ES2699734T3 - Variantes de péptidos antimicrobianos y polinucleótidos que codifican las mismas - Google Patents

Info

Publication number

ES2699734T3

ES2699734T3 ES11724247T ES11724247T ES2699734T3 ES 2699734 T3 ES2699734 T3 ES 2699734T3 ES 11724247 T ES11724247 T ES 11724247T ES 11724247 T ES11724247 T ES 11724247T ES 2699734 T3 ES2699734 T3 ES 2699734T3

Authority

ES

Spain

Prior art keywords

mice

variant

blood

treatment

plant

Prior art date

2010-06-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Active

Links

• Espacenet
• Global Dossier
• Discuss

• 108700042778 Antimicrobial Peptides Proteins 0.000 title claims abstract description 20
• 102000044503 Antimicrobial Peptides Human genes 0.000 title claims abstract description 20
• 108091033319 polynucleotide Proteins 0.000 title claims description 39
• 102000040430 polynucleotide Human genes 0.000 title claims description 39
• 239000002157 polynucleotide Substances 0.000 title claims description 39
• 239000003910 polypeptide antibiotic agent Substances 0.000 claims abstract description 16
• 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 2
• 238000011282 treatment Methods 0.000 claims description 63
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 47
• 208000015181 infectious disease Diseases 0.000 claims description 25
• 150000007523 nucleic acids Chemical class 0.000 claims description 13
• 102000039446 nucleic acids Human genes 0.000 claims description 12
• 108020004707 nucleic acids Proteins 0.000 claims description 12
• 230000000813 microbial effect Effects 0.000 claims description 11
• 239000003814 drug Substances 0.000 claims description 9
• 239000013604 expression vector Substances 0.000 claims description 9
• 238000004519 manufacturing process Methods 0.000 claims description 9
• 238000012258 culturing Methods 0.000 claims description 3
• 210000004027 cell Anatomy 0.000 description 112
• 241000699670 Mus sp. Species 0.000 description 74
• 241000196324 Embryophyta Species 0.000 description 72
• 210000004369 blood Anatomy 0.000 description 51
• 239000008280 blood Substances 0.000 description 51
• 238000000034 method Methods 0.000 description 45
• 108090000623 proteins and genes Proteins 0.000 description 45
• 239000003981 vehicle Substances 0.000 description 44
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 43
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 43
• 230000000845 anti-microbial effect Effects 0.000 description 36
• 102000004196 processed proteins & peptides Human genes 0.000 description 36
• 239000000203 mixture Substances 0.000 description 34
• 239000013598 vector Substances 0.000 description 31
• 229920001184 polypeptide Polymers 0.000 description 29
• 210000003567 ascitic fluid Anatomy 0.000 description 27
• 239000000243 solution Substances 0.000 description 27
• 241000588724 Escherichia coli Species 0.000 description 26
• DMJNNHOOLUXYBV-PQTSNVLCSA-N meropenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](C(=O)N(C)C)C1 DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 25
• 229960002260 meropenem Drugs 0.000 description 25
• 150000001875 compounds Chemical class 0.000 description 24
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 19
• 108091026890 Coding region Proteins 0.000 description 18
• 108010076504 Protein Sorting Signals Proteins 0.000 description 18
• 230000000694 effects Effects 0.000 description 18
• 239000011780 sodium chloride Substances 0.000 description 18
• 241000283073 Equus caballus Species 0.000 description 17
• 230000010076 replication Effects 0.000 description 17
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 16
• 229960004397 cyclophosphamide Drugs 0.000 description 16
• 238000009472 formulation Methods 0.000 description 16
• 210000002966 serum Anatomy 0.000 description 16
• 241001465754 Metazoa Species 0.000 description 15
• 230000002538 fungal effect Effects 0.000 description 15
• 238000002360 preparation method Methods 0.000 description 15
• 230000009466 transformation Effects 0.000 description 15
• 241000894006 Bacteria Species 0.000 description 13
• 235000018102 proteins Nutrition 0.000 description 13
• 102000004169 proteins and genes Human genes 0.000 description 13
• 230000001105 regulatory effect Effects 0.000 description 13
• 229920001817 Agar Polymers 0.000 description 12
• 240000006439 Aspergillus oryzae Species 0.000 description 12
• 235000002247 Aspergillus oryzae Nutrition 0.000 description 12
• 241000499912 Trichoderma reesei Species 0.000 description 12
• 239000008272 agar Substances 0.000 description 12
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
• 108020004414 DNA Proteins 0.000 description 11
• 230000015572 biosynthetic process Effects 0.000 description 11
• 230000004075 alteration Effects 0.000 description 10
• 239000013612 plasmid Substances 0.000 description 10
• 210000001519 tissue Anatomy 0.000 description 10
• 229920000936 Agarose Polymers 0.000 description 9
• 241000351920 Aspergillus nidulans Species 0.000 description 9
• 241000228245 Aspergillus niger Species 0.000 description 9
• 241000233866 Fungi Species 0.000 description 9
• 241000699666 Mus <mouse, genus> Species 0.000 description 9
• 230000001580 bacterial effect Effects 0.000 description 9
• 230000033001 locomotion Effects 0.000 description 9
• 206010034674 peritonitis Diseases 0.000 description 9
• 238000005303 weighing Methods 0.000 description 9
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
• -1 amyL Chemical class 0.000 description 8
• 235000013305 food Nutrition 0.000 description 8
• 229930182830 galactose Natural products 0.000 description 8
• 239000008103 glucose Substances 0.000 description 8
• 238000011081 inoculation Methods 0.000 description 8
• 230000010354 integration Effects 0.000 description 8
• 239000002609 medium Substances 0.000 description 8
• 230000009467 reduction Effects 0.000 description 8
• 238000006722 reduction reaction Methods 0.000 description 8
• 239000000126 substance Substances 0.000 description 8
• 230000009261 transgenic effect Effects 0.000 description 8
• 239000004382 Amylase Substances 0.000 description 7
• 108010065511 Amylases Proteins 0.000 description 7
• 102000013142 Amylases Human genes 0.000 description 7
• 244000063299 Bacillus subtilis Species 0.000 description 7
• 235000014469 Bacillus subtilis Nutrition 0.000 description 7
• 206010052428 Wound Diseases 0.000 description 7
• 208000027418 Wounds and injury Diseases 0.000 description 7
• 108090000637 alpha-Amylases Proteins 0.000 description 7
• 235000019418 amylase Nutrition 0.000 description 7
• 239000000463 material Substances 0.000 description 7
• 210000001938 protoplast Anatomy 0.000 description 7
• 239000007261 sc medium Substances 0.000 description 7
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 6
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
• 241000193830 Bacillus <bacterium> Species 0.000 description 6
• 241000194108 Bacillus licheniformis Species 0.000 description 6
• 241000146399 Ceriporiopsis Species 0.000 description 6
• 240000007594 Oryza sativa Species 0.000 description 6
• 235000007164 Oryza sativa Nutrition 0.000 description 6
• 206010035039 Piloerection Diseases 0.000 description 6
• 239000003708 ampul Substances 0.000 description 6
• 238000004364 calculation method Methods 0.000 description 6
• MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 6
• 238000000576 coating method Methods 0.000 description 6
• 231100000673 dose–response relationship Toxicity 0.000 description 6
• 238000004520 electroporation Methods 0.000 description 6
• 230000002068 genetic effect Effects 0.000 description 6
• 230000012010 growth Effects 0.000 description 6
• 238000001990 intravenous administration Methods 0.000 description 6
• 150000002632 lipids Chemical class 0.000 description 6
• 239000002502 liposome Substances 0.000 description 6
• 239000003550 marker Substances 0.000 description 6
• 230000005371 pilomotor reflex Effects 0.000 description 6
