TWI685487B - ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形 - Google Patents

｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形 Download PDF

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Publication number
TWI685487B
TWI685487B TW103102462A TW103102462A TWI685487B TW I685487 B TWI685487 B TW I685487B TW 103102462 A TW103102462 A TW 103102462A TW 103102462 A TW103102462 A TW 103102462A TW I685487 B TWI685487 B TW I685487B
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Taiwan
Prior art keywords
compound
crystal form
acetic acid
chlorophenoxy
isoquinoline
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TW103102462A
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English (en)
Chinese (zh)
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TW201444800A (zh
Inventor
克勞蒂亞 威其
邁克爾 湯普森
朴貞玟
邁克爾 阿倫德
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美商費比羅根公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW103102462A 2013-01-24 2014-01-23 ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形 TWI685487B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361756361P 2013-01-24 2013-01-24
US61/756,361 2013-01-24

Publications (2)

Publication Number Publication Date
TW201444800A TW201444800A (zh) 2014-12-01
TWI685487B true TWI685487B (zh) 2020-02-21

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TW103102462A TWI685487B (zh) 2013-01-24 2014-01-23 ｛［１-氰基-５-（４-氯苯氧基）-４-羥基-異喹啉-３-羰基］-胺基｝-乙酸之晶形

Country Status (15)

Country Link
US (1) US9643928B2 (https=)
EP (1) EP2951159B1 (https=)
JP (1) JP6437456B2 (https=)
KR (1) KR102233081B1 (https=)
CN (1) CN105452227B (https=)
AU (1) AU2014209319B2 (https=)
CA (1) CA2899024C (https=)
DK (1) DK2951159T3 (https=)
ES (1) ES2694297T3 (https=)
IL (1) IL240066B (https=)
MX (1) MX360048B (https=)
RU (1) RU2666144C2 (https=)
SG (2) SG10202009266PA (https=)
TW (1) TWI685487B (https=)
WO (1) WO2014116849A1 (https=)

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KR20210130849A (ko) 2012-07-16 2021-11-01 피브로겐, 인크. 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
EP2872487B1 (en) 2012-07-16 2017-04-26 Fibrogen, Inc. Process for making isoquinoline compounds
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
CA2899024C (en) 2013-01-24 2022-01-04 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
KR20210104173A (ko) 2013-06-06 2021-08-24 피브로겐, 인크. Hif 하이드록실라제 억제자의 약학적 제형
JP6506390B2 (ja) 2014-09-02 2019-04-24 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． キノリノン系化合物及びその薬物への使用
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Publication number Publication date
MX360048B (es) 2018-10-19
JP2016505071A (ja) 2016-02-18
EP2951159A1 (en) 2015-12-09
JP6437456B2 (ja) 2018-12-12
CN105452227B (zh) 2018-05-29
CA2899024C (en) 2022-01-04
IL240066A0 (en) 2015-09-24
DK2951159T3 (en) 2018-11-19
RU2015134420A (ru) 2017-03-03
CA2899024A1 (en) 2014-07-31
MX2015009617A (es) 2016-04-20
AU2014209319A1 (en) 2015-08-27
RU2666144C2 (ru) 2018-09-06
HK1217331A1 (en) 2017-01-06
US20160002170A1 (en) 2016-01-07
KR20150129679A (ko) 2015-11-20
ES2694297T3 (es) 2018-12-19
KR102233081B1 (ko) 2021-03-29
SG11201505748UA (en) 2015-08-28
AU2014209319B2 (en) 2018-04-19
EP2951159B1 (en) 2018-08-22
TW201444800A (zh) 2014-12-01
SG10202009266PA (en) 2020-10-29
US9643928B2 (en) 2017-05-09
CN105452227A (zh) 2016-03-30
IL240066B (en) 2019-08-29
WO2014116849A1 (en) 2014-07-31

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