TWI639702B - 使用酵素之二環性化合物之光學離析方法 - Google Patents
使用酵素之二環性化合物之光學離析方法 Download PDFInfo
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- TWI639702B TWI639702B TW102112438A TW102112438A TWI639702B TW I639702 B TWI639702 B TW I639702B TW 102112438 A TW102112438 A TW 102112438A TW 102112438 A TW102112438 A TW 102112438A TW I639702 B TWI639702 B TW I639702B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012-089481 | 2012-04-10 | ||
| JP2012089481 | 2012-04-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201346036A TW201346036A (zh) | 2013-11-16 |
| TWI639702B true TWI639702B (zh) | 2018-11-01 |
Family
ID=49327629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102112438A TWI639702B (zh) | 2012-04-10 | 2013-04-09 | 使用酵素之二環性化合物之光學離析方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9394235B2 (enExample) |
| EP (1) | EP2837689B1 (enExample) |
| JP (1) | JP6023794B2 (enExample) |
| KR (1) | KR101976891B1 (enExample) |
| CN (1) | CN104245951B (enExample) |
| BR (1) | BR112014025158B1 (enExample) |
| CA (1) | CA2869994C (enExample) |
| ES (1) | ES2624314T3 (enExample) |
| HU (1) | HUE033397T2 (enExample) |
| IL (1) | IL235002B (enExample) |
| IN (1) | IN2014DN07923A (enExample) |
| TW (1) | TWI639702B (enExample) |
| WO (1) | WO2013154066A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI635071B (zh) * | 2013-07-08 | 2018-09-11 | 第一三共股份有限公司 | 光學活性二環γ－胺基酸衍生物及其製造方法 |
| RU2734475C2 (ru) * | 2015-05-27 | 2020-10-16 | Новассай Са | Разделение энантиомеров 3-этилбицикло [3.2.0] гепт-3-ен-6-она |
| CN116903468B (zh) * | 2023-07-14 | 2024-01-26 | 山东新时代药业有限公司 | 一种米洛巴林中间体的制备方法 |
| WO2025118134A1 (zh) * | 2023-12-05 | 2025-06-12 | 浙江天宇药业股份有限公司 | 一种苯磺酸米洛巴林的合成方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100249229A1 (en) * | 2007-09-28 | 2010-09-30 | Kousei Shimada | BICYCLIC gamma-AMINO ACID DERIVATIVE |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60169434A (ja) * | 1984-02-14 | 1985-09-02 | Ube Ind Ltd | 光学活性なビシクロケトン類の製法 |
| DE69834204T2 (de) | 1997-10-27 | 2007-03-29 | Warner-Lambert Co. Llc | Zyklische aminosäuren und deren derivate als arzneimittel |
| HN2000000224A (es) | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| EA006396B1 (ru) | 2001-04-19 | 2005-12-29 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си | Конденсированные бициклические аминокислоты |
| CA2492022A1 (en) | 2002-07-11 | 2004-01-22 | Merck & Co., Inc. | Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds |
| WO2010084798A1 (ja) * | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | ３環性化合物 |
| CA2756750C (en) * | 2009-03-26 | 2014-05-13 | Daiichi Sankyo Company, Limited | A method for producing bicyclic .gamma.-amino acid derivative |
| CN103582622B (zh) | 2011-06-08 | 2015-06-10 | 第一三共株式会社 | 经由亚胺鎓盐制备双环化合物的方法 |
| KR101816337B1 (ko) * | 2011-06-08 | 2018-01-08 | 다이이찌 산쿄 가부시키가이샤 | 클라이젠 전위 반응에 의한 2 고리성 화합물의 제조 방법 |
-
2013
- 2013-04-08 EP EP13775061.8A patent/EP2837689B1/en active Active
- 2013-04-08 IN IN7923DEN2014 patent/IN2014DN07923A/en unknown
- 2013-04-08 JP JP2014510158A patent/JP6023794B2/ja active Active
- 2013-04-08 HU HUE13775061A patent/HUE033397T2/en unknown
- 2013-04-08 CA CA2869994A patent/CA2869994C/en active Active
- 2013-04-08 BR BR112014025158-4A patent/BR112014025158B1/pt active IP Right Grant
- 2013-04-08 CN CN201380019311.6A patent/CN104245951B/zh active Active
- 2013-04-08 KR KR1020147028140A patent/KR101976891B1/ko active Active
- 2013-04-08 ES ES13775061.8T patent/ES2624314T3/es active Active
- 2013-04-08 WO PCT/JP2013/060597 patent/WO2013154066A1/ja not_active Ceased
- 2013-04-09 TW TW102112438A patent/TWI639702B/zh active
-
2014
- 2014-10-06 IL IL235002A patent/IL235002B/en active IP Right Grant
- 2014-10-10 US US14/511,386 patent/US9394235B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100249229A1 (en) * | 2007-09-28 | 2010-09-30 | Kousei Shimada | BICYCLIC gamma-AMINO ACID DERIVATIVE |
Non-Patent Citations (6)
| Title |
|---|
| Bortolini, O. et la., J. Org. Chem., 1997, 62: 1854-1856 |
| Butt, S. et al., Tetrahedron Letter, 1985, 26(41): 5077-5080 |
| Butt, S. et al., Tetrahedron Letter, 1985, 26(41): 5077-5080 Dawson, M. J. et la., J. Chem. Soc. Perkin Trans. I, 1983, 2119-2125 * |
| Dawson, M. J. et la., J. Chem. Soc. Perkin Trans. I, 1983, 2119-2125 |
| Fantin, G. et la., Chemistry Letters, 1996, 511-512 |
| Fantin, G. et la., Chemistry Letters, 1996, 511-512 Bortolini, O. et la., J. Org. Chem., 1997, 62: 1854-1856 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6023794B2 (ja) | 2016-11-09 |
| IN2014DN07923A (enExample) | 2015-05-01 |
| KR20150004804A (ko) | 2015-01-13 |
| HUE033397T2 (en) | 2017-12-28 |
| US9394235B2 (en) | 2016-07-19 |
| BR112014025158A2 (pt) | 2017-07-18 |
| EP2837689B1 (en) | 2017-02-15 |
| HK1205192A1 (en) | 2015-12-11 |
| IL235002B (en) | 2018-04-30 |
| CN104245951A (zh) | 2014-12-24 |
| TW201346036A (zh) | 2013-11-16 |
| CN104245951B (zh) | 2018-08-24 |
| KR101976891B1 (ko) | 2019-05-09 |
| EP2837689A1 (en) | 2015-02-18 |
| WO2013154066A1 (ja) | 2013-10-17 |
| CA2869994A1 (en) | 2013-10-17 |
| BR112014025158B1 (pt) | 2021-09-21 |
| US20150038738A1 (en) | 2015-02-05 |
| EP2837689A4 (en) | 2015-09-09 |
| JPWO2013154066A1 (ja) | 2015-12-17 |
| CA2869994C (en) | 2017-05-30 |
| ES2624314T3 (es) | 2017-07-13 |
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