TWI765002B - 受體拮抗劑之皮下投藥 - Google Patents
受體拮抗劑之皮下投藥 Download PDFInfo
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- TWI765002B TWI765002B TW107108546A TW107108546A TWI765002B TW I765002 B TWI765002 B TW I765002B TW 107108546 A TW107108546 A TW 107108546A TW 107108546 A TW107108546 A TW 107108546A TW I765002 B TWI765002 B TW I765002B
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- administered
- receptor antagonist
- patient
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- pharmaceutically acceptable
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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| MX381590B (es) | 2016-09-22 | 2025-03-12 | Idorsia Pharmaceuticals Ltd | Una forma cristalina de clorhidrato de éster butílico del ácido 4-((r)-2-{[6-((s)-3-metoxi-pirrolidina-1-il)-2-fenil-pirimidina-4-carbonil]-amino}-3-fosfonopropionil)-piperazin-1-carboxílico. |
| KR20230041732A (ko) | 2020-07-15 | 2023-03-24 | 이도르시아 파마슈티컬스 리미티드 | P2y12 수용체 안타고니스트를 포함하는 수성 약제학적 조성물 |
| KR20240033005A (ko) | 2021-07-13 | 2024-03-12 | 이도르시아 파마슈티컬스 리미티드 | 4-((r)-2-｛[6-((s)-3-메톡시-피롤리딘-1-일)-2-페닐-피리미딘-4-카르보닐]-아미노｝-3-포스포노-프로피오닐)-피페라진-1-카르복실산부틸 에스테르의 합성 방법 |
| WO2023174810A1 (en) | 2022-03-14 | 2023-09-21 | Idorsia Pharmaceuticals Ltd | A process for the synthesis of ( r)-2-(( tert-butoxycarbonyl)amino)-3-(diethoxyphosphoryl)propanoic acid or of phosphonate derivatives thereof |
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| US3870035A (en) | 1970-07-17 | 1975-03-11 | Survival Technology | Method and apparatus for self-administering pre-hospital phase treatment of coronary prone individuals in the early minutes or hours after the onset of heart attack symptoms |
| US4004577A (en) | 1972-12-04 | 1977-01-25 | Survival Technology, Inc. | Method of treating heart attack patients prior to the establishment of qualified direct contact personal care |
| JPS5373586A (en) | 1976-12-09 | 1978-06-30 | Mitsubishi Chem Ind Ltd | New penicillin derivatives |
| US5078680A (en) | 1984-08-08 | 1992-01-07 | Survival Technology, Inc. | Automatic injector for emergency treatment |
| US4795433A (en) | 1985-05-20 | 1989-01-03 | Survival Technology, Inc. | Automatic injector for emergency treatment |
| US4658830A (en) | 1984-08-08 | 1987-04-21 | Survival Technology, Inc. | Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms |
| GR861289B (en) | 1985-05-20 | 1986-09-16 | Survival Technology | Injection method and apparatus with electrical blood absorbing stimulation |
| CA2020437A1 (en) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Cinnamamide derivative |
| JP2003502314A (ja) | 1999-06-14 | 2003-01-21 | イーライ・リリー・アンド・カンパニー | 化合物 |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| MXPA05006302A (es) | 2002-12-11 | 2005-08-29 | Schering Ag | Compuestos de 2-aminocarbonilquinolina como antagonistas de receptor de difosfato de adenosina plaquetario. |
| MXPA05010760A (es) | 2003-04-09 | 2005-12-12 | Wyeth Corp | Derivados de acido 2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)alquil fosfonico y su uso como antagonistas de receptor de n-metil-d-aspartato (nmda). |
| AU2003249865A1 (en) | 2003-06-24 | 2005-01-21 | Actelion Pharmaceuticals Ltd | Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors |
| TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| MY147373A (en) | 2005-10-21 | 2012-11-30 | Actelion Pharmaceuticals Ltd | Piperazine derivatives as antimalarial agents |
| AR063258A1 (es) | 2006-10-13 | 2009-01-14 | Actelion Pharmaceuticals Ltd | Derivados de 2-aminocarbonil-piridina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de trastornos vasculares oclusivos. |
