TWI654933B - 抗微生物胜肽變異體及編碼其之多核苷酸 - Google Patents

抗微生物胜肽變異體及編碼其之多核苷酸 Download PDF

Info

Publication number
TWI654933B
TWI654933B TW100119540A TW100119540A TWI654933B TW I654933 B TWI654933 B TW I654933B TW 100119540 A TW100119540 A TW 100119540A TW 100119540 A TW100119540 A TW 100119540A TW I654933 B TWI654933 B TW I654933B
Authority
TW
Taiwan
Prior art keywords
seq
variant
prt
artificial
peptide
Prior art date
Application number
TW100119540A
Other languages
English (en)
Chinese (zh)
Other versions
TW201206353A (en
Inventor
漢斯 亨利克 克利斯登森 霍根豪格
波 候塞 米俊德
湯瑪斯 克魯斯
多羅帝 拉文托斯 塞古拉
朵特 何哲 珊德范
索倫 尼夫
Original Assignee
丹麥商亞德尼曼生物技術公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 丹麥商亞德尼曼生物技術公司 filed Critical 丹麥商亞德尼曼生物技術公司
Publication of TW201206353A publication Critical patent/TW201206353A/zh
Application granted granted Critical
Publication of TWI654933B publication Critical patent/TWI654933B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW100119540A 2010-06-12 2011-06-03 抗微生物胜肽變異體及編碼其之多核苷酸 TWI654933B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP10165773 2010-06-12
??10165773.2 2010-06-12
??10166483.7 2010-06-18
EP10166483 2010-06-18
??10176204.5 2010-09-10
EP10176204 2010-09-10

Publications (2)

Publication Number Publication Date
TW201206353A TW201206353A (en) 2012-02-16
TWI654933B true TWI654933B (zh) 2019-04-01

Family

ID=44246475

Family Applications (1)

Application Number Title Priority Date Filing Date
TW100119540A TWI654933B (zh) 2010-06-12 2011-06-03 抗微生物胜肽變異體及編碼其之多核苷酸

Country Status (11)

