EA029392B1 - Агонисты рецептора вазопрессина-2 - Google Patents
Агонисты рецептора вазопрессина-2 Download PDFInfo
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- EA029392B1 EA029392B1 EA201690219A EA201690219A EA029392B1 EA 029392 B1 EA029392 B1 EA 029392B1 EA 201690219 A EA201690219 A EA 201690219A EA 201690219 A EA201690219 A EA 201690219A EA 029392 B1 EA029392 B1 EA 029392B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- compound according
- compound
- peptide
- mmol
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361859024P | 2013-07-26 | 2013-07-26 | |
| US201461952073P | 2014-03-12 | 2014-03-12 | |
| PCT/US2014/048317 WO2015013690A1 (en) | 2013-07-26 | 2014-07-25 | Vasopressin-2 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201690219A1 EA201690219A1 (ru) | 2016-11-30 |
| EA029392B1 true EA029392B1 (ru) | 2018-03-30 |
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| EA201690219A EA029392B1 (ru) | 2013-07-26 | 2014-07-25 | Агонисты рецептора вазопрессина-2 |
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| US (2) | US10131692B2 (https=) |
| EP (1) | EP3024829B1 (https=) |
| JP (1) | JP6387095B2 (https=) |
| KR (1) | KR102198130B1 (https=) |
| CN (1) | CN105492441B (https=) |
| AU (1) | AU2014292860B2 (https=) |
| BR (1) | BR112016000436B1 (https=) |
| CA (1) | CA2919208A1 (https=) |
| DK (1) | DK3024829T3 (https=) |
| EA (1) | EA029392B1 (https=) |
| ES (1) | ES2656039T3 (https=) |
| HR (1) | HRP20180009T1 (https=) |
| HU (1) | HUE035252T2 (https=) |
| IL (1) | IL243730B (https=) |
| JO (1) | JO3371B1 (https=) |
| LT (1) | LT3024829T (https=) |
| MX (1) | MX363355B (https=) |
| MY (1) | MY183429A (https=) |
| PH (1) | PH12016500044A1 (https=) |
| PL (1) | PL3024829T3 (https=) |
| PT (1) | PT3024829T (https=) |
| RS (1) | RS56604B1 (https=) |
| SG (1) | SG11201600031RA (https=) |
| SI (1) | SI3024829T1 (https=) |
| TW (1) | TWI640542B (https=) |
| WO (1) | WO2015013690A1 (https=) |
| ZA (1) | ZA201600145B (https=) |
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| CN102176900B (zh) | 2008-09-17 | 2017-09-26 | 克艾思马有限公司 | 药物组合物和相关的给药方法 |
| CA3037581A1 (en) | 2016-10-21 | 2018-04-26 | Chiasma, Inc. | Terlipressin compositions and their methods of use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995001373A1 (en) * | 1993-06-29 | 1995-01-12 | Ferring B.V. | Process for manufacture of 1-deamino-8-d-arginine vasopressin |
| US5698516A (en) * | 1993-06-18 | 1997-12-16 | Ferring B.V. | Biologically active vasopressin analogues |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE399252B (sv) * | 1976-05-24 | 1978-02-06 | Ferring Ab | Forfarande for framstellnign av antidiuretiskt verkande desamino-asparagin 4-d-arginin8-vasopressin |
| CA1246055A (en) * | 1980-03-24 | 1988-12-06 | Joseph H. Cort | N-.omega.-substituted hormonogens of vasopressin and its synthetic analogs |
| DK153883A (da) | 1982-04-20 | 1983-10-21 | Ceskoslovenska Akademie Ved | Vasopressin-analoge |
| CZ292131B6 (cs) | 2000-02-16 | 2003-08-13 | Ústav organické chemie a biochemie AV ČR | Synthetické analogy Desmopressinu chráněné v C-terminální sekvenci proti karboxyamidasovému štěpení |
| JP6131120B2 (ja) * | 2013-06-19 | 2017-05-17 | 株式会社パイオラックス | コネクタ |
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Patent Citations (2)
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| US5698516A (en) * | 1993-06-18 | 1997-12-16 | Ferring B.V. | Biologically active vasopressin analogues |
| WO1995001373A1 (en) * | 1993-06-29 | 1995-01-12 | Ferring B.V. | Process for manufacture of 1-deamino-8-d-arginine vasopressin |
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| CALLRÉUS T, LUNDAHL J, BROEDERS A, HÖGLUND P.: "Pharmacokinetics and antidiuretic effect of a new vasopressin analogue (F992) in overhydrated male volunteers", EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY., SPRINGER VERLAG., DE, vol. 55, no. 4, 1 June 1999 (1999-06-01), DE, pages 293 - 298, XP002731645, ISSN: 0031-6970, DOI: 10.1007/s002280050631 * |
| MANNING M, MISICKA A, OLMA A, KLIS W A, BANKOWSKI K, NAWROCKA E, KRUSZYNSKI M, KOLODZIEJCZYK A, CHENG L L, SETO J, NGA CHING WO, S: "C-Terminal deletions in agonistic and antagonistic analogues of vasopressin that improve their specifities for antidiuretic (V2) and vasopressor (V1) receptors", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 30, no. 12, 1 December 1987 (1987-12-01), pages 2245 - 2252, XP002731644, ISSN: 0022-2623, DOI: 10.1021/jm00395a012 * |
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