TWI685347B - 用於在活體中遞送ＲＮＡｉ觸發子至腫瘤細胞之聚結合物 - Google Patents

用於在活體中遞送ＲＮＡｉ觸發子至腫瘤細胞之聚結合物 Download PDF

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TWI685347B
TWI685347B TW103127144A TW103127144A TWI685347B TW I685347 B TWI685347 B TW I685347B TW 103127144 A TW103127144 A TW 103127144A TW 103127144 A TW103127144 A TW 103127144A TW I685347 B TWI685347 B TW I685347B
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polymer
peg
rgd
mmol
fmoc
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TW103127144A
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TW201601742A (zh
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為軍 承
素珍 黃
艾倫Ｍ 艾爾梅達
大衛Ｂ 羅薩馬
安卓Ｖ 布洛克希
傑佛瑞Ｃ 卡爾森
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愛羅海德製藥公司
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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    • C07K5/08—Tripeptides
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    • C12N2310/3535—Nitrogen
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    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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TW103127144A 2013-08-07 2014-08-07 用於在活體中遞送ＲＮＡｉ觸發子至腫瘤細胞之聚結合物 TWI685347B (zh)

Applications Claiming Priority (2)

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US201361863056P 2013-08-07 2013-08-07
US61/863,056 2013-08-07

Publications (2)

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TW201601742A TW201601742A (zh) 2016-01-16
TWI685347B true TWI685347B (zh) 2020-02-21

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US (3) US9487556B2 (OSRAM)
EP (1) EP3030244B1 (OSRAM)
JP (1) JP6433001B2 (OSRAM)
KR (1) KR20160035081A (OSRAM)
CN (1) CN105451743B (OSRAM)
AU (1) AU2014306021B2 (OSRAM)
CA (1) CA2919088A1 (OSRAM)
EA (1) EA201690051A1 (OSRAM)
IL (1) IL243941B (OSRAM)
MX (1) MX2016001006A (OSRAM)
SG (1) SG11201600379TA (OSRAM)
TW (1) TWI685347B (OSRAM)
WO (1) WO2015021092A1 (OSRAM)

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SG11201600379TA (en) * 2013-08-07 2016-02-26 Arrowhead Res Corp Polyconjugates for delivery of rnai triggers to tumor cells in vivo
EP3271482A4 (en) 2015-03-17 2019-02-13 Arrowhead Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR INHIBITING THE GENE EXPRESSION OF FACTOR XII
CN107635550B (zh) * 2015-03-17 2021-12-24 箭头药业股份有限公司 改良的含二硫化物的炔烃交联剂
SG11201708602XA (en) 2015-05-29 2017-12-28 Arrowhead Pharmaceuticals Inc Biologically cleavable tetrapeptide linking agents
BR112017025698A2 (pt) 2015-05-29 2018-08-14 Arrowhead Pharmaceuticals Inc composições e métodos para inibir a expressão do gene de hif2alfa
EP3252082A1 (en) * 2016-05-31 2017-12-06 Galderma S.A. Method for deacetylation of biopolymers
SI3397651T1 (sl) 2015-12-29 2020-11-30 Galderma S.A. Oglikovodično zamreževalo
PT3623390T (pt) * 2016-05-31 2023-10-27 Galderma Sa Reticulador de hidrato de carbono
US11629122B2 (en) 2017-05-24 2023-04-18 The Board Of Regents Of The University Of Texas System Linkers for antibody drug conjugates
EP3784269B1 (en) 2018-04-27 2024-06-05 Arrowhead Pharmaceuticals, Inc. Integrin targeting ligands and uses thereof
MX2021008261A (es) 2019-01-09 2021-08-16 Arrowhead Pharmaceuticals Inc Agentes de rnai para inhibir la expresion de hif-2 a (epas1), composiciones de estos y metodos de uso.
CN110240551B (zh) * 2019-06-25 2022-02-11 成都郑源生化科技有限公司 Fmoc-β-Ala-Gly-OH的制备方法
TWI894184B (zh) 2019-12-02 2025-08-21 瑞士商葛德瑪控股公司 高分子量美容組合物
CN113004515B (zh) * 2021-03-02 2023-02-24 厦门大学附属中山医院 一种仿透明质酸聚氨基酸衍生物、其制备方法及其应用

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WO2015021092A1 (en) 2015-02-12
EA201690051A1 (ru) 2016-06-30
MX2016001006A (es) 2016-04-19
CN105451743A (zh) 2016-03-30
US9487556B2 (en) 2016-11-08
HK1220397A1 (zh) 2017-05-05
IL243941B (en) 2019-06-30
EP3030244A4 (en) 2017-06-28
EP3030244B1 (en) 2021-04-21
IL243941A0 (en) 2016-04-21
CN105451743B (zh) 2019-11-19
JP2016535058A (ja) 2016-11-10
SG11201600379TA (en) 2016-02-26
US20170022497A1 (en) 2017-01-26
US20190062748A1 (en) 2019-02-28
AU2014306021B2 (en) 2018-12-13
US20150045573A1 (en) 2015-02-12
EP3030244A1 (en) 2016-06-15
AU2014306021A2 (en) 2016-11-24
CA2919088A1 (en) 2015-02-12
AU2014306021A1 (en) 2016-01-28
KR20160035081A (ko) 2016-03-30
TW201601742A (zh) 2016-01-16
JP6433001B2 (ja) 2018-12-05

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