Country Link
US (3) US8835604B2 (cg-RX-API-DMAC7.html)
EP (1) EP2580235B1 (cg-RX-API-DMAC7.html)
JP (1) JP6120769B2 (cg-RX-API-DMAC7.html)
CN (1) CN103068840B (cg-RX-API-DMAC7.html)
AR (1) AR081866A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012031049A2 (cg-RX-API-DMAC7.html)
DK (1) DK2580235T3 (cg-RX-API-DMAC7.html)
ES (1) ES2699734T3 (cg-RX-API-DMAC7.html)
RU (1) RU2611173C2 (cg-RX-API-DMAC7.html)
TW (1) TWI654933B (cg-RX-API-DMAC7.html)
WO (1) WO2011154525A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100227803A1 (en) * 2005-12-14 2010-09-09 Novozymes A/S Polypeptides having antimicrobial activity and polynucleotides encoding same
KR20160144071A (ko) 2015-06-08 2016-12-16 이주호 토출 작동 중 역방향 유입이 방지되는 팬 보조장치
CN107188944B (zh) * 2017-06-08 2020-07-07 中国农业科学院饲料研究所 海蚯蚓抗菌肽nz17074衍生肽n6及其应用
CN107266547A (zh) * 2017-06-26 2017-10-20 北京生泰云科技有限公司 海蚯蚓抗菌肽nz17074衍生肽n2及其应用
CN112513251A (zh) * 2018-06-06 2021-03-16 辛格隆股份公司 改造的抗微生物肽
RU2721273C1 (ru) * 2019-04-22 2020-05-18 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Пептид никомицин из морского кольчатого червя nicomache minor, обладающий антимикробным и противоопухолевым действием.
CN110754400B (zh) * 2019-10-28 2022-04-26 长江大学 一种提高黄鳝苗种人工孵化率的方法
EP4198045A1 (en) * 2021-12-16 2023-06-21 Université de Lille Antimicrobial peptides, variants and chemical analogues thereof and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200734350A (en) * 2005-08-26 2007-09-16 Novozymes As Polypeptides having antimicrobial activity and polynucleotides encoding same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
PT97110B (pt) 1990-03-23 1998-11-30 Gist Brocades Nv Processo para catalisar reaccoes acelaraveis por enzimas, mediante adicao ao meio reaccional de sementes de plantas transgenicas e para obtencao das referidas sementes
US6395966B1 (en) 1990-08-09 2002-05-28 Dekalb Genetics Corp. Fertile transgenic maize plants containing a gene encoding the pat protein
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
DK0765394T3 (da) 1994-06-03 2001-12-10 Novozymes As Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse
EP1559776A3 (en) 1994-06-30 2006-01-11 Novozymes Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system and promoters and terminators for use therein
DK1124949T3 (da) 1998-10-26 2006-11-06 Novozymes As Konstruktion og screening af et DNA-bibliotek af interesse i trådformede svampeceller
EP2278016B1 (en) 1999-03-22 2012-09-26 Novozymes Inc. Promoter sequences derived from Fusarium Venenatum and uses thereof
US7151204B2 (en) 2001-01-09 2006-12-19 Monsanto Technology Llc Maize chloroplast aldolase promoter compositions and methods for use thereof
ATE375388T1 (de) 2001-07-27 2007-10-15 Us Gov Health & Human Serv Systeme zur stellengerichteten in-vivo-mutagenese mit oligonukleotiden
US20080032924A1 (en) * 2004-02-24 2008-02-07 Peter David East Antifungal Peptides
EP1863836B1 (en) * 2005-03-18 2012-07-11 Novozymes Adenium Biotech A/S Polypeptides having antimicrobial activity and polynucleotides encoding same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200734350A (en) * 2005-08-26 2007-09-16 Novozymes As Polypeptides having antimicrobial activity and polynucleotides encoding same

Also Published As

Publication number Publication date
ES2699734T3 (es) 2019-02-12
BR112012031049A2 (pt) 2017-06-20
RU2611173C2 (ru) 2017-02-21
JP2013531491A (ja) 2013-08-08
US8835604B2 (en) 2014-09-16
US20110306750A1 (en) 2011-12-15
DK2580235T3 (en) 2019-01-28
EP2580235B1 (en) 2018-10-17
CN103068840B (zh) 2016-11-16
AR081866A1 (es) 2012-10-24
US20150031601A1 (en) 2015-01-29
TW201206353A (en) 2012-02-16
WO2011154525A1 (en) 2011-12-15
CN103068840A (zh) 2013-04-24
EP2580235A1 (en) 2013-04-17
JP6120769B2 (ja) 2017-04-26
RU2012148781A (ru) 2014-07-20
US20160158317A1 (en) 2016-06-09

Similar Documents

Publication Publication Date Title
TWI654933B (zh) 抗微生物胜肽變異體及編碼其之多核苷酸
JP5118023B2 (ja) 抗菌作用を有するポリペプチド、およびそのポリペプチドをコードするポリヌクレオチド
US20100093633A1 (en) Polypeptides having antimicrobial activity
US8192925B2 (en) Polypeptides having antimicrobial activity and polynucleotides encoding same
JP2012191951A (ja) 抗菌活性を有するポリペプチド及びそれをコードするポリヌクレオチド
TWI386416B (zh) 具有抗微生物活性的多肽與編碼其之多核苷酸
RU2393224C2 (ru) Полипептиды с противомикробной активностью и кодирующие их полинуклеотиды
US20110160122A1 (en) Polypeptides having Antimicrobial Activity and Polynucleotides Encoding Same
TW200804594A (en) Polypeptides having antimicrobial activity and polynucleotides encoding same
RU2403260C2 (ru) Полипептиды, обладающие противомикробным действием, и кодирующие их полинуклеотиды

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees