TWI720272B - 雜芳基苯氧基苯甲醯胺kappa類鴉片配體 - Google Patents

雜芳基苯氧基苯甲醯胺kappa類鴉片配體 Download PDF

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Publication number
TWI720272B
TWI720272B TW106141134A TW106141134A TWI720272B TW I720272 B TWI720272 B TW I720272B TW 106141134 A TW106141134 A TW 106141134A TW 106141134 A TW106141134 A TW 106141134A TW I720272 B TWI720272 B TW I720272B
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Taiwan
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methyl
compound
pyrazol
phenoxy
pyrrolidin
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TW106141134A
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Chinese (zh)
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TW201831460A (zh
Inventor
卡匹代夫 卡續米里拉 阿羅拉
馬修 法蘭西斯 杜恩
麥可 艾倫 布羅德尼
麥可 艾瑞克 格林
娜塔莎 瑪莉業姆 卡布拉奧依
貴戈里 韋恩 考夫曼
史考特 理查 曼特
賈斯汀 伊恩 蒙歌瑪利
丹妮卡 安東尼雅 藍奇
布魯斯 尼爾森 羅傑斯
派崔克 羅伯特 維哈斯特
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美商輝瑞大藥廠
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW106141134A 2016-11-28 2017-11-27 雜芳基苯氧基苯甲醯胺kappa類鴉片配體 TWI720272B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662426980P 2016-11-28 2016-11-28
US62/426,980 2016-11-28
US201762576435P 2017-10-24 2017-10-24
US62/576,435 2017-10-24
US201762585016P 2017-11-13 2017-11-13
US62/585,016 2017-11-13

Publications (2)

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TW201831460A TW201831460A (zh) 2018-09-01
TWI720272B true TWI720272B (zh) 2021-03-01

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US (1) US10316021B2 (enExample)
EP (1) EP3544972B8 (enExample)
JP (1) JP7051853B2 (enExample)
CN (1) CN110234638B (enExample)
AU (1) AU2017365123B2 (enExample)
DK (1) DK3544972T3 (enExample)
ES (1) ES2947293T3 (enExample)
FI (1) FI3544972T3 (enExample)
HR (1) HRP20230518T1 (enExample)
HU (1) HUE061945T2 (enExample)
IL (1) IL266962B (enExample)
MX (1) MX389806B (enExample)
PH (1) PH12019501172A1 (enExample)
PL (1) PL3544972T3 (enExample)
PT (1) PT3544972T (enExample)
RS (1) RS64258B1 (enExample)
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WO2018154118A2 (en) * 2017-02-24 2018-08-30 Reinmueller Viktoria Novel aromatic compounds
EP3585485A2 (en) * 2017-02-24 2020-01-01 Xeniopro GmbH Aromatic compounds which enhance notch signaling, for use in therapy
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
CN111233768B (zh) * 2020-03-18 2021-08-03 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法
PH12021552872A1 (en) * 2020-04-05 2022-03-21 Pfizer Compounds and methods for the treatment of covid-19
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
PE20242109A1 (es) * 2022-03-07 2024-10-28 Janssen Pharmaceuticals Inc Formas puras de aticaprant cristalino
CA3254546A1 (en) 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. COMPOSITIONS CONTAINING ATICAPRANT
WO2023170550A1 (en) 2022-03-07 2023-09-14 Janssen Pharmaceuticals, Inc. Polymorph forms of aticaprant for use in treating major depressive disorder
WO2024079733A1 (en) * 2022-10-12 2024-04-18 Adama Makhteshim Ltd. Process for the preparation of aminopyridazine derivatives

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PH12019501172A1 (en) 2019-12-11
WO2018096510A1 (en) 2018-05-31
AU2017365123A1 (en) 2019-07-11
NZ754862A (en) 2024-11-29
TW201831460A (zh) 2018-09-01
HRP20230518T1 (hr) 2023-08-04
US10316021B2 (en) 2019-06-11
MX2019006220A (es) 2019-10-07
PT3544972T (pt) 2023-06-20
JP7051853B2 (ja) 2022-04-11
HUE061945T2 (hu) 2023-09-28
DK3544972T3 (da) 2023-05-30
CN110234638B (zh) 2022-10-21
MX389806B (es) 2025-03-20
EP3544972B8 (en) 2023-06-07
EP3544972A1 (en) 2019-10-02
CN110234638A (zh) 2019-09-13
US20180148432A1 (en) 2018-05-31
CA3045242A1 (en) 2018-05-31
AU2017365123B2 (en) 2022-02-17
IL266962B (en) 2022-02-01
JP2019535799A (ja) 2019-12-12
ES2947293T3 (es) 2023-08-04
RS64258B1 (sr) 2023-07-31
EP3544972B1 (en) 2023-04-26
PL3544972T3 (pl) 2023-07-24
FI3544972T3 (fi) 2023-06-02
IL266962A (en) 2019-07-31

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