TWI619729B - 抗－ｈｌａ－ｂ*２７抗體及其用途 - Google Patents
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- TWI619729B TWI619729B TW102111629A TW102111629A TWI619729B TW I619729 B TWI619729 B TW I619729B TW 102111629 A TW102111629 A TW 102111629A TW 102111629 A TW102111629 A TW 102111629A TW I619729 B TWI619729 B TW I619729B
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
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- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US201261618969P | 2012-04-02 | 2012-04-02 | |
| US61/618,969 | 2012-04-02 | ||
| US201361778703P | 2013-03-13 | 2013-03-13 | |
| US61/778,703 | 2013-03-13 |
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| TW201343675A TW201343675A (zh) | 2013-11-01 |
| TWI619729B true TWI619729B (zh) | 2018-04-01 |
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| US (1) | US9790273B2 (OSRAM) |
| EP (1) | EP2834272B1 (OSRAM) |
| JP (1) | JP6320993B2 (OSRAM) |
| KR (1) | KR20150003256A (OSRAM) |
| CN (1) | CN104169302A (OSRAM) |
| AR (1) | AR090585A1 (OSRAM) |
| AU (1) | AU2013243644C1 (OSRAM) |
| BR (1) | BR112014024622A2 (OSRAM) |
| CA (1) | CA2868907C (OSRAM) |
| CL (1) | CL2014002631A1 (OSRAM) |
| CO (1) | CO7121320A2 (OSRAM) |
| EA (1) | EA201491827A1 (OSRAM) |
| HK (1) | HK1207092A1 (OSRAM) |
| IL (2) | IL234707A0 (OSRAM) |
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| MY (1) | MY171180A (OSRAM) |
| NZ (1) | NZ700650A (OSRAM) |
| PH (1) | PH12014502184A1 (OSRAM) |
| SG (2) | SG10201608136SA (OSRAM) |
| TW (1) | TWI619729B (OSRAM) |
| UY (1) | UY34721A (OSRAM) |
| WO (1) | WO2013152001A2 (OSRAM) |
Families Citing this family (42)
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| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| CA2700701C (en) | 2007-09-26 | 2020-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| NZ717429A (en) | 2008-04-11 | 2018-07-27 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| CN108715614A (zh) | 2010-11-30 | 2018-10-30 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| TWI687441B (zh) | 2011-06-30 | 2020-03-11 | 中外製藥股份有限公司 | 異源二聚化多胜肽 |
| US20150050269A1 (en) | 2011-09-30 | 2015-02-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| EP2787081A4 (en) | 2011-11-30 | 2015-10-07 | Chugai Pharmaceutical Co Ltd | PHARMACEUTICAL CARRIER IN CELLS FOR THE FORMATION OF AN IMMUNOMOPLEX |
| TWI619729B (zh) | 2012-04-02 | 2018-04-01 | 再生元醫藥公司 | 抗－ｈｌａ－ｂ*２７抗體及其用途 |
| DK2877580T3 (en) | 2012-07-27 | 2019-04-23 | Hope City | VAT VACCINE TO DELIVER A UL128 COMPLEX AND PREVENT CMV INFECTION |
| EP3721900A1 (en) | 2012-08-24 | 2020-10-14 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-specific fc region variant |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| KR102249779B1 (ko) | 2012-12-27 | 2021-05-07 | 추가이 세이야쿠 가부시키가이샤 | 헤테로이량화 폴리펩티드 |
| KR102318483B1 (ko) | 2013-04-02 | 2021-10-27 | 추가이 세이야쿠 가부시키가이샤 | Ｆｃ영역 개변체 |
| KR102650420B1 (ko) | 2014-12-19 | 2024-03-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| TWI617580B (zh) | 2014-12-19 | 2018-03-11 | 中外製藥股份有限公司 | 抗ｃ５抗體及使用方法 |
| WO2016124661A1 (en) * | 2015-02-04 | 2016-08-11 | Universität Zürich | Use of hla-b27 homodimers for cancer treatment |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| IL254141B (en) | 2015-02-27 | 2022-07-01 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars) focusing on hematological malignancies, preparations and methods for their use |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| TW202444897A (zh) | 2015-06-25 | 2024-11-16 | 美商生物細胞基因治療有限公司 | 嵌合抗原受體(car)、組合物及其使用方法 |
| WO2017035185A1 (en) | 2015-08-24 | 2017-03-02 | University Of Cincinnati | Methods and compositions for the detection of fc receptor binding activity of antibodies |
| WO2017044895A2 (en) | 2015-09-10 | 2017-03-16 | City Of Hope | MVA-gH/gL-PC VACCINE DERIVED ANTIBODIES NEUTRALIZING HUMAN CYTOMEGALOVIRUS INFECTIVITY AND METHODS THEREOF |
| TWI747936B (zh) * | 2015-12-18 | 2021-12-01 | 日商中外製藥股份有限公司 | 抗ｃ５抗體及使用方法 |
| TWI605057B (zh) * | 2015-12-18 | 2017-11-11 | 中外製藥股份有限公司 | 抗肌抑素抗體、含變異ｆｃ區之多肽及使用方法 |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
| MX392624B (es) | 2016-03-08 | 2025-03-24 | Univ Zuerich | Conformeros abiertos hla-b57 |
| CA3029197A1 (en) | 2016-06-24 | 2017-12-28 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
| TW202300168A (zh) | 2016-08-05 | 2023-01-01 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
| CN109562171B (zh) | 2016-08-10 | 2023-10-17 | 苏黎世大学 | MHC Ia类开放型构象异构体 |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
| KR20190133718A (ko) * | 2017-03-31 | 2019-12-03 | 알마 바이오 테라퓨틱스 | Hla-b27 관련 염증성 질환의 치료 방법 및 이와 관련된 조성물 |
| WO2018237022A1 (en) | 2017-06-21 | 2018-12-27 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
| CN111556895B (zh) | 2017-11-14 | 2024-09-13 | 中外制药株式会社 | 抗-c1s抗体及使用方法 |
| CN108486226B (zh) * | 2018-04-01 | 2022-04-12 | 广东辉锦创兴生物医学科技有限公司 | Hla-b27等位基因的检测试剂盒及其应用 |
| SG10202106830VA (en) | 2018-08-10 | 2021-08-30 | Chugai Pharmaceutical Co Ltd | Anti-cd137 antigen-binding molecule and utilization thereof |
| EP3941489A4 (en) * | 2019-03-21 | 2022-12-28 | Gamida-Cell Ltd. | EXTENDED NK CELL FRACTIONS SUITABLE FOR POLYTHERAPY TRANSPLANTATION |
| US12473353B2 (en) | 2019-05-15 | 2025-11-18 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule, a pharmaceutical composition, and a method |
| CN111175490A (zh) * | 2020-01-19 | 2020-05-19 | 泛肽生物科技(浙江)有限公司 | 一种定性检测hla-b27的试剂盒及其检测方法 |
| AU2022256043A1 (en) * | 2021-04-07 | 2023-10-12 | Regeneron Pharmaceuticals, Inc. | A composition for use in treating mhc-1-opathies |
| WO2023064850A1 (en) * | 2021-10-14 | 2023-04-20 | Regeneron Pharmaceuticals, Inc. | Treatment of uveitis with endoplasmic reticulum aminopeptidase 1 (erap1) inhibitors |
| US20250302956A1 (en) * | 2022-05-13 | 2025-10-02 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for modulating tcr specificity |
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| EP0213824A2 (en) * | 1985-08-16 | 1987-03-11 | Genetic Systems Corporation | Monoclonal antibody to polymorphic HLA determinant-B27 |
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| US5369010A (en) | 1985-08-16 | 1994-11-29 | Genetic Systems Corporation | Monoclonal antibody to polymorphic HLA determinant -B27 |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE122004000008I1 (de) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
| US5734023A (en) * | 1991-11-19 | 1998-03-31 | Anergen Inc. | MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| JP5848861B2 (ja) | 2004-04-20 | 2016-01-27 | ジェンマブ エー／エスＧｅｎｍａｂ Ａ／Ｓ | Ｃｄ２０に対するヒトモノクローナル抗体 |
