CA2933200C - RSV-SPECIFIC ANTIBODIES AND THEIR FUNCTIONAL PARTS - Google Patents

RSV-SPECIFIC ANTIBODIES AND THEIR FUNCTIONAL PARTS

Info

Publication number
CA2933200C
CA2933200C CA2933200A CA2933200A CA2933200C CA 2933200 C CA2933200 C CA 2933200C CA 2933200 A CA2933200 A CA 2933200A CA 2933200 A CA2933200 A CA 2933200A CA 2933200 C CA2933200 C CA 2933200C
Authority
CA
Canada
Prior art keywords
antibody
seq
antigen
amino acid
chain variable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
Application number
CA2933200A
Other languages
English (en)
French (fr)
Other versions
CA2933200A1 (en
Inventor
Nicole Kallewaard-LeLay
Andy Q. Yuan
Bettina Richter
Nancy Ulbrandt
Original Assignee
MedImmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Publication of CA2933200A1 publication Critical patent/CA2933200A1/en
Application granted granted Critical
Publication of CA2933200C publication Critical patent/CA2933200C/en
Active legal-status Critical Current
Adjusted expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2933200A 2014-01-15 2015-01-14 RSV-SPECIFIC ANTIBODIES AND THEIR FUNCTIONAL PARTS Active 2037-01-14 CA2933200C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461927819P 2014-01-15 2014-01-15
US61/927,819 2014-01-15
PCT/US2015/011391 WO2015108967A2 (en) 2014-01-15 2015-01-14 Rsv-specific antibodies and functional parts thereof

Publications (2)

Publication Number Publication Date
CA2933200A1 CA2933200A1 (en) 2015-07-23
CA2933200C true CA2933200C (en) 2025-05-06

Family

ID=53543612

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2933200A Active 2037-01-14 CA2933200C (en) 2014-01-15 2015-01-14 RSV-SPECIFIC ANTIBODIES AND THEIR FUNCTIONAL PARTS

Country Status (26)

Country Link
US (6) US20160340414A1 (enExample)
EP (3) EP3741390A1 (enExample)
JP (4) JP6836398B2 (enExample)
KR (1) KR102188437B1 (enExample)
CN (2) CN105916520A (enExample)
AU (4) AU2015206570A1 (enExample)
CA (1) CA2933200C (enExample)
CY (2) CY1123425T1 (enExample)
DK (1) DK3094353T3 (enExample)
ES (1) ES2795727T3 (enExample)
FI (1) FIC20230016I1 (enExample)
FR (1) FR23C1016I1 (enExample)
HR (1) HRP20200607T1 (enExample)
HU (2) HUE048855T2 (enExample)
LT (2) LT3094353T (enExample)
LU (1) LUC00305I2 (enExample)
MX (1) MX374517B (enExample)
NL (1) NL301228I2 (enExample)
NO (1) NO2023016I1 (enExample)
PL (1) PL3094353T3 (enExample)
PT (1) PT3094353T (enExample)
RS (1) RS60387B1 (enExample)
SI (1) SI3094353T1 (enExample)
SM (1) SMT202000282T1 (enExample)
TW (1) TWI705974B (enExample)
WO (1) WO2015108967A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
KR102188437B1 (ko) 2014-01-15 2020-12-08 메디뮨 엘엘씨 Rsv 특이적 항체 및 이의 기능적 부위
EP3529272A2 (en) 2016-10-21 2019-08-28 Adimab, LLC Anti-respiratory syncytial virus antibodies, and methods of their generation and use
TWI911431B (zh) * 2017-03-01 2026-01-11 英商梅迪繆思有限公司 抗rsv單株抗體配製物
SG11202007241WA (en) * 2018-01-31 2020-08-28 Wistar Inst Nucleic acid antibody constructs for use against respiratory syncytial virus
CN111606993B (zh) * 2019-02-26 2022-06-28 中国科学院上海生命科学研究院 抗呼吸道合胞病毒的全人广谱中和抗体4f1及其应用
US12024553B2 (en) 2019-04-30 2024-07-02 Medimmune Limited Dosage regimens for and compositions including anti-RSV antibodies
TW202340237A (zh) 2021-09-13 2023-10-16 英商梅迪繆思有限公司 尼塞韋單抗預防呼吸道融合細胞病毒下呼吸道感染
CN119264248A (zh) * 2022-07-22 2025-01-07 北京智仁美博生物科技有限公司 抗呼吸道合胞病毒中和性抗体及其用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US20060115485A1 (en) * 2004-10-29 2006-06-01 Medimmune, Inc. Methods of preventing and treating RSV infections and related conditions
WO2007024249A2 (en) * 2004-11-10 2007-03-01 Macrogenics, Inc. Engineering fc antibody regions to confer effector function
ES2625798T3 (es) * 2006-10-02 2017-07-20 E. R. Squibb & Sons, L.L.C. Anticuerpos humanos que se unen a CXCR4 y usos de los mismos
MX2009009226A (es) 2007-03-06 2009-10-28 Symphogen As Anticuerpos recombinantes para el tratamiento de infecciones con el virus respiratorio sincitial.
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
EP2069400A4 (en) * 2007-06-26 2012-03-07 Medimmune Llc METHOD FOR THE TREATMENT OF RSV INFECTIONS AND RELATED DISEASES
US8092804B2 (en) * 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
BRPI0906490A2 (pt) 2008-01-15 2015-07-14 Abbott Lab Vetores de expressão de mamífero melhorados e uso dos mesmos
DK2454283T3 (en) * 2009-07-15 2018-05-07 Aimm Therapeutics Bv METHODS AND PROCEDURES FOR MANUFACTURING HIGH EFFICIENCY ANTIBODIES
DK2464664T3 (da) * 2009-08-13 2016-01-18 Crucell Holland Bv Antistoffer mod humant respiratorisk syncytialvirus (rsv) og fremgangsmåder til anvendelse deraf
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
AU2009353693B2 (en) * 2009-10-06 2016-07-21 Medimmune Ltd RSV-specific binding molecule
US20120263715A1 (en) 2009-10-28 2012-10-18 Medimmune, Llc Topical Methods Of Treating RSV Infections And Related Conditions
EP2591000B1 (en) * 2010-07-09 2017-05-17 Janssen Vaccines & Prevention B.V. Anti-human respiratory syncytial virus (rsv) antibodies and methods of use
US9228006B2 (en) * 2012-03-16 2016-01-05 University Health Network Methods and compositions for modulating Toso activity
CN104487091A (zh) 2012-05-22 2015-04-01 夏尔人类遗传性治疗公司 用于治疗硬皮病的抗ccl2抗体
ES2778899T3 (es) 2013-02-01 2020-08-12 Medimmune Llc Epítopos de proteína F del virus sincitial respiratorio
KR102188437B1 (ko) 2014-01-15 2020-12-08 메디뮨 엘엘씨 Rsv 특이적 항체 및 이의 기능적 부위
TWI911431B (zh) 2017-03-01 2026-01-11 英商梅迪繆思有限公司 抗rsv單株抗體配製物
BR112019018022A2 (pt) 2017-03-01 2020-06-02 Medimmune Limited Formulações de anticorpos monoclonais

