 107108546 A TW107108546 A TW 107108546A TW I765002 B TWI765002 B TW I765002B
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TW
Taiwan
Prior art keywords
administered
receptor antagonist
patient
administration
pharmaceutically acceptable
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TW107108546A
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English (en)
Chinese (zh)
Other versions
TW201840323A (zh
Inventor
馬丁 保門
馬克思 坎伯
馬克思 瑞
馬克思 萊德爾
賽巴斯汀 羅克斯
Original Assignee
瑞士商愛杜西亞製藥有限公司
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Publication of TW201840323A publication Critical patent/TW201840323A/zh
Application granted granted Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW107108546A 2017-03-15 2018-03-14 受體拮抗劑之皮下投藥 TWI765002B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
??PCT/EP2017/056175 2017-03-15
EP2017056175 2017-03-15
WOPCT/EP2017/056175 2017-03-15

Publications (2)

Publication Number Publication Date
TW201840323A TW201840323A (zh) 2018-11-16
TWI765002B true TWI765002B (zh) 2022-05-21

Family

ID=61899166

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107108546A TWI765002B (zh) 2017-03-15 2018-03-14 受體拮抗劑之皮下投藥

Country Status (18)

Country Link
US (1) US11179390B2 (enExample)
EP (1) EP3595666A1 (enExample)
JP (2) JP7580918B2 (enExample)
KR (1) KR102510832B1 (enExample)
CN (1) CN110381947A (enExample)
AU (1) AU2018234056B2 (enExample)
BR (1) BR112019014567A2 (enExample)
CL (1) CL2019002318A1 (enExample)
EA (1) EA201992123A1 (enExample)
IL (1) IL269286B2 (enExample)
MA (1) MA49887A (enExample)
MX (1) MX393334B (enExample)
MY (1) MY205605A (enExample)
PH (1) PH12019502111A1 (enExample)
SG (1) SG11201908128YA (enExample)
TW (1) TWI765002B (enExample)
UA (1) UA125531C2 (enExample)
WO (1) WO2018167139A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109715639B (zh) 2016-09-22 2022-04-19 爱杜西亚药品有限公司 结晶形式
TWI905227B (zh) * 2020-07-15 2025-11-21 新加坡商暉致亞太私人有限公司 包含p2y12受體拮抗劑的水性醫藥組合物
CA3223733A1 (en) 2021-07-13 2023-01-19 Nicole Blumer A process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl- pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1 -carboxylic acid butyl ester
CN118871446A (zh) 2022-03-14 2024-10-29 晖致亚太私人有限公司 (r)-2-((叔丁氧基羰基)氨基)-3-(二乙氧基磷酰基)丙酸或其膦酸酯衍生物的合成方法

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US4004577A (en) 1972-12-04 1977-01-25 Survival Technology, Inc. Method of treating heart attack patients prior to the establishment of qualified direct contact personal care
JPS5373586A (en) 1976-12-09 1978-06-30 Mitsubishi Chem Ind Ltd New penicillin derivatives
US5078680A (en) 1984-08-08 1992-01-07 Survival Technology, Inc. Automatic injector for emergency treatment
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US4658830A (en) 1984-08-08 1987-04-21 Survival Technology, Inc. Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms
GR861289B (en) 1985-05-20 1986-09-16 Survival Technology Injection method and apparatus with electrical blood absorbing stimulation
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US6861424B2 (en) 2001-06-06 2005-03-01 Schering Aktiengesellschaft Platelet adenosine diphosphate receptor antagonists
CN1747732A (zh) 2002-12-11 2006-03-15 舍林股份公司 作为血小板腺苷二磷酸受体拮抗剂的2－氨基羰基喹啉化合物
WO2004092189A1 (en) 2003-04-09 2004-10-28 Wyeth Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists
WO2005002574A1 (en) 2003-06-24 2005-01-13 Actelion Pharmaceuticals Ltd Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors
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JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
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期刊 EVA CAROFF et al.;"4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester(ACT-246475) and Its Prodrug (ACT-281959),a Novel P2Y 12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel";JOURNAL OF MEDICINAL CHEMISTRY, vol.58, no.23, 2015-12-10, pages 9133-9153 .; *
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Also Published As

Publication number Publication date
CL2019002318A1 (es) 2020-01-10
JP2020510043A (ja) 2020-04-02
US20200129510A1 (en) 2020-04-30
JP2023052576A (ja) 2023-04-11
IL269286B2 (en) 2023-08-01
MA49887A (fr) 2020-06-24
IL269286A (en) 2019-11-28
MX2019009559A (es) 2019-10-15
KR20190124297A (ko) 2019-11-04
WO2018167139A1 (en) 2018-09-20
JP2025060907A (ja) 2025-04-10
MX393334B (es) 2025-03-24
MY205605A (en) 2024-10-29
IL269286B1 (en) 2023-04-01
SG11201908128YA (en) 2019-10-30
UA125531C2 (uk) 2022-04-13
AU2018234056A1 (en) 2019-10-31
TW201840323A (zh) 2018-11-16
NZ757938A (en) 2024-07-05
EP3595666A1 (en) 2020-01-22
BR112019014567A2 (pt) 2020-02-18
JP7580918B2 (ja) 2024-11-12
AU2018234056B2 (en) 2023-05-25
PH12019502111A1 (en) 2020-03-16
CA3050831A1 (en) 2018-09-20
CN110381947A (zh) 2019-10-25
JP7902762B2 (ja) 2026-08-10
KR102510832B1 (ko) 2023-03-15
EA201992123A1 (ru) 2020-02-25
US11179390B2 (en) 2021-11-23

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