CN110234638B - 杂芳基苯氧基苯甲酰胺kappa阿片类配体 - Google Patents

杂芳基苯氧基苯甲酰胺kappa阿片类配体 Download PDF

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Publication number
CN110234638B
CN110234638B CN201780084763.0A CN201780084763A CN110234638B CN 110234638 B CN110234638 B CN 110234638B CN 201780084763 A CN201780084763 A CN 201780084763A CN 110234638 B CN110234638 B CN 110234638B
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methyl
pyrazol
pyrrolidin
phenoxy
benzamide
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Chinese (zh)
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CN110234638A (zh
Inventor
K·K·阿罗拉
M·A·布罗德尼
M·F·邓恩
M·E·格林
N·M·卡布劳乌伊
G·W·考夫曼
S·R·门特
J·I·蒙哥马利
D·A·兰基奇
B·N·罗杰斯
P·R·费尔赫斯特
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Pfizer Corp SRL
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Pfizer Corp SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201780084763.0A 2016-11-28 2017-11-27 杂芳基苯氧基苯甲酰胺kappa阿片类配体 Active CN110234638B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426980P 2016-11-28 2016-11-28
US62/426,980 2016-11-28
US201762576435P 2017-10-24 2017-10-24
US62/576,435 2017-10-24
US201762585016P 2017-11-13 2017-11-13
US62/585,016 2017-11-13
PCT/IB2017/057418 WO2018096510A1 (en) 2016-11-28 2017-11-27 Heteroarylphenoxy benzamide kappa opioid ligands

Publications (2)

Publication Number Publication Date
CN110234638A CN110234638A (zh) 2019-09-13
CN110234638B true CN110234638B (zh) 2022-10-21

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US (1) US10316021B2 (enExample)
EP (1) EP3544972B8 (enExample)
JP (1) JP7051853B2 (enExample)
CN (1) CN110234638B (enExample)
AU (1) AU2017365123B2 (enExample)
DK (1) DK3544972T3 (enExample)
ES (1) ES2947293T3 (enExample)
FI (1) FI3544972T3 (enExample)
HR (1) HRP20230518T1 (enExample)
HU (1) HUE061945T2 (enExample)
IL (1) IL266962B (enExample)
MX (1) MX389806B (enExample)
PH (1) PH12019501172A1 (enExample)
PL (1) PL3544972T3 (enExample)
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WO2018154118A2 (en) * 2017-02-24 2018-08-30 Reinmueller Viktoria Novel aromatic compounds
US11591289B2 (en) 2017-02-24 2023-02-28 Xeniopro GmbH Aromatic compounds
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
CN111233768B (zh) * 2020-03-18 2021-08-03 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法
TWI807291B (zh) * 2020-04-05 2023-07-01 美商輝瑞大藥廠 用於治療covid-19之化合物及方法
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
IL315415A (en) 2022-03-07 2024-11-01 Janssen Pharmaceuticals Inc The compositions containing eticarpant
KR20240156409A (ko) * 2022-03-07 2024-10-29 얀센 파마슈티칼즈, 인코포레이티드 주요 우울 장애 치료에 사용을 위한 아티카프란트의 다형 형태
IL315411A (en) * 2022-03-07 2024-11-01 Janssen Pharmaceuticals Inc Pure forms of crystalline eticarpant
PE20251585A1 (es) * 2022-10-12 2025-06-16 Adama Makhteshim Ltd Proceso para la preparacion de derivados de aminopiridazina

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US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
WO2000017162A1 (en) * 1998-09-21 2000-03-30 Takeda Chemical Industries, Ltd. Novel thiol derivatives, process for producing the same and utilization thereof
JP2000159747A (ja) 1998-09-21 2000-06-13 Takeda Chem Ind Ltd 新規チオ―ル誘導体、その製造法および用途
IT1303737B1 (it) 1998-11-11 2001-02-23 Smithkline Beecham Spa Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1.
SI2208727T1 (sl) 2002-09-19 2012-11-30 Lilly Co Eli Diaril etri kot antagonisti opioidnega receptorja
US7365209B2 (en) 2003-02-11 2008-04-29 Pharmacopeia, Inc. Nitrogen heterocycle biaryls for osteoporosis and other diseases
CN1753884A (zh) 2003-03-07 2006-03-29 伊莱利利公司 阿片类受体拮抗剂
JP4736043B2 (ja) 2003-03-14 2011-07-27 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
CA2573223C (en) 2004-08-06 2013-05-21 Otsuka Pharmaceutical Co., Ltd. Aromatic compound
CN101120055B (zh) 2005-02-18 2014-07-23 日本曹达株式会社 有机无机复合体
JPWO2007105637A1 (ja) 2006-03-10 2009-07-30 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
PL2001456T3 (pl) 2006-04-04 2010-05-31 Emodys Gmbh Zastosowanie kompozycji zawierających antagonistę receptora opioidowego kappa do leczenia zaburzeń dysocjacyjnych
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AU2017365123A1 (en) 2019-07-11
HRP20230518T1 (hr) 2023-08-04
JP2019535799A (ja) 2019-12-12
US20180148432A1 (en) 2018-05-31
AU2017365123B2 (en) 2022-02-17
PH12019501172A1 (en) 2019-12-11
MX2019006220A (es) 2019-10-07
IL266962A (en) 2019-07-31
CA3045242A1 (en) 2018-05-31
US10316021B2 (en) 2019-06-11
WO2018096510A1 (en) 2018-05-31
EP3544972B8 (en) 2023-06-07
TW201831460A (zh) 2018-09-01
CN110234638A (zh) 2019-09-13
JP7051853B2 (ja) 2022-04-11
DK3544972T3 (da) 2023-05-30
ES2947293T3 (es) 2023-08-04
NZ754862A (en) 2024-11-29
PT3544972T (pt) 2023-06-20
IL266962B (en) 2022-02-01
TWI720272B (zh) 2021-03-01
PL3544972T3 (pl) 2023-07-24
RS64258B1 (sr) 2023-07-31
HUE061945T2 (hu) 2023-09-28
EP3544972B1 (en) 2023-04-26
FI3544972T3 (fi) 2023-06-02
MX389806B (es) 2025-03-20
EP3544972A1 (en) 2019-10-02

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