AU2016210887B2 - Anti-transthyretin antibodies - Google Patents

Anti-transthyretin antibodies Download PDF

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Publication number
AU2016210887B2
AU2016210887B2 AU2016210887A AU2016210887A AU2016210887B2 AU 2016210887 B2 AU2016210887 B2 AU 2016210887B2 AU 2016210887 A AU2016210887 A AU 2016210887A AU 2016210887 A AU2016210887 A AU 2016210887A AU 2016210887 B2 AU2016210887 B2 AU 2016210887B2
Authority
AU
Australia
Prior art keywords
ser
val
ttr
antibody
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016210887A
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English (en)
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AU2016210887A1 (en
Inventor
Avijit Chakrabartty
Jeffrey N. Higaki
Tarlochan S. Nijjar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Health Network
Novo Nordisk AS
Original Assignee
University Health Network
Novo Nordisk AS
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Publication of AU2016210887A1 publication Critical patent/AU2016210887A1/en
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Assigned to UNIVERSITY HEALTH NETWORK (UHN), NEOTOPE NEUROSCIENCE LIMITED reassignment UNIVERSITY HEALTH NETWORK (UHN) Request for Assignment Assignors: PROTHENA BIOSCIENCES LIMITED, UNIVERSITY HEALTH NETWORK (UHN)
Assigned to UNIVERSITY HEALTH NETWORK (UHN), NOVO NORDISK A/S reassignment UNIVERSITY HEALTH NETWORK (UHN) Request for Assignment Assignors: NEOTOPE NEUROSCIENCE LIMITED, UNIVERSITY HEALTH NETWORK (UHN)
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2016210887A 2015-01-28 2016-01-28 Anti-transthyretin antibodies Ceased AU2016210887B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562109001P 2015-01-28 2015-01-28
US62/109,001 2015-01-28
US201562266557P 2015-12-11 2015-12-11
US62/266,557 2015-12-11
PCT/IB2016/050414 WO2016120809A1 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Publications (2)

Publication Number Publication Date
AU2016210887A1 AU2016210887A1 (en) 2017-08-10
AU2016210887B2 true AU2016210887B2 (en) 2021-11-04

Family

ID=55361912

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016210887A Ceased AU2016210887B2 (en) 2015-01-28 2016-01-28 Anti-transthyretin antibodies

Country Status (19)

Country Link
US (1) US20160257736A1 (enExample)
EP (1) EP3250594B1 (enExample)
JP (2) JP6875280B2 (enExample)
KR (1) KR102619359B1 (enExample)
CN (1) CN107428822B (enExample)
AU (1) AU2016210887B2 (enExample)
CA (1) CA2974911A1 (enExample)
CO (1) CO2017008469A2 (enExample)
CU (1) CU24532B1 (enExample)
EA (1) EA036048B1 (enExample)
ES (1) ES2905311T3 (enExample)
MX (1) MX391789B (enExample)
MY (1) MY193674A (enExample)
PE (1) PE20180200A1 (enExample)
SA (1) SA517381991B1 (enExample)
SG (1) SG11201706125QA (enExample)
TW (2) TWI718121B (enExample)
WO (1) WO2016120809A1 (enExample)
ZA (1) ZA201705662B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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US10464999B2 (en) 2015-01-28 2019-11-05 Prothena Biosciences Limited Anti-transthyretin antibodies
US10633433B2 (en) 2015-01-28 2020-04-28 Prothena Biosciences Limited Anti-transthyretin antibodies
US9879080B2 (en) 2015-01-28 2018-01-30 Prothena Biosciences Limited Anti-transthyretin antibodies
TWI718121B (zh) * 2015-01-28 2021-02-11 愛爾蘭商普羅佘納生物科技有限公司 抗甲狀腺素運送蛋白抗體
EP3478714A2 (en) * 2016-07-02 2019-05-08 Prothena Biosciences Limited Anti-transthyretin antibodies
JP7017013B2 (ja) * 2016-07-02 2022-02-08 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
JP7016470B2 (ja) * 2016-07-02 2022-02-07 プロセナ バイオサイエンシーズ リミテッド 抗トランスサイレチン抗体
WO2019067875A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE
SG11202002489YA (en) 2017-10-06 2020-04-29 Prothena Biosciences Ltd Anti-transthyretin antibodies
KR102581734B1 (ko) * 2017-10-06 2023-09-22 네오토프 뉴로사이언스 리미티드 트랜스타이레틴의 검출 방법
MA51223A (fr) 2017-11-29 2020-10-07 Prothena Biosciences Ltd Formulation lyophilisée d'un anticorps monoclonal contre la transthyrétine
WO2020247452A1 (en) * 2019-06-04 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
CN112816453B (zh) * 2021-02-09 2022-07-08 黑龙江大学 蛋白在预测药物性能上的应用
CN117603921A (zh) * 2023-11-27 2024-02-27 四川大学华西医院 一种重组腺相关病毒及轻链型淀粉样变动物模型的构建方法
CN122374011A (zh) 2023-12-15 2026-07-10 诺和诺德股份有限公司 稳定的液体制剂

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US20140056904A1 (en) * 2012-08-24 2014-02-27 University Health Network Antibodies to TTR and Methods of Use

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Also Published As

Publication number Publication date
EP3250594A1 (en) 2017-12-06
KR102619359B1 (ko) 2024-01-02
MX391789B (es) 2025-03-21
WO2016120809A1 (en) 2016-08-04
CN107428822B (zh) 2021-11-23
MY193674A (en) 2022-10-24
JP2018509889A (ja) 2018-04-12
AU2016210887A1 (en) 2017-08-10
CN107428822A (zh) 2017-12-01
CU24532B1 (es) 2021-07-02
ZA201705662B (en) 2018-08-29
TWI781507B (zh) 2022-10-21
CA2974911A1 (en) 2016-08-04
TW201636372A (zh) 2016-10-16
JP7219928B2 (ja) 2023-02-09
KR20170120607A (ko) 2017-10-31
TWI718121B (zh) 2021-02-11
ES2905311T3 (es) 2022-04-07
EA036048B1 (ru) 2020-09-18
EP3250594B1 (en) 2021-11-17
CU20170096A7 (es) 2018-03-13
PE20180200A1 (es) 2018-01-31
SG11201706125QA (en) 2017-08-30
BR112017016324A2 (pt) 2018-03-27
JP2021129562A (ja) 2021-09-09
US20160257736A1 (en) 2016-09-08
MX2017009804A (es) 2018-08-15
EA201791711A1 (ru) 2017-11-30
SA517381991B1 (ar) 2021-12-13
TW202118782A (zh) 2021-05-16
JP6875280B2 (ja) 2021-05-26
CO2017008469A2 (es) 2018-01-16

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Owner name: UNIVERSITY HEALTH NETWORK (UHN)

Free format text: FORMER APPLICANT(S): UNIVERSITY HEALTH NETWORK (UHN); PROTHENA BIOSCIENCES LIMITED

Owner name: NEOTOPE NEUROSCIENCE LIMITED

Free format text: FORMER APPLICANT(S): UNIVERSITY HEALTH NETWORK (UHN); PROTHENA BIOSCIENCES LIMITED

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Free format text: FORMER OWNER(S): NEOTOPE NEUROSCIENCE LIMITED; UNIVERSITY HEALTH NETWORK (UHN)

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Free format text: FORMER OWNER(S): NEOTOPE NEUROSCIENCE LIMITED; UNIVERSITY HEALTH NETWORK (UHN)