• 235000009566 rice Nutrition 0.000 description 6
• 238000005070 sampling Methods 0.000 description 6
• 239000011550 stock solution Substances 0.000 description 6
• 210000000689 upper leg Anatomy 0.000 description 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 5
• 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 5
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 5
• 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 5
• 108700015934 Triose-phosphate isomerases Proteins 0.000 description 5
• 102000004139 alpha-Amylases Human genes 0.000 description 5
• 229940024171 alpha-amylase Drugs 0.000 description 5
• 150000001413 amino acids Chemical group 0.000 description 5
• 229960000723 ampicillin Drugs 0.000 description 5
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 5
• 239000004599 antimicrobial Substances 0.000 description 5
• 239000003795 chemical substances by application Substances 0.000 description 5
• 239000011248 coating agent Substances 0.000 description 5
• 238000010276 construction Methods 0.000 description 5
• 239000002552 dosage form Substances 0.000 description 5
• 239000007943 implant Substances 0.000 description 5
• 230000001976 improved effect Effects 0.000 description 5
• 238000000338 in vitro Methods 0.000 description 5
• 239000007924 injection Substances 0.000 description 5
• 238000002347 injection Methods 0.000 description 5
• 244000005700 microbiome Species 0.000 description 5
• 230000007935 neutral effect Effects 0.000 description 5
• 210000004303 peritoneum Anatomy 0.000 description 5
• 239000013641 positive control Substances 0.000 description 5
• 239000000829 suppository Substances 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• 239000003826 tablet Substances 0.000 description 5
• 238000013518 transcription Methods 0.000 description 5
• 230000035897 transcription Effects 0.000 description 5
• 102000004506 Blood Proteins Human genes 0.000 description 4
• 108010017384 Blood Proteins Proteins 0.000 description 4
• 241000223218 Fusarium Species 0.000 description 4
• 241000223221 Fusarium oxysporum Species 0.000 description 4
• 241000567178 Fusarium venenatum Species 0.000 description 4
• 241000193385 Geobacillus stearothermophilus Species 0.000 description 4
• 102100022624 Glucoamylase Human genes 0.000 description 4
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
• 108091028043 Nucleic acid sequence Proteins 0.000 description 4
• 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 4
• 206010040047 Sepsis Diseases 0.000 description 4
• 102000005924 Triose-Phosphate Isomerase Human genes 0.000 description 4
• 210000001015 abdomen Anatomy 0.000 description 4
• 108010048241 acetamidase Proteins 0.000 description 4
• 239000000654 additive Substances 0.000 description 4
• 150000001408 amides Chemical class 0.000 description 4
• 239000003242 anti bacterial agent Substances 0.000 description 4
• 229940088710 antibiotic agent Drugs 0.000 description 4
• 239000002775 capsule Substances 0.000 description 4
• 210000000349 chromosome Anatomy 0.000 description 4
• 230000021615 conjugation Effects 0.000 description 4
• 238000007796 conventional method Methods 0.000 description 4
• 238000001816 cooling Methods 0.000 description 4
• 239000003085 diluting agent Substances 0.000 description 4
• 230000006801 homologous recombination Effects 0.000 description 4
• 238000002744 homologous recombination Methods 0.000 description 4
• 239000008101 lactose Substances 0.000 description 4
• 238000010172 mouse model Methods 0.000 description 4
• 235000015097 nutrients Nutrition 0.000 description 4
• 239000000123 paper Substances 0.000 description 4
• 230000008488 polyadenylation Effects 0.000 description 4
• 238000003259 recombinant expression Methods 0.000 description 4
• 230000004044 response Effects 0.000 description 4
• 238000012216 screening Methods 0.000 description 4
• 239000008223 sterile water Substances 0.000 description 4
• 238000003786 synthesis reaction Methods 0.000 description 4
• 230000001225 therapeutic effect Effects 0.000 description 4
• 239000002023 wood Substances 0.000 description 4
• UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 3
• 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 description 3
• 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 description 3
• 108010037870 Anthranilate Synthase Proteins 0.000 description 3
• WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 description 3
• 102000004580 Aspartic Acid Proteases Human genes 0.000 description 3
• 108010017640 Aspartic Acid Proteases Proteins 0.000 description 3
• 241000228212 Aspergillus Species 0.000 description 3
• 108010059892 Cellulase Proteins 0.000 description 3
• 229920002261 Corn starch Polymers 0.000 description 3
• 241000588722 Escherichia Species 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
• 241000221779 Fusarium sambucinum Species 0.000 description 3
• 102000048120 Galactokinases Human genes 0.000 description 3
• 108700023157 Galactokinases Proteins 0.000 description 3
• 108700007698 Genetic Terminator Regions Proteins 0.000 description 3
• CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
• 229930182566 Gentamicin Natural products 0.000 description 3
• 241000282412 Homo Species 0.000 description 3
• 241001480714 Humicola insolens Species 0.000 description 3
• 206010061218 Inflammation Diseases 0.000 description 3
• 102100027612 Kallikrein-11 Human genes 0.000 description 3
• 241000209510 Liliopsida Species 0.000 description 3
• 229920004011 Macrolon® Polymers 0.000 description 3
• 238000011785 NMRI mouse Methods 0.000 description 3
• 241000219000 Populus Species 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 241000235403 Rhizomucor miehei Species 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 244000061456 Solanum tuberosum Species 0.000 description 3
• 235000002595 Solanum tuberosum Nutrition 0.000 description 3
• 241000194017 Streptococcus Species 0.000 description 3
• 241000187747 Streptomyces Species 0.000 description 3
• 101710152431 Trypsin-like protease Proteins 0.000 description 3
• IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 description 3
• 230000004308 accommodation Effects 0.000 description 3
• 239000003570 air Substances 0.000 description 3
• 239000012080 ambient air Substances 0.000 description 3
• 229940024606 amino acid Drugs 0.000 description 3
• 235000001014 amino acid Nutrition 0.000 description 3
• 230000000202 analgesic effect Effects 0.000 description 3
• 238000010171 animal model Methods 0.000 description 3
• 238000003556 assay Methods 0.000 description 3
• 229960003644 aztreonam Drugs 0.000 description 3
• WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 239000006161 blood agar Substances 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 229960000484 ceftazidime Drugs 0.000 description 3
• ORFOPKXBNMVMKC-DWVKKRMSSA-N ceftazidime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC(C)(C)C(O)=O)C=2N=C(N)SC=2)CC=1C[N+]1=CC=CC=C1 ORFOPKXBNMVMKC-DWVKKRMSSA-N 0.000 description 3
• 239000001913 cellulose Substances 0.000 description 3
• 229920002678 cellulose Polymers 0.000 description 3
• 229960003405 ciprofloxacin Drugs 0.000 description 3
• 230000001332 colony forming effect Effects 0.000 description 3
• 239000008120 corn starch Substances 0.000 description 3
• 230000034994 death Effects 0.000 description 3
• 230000009429 distress Effects 0.000 description 3
• 229960002518 gentamicin Drugs 0.000 description 3
• 238000010438 heat treatment Methods 0.000 description 3
• 229910001385 heavy metal Inorganic materials 0.000 description 3
• 229960001680 ibuprofen Drugs 0.000 description 3
• 238000001727 in vivo Methods 0.000 description 3
• 230000004054 inflammatory process Effects 0.000 description 3
• 238000001802 infusion Methods 0.000 description 3
• 239000002054 inoculum Substances 0.000 description 3
• 238000002955 isolation Methods 0.000 description 3
• 230000001404 mediated effect Effects 0.000 description 3
• 229940048895 meronem Drugs 0.000 description 3
• 229910052757 nitrogen Inorganic materials 0.000 description 3
• 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 3
• 239000002245 particle Substances 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 238000012552 review Methods 0.000 description 3
• 206010040872 skin infection Diseases 0.000 description 3
• 239000007787 solid Substances 0.000 description 3
• 208000024891 symptom Diseases 0.000 description 3
• 238000013519 translation Methods 0.000 description 3
• 210000003462 vein Anatomy 0.000 description 3
• OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 description 2
• JLIDBLDQVAYHNE-YKALOCIXSA-N Abscisic acid Natural products OC(=O)/C=C(/C)\C=C\[C@@]1(O)C(C)=CC(=O)CC1(C)C JLIDBLDQVAYHNE-YKALOCIXSA-N 0.000 description 2
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
• 101710197633 Actin-1 Proteins 0.000 description 2
• 102000007698 Alcohol dehydrogenase Human genes 0.000 description 2
• 108010021809 Alcohol dehydrogenase Proteins 0.000 description 2
• 101100163849 Arabidopsis thaliana ARS1 gene Proteins 0.000 description 2
• 101000757144 Aspergillus niger Glucoamylase Proteins 0.000 description 2
• 241000193744 Bacillus amyloliquefaciens Species 0.000 description 2
• 208000035143 Bacterial infection Diseases 0.000 description 2
• 240000002791 Brassica napus Species 0.000 description 2
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
• 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 description 2
• 241000606153 Chlamydia trachomatis Species 0.000 description 2
• 241000123346 Chrysosporium Species 0.000 description 2
• 108090000204 Dipeptidase 1 Proteins 0.000 description 2
• 102000010911 Enzyme Precursors Human genes 0.000 description 2
• 108010062466 Enzyme Precursors Proteins 0.000 description 2
• 241000567163 Fusarium cerealis Species 0.000 description 2
• 241000146406 Fusarium heterosporum Species 0.000 description 2
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 2
• 101100369308 Geobacillus stearothermophilus nprS gene Proteins 0.000 description 2
• 206010020649 Hyperkeratosis Diseases 0.000 description 2
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
• 208000032376 Lung infection Diseases 0.000 description 2
• 241000555688 Malassezia furfur Species 0.000 description 2
• 102100024295 Maltase-glucoamylase Human genes 0.000 description 2
• 108090000157 Metallothionein Proteins 0.000 description 2
• 108091005507 Neutral proteases Proteins 0.000 description 2
• 102000035092 Neutral proteases Human genes 0.000 description 2
• 241000233654 Oomycetes Species 0.000 description 2
• 229930182555 Penicillin Natural products 0.000 description 2
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 2
• 241000235648 Pichia Species 0.000 description 2
• 206010035664 Pneumonia Diseases 0.000 description 2
• ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
• 241000589516 Pseudomonas Species 0.000 description 2
• 108020004511 Recombinant DNA Proteins 0.000 description 2
• 101100097319 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ala1 gene Proteins 0.000 description 2
• 241000191967 Staphylococcus aureus Species 0.000 description 2
• 241000191963 Staphylococcus epidermidis Species 0.000 description 2
• 241000193998 Streptococcus pneumoniae Species 0.000 description 2
• 241000193996 Streptococcus pyogenes Species 0.000 description 2
• 241000194054 Streptococcus uberis Species 0.000 description 2
• 241000187432 Streptomyces coelicolor Species 0.000 description 2
• 239000004098 Tetracycline Substances 0.000 description 2
• 241000223258 Thermomyces lanuginosus Species 0.000 description 2
• 241001313536 Thermothelomyces thermophila Species 0.000 description 2
• 108700019146 Transgenes Proteins 0.000 description 2
• 241000223259 Trichoderma Species 0.000 description 2
• 240000006677 Vicia faba Species 0.000 description 2
• 235000010749 Vicia faba Nutrition 0.000 description 2
• 241000700605 Viruses Species 0.000 description 2
• 240000008042 Zea mays Species 0.000 description 2
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
• 239000002253 acid Substances 0.000 description 2
• 239000004480 active ingredient Substances 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 239000000443 aerosol Substances 0.000 description 2
• 125000001931 aliphatic group Chemical group 0.000 description 2
• 108010028144 alpha-Glucosidases Proteins 0.000 description 2
• 101150078331 ama-1 gene Proteins 0.000 description 2
• 125000003277 amino group Chemical group 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 2
• 239000012736 aqueous medium Substances 0.000 description 2
• 208000022362 bacterial infectious disease Diseases 0.000 description 2
• 239000011230 binding agent Substances 0.000 description 2
• 230000003115 biocidal effect Effects 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 230000015556 catabolic process Effects 0.000 description 2
• 229960005091 chloramphenicol Drugs 0.000 description 2
• WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
• 210000003763 chloroplast Anatomy 0.000 description 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
• 230000002759 chromosomal effect Effects 0.000 description 2
• 235000005822 corn Nutrition 0.000 description 2
• 239000006071 cream Substances 0.000 description 2
• 230000001419 dependent effect Effects 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 230000035622 drinking Effects 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• 235000013399 edible fruits Nutrition 0.000 description 2
• 210000002257 embryonic structure Anatomy 0.000 description 2
• 230000001804 emulsifying effect Effects 0.000 description 2
• 108010092413 endoglucanase V Proteins 0.000 description 2
• 238000005516 engineering process Methods 0.000 description 2
• 230000002255 enzymatic effect Effects 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 description 2
• 238000000605 extraction Methods 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 230000004927 fusion Effects 0.000 description 2
• 239000000499 gel Substances 0.000 description 2
• 108010061330 glucan 1,4-alpha-maltohydrolase Proteins 0.000 description 2
• 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
• 239000008187 granular material Substances 0.000 description 2
• 238000004128 high performance liquid chromatography Methods 0.000 description 2
• 210000000548 hind-foot Anatomy 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 238000003780 insertion Methods 0.000 description 2
• 230000037431 insertion Effects 0.000 description 2
• 238000007912 intraperitoneal administration Methods 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• 239000006210 lotion Substances 0.000 description 2
• 239000006166 lysate Substances 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 108020004999 messenger RNA Proteins 0.000 description 2
• 239000004005 microsphere Substances 0.000 description 2
• 239000002773 nucleotide Substances 0.000 description 2
• 125000003729 nucleotide group Chemical group 0.000 description 2
• 239000002674 ointment Substances 0.000 description 2
• 150000002960 penicillins Chemical class 0.000 description 2
• 239000000546 pharmaceutical excipient Substances 0.000 description 2
• 230000003285 pharmacodynamic effect Effects 0.000 description 2
• 229920000642 polymer Polymers 0.000 description 2
• 229920001592 potato starch Polymers 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 238000001556 precipitation Methods 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 230000002035 prolonged effect Effects 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• 101150054232 pyrG gene Proteins 0.000 description 2
• 230000002829 reductive effect Effects 0.000 description 2
• 230000008929 regeneration Effects 0.000 description 2
• 238000011069 regeneration method Methods 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 230000003248 secreting effect Effects 0.000 description 2
• 210000003491 skin Anatomy 0.000 description 2
• 239000003381 stabilizer Substances 0.000 description 2
• UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
• KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
• 230000009885 systemic effect Effects 0.000 description 2
• 238000012360 testing method Methods 0.000 description 2
• 235000019364 tetracycline Nutrition 0.000 description 2
• 150000003522 tetracyclines Chemical class 0.000 description 2
• 150000003568 thioethers Chemical class 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• 230000001131 transforming effect Effects 0.000 description 2
• 201000008827 tuberculosis Diseases 0.000 description 2
• 230000009105 vegetative growth Effects 0.000 description 2
• 239000000080 wetting agent Substances 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
• FQVLRGLGWNWPSS-BXBUPLCLSA-N (4r,7s,10s,13s,16r)-16-acetamido-13-(1h-imidazol-5-ylmethyl)-10-methyl-6,9,12,15-tetraoxo-7-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide Chemical compound N1C(=O)[C@@H](NC(C)=O)CSSC[C@@H](C(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CC1=CN=CN1 FQVLRGLGWNWPSS-BXBUPLCLSA-N 0.000 description 1
• TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
• NBWRJAOOMGASJP-UHFFFAOYSA-N 2-(3,5-diphenyl-1h-tetrazol-1-ium-2-yl)-4,5-dimethyl-1,3-thiazole;bromide Chemical compound [Br-].S1C(C)=C(C)N=C1N1N(C=2C=CC=CC=2)N=C(C=2C=CC=CC=2)[NH2+]1 NBWRJAOOMGASJP-UHFFFAOYSA-N 0.000 description 1
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
• 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
• 101150104118 ANS1 gene Proteins 0.000 description 1
• 208000002874 Acne Vulgaris Diseases 0.000 description 1
• 208000020154 Acnes Diseases 0.000 description 1
• 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 description 1
• 101100510736 Actinidia chinensis var. chinensis LDOX gene Proteins 0.000 description 1
• 229930024421 Adenine Natural products 0.000 description 1
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
• 241000589155 Agrobacterium tumefaciens Species 0.000 description 1
• 241000743339 Agrostis Species 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 102100034035 Alcohol dehydrogenase 1A Human genes 0.000 description 1
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 description 1
• 241000534414 Anotopterus nikparini Species 0.000 description 1
• 241000219195 Arabidopsis thaliana Species 0.000 description 1
• 241000243813 Arenicola Species 0.000 description 1
• 241000235349 Ascomycota Species 0.000 description 1
• 241001513093 Aspergillus awamori Species 0.000 description 1
• 101000961203 Aspergillus awamori Glucoamylase Proteins 0.000 description 1
• 241000892910 Aspergillus foetidus Species 0.000 description 1
• 241001225321 Aspergillus fumigatus Species 0.000 description 1
• 241001480052 Aspergillus japonicus Species 0.000 description 1
• 101000756530 Aspergillus niger Endo-1,4-beta-xylanase B Proteins 0.000 description 1
• 241000223651 Aureobasidium Species 0.000 description 1
• 244000075850 Avena orientalis Species 0.000 description 1
• 235000007319 Avena orientalis Nutrition 0.000 description 1
• 108090000145 Bacillolysin Proteins 0.000 description 1
• 241000193752 Bacillus circulans Species 0.000 description 1
• 241001328122 Bacillus clausii Species 0.000 description 1
• 241000193749 Bacillus coagulans Species 0.000 description 1
• 241000193747 Bacillus firmus Species 0.000 description 1
• 241000193422 Bacillus lentus Species 0.000 description 1
• 241000194107 Bacillus megaterium Species 0.000 description 1
• 241000194103 Bacillus pumilus Species 0.000 description 1
• 241000193388 Bacillus thuringiensis Species 0.000 description 1
• 108091005658 Basic proteases Proteins 0.000 description 1
• 241000221198 Basidiomycota Species 0.000 description 1
• 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
• 102100030981 Beta-alanine-activating enzyme Human genes 0.000 description 1
• 241000222490 Bjerkandera Species 0.000 description 1
• 241000222478 Bjerkandera adusta Species 0.000 description 1
• 241000588779 Bordetella bronchiseptica Species 0.000 description 1
• 241000588780 Bordetella parapertussis Species 0.000 description 1
• 241000588832 Bordetella pertussis Species 0.000 description 1
• 241001135529 Bordetella sp. Species 0.000 description 1
• 241000589972 Borrelia sp. Species 0.000 description 1
• 241000589969 Borreliella burgdorferi Species 0.000 description 1
• 235000011293 Brassica napus Nutrition 0.000 description 1
• 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 1
• 240000003259 Brassica oleracea var. botrytis Species 0.000 description 1
• 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
• 241000219193 Brassicaceae Species 0.000 description 1
• 241000193764 Brevibacillus brevis Species 0.000 description 1
• 240000005430 Bromus catharticus Species 0.000 description 1
• 241000508772 Brucella sp. Species 0.000 description 1
• 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 1
• 101100520142 Caenorhabditis elegans pin-2 gene Proteins 0.000 description 1
• 241000589876 Campylobacter Species 0.000 description 1
• 241000589875 Campylobacter jejuni Species 0.000 description 1
• 241000589994 Campylobacter sp. Species 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 244000025254 Cannabis sativa Species 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 108010084185 Cellulases Proteins 0.000 description 1
• 102000005575 Cellulases Human genes 0.000 description 1
• 102100037633 Centrin-3 Human genes 0.000 description 1
• 229930186147 Cephalosporin Natural products 0.000 description 1
• 241001466517 Ceriporiopsis aneirina Species 0.000 description 1
• 241001646018 Ceriporiopsis gilvescens Species 0.000 description 1
• 229920002101 Chitin Polymers 0.000 description 1
• 229920001661 Chitosan Polymers 0.000 description 1
• 241000606161 Chlamydia Species 0.000 description 1
• 241001647372 Chlamydia pneumoniae Species 0.000 description 1
• 241001647378 Chlamydia psittaci Species 0.000 description 1
• 241001495184 Chlamydia sp. Species 0.000 description 1
• 241000701248 Chlorella virus Species 0.000 description 1
• 241000985909 Chrysosporium keratinophilum Species 0.000 description 1
• 241001674013 Chrysosporium lucknowense Species 0.000 description 1
• 241001556045 Chrysosporium merdarium Species 0.000 description 1
• 241000080524 Chrysosporium queenslandicum Species 0.000 description 1
• 241001674001 Chrysosporium tropicum Species 0.000 description 1
• 241000355696 Chrysosporium zonatum Species 0.000 description 1
• 241000233652 Chytridiomycota Species 0.000 description 1
• 241000873310 Citrobacter sp. Species 0.000 description 1
• 241000193403 Clostridium Species 0.000 description 1
• 241000222511 Coprinus Species 0.000 description 1
• 244000251987 Coprinus macrorhizus Species 0.000 description 1
• 235000001673 Coprinus macrorhizus Nutrition 0.000 description 1
• 241000222356 Coriolus Species 0.000 description 1
• 241001337994 Cryptococcus <scale insect> Species 0.000 description 1
• 241000694959 Cryptococcus sp. Species 0.000 description 1
• 201000003883 Cystic fibrosis Diseases 0.000 description 1
• 102000018832 Cytochromes Human genes 0.000 description 1
• 108010052832 Cytochromes Proteins 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 1
• MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 description 1
• 229930182845 D-isoleucine Natural products 0.000 description 1
• 230000004544 DNA amplification Effects 0.000 description 1
• 108010002069 Defensins Proteins 0.000 description 1
• 102000000541 Defensins Human genes 0.000 description 1
• 101710088194 Dehydrogenase Proteins 0.000 description 1
• 206010012438 Dermatitis atopic Diseases 0.000 description 1
• 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
• 101100342470 Dictyostelium discoideum pkbA gene Proteins 0.000 description 1
