TWI640542B - 血管加壓素－２受器促效劑 - Google Patents
血管加壓素－２受器促效劑 Download PDFInfo
- Publication number
- TWI640542B TWI640542B TW103125533A TW103125533A TWI640542B TW I640542 B TWI640542 B TW I640542B TW 103125533 A TW103125533 A TW 103125533A TW 103125533 A TW103125533 A TW 103125533A TW I640542 B TWI640542 B TW I640542B
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- peptide
- alkyl
- dmf
- mmol
- Prior art date
Links
- 0 CC(C)CNC([C@](CCCNC(N)=N)NC([C@](CCC1)N1C([C@](CSCCCC(N[C@@](Cc(cc1)ccc1Cl)C(N[C@@](Cc1ccc[s]1)C(N[C@@](C(C)C)C(N[C@]1CCC(N)=O)=O)=O)=O)=O)*C1=O)=O)=O)=O Chemical compound CC(C)CNC([C@](CCCNC(N)=N)NC([C@](CCC1)N1C([C@](CSCCCC(N[C@@](Cc(cc1)ccc1Cl)C(N[C@@](Cc1ccc[s]1)C(N[C@@](C(C)C)C(N[C@]1CCC(N)=O)=O)=O)=O)=O)*C1=O)=O)=O)=O 0.000 description 2
- KELMVSJFGCWRLO-MLMVTELGSA-N CCN(CC)C([C@@H](CCCNC(N)=N)NC([C@H](CCC1)N1C([C@H](CSCCCC(N[C@@H](Cc(cc1)ccc1Cl)C(N[C@@H](Cc1ccc[s]1)C(N[C@@H](C(C)C)C(N[C@H]1CC(N)=O)=O)=O)=O)=O)NC1=O)=O)=O)=O Chemical compound CCN(CC)C([C@@H](CCCNC(N)=N)NC([C@H](CCC1)N1C([C@H](CSCCCC(N[C@@H](Cc(cc1)ccc1Cl)C(N[C@@H](Cc1ccc[s]1)C(N[C@@H](C(C)C)C(N[C@H]1CC(N)=O)=O)=O)=O)=O)NC1=O)=O)=O)=O KELMVSJFGCWRLO-MLMVTELGSA-N 0.000 description 1
- MUGWQPUJIFAJRC-UMAAOLLXSA-N CCNC([C@@H](CCCNC(N)=N)NC([C@H](C[C@H](C1)[O]#C)N1C([C@H](CCSCCC(N[C@@H](Cc(cc1)ccc1Cl)C(N[C@@H](Cc1ccc[s]1)C(N[C@@H](C(C)C)C(N[C@H]1CC(N)=O)=O)=O)=O)=O)NC1=O)=O)=O)=O Chemical compound CCNC([C@@H](CCCNC(N)=N)NC([C@H](C[C@H](C1)[O]#C)N1C([C@H](CCSCCC(N[C@@H](Cc(cc1)ccc1Cl)C(N[C@@H](Cc1ccc[s]1)C(N[C@@H](C(C)C)C(N[C@H]1CC(N)=O)=O)=O)=O)=O)NC1=O)=O)=O)=O MUGWQPUJIFAJRC-UMAAOLLXSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361859024P | 2013-07-26 | 2013-07-26 | |
| US61/859,024 | 2013-07-26 | ||
| US201461952073P | 2014-03-12 | 2014-03-12 | |
| US61/952,073 | 2014-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201536815A TW201536815A (zh) | 2015-10-01 |
| TWI640542B true TWI640542B (zh) | 2018-11-11 |
Family
ID=51398870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW103125533A TWI640542B (zh) | 2013-07-26 | 2014-07-25 | 血管加壓素－２受器促效劑 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10131692B2 (https=) |
| EP (1) | EP3024829B1 (https=) |
| JP (1) | JP6387095B2 (https=) |
| KR (1) | KR102198130B1 (https=) |
| CN (1) | CN105492441B (https=) |
| AU (1) | AU2014292860B2 (https=) |
| BR (1) | BR112016000436B1 (https=) |
| CA (1) | CA2919208A1 (https=) |
| DK (1) | DK3024829T3 (https=) |
| EA (1) | EA029392B1 (https=) |
| ES (1) | ES2656039T3 (https=) |
| HR (1) | HRP20180009T1 (https=) |
| HU (1) | HUE035252T2 (https=) |
| IL (1) | IL243730B (https=) |
| JO (1) | JO3371B1 (https=) |
| LT (1) | LT3024829T (https=) |
| MX (1) | MX363355B (https=) |
| MY (1) | MY183429A (https=) |
| PH (1) | PH12016500044A1 (https=) |
| PL (1) | PL3024829T3 (https=) |
| PT (1) | PT3024829T (https=) |
| RS (1) | RS56604B1 (https=) |
| SG (1) | SG11201600031RA (https=) |
| SI (1) | SI3024829T1 (https=) |
| TW (1) | TWI640542B (https=) |
| WO (1) | WO2015013690A1 (https=) |
| ZA (1) | ZA201600145B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102176900B (zh) | 2008-09-17 | 2017-09-26 | 克艾思马有限公司 | 药物组合物和相关的给药方法 |
