JP7051853B2 - ヘテロアリールフェノキシベンズアミドカッパオピオイドリガンド - Google Patents

ヘテロアリールフェノキシベンズアミドカッパオピオイドリガンド Download PDF

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JP7051853B2
JP7051853B2 JP2019528746A JP2019528746A JP7051853B2 JP 7051853 B2 JP7051853 B2 JP 7051853B2 JP 2019528746 A JP2019528746 A JP 2019528746A JP 2019528746 A JP2019528746 A JP 2019528746A JP 7051853 B2 JP7051853 B2 JP 7051853B2
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methyl
pyrazole
phenoxy
pyrrolidine
benzamide
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JP2019535799A (ja
JP2019535799A5 (enExample
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アローラ，カピルデブ・カシュミライラル
ブロドニー，マイケル・アーロン
ダン，マシュー・フランシス
グリーン，マイケル・エリック
カブラオイ，ナターシャ・マリアム
カーフマン，グレゴリー・ウェイン
メンテ，スコット・リチャード
モンゴメリー，ジャスティン・イアン
ランキック，ダニカ，アントニア
ロジャース，ブルース・ネルセン
バーホースト，パトリック・ロバート
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ファイザー・インク
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019528746A 2016-11-28 2017-11-27 ヘテロアリールフェノキシベンズアミドカッパオピオイドリガンド Active JP7051853B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426980P 2016-11-28 2016-11-28
US62/426,980 2016-11-28
US201762576435P 2017-10-24 2017-10-24
US62/576,435 2017-10-24
US201762585016P 2017-11-13 2017-11-13
US62/585,016 2017-11-13
PCT/IB2017/057418 WO2018096510A1 (en) 2016-11-28 2017-11-27 Heteroarylphenoxy benzamide kappa opioid ligands

Publications (3)

Publication Number Publication Date
JP2019535799A JP2019535799A (ja) 2019-12-12
JP2019535799A5 JP2019535799A5 (enExample) 2021-01-14
JP7051853B2 true JP7051853B2 (ja) 2022-04-11

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JP2019528746A Active JP7051853B2 (ja) 2016-11-28 2017-11-27 ヘテロアリールフェノキシベンズアミドカッパオピオイドリガンド

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Country Link
US (1) US10316021B2 (enExample)
EP (1) EP3544972B8 (enExample)
JP (1) JP7051853B2 (enExample)
CN (1) CN110234638B (enExample)
AU (1) AU2017365123B2 (enExample)
DK (1) DK3544972T3 (enExample)
ES (1) ES2947293T3 (enExample)
FI (1) FI3544972T3 (enExample)
HR (1) HRP20230518T1 (enExample)
HU (1) HUE061945T2 (enExample)
IL (1) IL266962B (enExample)
MX (1) MX389806B (enExample)
PH (1) PH12019501172A1 (enExample)
PL (1) PL3544972T3 (enExample)
PT (1) PT3544972T (enExample)
RS (1) RS64258B1 (enExample)
TW (1) TWI720272B (enExample)
WO (1) WO2018096510A1 (enExample)

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WO2018154118A2 (en) * 2017-02-24 2018-08-30 Reinmueller Viktoria Novel aromatic compounds
AU2018223177B2 (en) * 2017-02-24 2024-05-02 Xeniopro GmbH Aromatic compounds which enhance notch signaling, for use in therapy
US11266627B1 (en) 2021-05-04 2022-03-08 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
CN111233768B (zh) * 2020-03-18 2021-08-03 徐州圣元化工有限公司 一种3-(二氟甲基)-1-甲基-1h-吡唑-4-羧酸乙酯的制备方法
KR20210151949A (ko) * 2020-04-05 2021-12-14 화이자 인코포레이티드 Covid-19의 치료를 위한 화합물 및 방법
US12161622B2 (en) 2021-05-04 2024-12-10 Janssen Pharmaceuticals, Inc. Compositions and methods for the treatment of depression
TW202345795A (zh) * 2022-03-07 2023-12-01 美商健生醫藥公司 純質形式之結晶型阿替卡普蘭
US11998524B2 (en) * 2022-03-07 2024-06-04 Janssen Pharmaceuticals, Inc. Forms of aticaprant
IL315415A (en) 2022-03-07 2024-11-01 Janssen Pharmaceuticals Inc The compositions containing eticarpant
AR130742A1 (es) * 2022-10-12 2025-01-15 Adama Makhteshim Ltd Proceso para la preparación de derivados de aminopiridazina

Citations (2)

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JP2000159747A (ja) 1998-09-21 2000-06-13 Takeda Chem Ind Ltd 新規チオ―ル誘導体、その製造法および用途
JP2011524850A (ja) 2008-01-22 2011-09-08 イーライ リリー アンド カンパニー κ選択的オピオイド受容体アンタゴニスト

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KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
CA2344412A1 (en) 1998-09-21 2000-03-30 Takeda Chemical Industries, Ltd. Thiol compound, their production and use
IT1303737B1 (it) 1998-11-11 2001-02-23 Smithkline Beecham Spa Derivati fenilpiperidinici procedimento per la loro preparazione eloro uso come ligandi del recettore orl-1.
SI2208727T1 (sl) 2002-09-19 2012-11-30 Lilly Co Eli Diaril etri kot antagonisti opioidnega receptorja
US7365209B2 (en) 2003-02-11 2008-04-29 Pharmacopeia, Inc. Nitrogen heterocycle biaryls for osteoporosis and other diseases
BRPI0408108A (pt) 2003-03-07 2006-03-01 Lilly Co Eli composto, composição farmacêutica, métodos para bloquear em receptor mu, kappa, delta ou uma combinação de receptores dos mesmos em um mamìfero, para tratar ou prevenir obesidade e doenças relacionadas e para suprimir apetite, e, uso de um composto
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RU2416608C2 (ru) 2004-08-06 2011-04-20 Оцука Фармасьютикал Ко., Лтд. Ароматическое соединение
CN101120055B (zh) 2005-02-18 2014-07-23 日本曹达株式会社 有机无机复合体
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WO2013059648A1 (en) 2011-10-21 2013-04-25 Neurotherapeutics Pharma, Inc. 2,3,5 trisubstituted aryl and heteroaryl amino derivatives, compositions, and methods of use
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WO2015109080A1 (en) 2014-01-15 2015-07-23 Research Triangle Institute Kappa-opioid receptor selective opioid receptor antagonists
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JP2000159747A (ja) 1998-09-21 2000-06-13 Takeda Chem Ind Ltd 新規チオ―ル誘導体、その製造法および用途
JP2011524850A (ja) 2008-01-22 2011-09-08 イーライ リリー アンド カンパニー κ選択的オピオイド受容体アンタゴニスト

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US20180148432A1 (en) 2018-05-31
US10316021B2 (en) 2019-06-11
JP2019535799A (ja) 2019-12-12
IL266962B (en) 2022-02-01
EP3544972A1 (en) 2019-10-02
WO2018096510A1 (en) 2018-05-31
ES2947293T3 (es) 2023-08-04
CA3045242A1 (en) 2018-05-31
EP3544972B8 (en) 2023-06-07
PL3544972T3 (pl) 2023-07-24
IL266962A (en) 2019-07-31
HRP20230518T1 (hr) 2023-08-04
PH12019501172A1 (en) 2019-12-11
NZ754862A (en) 2024-11-29
AU2017365123A1 (en) 2019-07-11
TW201831460A (zh) 2018-09-01
DK3544972T3 (da) 2023-05-30
EP3544972B1 (en) 2023-04-26
RS64258B1 (sr) 2023-07-31
AU2017365123B2 (en) 2022-02-17
FI3544972T3 (fi) 2023-06-02
MX389806B (es) 2025-03-20
CN110234638A (zh) 2019-09-13
CN110234638B (zh) 2022-10-21
MX2019006220A (es) 2019-10-07
HUE061945T2 (hu) 2023-09-28
PT3544972T (pt) 2023-06-20
TWI720272B (zh) 2021-03-01

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