TWI725442B - 包含西洛他唑及他汀衍生物的醫藥組合物 - Google Patents

包含西洛他唑及他汀衍生物的醫藥組合物 Download PDF

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Publication number
TWI725442B
TWI725442B TW108119051A TW108119051A TWI725442B TW I725442 B TWI725442 B TW I725442B TW 108119051 A TW108119051 A TW 108119051A TW 108119051 A TW108119051 A TW 108119051A TW I725442 B TWI725442 B TW I725442B
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TW
Taiwan
Prior art keywords
cilostazol
release
sustained
active ingredient
hmg
Prior art date
Application number
TW108119051A
Other languages
English (en)
Chinese (zh)
Other versions
TW202015662A (zh
Inventor
崔然雄
張宰常
李南松
全亨濬
Original Assignee
南韓商韓國聯合製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 南韓商韓國聯合製藥股份有限公司 filed Critical 南韓商韓國聯合製藥股份有限公司
Publication of TW202015662A publication Critical patent/TW202015662A/zh
Application granted granted Critical
Publication of TWI725442B publication Critical patent/TWI725442B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
TW108119051A 2018-06-19 2019-05-31 包含西洛他唑及他汀衍生物的醫藥組合物 TWI725442B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020180069955A KR102145853B1 (ko) 2018-06-19 2018-06-19 실로스타졸과 스타틴계약물을 함유하는 약학 조성물
KR10-2018-0069955 2018-06-19

Publications (2)

Publication Number Publication Date
TW202015662A TW202015662A (zh) 2020-05-01
TWI725442B true TWI725442B (zh) 2021-04-21

Family

ID=68982887

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108119051A TWI725442B (zh) 2018-06-19 2019-05-31 包含西洛他唑及他汀衍生物的醫藥組合物

Country Status (3)

Country Link
KR (1) KR102145853B1 (fr)
TW (1) TWI725442B (fr)
WO (1) WO2019245150A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114533690B (zh) * 2022-03-22 2023-03-21 许昌市中心医院 含抗凝血药物西洛他唑的新制剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102548544A (zh) * 2009-10-09 2012-07-04 永进药品工业株式会社 同时具有速效特性和长效特性的药物组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
KR20090114333A (ko) * 2008-04-29 2009-11-03 한올제약주식회사 약제학적 제제
KR101008540B1 (ko) 2008-09-02 2011-01-14 한국유나이티드제약 주식회사 용출률 향상과 부작용 발현이 최소화된 실로스타졸 서방정
KR20160129122A (ko) * 2015-04-29 2016-11-09 가톨릭대학교 산학협력단 실로스타졸 및 로수바스타틴을 유효성분으로 함유하는 신장질환 예방 또는 치료용 약학조성물
KR101869406B1 (ko) * 2015-11-25 2018-07-24 한국유나이티드제약 주식회사 방출제어형 경질캡슐 제제

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102548544A (zh) * 2009-10-09 2012-07-04 永进药品工业株式会社 同时具有速效特性和长效特性的药物组合物

Also Published As

Publication number Publication date
WO2019245150A1 (fr) 2019-12-26
KR20190142809A (ko) 2019-12-30
KR102145853B1 (ko) 2020-08-19
TW202015662A (zh) 2020-05-01

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