| CA3037581A1 (en) | 2016-10-21 | 2018-04-26 | Chiasma, Inc. | Terlipressin compositions and their methods of use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995001373A1 (en) * | 1993-06-29 | 1995-01-12 | Ferring B.V. | Process for manufacture of 1-deamino-8-d-arginine vasopressin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE399252B (sv) * | 1976-05-24 | 1978-02-06 | Ferring Ab | Forfarande for framstellnign av antidiuretiskt verkande desamino-asparagin 4-d-arginin8-vasopressin |
| CA1246055A (en) * | 1980-03-24 | 1988-12-06 | Joseph H. Cort | N-.omega.-substituted hormonogens of vasopressin and its synthetic analogs |
| DK153883A (da) | 1982-04-20 | 1983-10-21 | Ceskoslovenska Akademie Ved | Vasopressin-analoge |
| SE501677C2 (sv) * | 1993-06-18 | 1995-04-10 | Ferring Bv | Biologiskt aktiva vasopressinanaloger, farmaceutiska preparat innehållande dem samt deras användning för framställning av läkemedel |
| CZ292131B6 (cs) | 2000-02-16 | 2003-08-13 | Ústav organické chemie a biochemie AV ČR | Synthetické analogy Desmopressinu chráněné v C-terminální sekvenci proti karboxyamidasovému štěpení |
| JP6131120B2 (ja) * | 2013-06-19 | 2017-05-17 | 株式会社パイオラックス | コネクタ |
-
2014
- 2014-07-24 JO JOP/2014/0234A patent/JO3371B1/ar active
- 2014-07-25 CN CN201480041380.1A patent/CN105492441B/zh not_active Expired - Fee Related
- 2014-07-25 DK DK14755464.6T patent/DK3024829T3/en active
- 2014-07-25 PL PL14755464T patent/PL3024829T3/pl unknown
- 2014-07-25 MX MX2016000525A patent/MX363355B/es unknown
- 2014-07-25 CA CA2919208A patent/CA2919208A1/en not_active Abandoned
- 2014-07-25 BR BR112016000436-1A patent/BR112016000436B1/pt not_active IP Right Cessation
- 2014-07-25 MY MYPI2016700251A patent/MY183429A/en unknown
- 2014-07-25 ES ES14755464.6T patent/ES2656039T3/es active Active
- 2014-07-25 EA EA201690219A patent/EA029392B1/ru not_active IP Right Cessation
- 2014-07-25 SI SI201430496T patent/SI3024829T1/en unknown
- 2014-07-25 WO PCT/US2014/048317 patent/WO2015013690A1/en not_active Ceased
- 2014-07-25 JP JP2016530091A patent/JP6387095B2/ja not_active Expired - Fee Related
- 2014-07-25 AU AU2014292860A patent/AU2014292860B2/en not_active Ceased
- 2014-07-25 EP EP14755464.6A patent/EP3024829B1/en active Active
- 2014-07-25 HR HRP20180009TT patent/HRP20180009T1/hr unknown
- 2014-07-25 TW TW103125533A patent/TWI640542B/zh not_active IP Right Cessation
- 2014-07-25 SG SG11201600031RA patent/SG11201600031RA/en unknown
- 2014-07-25 PT PT147554646T patent/PT3024829T/pt unknown
- 2014-07-25 US US14/647,357 patent/US10131692B2/en active Active
- 2014-07-25 RS RS20171214A patent/RS56604B1/sr unknown
- 2014-07-25 KR KR1020167003247A patent/KR102198130B1/ko not_active Expired - Fee Related
- 2014-07-25 HU HUE14755464A patent/HUE035252T2/en unknown
- 2014-07-25 LT LTEP14755464.6T patent/LT3024829T/lt unknown
-
2016
- 2016-01-07 PH PH12016500044A patent/PH12016500044A1/en unknown
- 2016-01-08 ZA ZA2016/00145A patent/ZA201600145B/en unknown
- 2016-01-22 IL IL243730A patent/IL243730B/en active IP Right Grant
-
2018
- 2018-09-27 US US16/145,073 patent/US10745443B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995001373A1 (en) * | 1993-06-29 | 1995-01-12 | Ferring B.V. | Process for manufacture of 1-deamino-8-d-arginine vasopressin |
Non-Patent Citations (1)
| Title |
|---|
| Manning, Maurice, et al. "C-Terminal deletions in antagonistic analogs of vasopressin that improve their specificities for antidiuretic (V2) and vasopressor (V1) receptors." Journal of medicinal chemistry 30.12 (1987): 2245-2252. * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |