CN105492441B - 血管加压素-2受体激动剂 - Google Patents

血管加压素-2受体激动剂 Download PDF

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Publication number
CN105492441B
CN105492441B CN201480041380.1A CN201480041380A CN105492441B CN 105492441 B CN105492441 B CN 105492441B CN 201480041380 A CN201480041380 A CN 201480041380A CN 105492441 B CN105492441 B CN 105492441B
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CN
China
Prior art keywords
compound
peptide
alkyl
mmol
dmf
Prior art date
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Expired - Fee Related
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CN201480041380.1A
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English (en)
Chinese (zh)
Other versions
CN105492441A (zh
Inventor
卡齐米日·维希涅夫斯基
克劳迪奥·施泰加特
皮埃尔·里维埃
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Ferring BV
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Ferring BV
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
CN201480041380.1A 2013-07-26 2014-07-25 血管加压素-2受体激动剂 Expired - Fee Related CN105492441B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361859024P 2013-07-26 2013-07-26
US61/859,024 2013-07-26
US201461952073P 2014-03-12 2014-03-12
US61/952,073 2014-03-12
PCT/US2014/048317 WO2015013690A1 (en) 2013-07-26 2014-07-25 Vasopressin-2 receptor agonists

Publications (2)

Publication Number Publication Date
CN105492441A CN105492441A (zh) 2016-04-13
CN105492441B true CN105492441B (zh) 2019-09-10

Family

ID=51398870

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480041380.1A Expired - Fee Related CN105492441B (zh) 2013-07-26 2014-07-25 血管加压素-2受体激动剂

Country Status (27)

Country Link
US (2) US10131692B2 (https=)
EP (1) EP3024829B1 (https=)
JP (1) JP6387095B2 (https=)
KR (1) KR102198130B1 (https=)
CN (1) CN105492441B (https=)
AU (1) AU2014292860B2 (https=)
BR (1) BR112016000436B1 (https=)
CA (1) CA2919208A1 (https=)
DK (1) DK3024829T3 (https=)
EA (1) EA029392B1 (https=)
ES (1) ES2656039T3 (https=)
HR (1) HRP20180009T1 (https=)
HU (1) HUE035252T2 (https=)
IL (1) IL243730B (https=)
JO (1) JO3371B1 (https=)
LT (1) LT3024829T (https=)
MX (1) MX363355B (https=)
MY (1) MY183429A (https=)
PH (1) PH12016500044A1 (https=)
PL (1) PL3024829T3 (https=)
PT (1) PT3024829T (https=)
RS (1) RS56604B1 (https=)
SG (1) SG11201600031RA (https=)
SI (1) SI3024829T1 (https=)
TW (1) TWI640542B (https=)
WO (1) WO2015013690A1 (https=)
ZA (1) ZA201600145B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102176900B (zh) 2008-09-17 2017-09-26 克艾思马有限公司 药物组合物和相关的给药方法
CA3037581A1 (en) 2016-10-21 2018-04-26 Chiasma, Inc. Terlipressin compositions and their methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1125451A (zh) * 1993-06-18 1996-06-26 费灵有限公司 生物活性加压素类似物
CN1125952A (zh) * 1993-06-29 1996-07-03 凡林有限公司 1-脱氨基-8-d-精氨酸抗利尿激素的制造方法
JP6131120B2 (ja) * 2013-06-19 2017-05-17 株式会社パイオラックス コネクタ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE399252B (sv) * 1976-05-24 1978-02-06 Ferring Ab Forfarande for framstellnign av antidiuretiskt verkande desamino-asparagin Ÿ4-d-argininŸ8-vasopressin
CA1246055A (en) * 1980-03-24 1988-12-06 Joseph H. Cort N-.omega.-substituted hormonogens of vasopressin and its synthetic analogs
DK153883A (da) 1982-04-20 1983-10-21 Ceskoslovenska Akademie Ved Vasopressin-analoge
CZ292131B6 (cs) 2000-02-16 2003-08-13 Ústav organické chemie a biochemie AV ČR Synthetické analogy Desmopressinu chráněné v C-terminální sekvenci proti karboxyamidasovému štěpení

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1125451A (zh) * 1993-06-18 1996-06-26 费灵有限公司 生物活性加压素类似物
CN1125952A (zh) * 1993-06-29 1996-07-03 凡林有限公司 1-脱氨基-8-d-精氨酸抗利尿激素的制造方法
JP6131120B2 (ja) * 2013-06-19 2017-05-17 株式会社パイオラックス コネクタ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C-Terminal Deletions in Agonistic and Antagonistic Analogues of Vasopressin That Improve Their Specificities for Antidiuretic (V2) and Vasopressor (V1) Receptors;Maurice Manning，等;《J. Med. Chem.》;19871231;第30卷(第12期);摘要、第2246-2247页 *

Also Published As

Publication number Publication date
US10745443B2 (en) 2020-08-18
EP3024829B1 (en) 2017-11-08
PH12016500044B1 (en) 2016-03-28
JP2016527255A (ja) 2016-09-08
JP6387095B2 (ja) 2018-09-05
HK1218647A1 (en) 2017-03-03
DK3024829T3 (en) 2017-12-04
ES2656039T3 (es) 2018-02-22
PT3024829T (pt) 2017-12-18
MY183429A (en) 2021-02-18
IL243730B (en) 2019-09-26
AU2014292860A1 (en) 2016-01-28
EA029392B1 (ru) 2018-03-30
MX2016000525A (es) 2016-04-07
HRP20180009T1 (hr) 2018-02-09
HUE035252T2 (en) 2018-05-02
US20150307555A1 (en) 2015-10-29
EA201690219A1 (ru) 2016-11-30
TW201536815A (zh) 2015-10-01
US20190194257A1 (en) 2019-06-27
NZ716342A (en) 2021-03-26
SI3024829T1 (en) 2018-01-31
US10131692B2 (en) 2018-11-20
RS56604B1 (sr) 2018-02-28
PH12016500044A1 (en) 2016-03-28
MX363355B (es) 2019-03-21
PL3024829T3 (pl) 2018-04-30
IL243730A0 (en) 2016-04-21
WO2015013690A1 (en) 2015-01-29
KR102198130B1 (ko) 2021-01-05
AU2014292860B2 (en) 2017-10-05
BR112016000436A2 (https=) 2017-07-25
LT3024829T (lt) 2017-12-27
JO3371B1 (ar) 2019-03-13
CA2919208A1 (en) 2015-01-29
SG11201600031RA (en) 2016-02-26
CN105492441A (zh) 2016-04-13
ZA201600145B (en) 2020-01-29
BR112016000436B1 (pt) 2022-07-05
TWI640542B (zh) 2018-11-11
KR20160034943A (ko) 2016-03-30
EP3024829A1 (en) 2016-06-01

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