KR102188437B1 - Rsv 특이적 항체 및 이의 기능적 부위 - Google Patents

Rsv 특이적 항체 및 이의 기능적 부위 Download PDF

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KR102188437B1
KR102188437B1 KR1020167020393A KR20167020393A KR102188437B1 KR 102188437 B1 KR102188437 B1 KR 102188437B1 KR 1020167020393 A KR1020167020393 A KR 1020167020393A KR 20167020393 A KR20167020393 A KR 20167020393A KR 102188437 B1 KR102188437 B1 KR 102188437B1
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seq
delete delete
antibody
chain variable
variable region
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KR20160104018A (ko
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낸시 울브란트
니콜 캘리워드-릴레이
앤디 큐 위안
베티나 리히터
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메디뮨 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167020393A 2014-01-15 2015-01-14 Rsv 특이적 항체 및 이의 기능적 부위 Active KR102188437B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461927819P 2014-01-15 2014-01-15
US61/927,819 2014-01-15
PCT/US2015/011391 WO2015108967A2 (en) 2014-01-15 2015-01-14 Rsv-specific antibodies and functional parts thereof

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Publication Number Publication Date
KR20160104018A KR20160104018A (ko) 2016-09-02
KR102188437B1 true KR102188437B1 (ko) 2020-12-08

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US (6) US20160340414A1 (enExample)
EP (3) EP4353316A3 (enExample)
JP (4) JP6836398B2 (enExample)
KR (1) KR102188437B1 (enExample)
CN (2) CN105916520A (enExample)
AU (4) AU2015206570A1 (enExample)
CA (1) CA2933200C (enExample)
CY (2) CY1123425T1 (enExample)
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SI (1) SI3094353T1 (enExample)
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
SI3094353T1 (sl) 2014-01-15 2020-07-31 Medimmune, Llc RSY-specifična protitelesa in njihovi funkcionalni deli
US11479600B2 (en) 2016-10-21 2022-10-25 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
TW202228779A (zh) * 2017-03-01 2022-08-01 英商梅迪繆思有限公司 抗rsv單株抗體配製物
WO2019152600A1 (en) * 2018-01-31 2019-08-08 The Wistar Institute Of Anatomy And Biology Nucleic acid antibody constructs for use against respiratory syncytial virus
CN111606993B (zh) * 2019-02-26 2022-06-28 中国科学院上海生命科学研究院 抗呼吸道合胞病毒的全人广谱中和抗体4f1及其应用
US12024553B2 (en) 2019-04-30 2024-07-02 Medimmune Limited Dosage regimens for and compositions including anti-RSV antibodies
EP4402166A2 (en) 2021-09-13 2024-07-24 MedImmune Limited Prevention of respiratory syncytial virus lower respiratory tract infection with nirsevimab
CN116987183B (zh) * 2022-07-22 2024-10-15 北京智仁美博生物科技有限公司 抗呼吸道合胞病毒中和性抗体及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013136193A2 (en) 2012-03-16 2013-09-19 University Health Network Methods and compositions for modulating toso activity
WO2013177264A1 (en) 2012-05-22 2013-11-28 Shire Human Genetic Therapies, Inc. Anti-ccl2 antibodies for treatment of scleroderma

