TWI705974B - Rsv-專一性抗體及其功能性部位 - Google Patents

Rsv-專一性抗體及其功能性部位 Download PDF

Info

Publication number
TWI705974B
TWI705974B TW104101373A TW104101373A TWI705974B TW I705974 B TWI705974 B TW I705974B TW 104101373 A TW104101373 A TW 104101373A TW 104101373 A TW104101373 A TW 104101373A TW I705974 B TWI705974 B TW I705974B
Authority
TW
Taiwan
Prior art keywords
seq
variable region
antibody
sequence
chain variable
Prior art date
Application number
TW104101373A
Other languages
English (en)
Chinese (zh)
Other versions
TW201612191A (en
Inventor
南西 奧布萊蒂
利來 妮可 卡利瓦德
安迪Ｑ 元
貝提那 里契德
Original Assignee
美商麥迪紐有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商麥迪紐有限責任公司 filed Critical 美商麥迪紐有限責任公司
Publication of TW201612191A publication Critical patent/TW201612191A/zh
Application granted granted Critical
Publication of TWI705974B publication Critical patent/TWI705974B/zh

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW104101373A 2014-01-15 2015-01-15 Rsv-專一性抗體及其功能性部位 TWI705974B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461927819P 2014-01-15 2014-01-15
US61/927,819 2014-01-15

Publications (2)

Publication Number Publication Date
TW201612191A TW201612191A (en) 2016-04-01
TWI705974B true TWI705974B (zh) 2020-10-01

Family

ID=53543612

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104101373A TWI705974B (zh) 2014-01-15 2015-01-15 Rsv-專一性抗體及其功能性部位

Country Status (26)