Also Published As

Publication number Publication date
HRP20200607T1 (hr) 2020-07-10
MX2016008639A (es) 2017-02-15
LUC00305I2 (enExample) 2025-09-22
LTC3094353I2 (enExample) 2025-07-10
US11186628B2 (en) 2021-11-30
US20220098285A1 (en) 2022-03-31
CA2933200A1 (en) 2015-07-23
US20190106482A1 (en) 2019-04-11
US10689437B2 (en) 2020-06-23
US20200331989A1 (en) 2020-10-22
TWI705974B (zh) 2020-10-01
PL3094353T3 (pl) 2020-09-07
WO2015108967A8 (en) 2015-10-01
NL301228I1 (enExample) 2023-05-03
AU2025201056A1 (en) 2025-03-06
US20250179153A1 (en) 2025-06-05
LT3094353T (lt) 2020-08-10
US20160340414A1 (en) 2016-11-24
WO2015108967A3 (en) 2015-09-03
AU2021204339B2 (en) 2024-11-14
ES2795727T9 (en) 2026-01-21
JP6836398B2 (ja) 2021-03-03
HUE048855T2 (hu) 2020-08-28
RU2016133247A3 (enExample) 2019-01-16
FR23C1016I1 (fr) 2023-06-23
US12173050B2 (en) 2024-12-24
CY2023011I1 (el) 2023-11-15
EP4353316A3 (en) 2024-08-21
CY1123425T1 (el) 2021-12-31
DK3094353T3 (da) 2020-06-02
WO2015108967A2 (en) 2015-07-23
LTPA2023514I1 (enExample) 2023-05-25
BR112016015044A2 (pt) 2017-09-19
MX374517B (es) 2025-03-06
SMT202000282T1 (it) 2020-07-08
CY2023011I2 (el) 2023-11-15
US20230365660A1 (en) 2023-11-16
ES2795727T3 (es) 2020-11-24
EP3094353B1 (en) 2020-04-01
EP3741390A1 (en) 2020-11-25
RS60387B1 (sr) 2020-07-31
US11661449B2 (en) 2023-05-30
TW201612191A (en) 2016-04-01
CN105916520A (zh) 2016-08-31
AU2015206570A1 (en) 2016-07-14
JP2017504321A (ja) 2017-02-09
EP4353316A2 (en) 2024-04-17
KR102188437B1 (ko) 2020-12-08
NO2023016I1 (no) 2023-04-25
JP2020103293A (ja) 2020-07-09
FIC20230016I1 (fi) 2023-04-26
AU2021204339A1 (en) 2021-07-22
AU2020203831A1 (en) 2020-07-02
EP3094353A4 (en) 2017-09-06
SI3094353T1 (sl) 2020-07-31
HK1225992A1 (en) 2017-09-22
KR20160104018A (ko) 2016-09-02
JP2023052693A (ja) 2023-04-11
EP3094353A2 (en) 2016-11-23
CN116355080A (zh) 2023-06-30
JP2025063143A (ja) 2025-04-15
RU2016133247A (ru) 2018-02-20
NL301228I2 (nl) 2023-09-13
HUS2300019I1 (hu) 2023-05-28
PT3094353T (pt) 2020-06-08
BR112016015044A8 (pt) 2023-04-11

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