| CL2007003038A1 (es) | 2006-10-25 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos. |
| JP4785881B2 (ja) | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| AU2008241091B2 (en) | 2007-04-23 | 2013-05-09 | Sanofi-Aventis | Quinoline-carboxamide derivatives as P2Y12 antagonists |
| BRPI0811476A2 (pt) | 2007-05-02 | 2014-11-04 | Portola Pharm Inc | Dosagem intravenosa e oral de um inibidor de p2y12 de ação direta e reversível |
| AU2008331163B2 (en) | 2007-11-29 | 2014-01-30 | Viatris Asia Pacific Pte. Ltd. | Phosphonic acid derivates and their use as P2Y12 receptor antagonists |
| EP2238127B1 (en) | 2007-12-26 | 2012-08-15 | Sanofi | Pyrazole-carboxamide derivatives as p2y12 antagonists |
| EP2238128B1 (en) | 2007-12-26 | 2012-08-22 | Sanofi | Heterocyclic pyrazole-carboxamides as p2y12 antagonists |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| JP5536873B2 (ja) | 2009-04-08 | 2014-07-02 | アクテリオン ファーマシューティカルズ リミテッド | ６−（３−アザ−ビシクロ［３．１．０］ヘクス−３−イル）−２−フェニル−ピリミジン（６−（３−ａｚａ−ｂｉｃｙｃｌｏ［３．１．０］ｈｅｘ−３−ｙｌ）−２−ｐｈｅｎｙｌ−ｐｙｒｉｍｉｄｉｎｅｓ） |
| CN102405220B (zh) | 2009-04-22 | 2015-05-27 | 埃科特莱茵药品有限公司 | 噻唑衍生物及其作为p2y12受体拮抗剂的用途 |
| WO2011137459A1 (en) | 2010-04-30 | 2011-11-03 | Portola Pharmaceuticals, Inc. | Dosage forms of elinogrel and methods of injectable administration thereof |
| WO2011160768A1 (en) | 2010-06-23 | 2011-12-29 | Stefan Kralev | Medical device for self-administration of patients with acute coronary events |
| MX381590B (es) | 2016-09-22 | 2025-03-12 | Idorsia Pharmaceuticals Ltd | Una forma cristalina de clorhidrato de éster butílico del ácido 4-((r)-2-{[6-((s)-3-metoxi-pirrolidina-1-il)-2-fenil-pirimidina-4-carbonil]-amino}-3-fosfonopropionil)-piperazin-1-carboxílico. |
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- 2018-03-14 EA EA201992123A patent/EA201992123A1/ru unknown
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2019
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2023
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2024
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Non-Patent Citations (2)
| Title |
|---|
| 期刊 EVA CAROFF et al.;"4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester(ACT-246475) and Its Prodrug (ACT-281959),a Novel P2Y 12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel";JOURNAL OF MEDICINAL CHEMISTRY, vol.58, no.23, 2015-12-10, pages 9133-9153 .; * |
| 期刊 PEER TFELT-HANSEN;Parenteral vs. oral sumatriptan and naratriptan:plasma levels and efficacy in migraine.A comment,THE JOURNAL OF HEADACHE AND PAIN, vol.8, no.5, 2007-10-23, pages 273-276 . * |
Also Published As
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| IL269286A (en) | 2019-11-28 |
| AU2018234056B2 (en) | 2023-05-25 |
| JP2023052576A (ja) | 2023-04-11 |
| CA3050831A1 (en) | 2018-09-20 |
| MY205605A (en) | 2024-10-29 |
| IL269286B2 (en) | 2023-08-01 |
| JP7580918B2 (ja) | 2024-11-12 |
| US11179390B2 (en) | 2021-11-23 |
| US20200129510A1 (en) | 2020-04-30 |
| AU2018234056A1 (en) | 2019-10-31 |
| BR112019014567A2 (pt) | 2020-02-18 |
| JP2020510043A (ja) | 2020-04-02 |
| KR102510832B1 (ko) | 2023-03-15 |
| EA201992123A1 (ru) | 2020-02-25 |
| NZ757938A (en) | 2024-07-05 |
| MA49887A (fr) | 2020-06-24 |
| TW201840323A (zh) | 2018-11-16 |
| IL269286B1 (en) | 2023-04-01 |
| CL2019002318A1 (es) | 2020-01-10 |
| MX2019009559A (es) | 2019-10-15 |
| PH12019502111A1 (en) | 2020-03-16 |
| EP3595666A1 (en) | 2020-01-22 |
| SG11201908128YA (en) | 2019-10-30 |
| KR20190124297A (ko) | 2019-11-04 |
| CN110381947A (zh) | 2019-10-25 |
| UA125531C2 (uk) | 2022-04-13 |
| WO2018167139A1 (en) | 2018-09-20 |
| JP2025060907A (ja) | 2025-04-10 |
| MX393334B (es) | 2025-03-24 |
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