Country Link
US (6) US20160340414A1 (enExample)
EP (3) EP3094353B1 (enExample)
JP (3) JP6836398B2 (enExample)
KR (1) KR102188437B1 (enExample)
CN (2) CN116355080A (enExample)
AU (4) AU2015206570A1 (enExample)
CA (1) CA2933200C (enExample)
CY (2) CY1123425T1 (enExample)
DK (1) DK3094353T3 (enExample)
ES (1) ES2795727T3 (enExample)
FI (1) FIC20230016I1 (enExample)
FR (1) FR23C1016I2 (enExample)
HR (1) HRP20200607T1 (enExample)
HU (2) HUE048855T2 (enExample)
LT (2) LT3094353T (enExample)
LU (1) LUC00305I2 (enExample)
MX (1) MX374517B (enExample)
NL (1) NL301228I2 (enExample)
NO (1) NO2023016I1 (enExample)
PL (1) PL3094353T3 (enExample)
PT (1) PT3094353T (enExample)
RS (1) RS60387B1 (enExample)
SI (1) SI3094353T1 (enExample)
SM (1) SMT202000282T1 (enExample)
TW (1) TWI705974B (enExample)
WO (1) WO2015108967A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
RS60387B1 (sr) 2014-01-15 2020-07-31 Medimmune Llc Rsv-specifična antitela i njihovi funkcionalni delovi
WO2018075954A2 (en) * 2016-10-21 2018-04-26 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
TWI911431B (zh) * 2017-03-01 2026-01-11 英商梅迪繆思有限公司 抗rsv單株抗體配製物
KR20200140799A (ko) * 2018-01-31 2020-12-16 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 호흡기 세포융합 바이러스에 대하여 사용하기 위한 핵산 항체 작제물
CN111606993B (zh) * 2019-02-26 2022-06-28 中国科学院上海生命科学研究院 抗呼吸道合胞病毒的全人广谱中和抗体4f1及其应用
US12024553B2 (en) 2019-04-30 2024-07-02 Medimmune Limited Dosage regimens for and compositions including anti-RSV antibodies
KR20240055097A (ko) 2021-09-13 2024-04-26 메디뮨 리미티드 니르세비맙을 사용한 호흡기 세포융합 바이러스 하기도 감염의 예방
CN116987183B (zh) * 2022-07-22 2024-10-15 北京智仁美博生物科技有限公司 抗呼吸道合胞病毒中和性抗体及其用途
CN122057014A (zh) * 2024-11-08 2026-05-19 珠海泰诺麦博制药股份有限公司 一种抗rsv抗体在预防和治疗rsv中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101778866A (zh) * 2007-06-01 2010-07-14 米迪缪尼有限公司 Rsv特异性结合分子和产生它们的方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
CA2585891A1 (en) * 2004-10-29 2006-05-11 Medimmune, Inc. Methods of preventing and treating rsv infections and related conditions
AU2005335714B2 (en) * 2004-11-10 2012-07-26 Macrogenics, Inc. Engineering Fc antibody regions to confer effector function
SI2066351T1 (sl) 2006-10-02 2016-02-29 E.R. Squibb & Sons, L.L.C. Humana protitelesa, ki vežejo cxcr4 in njihova uporaba
CA2678628A1 (en) 2007-03-06 2008-09-12 Symphogen A/S Recombinant antibodies for treatment of respiratory syncytial virus infections
US20110008329A1 (en) * 2007-06-26 2011-01-13 Medlmmune, Llc Methods of Treating RSV Infections And Related Conditions
US8092804B2 (en) * 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
ES2579231T3 (es) 2008-01-15 2016-08-08 Abbvie Inc Vectores de expresión de mamíferos mejorados y usos de los mismos
WO2011008093A1 (en) * 2009-07-15 2011-01-20 Aimm Therapeutics B.V. Means and methods for producing high affinity antibodies
MX2012001882A (es) * 2009-08-13 2012-04-11 Crucell Holland Bv Anticuerpos contra el virus sincitial respiratorio (rsv) humano y metodos de uso.
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
WO2011043643A1 (en) * 2009-10-06 2011-04-14 Medimmune Ltd Rsv-specific binding molecule
US20120263715A1 (en) 2009-10-28 2012-10-18 Medimmune, Llc Topical Methods Of Treating RSV Infections And Related Conditions
EP2591000B1 (en) * 2010-07-09 2017-05-17 Janssen Vaccines & Prevention B.V. Anti-human respiratory syncytial virus (rsv) antibodies and methods of use
AU2013234046B2 (en) * 2012-03-16 2017-09-07 University Health Network Methods and compositions for modulating Toso activity
US20150158942A1 (en) * 2012-05-22 2015-06-11 Shire Human Genetic Therapies, Inc. Anti-ccl2 antibodies for treatment of scleroderma
RS60056B1 (sr) 2013-02-01 2020-04-30 Medimmune Llc Epitopi f proteina respiratornog sincicijalnog virusa
RS60387B1 (sr) 2014-01-15 2020-07-31 Medimmune Llc Rsv-specifična antitela i njihovi funkcionalni delovi
JP2020509025A (ja) 2017-03-01 2020-03-26 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ モノクローナル抗体製剤
TWI911431B (zh) 2017-03-01 2026-01-11 英商梅迪繆思有限公司 抗rsv單株抗體配製物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101778866A (zh) * 2007-06-01 2010-07-14 米迪缪尼有限公司 Rsv特异性结合分子和产生它们的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Kwakkenbos MJ et al., "Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming", Nature medicine, vol.16, p.123-128, 2009/12/20 *

