JP7580918B2 - Ｐ２ｙ１２受容体アンタゴニストの皮下投与 - Google Patents

Ｐ２ｙ１２受容体アンタゴニストの皮下投与 Download PDF

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Publication number
JP7580918B2
JP7580918B2 JP2019549420A JP2019549420A JP7580918B2 JP 7580918 B2 JP7580918 B2 JP 7580918B2 JP 2019549420 A JP2019549420 A JP 2019549420A JP 2019549420 A JP2019549420 A JP 2019549420A JP 7580918 B2 JP7580918 B2 JP 7580918B2
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receptor antagonist
administered
pharma
acceptable salt
ceutically acceptable
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JP2020510043A (ja
JP2020510043A5 (enExample
Inventor
バウマン マルティーヌ
クラムベルク マルクス
レイ マルクス
リーダラー マルクス
ルー セバスチャン
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Idorsia Pharmaceuticals Ltd
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Idorsia Pharmaceuticals Ltd
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Priority to JP2023008155A priority Critical patent/JP7902762B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019549420A 2017-03-15 2018-03-14 Ｐ２ｙ１２受容体アンタゴニストの皮下投与 Active JP7580918B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023008155A JP7902762B2 (ja) 2017-03-15 2023-01-23 Ｐ２ｙ１２受容体アンタゴニストの皮下投与
JP2024230902A JP7906844B2 (ja) 2017-03-15 2024-12-26 Ｐ２ｙ１２受容体アンタゴニストの皮下投与

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2017056175 2017-03-15
EPPCT/EP2017/056175 2017-03-15
PCT/EP2018/056372 WO2018167139A1 (en) 2017-03-15 2018-03-14 Subcutaneous administration of a p2y12 receptor antagonist

Related Child Applications (1)

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JP2023008155A Division JP7902762B2 (ja) 2017-03-15 2023-01-23 Ｐ２ｙ１２受容体アンタゴニストの皮下投与

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JP2020510043A JP2020510043A (ja) 2020-04-02
JP2020510043A5 JP2020510043A5 (enExample) 2021-04-22
JP7580918B2 true JP7580918B2 (ja) 2024-11-12

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JP2019549420A Active JP7580918B2 (ja) 2017-03-15 2018-03-14 Ｐ２ｙ１２受容体アンタゴニストの皮下投与
JP2023008155A Active JP7902762B2 (ja) 2017-03-15 2023-01-23 Ｐ２ｙ１２受容体アンタゴニストの皮下投与

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Country Link
US (1) US11179390B2 (enExample)
EP (1) EP3595666A1 (enExample)
JP (2) JP7580918B2 (enExample)
KR (1) KR102510832B1 (enExample)
CN (1) CN110381947A (enExample)
AU (1) AU2018234056B2 (enExample)
BR (1) BR112019014567A2 (enExample)
CL (1) CL2019002318A1 (enExample)
EA (1) EA201992123A1 (enExample)
IL (1) IL269286B2 (enExample)
MA (1) MA49887A (enExample)
MX (1) MX393334B (enExample)
MY (1) MY205605A (enExample)
PH (1) PH12019502111A1 (enExample)
SG (1) SG11201908128YA (enExample)
TW (1) TWI765002B (enExample)
UA (1) UA125531C2 (enExample)
WO (1) WO2018167139A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025060907A (ja) * 2017-03-15 2025-04-10 イドルシア・ファーマシューティカルズ・リミテッド Ｐ２ｙ１２受容体アンタゴニストの皮下投与
JP7906844B2 (ja) 2017-03-15 2026-08-18 イドルシア・ファーマシューティカルズ・リミテッド Ｐ２ｙ１２受容体アンタゴニストの皮下投与

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109715639B (zh) 2016-09-22 2022-04-19 爱杜西亚药品有限公司 结晶形式
TWI905227B (zh) * 2020-07-15 2025-11-21 新加坡商暉致亞太私人有限公司 包含p2y12受體拮抗劑的水性醫藥組合物
CA3223733A1 (en) 2021-07-13 2023-01-19 Nicole Blumer A process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl- pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1 -carboxylic acid butyl ester
CN118871446A (zh) 2022-03-14 2024-10-29 晖致亚太私人有限公司 (r)-2-((叔丁氧基羰基)氨基)-3-(二乙氧基磷酰基)丙酸或其膦酸酯衍生物的合成方法

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WO2011137459A1 (en) 2010-04-30 2011-11-03 Portola Pharmaceuticals, Inc. Dosage forms of elinogrel and methods of injectable administration thereof

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WO2011137459A1 (en) 2010-04-30 2011-11-03 Portola Pharmaceuticals, Inc. Dosage forms of elinogrel and methods of injectable administration thereof

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Ｃｌｉｎ Ｄｒｕｇ Ｉｎｖｅｓｔｉｇ，２０１４年，Ｖｏｌ．３４，ｐ．８０７－８１８
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，２０１５年，Ｖｏｌ．５８，ｐ．９１３３－９１５３

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025060907A (ja) * 2017-03-15 2025-04-10 イドルシア・ファーマシューティカルズ・リミテッド Ｐ２ｙ１２受容体アンタゴニストの皮下投与
JP7906844B2 (ja) 2017-03-15 2026-08-18 イドルシア・ファーマシューティカルズ・リミテッド Ｐ２ｙ１２受容体アンタゴニストの皮下投与

Also Published As

Publication number Publication date
CL2019002318A1 (es) 2020-01-10
JP2020510043A (ja) 2020-04-02
US20200129510A1 (en) 2020-04-30
JP2023052576A (ja) 2023-04-11
IL269286B2 (en) 2023-08-01
MA49887A (fr) 2020-06-24
IL269286A (en) 2019-11-28
MX2019009559A (es) 2019-10-15
KR20190124297A (ko) 2019-11-04
WO2018167139A1 (en) 2018-09-20
JP2025060907A (ja) 2025-04-10
MX393334B (es) 2025-03-24
MY205605A (en) 2024-10-29
IL269286B1 (en) 2023-04-01
SG11201908128YA (en) 2019-10-30
UA125531C2 (uk) 2022-04-13
AU2018234056A1 (en) 2019-10-31
TW201840323A (zh) 2018-11-16
NZ757938A (en) 2024-07-05
EP3595666A1 (en) 2020-01-22
BR112019014567A2 (pt) 2020-02-18
AU2018234056B2 (en) 2023-05-25
TWI765002B (zh) 2022-05-21
PH12019502111A1 (en) 2020-03-16
CA3050831A1 (en) 2018-09-20
CN110381947A (zh) 2019-10-25
JP7902762B2 (ja) 2026-08-10
KR102510832B1 (ko) 2023-03-15
EA201992123A1 (ru) 2020-02-25
US11179390B2 (en) 2021-11-23

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