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
JP2008518936A (ja) * 2004-10-29 2008-06-05 メディミューン，インコーポレーテッド Ｒｓｖ感染症および関連状態を予防および治療する方法
AU2005335714B2 (en) * 2004-11-10 2012-07-26 Macrogenics, Inc. Engineering Fc antibody regions to confer effector function
SG178712A1 (en) 2006-10-02 2012-03-29 Medarex Inc Human antibodies that bind cxcr4 and uses thereof
CN101679513A (zh) 2007-03-06 2010-03-24 西福根有限公司 用于治疗呼吸道合胞病毒感染的重组抗体
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
AU2008268362A1 (en) 2007-06-26 2008-12-31 Medimmune, Llc Methods of treating RSV infections and related conditions
US8092804B2 (en) * 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
EP2240581B1 (en) 2008-01-15 2016-05-11 AbbVie Inc. Improved mammalian expression vectors and uses thereof
ES2666584T3 (es) * 2009-07-15 2018-05-07 Aimm Therapeutics B.V. Medios y métodos para producir anticuerpos de alta afinidad
CA2776249C (en) 2009-10-06 2021-01-19 Medimmune Ltd Rsv-specific binding molecule
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
US20120263715A1 (en) 2009-10-28 2012-10-18 Medimmune, Llc Topical Methods Of Treating RSV Infections And Related Conditions
DK2950886T3 (da) 2013-02-01 2020-03-23 Medimmune Llc Respiratorisk syncytialvirus-f-protein-epitoper
SI3094353T1 (sl) 2014-01-15 2020-07-31 Medimmune, Llc RSY-specifična protitelesa in njihovi funkcionalni deli
EP3589318A1 (en) 2017-03-01 2020-01-08 MedImmune Limited Formulations of monoclonal antibodies
TW202228779A (zh) 2017-03-01 2022-08-01 英商梅迪繆思有限公司 抗rsv單株抗體配製物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013136193A2 (en) 2012-03-16 2013-09-19 University Health Network Methods and compositions for modulating toso activity
WO2013177264A1 (en) 2012-05-22 2013-11-28 Shire Human Genetic Therapies, Inc. Anti-ccl2 antibodies for treatment of scleroderma

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AU2020203831A1 (en) 2020-07-02
LT3094353T (lt) 2020-08-10
CN116355080A (zh) 2023-06-30
CN105916520A (zh) 2016-08-31
AU2021204339B2 (en) 2024-11-14
MX374517B (es) 2025-03-06
BR112016015044A2 (pt) 2017-09-19
US20190106482A1 (en) 2019-04-11
CA2933200C (en) 2025-05-06
JP6836398B2 (ja) 2021-03-03
WO2015108967A8 (en) 2015-10-01
LTPA2023514I1 (enExample) 2023-05-25
CA2933200A1 (en) 2015-07-23
WO2015108967A2 (en) 2015-07-23
LTC3094353I2 (enExample) 2025-07-10
US11186628B2 (en) 2021-11-30
US11661449B2 (en) 2023-05-30
TW201612191A (en) 2016-04-01
AU2025201056A1 (en) 2025-03-06
HUS2300019I1 (hu) 2023-05-28
US20230365660A1 (en) 2023-11-16
MX2016008639A (es) 2017-02-15
JP2023052693A (ja) 2023-04-11
CY1123425T1 (el) 2021-12-31
SI3094353T1 (sl) 2020-07-31
RS60387B1 (sr) 2020-07-31
HUE048855T2 (hu) 2020-08-28
NL301228I1 (enExample) 2023-05-03
ES2795727T3 (es) 2020-11-24
SMT202000282T1 (it) 2020-07-08
US20250179153A1 (en) 2025-06-05
AU2021204339A1 (en) 2021-07-22
US20200331989A1 (en) 2020-10-22
FR23C1016I1 (fr) 2023-06-23
US10689437B2 (en) 2020-06-23
FIC20230016I1 (fi) 2023-04-26
EP3094353B1 (en) 2020-04-01
NO2023016I1 (no) 2023-04-25
PL3094353T3 (pl) 2020-09-07
RU2016133247A3 (enExample) 2019-01-16
EP3741390A1 (en) 2020-11-25
CY2023011I1 (el) 2023-11-15
EP3094353A4 (en) 2017-09-06
WO2015108967A3 (en) 2015-09-03
NL301228I2 (nl) 2023-09-13
EP4353316A2 (en) 2024-04-17
AU2015206570A1 (en) 2016-07-14
HRP20200607T1 (hr) 2020-07-10
CY2023011I2 (el) 2023-11-15
DK3094353T3 (da) 2020-06-02
PT3094353T (pt) 2020-06-08
TWI705974B (zh) 2020-10-01
JP2017504321A (ja) 2017-02-09
US20160340414A1 (en) 2016-11-24
RU2016133247A (ru) 2018-02-20
JP2025063143A (ja) 2025-04-15
HK1225992A1 (en) 2017-09-22
US20220098285A1 (en) 2022-03-31
BR112016015044A8 (pt) 2023-04-11
US12173050B2 (en) 2024-12-24
LUC00305I2 (enExample) 2025-09-22
EP3094353A2 (en) 2016-11-23
KR20160104018A (ko) 2016-09-02
EP4353316A3 (en) 2024-08-21
JP2020103293A (ja) 2020-07-09

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