Also Published As

Publication number Publication date
WO2015108967A8 (en) 2015-10-01
LT3094353T (lt) 2020-08-10
NL301228I2 (nl) 2023-09-13
BR112016015044A2 (pt) 2017-09-19
CA2933200A1 (en) 2015-07-23
MX2016008639A (es) 2017-02-15
BR112016015044A8 (pt) 2023-04-11
US20250179153A1 (en) 2025-06-05
US12173050B2 (en) 2024-12-24
EP4353316A2 (en) 2024-04-17
CY2023011I1 (el) 2023-11-15
DK3094353T3 (da) 2020-06-02
AU2025201056A1 (en) 2025-03-06
SI3094353T1 (sl) 2020-07-31
KR102188437B1 (ko) 2020-12-08
AU2021204339A1 (en) 2021-07-22
CY2023011I2 (el) 2023-11-15
US20230365660A1 (en) 2023-11-16
AU2015206570A1 (en) 2016-07-14
JP2025063143A (ja) 2025-04-15
AU2020203831A1 (en) 2020-07-02
JP2023052693A (ja) 2023-04-11
EP3741390A1 (en) 2020-11-25
EP3094353B1 (en) 2020-04-01
WO2015108967A2 (en) 2015-07-23
RU2016133247A (ru) 2018-02-20
ES2795727T3 (es) 2020-11-24
JP2020103293A (ja) 2020-07-09
CA2933200C (en) 2025-05-06
LUC00305I2 (enExample) 2025-09-22
EP4353316A3 (en) 2024-08-21
HUS2300019I1 (hu) 2023-05-28
LTPA2023514I1 (enExample) 2023-05-25
RS60387B1 (sr) 2020-07-31
WO2015108967A3 (en) 2015-09-03
US11661449B2 (en) 2023-05-30
JP6836398B2 (ja) 2021-03-03
FIC20230016I1 (fi) 2023-04-26
PL3094353T3 (pl) 2020-09-07
EP3094353A2 (en) 2016-11-23
FR23C1016I1 (fr) 2023-06-23
EP3094353A4 (en) 2017-09-06
NL301228I1 (enExample) 2023-05-03
NO2023016I1 (no) 2023-04-25
US20220098285A1 (en) 2022-03-31
US20160340414A1 (en) 2016-11-24
PT3094353T (pt) 2020-06-08
CY1123425T1 (el) 2021-12-31
MX374517B (es) 2025-03-06
LTC3094353I2 (enExample) 2025-07-10
US11186628B2 (en) 2021-11-30
US20190106482A1 (en) 2019-04-11
CN105916520A (zh) 2016-08-31
KR20160104018A (ko) 2016-09-02
TW201612191A (en) 2016-04-01
HUE048855T2 (hu) 2020-08-28
HRP20200607T1 (hr) 2020-07-10
US10689437B2 (en) 2020-06-23
US20200331989A1 (en) 2020-10-22
CN116355080A (zh) 2023-06-30
JP2017504321A (ja) 2017-02-09
RU2016133247A3 (enExample) 2019-01-16
HK1225992A1 (en) 2017-09-22
FR23C1016I2 (fr) 2026-05-29
AU2021204339B2 (en) 2024-11-14
SMT202000282T1 (it) 2020-07-08
ES2795727T9 (en) 2026-01-21

Similar Documents

Publication Publication Date Title
US12173050B2 (en) RSV-specific antibodies and functional parts thereof
CN113354729B (zh) 一种抗新型冠状病毒的单克隆抗体及其应用
CN113354730B (zh) 一种抗新型冠状病毒的单克隆抗体及其应用
US20120114664A1 (en) Antibodies against h5n1 strains of influenza a virus
TW202126692A (zh) 抗人Claudin18.2抗體及其應用
WO2017092645A1 (zh) 一种抗呼吸道合胞病毒的全人源抗体
CN116836269A (zh) 抗呼吸道合胞病毒的单克隆抗体及其应用
RU2785598C2 (ru) Rsv-специфичные антитела и их функциональные части
HK40109087A (en) Rsv-specific antibodies and functional parts thereof
HK40041855A (en) Rsv-specific antibodies and functional parts thereof
HK1225992B (en) Rsv-specific antibodies and functional parts thereof
BR112016015044B1 (pt) Anticorpos específicos para rsv e partes funcionais dos mesmos