JP6385939B2 - Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 - Google Patents

Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 Download PDF

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JP6385939B2
JP6385939B2 JP2015538050A JP2015538050A JP6385939B2 JP 6385939 B2 JP6385939 B2 JP 6385939B2 JP 2015538050 A JP2015538050 A JP 2015538050A JP 2015538050 A JP2015538050 A JP 2015538050A JP 6385939 B2 JP6385939 B2 JP 6385939B2
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compound
formula
cancer
item
mixture
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JP2016503391A (ja
JP2016503391A5 (OSRAM
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クリストフ マックス クレル，
クリストフ マックス クレル，
マリアン ミスン，
マリアン ミスン，
ダニエル アンドレアス ニーデラー，
ダニエル アンドレアス ニーデラー，
ウェルナー ハインツ パッヒンガー，
ウェルナー ハインツ パッヒンガー，
マリー−クリスティーン ウォルフ，
マリー−クリスティーン ウォルフ，
ダニエル ジマーマン，
ダニエル ジマーマン，
ウェイドン リウ，
ウェイドン リウ，
ピーター ジェイ． ステンゲル，
ピーター ジェイ． ステンゲル，
ポール ニコルス，
ポール ニコルス，
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
アレイ バイオファーマ、インコーポレイテッド
アレイ バイオファーマ、インコーポレイテッド
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Application filed by ノバルティス アーゲー, ノバルティス アーゲー, アレイ バイオファーマ、インコーポレイテッド, アレイ バイオファーマ、インコーポレイテッド filed Critical ノバルティス アーゲー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/2004—Excipients; Inactive ingredients
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
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    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
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    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C30B7/08—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by cooling of the solution
    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biochemistry (AREA)
  • Nutrition Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2015538050A 2012-10-19 2013-10-18 Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 Active JP6385939B2 (ja)

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Application Number Priority Date Filing Date Title
US201261716169P 2012-10-19 2012-10-19
US61/716,169 2012-10-19
PCT/US2013/065633 WO2014063024A1 (en) 2012-10-19 2013-10-18 Preparation of and formulation comprising a mek inhibitor

Related Child Applications (1)

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JP2018109486A Division JP6737838B2 (ja) 2012-10-19 2018-06-07 Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤

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JP2016503391A JP2016503391A (ja) 2016-02-04
JP2016503391A5 JP2016503391A5 (OSRAM) 2016-12-01
JP6385939B2 true JP6385939B2 (ja) 2018-09-05

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JP2015538050A Active JP6385939B2 (ja) 2012-10-19 2013-10-18 Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤
JP2018109486A Active JP6737838B2 (ja) 2012-10-19 2018-06-07 Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤
JP2019149828A Pending JP2019194272A (ja) 2012-10-19 2019-08-19 Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤

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JP2019149828A Pending JP2019194272A (ja) 2012-10-19 2019-08-19 Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤

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US (7) US9238627B2 (OSRAM)
EP (3) EP4306171A3 (OSRAM)
JP (3) JP6385939B2 (OSRAM)
CN (3) CN109456272A (OSRAM)
AR (1) AR099630A1 (OSRAM)
BR (1) BR112015008623B1 (OSRAM)
CA (2) CA2888474C (OSRAM)
CY (1) CY1122670T1 (OSRAM)
DK (2) DK3702351T3 (OSRAM)
ES (2) ES2971077T3 (OSRAM)
FI (1) FI3702351T3 (OSRAM)
HR (1) HRP20240033T1 (OSRAM)
HU (2) HUE047708T2 (OSRAM)
JO (1) JOP20130304B1 (OSRAM)
LT (1) LT3702351T (OSRAM)
PL (2) PL3702351T3 (OSRAM)
PT (2) PT3702351T (OSRAM)
RS (1) RS65117B1 (OSRAM)
RU (2) RU2018127873A (OSRAM)
SI (2) SI3702351T1 (OSRAM)
SM (1) SMT202400044T1 (OSRAM)
TW (1) TWI650316B (OSRAM)
WO (1) WO2014063024A1 (OSRAM)

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JP2024521788A (ja) 2021-05-27 2024-06-04 ミラティ セラピューティクス， インコーポレイテッド 併用療法
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WO2024003942A1 (en) * 2022-07-01 2024-01-04 Natco Pharma Limited An improved process for the preparation of selumetinib sulfate
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US20160168102A1 (en) 2016-06-16
US10729678B2 (en) 2020-08-04
LT3702351T (lt) 2024-01-10
BR112015008623B1 (pt) 2022-10-25
HK1214254A1 (en) 2016-07-22
FI3702351T3 (fi) 2024-01-24
JP2016503391A (ja) 2016-02-04
PT3702351T (pt) 2024-01-17
CN109336824B (zh) 2022-11-11
US20200171002A1 (en) 2020-06-04
US9562016B2 (en) 2017-02-07
US20160168104A1 (en) 2016-06-16
WO2014063024A1 (en) 2014-04-24
EP4306171A2 (en) 2024-01-17
TW201427956A (zh) 2014-07-16
RU2015118572A (ru) 2016-12-20
CA2888474A1 (en) 2014-04-24
CA3079071A1 (en) 2014-04-24
US10398683B2 (en) 2019-09-03
JP2018135399A (ja) 2018-08-30
EP3702351A1 (en) 2020-09-02
DK3702351T3 (da) 2024-01-29
JP6737838B2 (ja) 2020-08-12
CY1122670T1 (el) 2021-03-12
ES2971077T3 (es) 2024-06-03
SI2909182T1 (sl) 2020-03-31
EP2909182A1 (en) 2015-08-26
EP2909182A4 (en) 2016-07-06
US9598376B2 (en) 2017-03-21
CN104870427A (zh) 2015-08-26
BR112015008623A2 (pt) 2017-07-04
DK2909182T3 (da) 2020-02-17
US9382212B1 (en) 2016-07-05
US20170231963A1 (en) 2017-08-17
CN104870427B (zh) 2018-10-23
US20140128442A1 (en) 2014-05-08
CN109456272A (zh) 2019-03-12
RS65117B1 (sr) 2024-02-29
CA2888474C (en) 2021-03-02
PL3702351T3 (pl) 2024-04-02
CA3079071C (en) 2022-06-07
US20180296533A1 (en) 2018-10-18
EP2909182B1 (en) 2019-12-04
US20160168103A1 (en) 2016-06-16
CN109336824A (zh) 2019-02-15
JOP20130304B1 (ar) 2021-08-17
RU2018127873A (ru) 2019-03-14
SI3702351T1 (sl) 2024-03-29
US9980944B2 (en) 2018-05-29
SMT202400044T1 (it) 2024-03-13
AR099630A1 (es) 2016-08-10
ES2772498T3 (es) 2020-07-07
US9238627B2 (en) 2016-01-19
EP3702351B1 (en) 2023-11-22
HUE047708T2 (hu) 2020-05-28
TWI650316B (zh) 2019-02-11
JP2019194272A (ja) 2019-11-07
RU2669391C2 (ru) 2018-10-11
PL2909182T3 (pl) 2020-06-01
PT2909182T (pt) 2020-03-02
HUE065433T2 (hu) 2024-05-28
HRP20240033T1 (hr) 2024-03-29
EP4306171A3 (en) 2024-04-03

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