| NZ573557A (en) | 2006-06-02 | 2010-08-27 | Regeneron Pharma | High affinity antibodies to human il-6 receptor |
| US20130315933A1 (en) | 2010-10-06 | 2013-11-28 | Christoph Renner | Antibodies Directed Against HLA-B27 Homodimers and Methods and Uses Thereof in Diagnosis and Therapy |
| TWI619729B (zh) | 2012-04-02 | 2018-04-01 | 再生元醫藥公司 | 抗－ｈｌａ－ｂ*２７抗體及其用途 |
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- 2013-04-02 HK HK15107698.3A patent/HK1207092A1/xx unknown
- 2013-04-02 EP EP13716138.6A patent/EP2834272B1/en active Active
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- 2013-04-02 SG SG11201405759UA patent/SG11201405759UA/en unknown
- 2013-04-02 US US13/855,448 patent/US9790273B2/en not_active Expired - Fee Related
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- 2013-04-02 MY MYPI2014002668A patent/MY171180A/en unknown
- 2013-04-02 CN CN201380015594.7A patent/CN104169302A/zh active Pending
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2014
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- 2014-10-30 CO CO14241139A patent/CO7121320A2/es unknown
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2018
- 2018-01-03 IL IL256716A patent/IL256716A/en unknown
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| EP0213824A2 (en) * | 1985-08-16 | 1987-03-11 | Genetic Systems Corporation | Monoclonal antibody to polymorphic HLA determinant-B27 |
Non-Patent Citations (2)
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|---|
| 2003年07月，Levering, W.H.B.M., et al., A.C.," Flow Cytometric HLA-B27 Screening: Cross-Reactivity Patterns of Commercially Available Anti–HLA-B27 Monoclonal Antibodies With Other HLA-B Antigens", Cytometry B Clin. Cytom., 2003, Vol.54, Issue 1, P.28-38. |
| 年07月，Levering, W.H.B.M., et al., A.C.," Flow Cytometric HLA-B27 Screening: Cross-Reactivity Patterns of Commercially Available Anti–HLA-B27 Monoclonal Antibodies With Other HLA-B Antigens", Cytometry B Clin. Cytom., 2003, Vol.54, Issue 1, P.28-38. * |
Also Published As
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|---|---|
| AR090585A1 (es) | 2014-11-26 |
| AU2013243644B2 (en) | 2018-02-08 |
| KR20150003256A (ko) | 2015-01-08 |
| AU2013243644C1 (en) | 2018-05-10 |
| US9790273B2 (en) | 2017-10-17 |
| TW201343675A (zh) | 2013-11-01 |
| AU2013243644A1 (en) | 2014-10-23 |
| EP2834272B1 (en) | 2020-06-24 |
| MY171180A (en) | 2019-09-30 |
| HK1207092A1 (en) | 2016-01-22 |
| SG11201405759UA (en) | 2014-11-27 |
| MX365690B (es) | 2019-06-11 |
| WO2013152001A3 (en) | 2013-12-27 |
| UY34721A (es) | 2013-10-31 |
| BR112014024622A2 (pt) | 2017-08-08 |
| CA2868907C (en) | 2022-01-04 |
| WO2013152001A2 (en) | 2013-10-10 |
| NZ700650A (en) | 2017-02-24 |
| IL256716A (en) | 2018-03-29 |
| CA2868907A1 (en) | 2013-10-10 |
| JP2015514110A (ja) | 2015-05-18 |
| CO7121320A2 (es) | 2014-11-20 |
| EA201491827A1 (ru) | 2015-03-31 |
| EP2834272A2 (en) | 2015-02-11 |
| CL2014002631A1 (es) | 2015-01-16 |
| CN104169302A (zh) | 2014-11-26 |
| MX2014011898A (es) | 2014-11-12 |
| SG10201608136SA (en) | 2016-11-29 |
| PH12014502184A1 (en) | 2014-12-10 |
| JP6320993B2 (ja) | 2018-05-09 |
| US20130259876A1 (en) | 2013-10-03 |
| IL234707A0 (en) | 2014-11-30 |
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