TWI650316B - Ｍｅｋ抑制劑之製備及包含ｍｅｋ抑制劑之調配物 - Google Patents
Ｍｅｋ抑制劑之製備及包含ｍｅｋ抑制劑之調配物 Download PDFInfo
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- TWI650316B TWI650316B TW102137813A TW102137813A TWI650316B TW I650316 B TWI650316 B TW I650316B TW 102137813 A TW102137813 A TW 102137813A TW 102137813 A TW102137813 A TW 102137813A TW I650316 B TWI650316 B TW I650316B
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
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| CN105566225A (zh) * | 2015-02-16 | 2016-05-11 | 苏州晶云药物科技有限公司 | 一种口服丝裂原活化蛋白激酶抑制剂的晶型及其制备方法 |
| DK3463345T3 (da) * | 2016-06-03 | 2023-01-09 | Array Biopharma Inc | Farmaceutiske kombinationer |
| EP3712133B1 (en) * | 2017-11-14 | 2025-12-24 | Shenzhen TargetRx, Inc. | Substituted benzimidazole compound and composition comprising same |
| TW201938165A (zh) | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | 治療癌症的方法及組合療法 |
| US11395823B2 (en) * | 2018-01-09 | 2022-07-26 | Duke University | Topical administration of MEK inhibiting agents for the treatment of skin disorders |
| WO2020212832A1 (en) * | 2019-04-16 | 2020-10-22 | Alembic Pharmaceuticals Limited | Process of preparation of benzimidazole compounds |
| WO2021116901A1 (en) * | 2019-12-09 | 2021-06-17 | Biocon Limited | Forms of binimetinib and process for preparation thereof |
| MX2023003867A (es) | 2020-10-05 | 2023-04-18 | Pf Medicament | Combinacion de encorafenib y binimetinib a manera de tratamiento adyuvante contra melanoma resecado en etapa ii. |
| CN112679438A (zh) * | 2020-12-31 | 2021-04-20 | 武汉九州钰民医药科技有限公司 | 制备司美替尼的方法 |
| JP2024521788A (ja) | 2021-05-27 | 2024-06-04 | ミラティ セラピューティクス， インコーポレイテッド | 併用療法 |
| WO2023084489A1 (en) | 2021-11-15 | 2023-05-19 | Pfizer Inc. | Methods of treating coronavirus disease 2019 |
| EP4460303A4 (en) * | 2022-01-06 | 2025-07-23 | Msn Laboratories Private Ltd R&D Center | IMPROVED PROCESS FOR THE PREPARATION OF 5-[(4-BROMO-2-FLUOROPHENYL)AMINO]-4-FLUORO-N-(2HYDROXYETHOXY)-1-METHYL-1H-BENZIMIDAZOLE-6-CARBOXAMIDE |
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| FR3159741A1 (fr) | 2024-03-04 | 2025-09-05 | Pierre Fabre Medicament | Formulation topique comprenant du binimetinib |
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| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
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| CN1652776A (zh) * | 2002-03-13 | 2005-08-10 | 阵列生物制药公司 | 作为mek抑制剂的n3烷基化苯并咪唑衍生物 |
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| IL147150A0 (en) * | 1999-07-16 | 2002-08-14 | Warner Lambert Co | Method for treating chronic pain using mek inhibitors |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| ES2331246T3 (es) * | 2003-07-24 | 2009-12-28 | Warner-Lambert Company Llc | Derivados de benzamidazol como inhibidores del mek. |
| WO2006030826A1 (ja) | 2004-09-17 | 2006-03-23 | Eisai R & D Management Co., Ltd. | 医薬組成物 |
| KR20140000721A (ko) | 2005-06-23 | 2014-01-03 | 어레이 바이오파마 인크. | 벤즈이미다졸 화합물의 제조 방법 |
| EP1904061B1 (en) | 2005-06-23 | 2018-12-26 | Array Biopharma, Inc. | SNAr PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS |
| US20090030058A1 (en) * | 2005-12-21 | 2009-01-29 | Mohammed Pervez | Tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide , mek inhibitor useful in the treatment of cancer |
| TWI405756B (zh) * | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| AU2008282338B2 (en) * | 2007-07-30 | 2015-02-12 | Ardea Biosciences, Inc. | Derivatives of N-(arylamino) sulfonamides including polymorphs as inhibitors of MEK as well as compositions, methods of use and methods for preparing the same |
| WO2009064675A1 (en) | 2007-11-12 | 2009-05-22 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors |
| EP2421612A1 (en) | 2009-04-21 | 2012-02-29 | Novartis AG | Heterocyclic compounds as mek inhibitors |
| WO2012145503A1 (en) | 2011-04-21 | 2012-10-26 | Novartis Ag | Pharmaceutical combinations |
| JP2014528928A (ja) | 2011-09-01 | 2014-10-30 | ノバルティス アーゲー | ヌーナン症候群の治療のための有機化合物の使用 |
| EP4306171A3 (en) | 2012-10-19 | 2024-04-03 | Array Biopharma, Inc. | Formulation comprising a mek inhibitor |
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| CN1652776A (zh) * | 2002-03-13 | 2005-08-10 | 阵列生物制药公司 | 作为mek抑制剂的n3烷基化苯并咪唑衍生物 |
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