JP6875280B2 - 抗トランスサイレチン抗体 - Google Patents

抗トランスサイレチン抗体 Download PDF

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Publication number
JP6875280B2
JP6875280B2 JP2017540249A JP2017540249A JP6875280B2 JP 6875280 B2 JP6875280 B2 JP 6875280B2 JP 2017540249 A JP2017540249 A JP 2017540249A JP 2017540249 A JP2017540249 A JP 2017540249A JP 6875280 B2 JP6875280 B2 JP 6875280B2
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JP
Japan
Prior art keywords
ttr
antibody
antibodies
seq
heavy chain
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Active
Application number
JP2017540249A
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English (en)
Japanese (ja)
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JP2018509889A (ja
JP2018509889A5 (enExample
Inventor
エス． ニハル，ターロチャン
エス． ニハル，ターロチャン
チャクラバーティー，アビジット
エヌ． ヒガキ，ジェフェリー
エヌ． ヒガキ，ジェフェリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prothena Biosciences Ltd
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Neotope Biosciences Ltd
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Publication of JP2018509889A publication Critical patent/JP2018509889A/ja
Publication of JP2018509889A5 publication Critical patent/JP2018509889A5/ja
Priority to JP2021072547A priority Critical patent/JP7219928B2/ja
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Publication of JP6875280B2 publication Critical patent/JP6875280B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017540249A 2015-01-28 2016-01-28 抗トランスサイレチン抗体 Active JP6875280B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021072547A JP7219928B2 (ja) 2015-01-28 2021-04-22 抗トランスサイレチン抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562109001P 2015-01-28 2015-01-28
US62/109,001 2015-01-28
US201562266557P 2015-12-11 2015-12-11
US62/266,557 2015-12-11
PCT/IB2016/050414 WO2016120809A1 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021072547A Division JP7219928B2 (ja) 2015-01-28 2021-04-22 抗トランスサイレチン抗体

Publications (3)

Publication Number Publication Date
JP2018509889A JP2018509889A (ja) 2018-04-12
JP2018509889A5 JP2018509889A5 (enExample) 2019-03-07
JP6875280B2 true JP6875280B2 (ja) 2021-05-26

Family

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Family Applications (2)

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JP2017540249A Active JP6875280B2 (ja) 2015-01-28 2016-01-28 抗トランスサイレチン抗体
JP2021072547A Active JP7219928B2 (ja) 2015-01-28 2021-04-22 抗トランスサイレチン抗体

Family Applications After (1)

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JP2021072547A Active JP7219928B2 (ja) 2015-01-28 2021-04-22 抗トランスサイレチン抗体

Country Status (19)

Country Link
US (1) US20160257736A1 (enExample)
EP (1) EP3250594B1 (enExample)
JP (2) JP6875280B2 (enExample)
KR (1) KR102619359B1 (enExample)
CN (1) CN107428822B (enExample)
AU (1) AU2016210887B2 (enExample)
CA (1) CA2974911A1 (enExample)
CO (1) CO2017008469A2 (enExample)
CU (1) CU24532B1 (enExample)
EA (1) EA036048B1 (enExample)
ES (1) ES2905311T3 (enExample)
MX (1) MX391789B (enExample)
MY (1) MY193674A (enExample)
PE (1) PE20180200A1 (enExample)
SA (1) SA517381991B1 (enExample)
SG (1) SG11201706125QA (enExample)
TW (2) TWI718121B (enExample)
WO (1) WO2016120809A1 (enExample)
ZA (1) ZA201705662B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021129562A (ja) * 2015-01-28 2021-09-09 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体

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US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7016470B2 (ja) * 2016-07-02 2022-02-07 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
WO2018007922A2 (en) * 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
WO2018007924A2 (en) * 2016-07-02 2018-01-11 Prothena Biosciences Limited Anti-transthyretin antibodies
US20190098879A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. Non-Human Animals Comprising A Humanized TTR Locus And Methods Of Use
AU2018345807B2 (en) * 2017-10-06 2025-02-06 Novo Nordisk A/S Methods of detecting transthyretin
CU24731B1 (es) 2017-10-06 2025-01-15 Prothena Biosciences Ltd Anticuerpos anti-transtiretina
PE20211453A1 (es) 2017-11-29 2021-08-05 Prothena Biosciences Ltd Formulacion liofilizada de un anticuerpo monoclonal contra transtirretina
US11891618B2 (en) 2019-06-04 2024-02-06 Regeneron Pharmaceuticals, Inc. Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
CN112816453B (zh) * 2021-02-09 2022-07-08 黑龙江大学 蛋白在预测药物性能上的应用
AR134700A1 (es) 2023-12-15 2026-03-04 Novo Nordisk As Formulaciones líquidas estables

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021129562A (ja) * 2015-01-28 2021-09-09 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
JP7219928B2 (ja) 2015-01-28 2023-02-09 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体

Also Published As

Publication number Publication date
CN107428822B (zh) 2021-11-23
AU2016210887B2 (en) 2021-11-04
CU20170096A7 (es) 2018-03-13
KR20170120607A (ko) 2017-10-31
EA201791711A1 (ru) 2017-11-30
WO2016120809A1 (en) 2016-08-04
EP3250594A1 (en) 2017-12-06
CA2974911A1 (en) 2016-08-04
TWI781507B (zh) 2022-10-21
ES2905311T3 (es) 2022-04-07
US20160257736A1 (en) 2016-09-08
CU24532B1 (es) 2021-07-02
AU2016210887A1 (en) 2017-08-10
EP3250594B1 (en) 2021-11-17
TWI718121B (zh) 2021-02-11
CO2017008469A2 (es) 2018-01-16
TW202118782A (zh) 2021-05-16
PE20180200A1 (es) 2018-01-31
BR112017016324A2 (pt) 2018-03-27
TW201636372A (zh) 2016-10-16
ZA201705662B (en) 2018-08-29
JP2018509889A (ja) 2018-04-12
KR102619359B1 (ko) 2024-01-02
JP7219928B2 (ja) 2023-02-09
EA036048B1 (ru) 2020-09-18
SG11201706125QA (en) 2017-08-30
CN107428822A (zh) 2017-12-01
JP2021129562A (ja) 2021-09-09
SA517381991B1 (ar) 2021-12-13
MX391789B (es) 2025-03-21
MY193674A (en) 2022-10-24
MX2017009804A (es) 2018-08-15

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