• JWCSIUVGFCSJCK-CAVRMKNVSA-N Disodium Moxalactam Chemical compound N([C@]1(OC)C(N2C(=C(CSC=3N(N=NN=3)C)CO[C@@H]21)C(O)=O)=O)C(=O)C(C(O)=O)C1=CC=C(O)C=C1 JWCSIUVGFCSJCK-CAVRMKNVSA-N 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 239000004129 EU approved improving agent Substances 0.000 description 1
• 101710132690 Endo-1,4-beta-xylanase A Proteins 0.000 description 1
• 241000147019 Enterobacter sp. Species 0.000 description 1
• 241000194033 Enterococcus Species 0.000 description 1
• 101100385973 Escherichia coli (strain K12) cycA gene Proteins 0.000 description 1
• 241000488157 Escherichia sp. Species 0.000 description 1
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
• 239000005977 Ethylene Substances 0.000 description 1
• 241000234642 Festuca Species 0.000 description 1
• 241000192125 Firmicutes Species 0.000 description 1
• 241000589565 Flavobacterium Species 0.000 description 1
• 206010017533 Fungal infection Diseases 0.000 description 1
• 241000145614 Fusarium bactridioides Species 0.000 description 1
• 241000223194 Fusarium culmorum Species 0.000 description 1
• 241000223195 Fusarium graminearum Species 0.000 description 1
• 241001112697 Fusarium reticulatum Species 0.000 description 1
• 241001014439 Fusarium sarcochroum Species 0.000 description 1
• 241000223192 Fusarium sporotrichioides Species 0.000 description 1
• 241001465753 Fusarium torulosum Species 0.000 description 1
• 241000605909 Fusobacterium Species 0.000 description 1
• 101150108358 GLAA gene Proteins 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 241000626621 Geobacillus Species 0.000 description 1
• 101100001650 Geobacillus stearothermophilus amyM gene Proteins 0.000 description 1
• 101100080316 Geobacillus stearothermophilus nprT gene Proteins 0.000 description 1
• 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 description 1
• 239000005980 Gibberellic acid Substances 0.000 description 1
• 108010044091 Globulins Proteins 0.000 description 1
• 102000006395 Globulins Human genes 0.000 description 1
• 229920001503 Glucan Polymers 0.000 description 1
• 108010068370 Glutens Proteins 0.000 description 1
• ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical group OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
• 206010018612 Gonorrhoea Diseases 0.000 description 1
• 101150009006 HIS3 gene Proteins 0.000 description 1
• 241000606768 Haemophilus influenzae Species 0.000 description 1
• 241000606841 Haemophilus sp. Species 0.000 description 1
• 101100295959 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) arcB gene Proteins 0.000 description 1
• 101100246753 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) pyrF gene Proteins 0.000 description 1
• 241000589989 Helicobacter Species 0.000 description 1
• 241000590008 Helicobacter sp. Species 0.000 description 1
• 241000238631 Hexapoda Species 0.000 description 1
• 101000780443 Homo sapiens Alcohol dehydrogenase 1A Proteins 0.000 description 1
• 101000773364 Homo sapiens Beta-alanine-activating enzyme Proteins 0.000 description 1
• 101000880522 Homo sapiens Centrin-3 Proteins 0.000 description 1
• 240000005979 Hordeum vulgare Species 0.000 description 1
• 235000007340 Hordeum vulgare Nutrition 0.000 description 1
• 241000223198 Humicola Species 0.000 description 1
• 241000411968 Ilyobacter Species 0.000 description 1
• 108010074328 Interferon-gamma Proteins 0.000 description 1
• 102000008070 Interferon-gamma Human genes 0.000 description 1
• 108010065805 Interleukin-12 Proteins 0.000 description 1
• 102000013462 Interleukin-12 Human genes 0.000 description 1
• 102000004195 Isomerases Human genes 0.000 description 1
• 108090000769 Isomerases Proteins 0.000 description 1
• 241000588754 Klebsiella sp. Species 0.000 description 1
• 241000235649 Kluyveromyces Species 0.000 description 1
• 241001138401 Kluyveromyces lactis Species 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• 108010029541 Laccase Proteins 0.000 description 1
• 241000235087 Lachancea kluyveri Species 0.000 description 1
• 241000186660 Lactobacillus Species 0.000 description 1
• 241000194036 Lactococcus Species 0.000 description 1
• 241000589242 Legionella pneumophila Species 0.000 description 1
• 241000589268 Legionella sp. Species 0.000 description 1
• 101710094902 Legumin Proteins 0.000 description 1
• 240000007472 Leucaena leucocephala Species 0.000 description 1
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
• 108010036940 Levansucrase Proteins 0.000 description 1
• OJMMVQQUTAEWLP-UHFFFAOYSA-N Lincomycin Natural products CN1CC(CCC)CC1C(=O)NC(C(C)O)C1C(O)C(O)C(O)C(SC)O1 OJMMVQQUTAEWLP-UHFFFAOYSA-N 0.000 description 1
• 108090001060 Lipase Proteins 0.000 description 1
• 102000004882 Lipase Human genes 0.000 description 1
• 239000004367 Lipase Substances 0.000 description 1
• 241000186779 Listeria monocytogenes Species 0.000 description 1
• 241001084338 Listeria sp. Species 0.000 description 1
• 241000209082 Lolium Species 0.000 description 1
• 208000019693 Lung disease Diseases 0.000 description 1
• 241000219745 Lupinus Species 0.000 description 1
• 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
• 101150068888 MET3 gene Proteins 0.000 description 1
• 241001344133 Magnaporthe Species 0.000 description 1
• 229920000057 Mannan Polymers 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
• 108060004795 Methyltransferase Proteins 0.000 description 1
• BYBLEWFAAKGYCD-UHFFFAOYSA-N Miconazole Chemical compound ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 BYBLEWFAAKGYCD-UHFFFAOYSA-N 0.000 description 1
• 241001169527 Morganella sp. (in: Fungi) Species 0.000 description 1
• 241000235395 Mucor Species 0.000 description 1
• 241001529936 Murinae Species 0.000 description 1
• 241000711408 Murine respirovirus Species 0.000 description 1
• 241000226677 Myceliophthora Species 0.000 description 1
• 241000186362 Mycobacterium leprae Species 0.000 description 1
• 241000187488 Mycobacterium sp. Species 0.000 description 1
• 241000204048 Mycoplasma hominis Species 0.000 description 1
• 241000202944 Mycoplasma sp. Species 0.000 description 1
• 208000031888 Mycoses Diseases 0.000 description 1
• 241000588653 Neisseria Species 0.000 description 1
• 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
• 241000588650 Neisseria meningitidis Species 0.000 description 1
• 241001440871 Neisseria sp. Species 0.000 description 1
• 241000233892 Neocallimastix Species 0.000 description 1
• 241000221960 Neurospora Species 0.000 description 1
• 241000221961 Neurospora crassa Species 0.000 description 1
• 101100022915 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-11 gene Proteins 0.000 description 1
• 244000061176 Nicotiana tabacum Species 0.000 description 1
• 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
• 108090000913 Nitrate Reductases Proteins 0.000 description 1
• 241001072230 Oceanobacillus Species 0.000 description 1
• 102000007981 Ornithine carbamoyltransferase Human genes 0.000 description 1
• 101710113020 Ornithine transcarbamylase, mitochondrial Proteins 0.000 description 1
• 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 description 1
• 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 241001236817 Paecilomyces <Clavicipitaceae> Species 0.000 description 1
• 241000194109 Paenibacillus lautus Species 0.000 description 1
• 206010034133 Pathogen resistance Diseases 0.000 description 1
• 229930195708 Penicillin V Natural products 0.000 description 1
• 241000228143 Penicillium Species 0.000 description 1
• KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 description 1
• 241000222385 Phanerochaete Species 0.000 description 1
• 241000222393 Phanerochaete chrysosporium Species 0.000 description 1
• 244000046052 Phaseolus vulgaris Species 0.000 description 1
• 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
• 241000222395 Phlebia Species 0.000 description 1
• 241000222397 Phlebia radiata Species 0.000 description 1
• 108091000080 Phosphotransferase Proteins 0.000 description 1
• 241000425347 Phyla <beetle> Species 0.000 description 1
• 241000235379 Piromyces Species 0.000 description 1
• 240000004713 Pisum sativum Species 0.000 description 1
• 235000010582 Pisum sativum Nutrition 0.000 description 1
• 241000223960 Plasmodium falciparum Species 0.000 description 1
• 241000222350 Pleurotus Species 0.000 description 1
• 244000252132 Pleurotus eryngii Species 0.000 description 1
• 235000001681 Pleurotus eryngii Nutrition 0.000 description 1
• 241000209504 Poaceae Species 0.000 description 1
• 241000276498 Pollachius virens Species 0.000 description 1
• 108010040201 Polymyxins Proteins 0.000 description 1
• 102000001253 Protein Kinase Human genes 0.000 description 1
• 241000334216 Proteus sp. Species 0.000 description 1
• 241000588774 Providencia sp. Species 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 241000589774 Pseudomonas sp. Species 0.000 description 1
• 102000018120 Recombinases Human genes 0.000 description 1
• 108010091086 Recombinases Proteins 0.000 description 1
• 241000235402 Rhizomucor Species 0.000 description 1
• 101000968489 Rhizomucor miehei Lipase Proteins 0.000 description 1
• 101100394989 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) hisI gene Proteins 0.000 description 1
• 241000606695 Rickettsia rickettsii Species 0.000 description 1
• 241000606714 Rickettsia sp. Species 0.000 description 1
• 241000606726 Rickettsia typhi Species 0.000 description 1
• 241000235070 Saccharomyces Species 0.000 description 1
• 235000003534 Saccharomyces carlsbergensis Nutrition 0.000 description 1
• 101900354623 Saccharomyces cerevisiae Galactokinase Proteins 0.000 description 1
• 235000001006 Saccharomyces cerevisiae var diastaticus Nutrition 0.000 description 1
• 244000206963 Saccharomyces cerevisiae var. diastaticus Species 0.000 description 1
• 241000204893 Saccharomyces douglasii Species 0.000 description 1
• 241001407717 Saccharomyces norbensis Species 0.000 description 1
• 241001123227 Saccharomyces pastorianus Species 0.000 description 1
• 241000235343 Saccharomycetales Species 0.000 description 1
• 241000607142 Salmonella Species 0.000 description 1
• 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
• 241000607149 Salmonella sp. Species 0.000 description 1
• 241000222480 Schizophyllum Species 0.000 description 1
• 241000235346 Schizosaccharomyces Species 0.000 description 1
• 101100022918 Schizosaccharomyces pombe (strain 972 / ATCC 24843) sua1 gene Proteins 0.000 description 1
• 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
• 241000209056 Secale Species 0.000 description 1
• 235000007238 Secale cereale Nutrition 0.000 description 1
• 241000607714 Serratia sp. Species 0.000 description 1
• 208000019802 Sexually transmitted disease Diseases 0.000 description 1
• 241000607758 Shigella sp. Species 0.000 description 1
• 240000003768 Solanum lycopersicum Species 0.000 description 1
• 240000006394 Sorghum bicolor Species 0.000 description 1
• 244000138286 Sorghum saccharatum Species 0.000 description 1
• 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
• 235000016536 Sporobolus cryptandrus Nutrition 0.000 description 1
• 241000295644 Staphylococcaceae Species 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 241000191965 Staphylococcus carnosus Species 0.000 description 1
• 241000191973 Staphylococcus xylosus Species 0.000 description 1
• 241000193985 Streptococcus agalactiae Species 0.000 description 1
• 241000264435 Streptococcus dysgalactiae subsp. equisimilis Species 0.000 description 1
• 241000194048 Streptococcus equi Species 0.000 description 1
• 241000194047 Streptococcus hyointestinalis Species 0.000 description 1
• 101100309436 Streptococcus mutans serotype c (strain ATCC 700610 / UA159) ftf gene Proteins 0.000 description 1
• 201000005010 Streptococcus pneumonia Diseases 0.000 description 1
• 241000958303 Streptomyces achromogenes Species 0.000 description 1
• 241001468227 Streptomyces avermitilis Species 0.000 description 1
• 101100370749 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) trpC1 gene Proteins 0.000 description 1
• 241000187392 Streptomyces griseus Species 0.000 description 1
• 241000187391 Streptomyces hygroscopicus Species 0.000 description 1
• 241000187398 Streptomyces lividans Species 0.000 description 1
• 108090000787 Subtilisin Proteins 0.000 description 1
• 235000021536 Sugar beet Nutrition 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
• 241000228341 Talaromyces Species 0.000 description 1
• 241001540751 Talaromyces ruber Species 0.000 description 1
• 244000269722 Thea sinensis Species 0.000 description 1
• 244000152045 Themeda triandra Species 0.000 description 1
• 101100157012 Thermoanaerobacterium saccharolyticum (strain DSM 8691 / JW/SL-YS485) xynB gene Proteins 0.000 description 1
• 241000228178 Thermoascus Species 0.000 description 1
• 241001494489 Thielavia Species 0.000 description 1
• 241001495429 Thielavia terrestris Species 0.000 description 1
• 108010022394 Threonine synthase Proteins 0.000 description 1
• 241001149964 Tolypocladium Species 0.000 description 1
• 241000222354 Trametes Species 0.000 description 1
• 241000222357 Trametes hirsuta Species 0.000 description 1
• 241000222355 Trametes versicolor Species 0.000 description 1
• 241000217816 Trametes villosa Species 0.000 description 1
• 241000589884 Treponema pallidum Species 0.000 description 1
• 241000589906 Treponema sp. Species 0.000 description 1
• 241000223260 Trichoderma harzianum Species 0.000 description 1
• 241000378866 Trichoderma koningii Species 0.000 description 1
• 241000223262 Trichoderma longibrachiatum Species 0.000 description 1
• 241000223261 Trichoderma viride Species 0.000 description 1
• 102100033598 Triosephosphate isomerase Human genes 0.000 description 1
• 235000021307 Triticum Nutrition 0.000 description 1
• 244000098338 Triticum aestivum Species 0.000 description 1
• 241000223105 Trypanosoma brucei Species 0.000 description 1
• 241000223093 Trypanosoma sp. Species 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• 101150050575 URA3 gene Proteins 0.000 description 1
• 108090000848 Ubiquitin Proteins 0.000 description 1
• 102000044159 Ubiquitin Human genes 0.000 description 1
• 241000202898 Ureaplasma Species 0.000 description 1
• 108010059993 Vancomycin Proteins 0.000 description 1
• 241000607626 Vibrio cholerae Species 0.000 description 1
• 241000607272 Vibrio parahaemolyticus Species 0.000 description 1
• 241000607284 Vibrio sp. Species 0.000 description 1
• 241000409279 Xerochrysium dermatitidis Species 0.000 description 1
• 241000235013 Yarrowia Species 0.000 description 1
• 241000235015 Yarrowia lipolytica Species 0.000 description 1
• 241000607447 Yersinia enterocolitica Species 0.000 description 1
• 241000607479 Yersinia pestis Species 0.000 description 1
• 241000607477 Yersinia pseudotuberculosis Species 0.000 description 1
• 241000131891 Yersinia sp. Species 0.000 description 1
• 241000758405 Zoopagomycotina Species 0.000 description 1
• ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 1
• 241000606834 [Haemophilus] ducreyi Species 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 230000002378 acidificating effect Effects 0.000 description 1
• 206010000496 acne Diseases 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 229960000643 adenine Drugs 0.000 description 1
• 239000000853 adhesive Substances 0.000 description 1
• 230000001070 adhesive effect Effects 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 238000001042 affinity chromatography Methods 0.000 description 1
• 108010045649 agarase Proteins 0.000 description 1
• 230000009418 agronomic effect Effects 0.000 description 1
• 108010050181 aleurone Proteins 0.000 description 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 229940126575 aminoglycoside Drugs 0.000 description 1
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
• 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
• 235000011130 ammonium sulphate Nutrition 0.000 description 1
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
• 229960003942 amphotericin b Drugs 0.000 description 1
• 229940121363 anti-inflammatory agent Drugs 0.000 description 1
• 239000002260 anti-inflammatory agent Substances 0.000 description 1
• 230000000433 anti-nutritional effect Effects 0.000 description 1
• 230000001166 anti-perspirative effect Effects 0.000 description 1
• 229940121375 antifungal agent Drugs 0.000 description 1
• 239000003429 antifungal agent Substances 0.000 description 1
• 239000003213 antiperspirant Substances 0.000 description 1
• 229940124976 antitubercular drug Drugs 0.000 description 1
• 101150009206 aprE gene Proteins 0.000 description 1
• 239000003125 aqueous solvent Substances 0.000 description 1
• 101150008194 argB gene Proteins 0.000 description 1
• 210000004507 artificial chromosome Anatomy 0.000 description 1
• 229940091771 aspergillus fumigatus Drugs 0.000 description 1
• 201000008937 atopic dermatitis Diseases 0.000 description 1
• 150000003851 azoles Chemical class 0.000 description 1
• 229940054340 bacillus coagulans Drugs 0.000 description 1
• 229940005348 bacillus firmus Drugs 0.000 description 1
• 229940097012 bacillus thuringiensis Drugs 0.000 description 1
• 101150103518 bar gene Proteins 0.000 description 1
• 239000003781 beta lactamase inhibitor Substances 0.000 description 1
• 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
• 108010047754 beta-Glucosidase Proteins 0.000 description 1
• 102000006995 beta-Glucosidase Human genes 0.000 description 1
• 102000006635 beta-lactamase Human genes 0.000 description 1
• 229940126813 beta-lactamase inhibitor Drugs 0.000 description 1
• 235000013361 beverage Nutrition 0.000 description 1
• 229920002988 biodegradable polymer Polymers 0.000 description 1
• 239000004621 biodegradable polymer Substances 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 238000010241 blood sampling Methods 0.000 description 1
• 230000036760 body temperature Effects 0.000 description 1
• 239000000872 buffer Substances 0.000 description 1
• 239000006172 buffering agent Substances 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 229940041011 carbapenems Drugs 0.000 description 1
• 229960003669 carbenicillin Drugs 0.000 description 1
• FPPNZSSZRUTDAP-UWFZAAFLSA-N carbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(O)=O)C1=CC=CC=C1 FPPNZSSZRUTDAP-UWFZAAFLSA-N 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 239000011111 cardboard Substances 0.000 description 1
• 230000003197 catalytic effect Effects 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 229960005361 cefaclor Drugs 0.000 description 1
• QYIYFLOTGYLRGG-GPCCPHFNSA-N cefaclor Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 QYIYFLOTGYLRGG-GPCCPHFNSA-N 0.000 description 1
• 229960001139 cefazolin Drugs 0.000 description 1
• MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 1
• 229960001668 cefuroxime Drugs 0.000 description 1
• JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 210000002421 cell wall Anatomy 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 229940106157 cellulase Drugs 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 229940124587 cephalosporin Drugs 0.000 description 1
• 150000001780 cephalosporins Chemical class 0.000 description 1
• 235000013339 cereals Nutrition 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• JQXXHWHPUNPDRT-BQVAUQFYSA-N chembl1523493 Chemical compound O([C@](C1=O)(C)O\C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2C=NN1CCN(C)CC1 JQXXHWHPUNPDRT-BQVAUQFYSA-N 0.000 description 1
• 238000006243 chemical reaction Methods 0.000 description 1
• 229940038705 chlamydia trachomatis Drugs 0.000 description 1
• 235000012000 cholesterol Nutrition 0.000 description 1
• 238000011098 chromatofocusing Methods 0.000 description 1
• 238000004587 chromatography analysis Methods 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 239000000356 contaminant Substances 0.000 description 1
• 238000011109 contamination Methods 0.000 description 1
• 238000013270 controlled release Methods 0.000 description 1
• 230000001276 controlling effect Effects 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 230000010154 cross-pollination Effects 0.000 description 1
• 235000018417 cysteine Nutrition 0.000 description 1
• 150000001945 cysteines Chemical class 0.000 description 1
• 210000000805 cytoplasm Anatomy 0.000 description 1
• 101150005799 dagA gene Proteins 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 239000002781 deodorant agent Substances 0.000 description 1
• 230000000249 desinfective effect Effects 0.000 description 1
• FCRACOPGPMPSHN-UHFFFAOYSA-N desoxyabscisic acid Natural products OC(=O)C=C(C)C=CC1C(C)=CC(=O)CC1(C)C FCRACOPGPMPSHN-UHFFFAOYSA-N 0.000 description 1
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
• 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
• 230000008034 disappearance Effects 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 239000007884 disintegrant Substances 0.000 description 1
• NEKNNCABDXGBEN-UHFFFAOYSA-L disodium;4-(4-chloro-2-methylphenoxy)butanoate;4-(2,4-dichlorophenoxy)butanoate Chemical compound [Na+].[Na+].CC1=CC(Cl)=CC=C1OCCCC([O-])=O.[O-]C(=O)CCCOC1=CC=C(Cl)C=C1Cl NEKNNCABDXGBEN-UHFFFAOYSA-L 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 150000002019 disulfides Chemical class 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 239000003995 emulsifying agent Substances 0.000 description 1
• 108010091371 endoglucanase 1 Proteins 0.000 description 1
• 108010091384 endoglucanase 2 Proteins 0.000 description 1
• 238000001952 enzyme assay Methods 0.000 description 1
• 210000002615 epidermis Anatomy 0.000 description 1
• 239000000262 estrogen Substances 0.000 description 1
• 229940011871 estrogen Drugs 0.000 description 1
• 229960000285 ethambutol Drugs 0.000 description 1
• 241001233957 eudicotyledons Species 0.000 description 1
• 210000003527 eukaryotic cell Anatomy 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 238000002270 exclusion chromatography Methods 0.000 description 1
• 108010038658 exo-1,4-beta-D-xylosidase Proteins 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
• 229960004884 fluconazole Drugs 0.000 description 1
• 239000006260 foam Substances 0.000 description 1
• 235000012041 food component Nutrition 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 239000005417 food ingredient Substances 0.000 description 1
• 244000053095 fungal pathogen Species 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• IXORZMNAPKEEDV-UHFFFAOYSA-N gibberellic acid GA3 Natural products OC(=O)C1C2(C3)CC(=C)C3(O)CCC2C2(C=CC3O)C1C3(C)C(=O)O2 IXORZMNAPKEEDV-UHFFFAOYSA-N 0.000 description 1
• IXORZMNAPKEEDV-OBDJNFEBSA-N gibberellin A3 Chemical compound C([C@@]1(O)C(=C)C[C@@]2(C1)[C@H]1C(O)=O)C[C@H]2[C@]2(C=C[C@@H]3O)[C@H]1[C@]3(C)C(=O)O2 IXORZMNAPKEEDV-OBDJNFEBSA-N 0.000 description 1
• 239000003292 glue Substances 0.000 description 1
• 150000004676 glycans Chemical class 0.000 description 1
• 125000005456 glyceride group Chemical group 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 208000001786 gonorrhea Diseases 0.000 description 1
• 239000001963 growth medium Substances 0.000 description 1
• 230000035876 healing Effects 0.000 description 1
• 235000014304 histidine Nutrition 0.000 description 1
• 150000002411 histidines Chemical class 0.000 description 1
• 108010002685 hygromycin-B kinase Proteins 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 229960003130 interferon gamma Drugs 0.000 description 1
• 229940117681 interleukin-12 Drugs 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 239000001573 invertase Substances 0.000 description 1
• 235000011073 invertase Nutrition 0.000 description 1
• 238000005342 ion exchange Methods 0.000 description 1
• 238000001155 isoelectric focusing Methods 0.000 description 1
• 229960003350 isoniazid Drugs 0.000 description 1
• QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 1
• 239000007951 isotonicity adjuster Substances 0.000 description 1
• 229960004130 itraconazole Drugs 0.000 description 1
• 229960000318 kanamycin Drugs 0.000 description 1
• 229930027917 kanamycin Natural products 0.000 description 1
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
• 229930182823 kanamycin A Natural products 0.000 description 1
• 229960004125 ketoconazole Drugs 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 229940039696 lactobacillus Drugs 0.000 description 1
• 229960000433 latamoxef Drugs 0.000 description 1
• 239000004816 latex Substances 0.000 description 1
• 229920000126 latex Polymers 0.000 description 1
• 239000010985 leather Substances 0.000 description 1
• 235000021374 legumes Nutrition 0.000 description 1
• 235000019421 lipase Nutrition 0.000 description 1
• 239000007788 liquid Substances 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 101150039489 lysZ gene Proteins 0.000 description 1
• 239000003120 macrolide antibiotic agent Substances 0.000 description 1
• 229940041033 macrolides Drugs 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 210000004379 membrane Anatomy 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 229910021645 metal ion Inorganic materials 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• 229960003085 meticillin Drugs 0.000 description 1
• 229960000282 metronidazole Drugs 0.000 description 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
• 229960002509 miconazole Drugs 0.000 description 1
• 230000002906 microbiologic effect Effects 0.000 description 1
• 238000000520 microinjection Methods 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 210000003470 mitochondria Anatomy 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 229940041009 monobactams Drugs 0.000 description 1
• 239000002324 mouth wash Substances 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 229960000515 nafcillin Drugs 0.000 description 1
• GPXLMGHLHQJAGZ-JTDSTZFVSA-N nafcillin Chemical compound C1=CC=CC2=C(C(=O)N[C@@H]3C(N4[C@H](C(C)(C)S[C@@H]43)C(O)=O)=O)C(OCC)=CC=C21 GPXLMGHLHQJAGZ-JTDSTZFVSA-N 0.000 description 1
• 239000013642 negative control Substances 0.000 description 1
• 101150095344 niaD gene Proteins 0.000 description 1
• 101150105920 npr gene Proteins 0.000 description 1
• 101150017837 nprM gene Proteins 0.000 description 1
• 230000000474 nursing effect Effects 0.000 description 1
• 230000031787 nutrient reservoir activity Effects 0.000 description 1
• 235000016709 nutrition Nutrition 0.000 description 1
• 229960000988 nystatin Drugs 0.000 description 1
• VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 210000000056 organ Anatomy 0.000 description 1
• 108090000021 oryzin Proteins 0.000 description 1
• 230000003204 osmotic effect Effects 0.000 description 1
• 229960001019 oxacillin Drugs 0.000 description 1
• UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 1
• 239000003002 pH adjusting agent Substances 0.000 description 1
• 235000019629 palatability Nutrition 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 230000037361 pathway Effects 0.000 description 1
• 101150019841 penP gene Proteins 0.000 description 1
• 230000035515 penetration Effects 0.000 description 1
• 229940056360 penicillin g Drugs 0.000 description 1
• 229940056367 penicillin v Drugs 0.000 description 1
• 229930192851 perforin Natural products 0.000 description 1
• 210000002824 peroxisome Anatomy 0.000 description 1
• 235000020030 perry Nutrition 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
• BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
• 108010082527 phosphinothricin N-acetyltransferase Proteins 0.000 description 1
• 102000020233 phosphotransferase Human genes 0.000 description 1
• 239000003375 plant hormone Substances 0.000 description 1
• 108010078656 plectasin Proteins 0.000 description 1
• 150000004291 polyenes Chemical class 0.000 description 1
• 229920001223 polyethylene glycol Polymers 0.000 description 1
• 229940041153 polymyxins Drugs 0.000 description 1
• 229920001282 polysaccharide Polymers 0.000 description 1
• 239000005017 polysaccharide Substances 0.000 description 1
• 235000012015 potatoes Nutrition 0.000 description 1
• 230000003389 potentiating effect Effects 0.000 description 1
• 238000004321 preservation Methods 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 108060006613 prolamin Proteins 0.000 description 1
• 230000001902 propagating effect Effects 0.000 description 1
• 239000001294 propane Substances 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• 238000000159 protein binding assay Methods 0.000 description 1
• 108060006633 protein kinase Proteins 0.000 description 1
• 238000001742 protein purification Methods 0.000 description 1
• 244000079416 protozoan pathogen Species 0.000 description 1
• 101150108007 prs gene Proteins 0.000 description 1
• 101150086435 prs1 gene Proteins 0.000 description 1
• 101150070305 prsA gene Proteins 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 150000007660 quinolones Chemical class 0.000 description 1
• 238000006268 reductive amination reaction Methods 0.000 description 1
• 229960001225 rifampicin Drugs 0.000 description 1
• 101150025220 sacB gene Proteins 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 208000008742 seborrheic dermatitis Diseases 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 238000012807 shake-flask culturing Methods 0.000 description 1
• 239000002453 shampoo Substances 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 239000000344 soap Substances 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
• 238000010563 solid-state fermentation Methods 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 238000000527 sonication Methods 0.000 description 1
• 229960000268 spectinomycin Drugs 0.000 description 1
• UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
• 238000001694 spray drying Methods 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 238000003860 storage Methods 0.000 description 1
• 229940115922 streptococcus uberis Drugs 0.000 description 1
• 229960005322 streptomycin Drugs 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 239000001384 succinic acid Substances 0.000 description 1
• 229940124530 sulfonamide Drugs 0.000 description 1
• 150000003456 sulfonamides Chemical class 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 235000020357 syrup Nutrition 0.000 description 1
• 239000006188 syrup Substances 0.000 description 1
• 238000007910 systemic administration Methods 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 229940040944 tetracyclines Drugs 0.000 description 1
• 239000004753 textile Substances 0.000 description 1
• 238000010257 thawing Methods 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 125000003396 thiol group Chemical group [H]S* 0.000 description 1
• 230000002103 transcriptional effect Effects 0.000 description 1
• 238000010361 transduction Methods 0.000 description 1
• 230000026683 transduction Effects 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 238000011426 transformation method Methods 0.000 description 1
• IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
• 229960001082 trimethoprim Drugs 0.000 description 1
• 101150016309 trpC gene Proteins 0.000 description 1
• 229960004799 tryptophan Drugs 0.000 description 1
• 239000000814 tuberculostatic agent Substances 0.000 description 1
• WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
• 229910052721 tungsten Inorganic materials 0.000 description 1
• 239000010937 tungsten Substances 0.000 description 1
• 241000712461 unidentified influenza virus Species 0.000 description 1
• 210000003934 vacuole Anatomy 0.000 description 1
• 229960003165 vancomycin Drugs 0.000 description 1
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• 238000009423 ventilation Methods 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 230000003442 weekly effect Effects 0.000 description 1
• 101150110790 xylB gene Proteins 0.000 description 1
• 210000005253 yeast cell Anatomy 0.000 description 1