TWI718121B - 抗甲狀腺素運送蛋白抗體 - Google Patents

抗甲狀腺素運送蛋白抗體 Download PDF

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Publication number
TWI718121B
TWI718121B TW105102534A TW105102534A TWI718121B TW I718121 B TWI718121 B TW I718121B TW 105102534 A TW105102534 A TW 105102534A TW 105102534 A TW105102534 A TW 105102534A TW I718121 B TWI718121 B TW I718121B
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Taiwan
Prior art keywords
antibody
ttr
seq
variable region
heavy chain
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TW105102534A
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English (en)
Chinese (zh)
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TW201636372A (zh
Inventor
班傑明 安德魯 雪弗
阿維吉特 查克拉波提
傑佛瑞 Ｎ 檜垣
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愛爾蘭商普羅佘納生物科技有限公司
大學健康網絡
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW105102534A 2015-01-28 2016-01-27 抗甲狀腺素運送蛋白抗體 TWI718121B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109001P 2015-01-28 2015-01-28
US62/109,001 2015-01-28
US201562266557P 2015-12-11 2015-12-11
US62/266,557 2015-12-11

Publications (2)

Publication Number Publication Date
TW201636372A TW201636372A (zh) 2016-10-16
TWI718121B true TWI718121B (zh) 2021-02-11

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
TW105102534A TWI718121B (zh) 2015-01-28 2016-01-27 抗甲狀腺素運送蛋白抗體
TW110100084A TWI781507B (zh) 2015-01-28 2016-01-27 抗甲狀腺素運送蛋白抗體

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TW110100084A TWI781507B (zh) 2015-01-28 2016-01-27 抗甲狀腺素運送蛋白抗體

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Country Link
US (1) US20160257736A1 (enExample)
EP (1) EP3250594B1 (enExample)
JP (2) JP6875280B2 (enExample)
KR (1) KR102619359B1 (enExample)
CN (1) CN107428822B (enExample)
AU (1) AU2016210887B2 (enExample)
CA (1) CA2974911A1 (enExample)
CO (1) CO2017008469A2 (enExample)
CU (1) CU24532B1 (enExample)
EA (1) EA036048B1 (enExample)
ES (1) ES2905311T3 (enExample)
MX (1) MX391789B (enExample)
MY (1) MY193674A (enExample)
PE (1) PE20180200A1 (enExample)
SA (1) SA517381991B1 (enExample)
SG (1) SG11201706125QA (enExample)
TW (2) TWI718121B (enExample)
WO (1) WO2016120809A1 (enExample)
ZA (1) ZA201705662B (enExample)

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US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
TWI718121B (zh) * 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
EP3478714A2 (en) * 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7017013B2 (ja) * 2016-07-02 2022-02-08 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
JP7016470B2 (ja) * 2016-07-02 2022-02-07 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
WO2019067875A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE
SG11202002489YA (en) 2017-10-06 2020-04-29 Prothena Biosciences Ltd Anti-transthyretin antibodies
KR102581734B1 (ko) * 2017-10-06 2023-09-22 네오토프 뉴로사이언스 리미티드 트랜스타이레틴의 검출 방법
MA51223A (fr) 2017-11-29 2020-10-07 Prothena Biosciences Ltd Formulation lyophilisée d'un anticorps monoclonal contre la transthyrétine
WO2020247452A1 (en) * 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
CN112816453B (zh) * 2021-02-09 2022-07-08 黑龙江大学 蛋白在预测药物性能上的应用
CN117603921A (zh) * 2023-11-27 2024-02-27 四川大学华西医院 一种重组腺相关病毒及轻链型淀粉样变动物模型的构建方法
CN122374011A (zh) 2023-12-15 2026-07-10 诺和诺德股份有限公司 稳定的液体制剂

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Also Published As

Publication number Publication date
EP3250594A1 (en) 2017-12-06
KR102619359B1 (ko) 2024-01-02
MX391789B (es) 2025-03-21
WO2016120809A1 (en) 2016-08-04
CN107428822B (zh) 2021-11-23
MY193674A (en) 2022-10-24
JP2018509889A (ja) 2018-04-12
AU2016210887A1 (en) 2017-08-10
CN107428822A (zh) 2017-12-01
CU24532B1 (es) 2021-07-02
ZA201705662B (en) 2018-08-29
TWI781507B (zh) 2022-10-21
CA2974911A1 (en) 2016-08-04
TW201636372A (zh) 2016-10-16
JP7219928B2 (ja) 2023-02-09
KR20170120607A (ko) 2017-10-31
ES2905311T3 (es) 2022-04-07
EA036048B1 (ru) 2020-09-18
AU2016210887B2 (en) 2021-11-04
EP3250594B1 (en) 2021-11-17
CU20170096A7 (es) 2018-03-13
PE20180200A1 (es) 2018-01-31
SG11201706125QA (en) 2017-08-30
BR112017016324A2 (pt) 2018-03-27
JP2021129562A (ja) 2021-09-09
US20160257736A1 (en) 2016-09-08
MX2017009804A (es) 2018-08-15
EA201791711A1 (ru) 2017-11-30
SA517381991B1 (ar) 2021-12-13
TW202118782A (zh) 2021-05-16
JP6875280B2 (ja) 2021-05-26
CO2017008469A2 (es) 2018-01-16

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