CO7121320A2 - Anticuerpos anti-hla-b*27 y usos de estos - Google Patents

Anticuerpos anti-hla-b*27 y usos de estos

Info

Publication number
CO7121320A2
CO7121320A2 CO14241139A CO14241139A CO7121320A2 CO 7121320 A2 CO7121320 A2 CO 7121320A2 CO 14241139 A CO14241139 A CO 14241139A CO 14241139 A CO14241139 A CO 14241139A CO 7121320 A2 CO7121320 A2 CO 7121320A2
Authority
CO
Colombia
Prior art keywords
hla
antibodies
nexde
pesta
annexes
Prior art date
Application number
CO14241139A
Other languages
English (en)
Spanish (es)
Inventor
Andrew J Murphy
Ana Kostic
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of CO7121320A2 publication Critical patent/CO7121320A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CO14241139A 2012-04-02 2014-10-30 Anticuerpos anti-hla-b*27 y usos de estos CO7121320A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261618969P 2012-04-02 2012-04-02
US201361778703P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
CO7121320A2 true CO7121320A2 (es) 2014-11-20

Family

ID=48093122

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14241139A CO7121320A2 (es) 2012-04-02 2014-10-30 Anticuerpos anti-hla-b*27 y usos de estos

Country Status (22)

Country Link
US (1) US9790273B2 (OSRAM)
EP (1) EP2834272B1 (OSRAM)
JP (1) JP6320993B2 (OSRAM)
KR (1) KR20150003256A (OSRAM)
CN (1) CN104169302A (OSRAM)
AR (1) AR090585A1 (OSRAM)
AU (1) AU2013243644C1 (OSRAM)
BR (1) BR112014024622A2 (OSRAM)
CA (1) CA2868907C (OSRAM)
CL (1) CL2014002631A1 (OSRAM)
CO (1) CO7121320A2 (OSRAM)
EA (1) EA201491827A1 (OSRAM)
HK (1) HK1207092A1 (OSRAM)
IL (2) IL234707A0 (OSRAM)
MX (1) MX365690B (OSRAM)
MY (1) MY171180A (OSRAM)
NZ (1) NZ700650A (OSRAM)
PH (1) PH12014502184A1 (OSRAM)
SG (2) SG10201608136SA (OSRAM)
TW (1) TWI619729B (OSRAM)
UY (1) UY34721A (OSRAM)
WO (1) WO2013152001A2 (OSRAM)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2006381B1 (en) 2006-03-31 2016-02-03 Chugai Seiyaku Kabushiki Kaisha Method for controlling blood pharmacokinetics of antibodies
CA2700701C (en) 2007-09-26 2020-12-29 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in cdr
NZ717429A (en) 2008-04-11 2018-07-27 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
CN108715614A (zh) 2010-11-30 2018-10-30 中外制药株式会社 与多分子的抗原重复结合的抗原结合分子
CN112812184A (zh) 2011-02-25 2021-05-18 中外制药株式会社 FcγRIIb特异性Fc抗体
TWI687441B (zh) 2011-06-30 2020-03-11 中外製藥股份有限公司 異源二聚化多胜肽
US20150050269A1 (en) 2011-09-30 2015-02-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
EP2787081A4 (en) 2011-11-30 2015-10-07 Chugai Pharmaceutical Co Ltd PHARMACEUTICAL CARRIER IN CELLS FOR THE FORMATION OF AN IMMUNOMOPLEX
TWI619729B (zh) 2012-04-02 2018-04-01 再生元醫藥公司 抗-hla-b*27抗體及其用途
DK2877580T3 (en) 2012-07-27 2019-04-23 Hope City VAT VACCINE TO DELIVER A UL128 COMPLEX AND PREVENT CMV INFECTION
EP3721900A1 (en) 2012-08-24 2020-10-14 Chugai Seiyaku Kabushiki Kaisha Fcgammariib-specific fc region variant
JP6774164B2 (ja) 2012-08-24 2020-10-21 中外製薬株式会社 マウスFcγRII特異的Fc抗体
KR102249779B1 (ko) 2012-12-27 2021-05-07 추가이 세이야쿠 가부시키가이샤 헤테로이량화 폴리펩티드
KR102318483B1 (ko) 2013-04-02 2021-10-27 추가이 세이야쿠 가부시키가이샤 Fc영역 개변체
KR102650420B1 (ko) 2014-12-19 2024-03-21 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
TWI617580B (zh) 2014-12-19 2018-03-11 中外製藥股份有限公司 抗c5抗體及使用方法
WO2016124661A1 (en) * 2015-02-04 2016-08-11 Universität Zürich Use of hla-b27 homodimers for cancer treatment
KR102605798B1 (ko) 2015-02-05 2023-11-23 추가이 세이야쿠 가부시키가이샤 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
IL254141B (en) 2015-02-27 2022-07-01 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars) focusing on hematological malignancies, preparations and methods for their use
US11173179B2 (en) 2015-06-25 2021-11-16 Icell Gene Therapeutics Llc Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
TW202444897A (zh) 2015-06-25 2024-11-16 美商生物細胞基因治療有限公司 嵌合抗原受體(car)、組合物及其使用方法
WO2017035185A1 (en) 2015-08-24 2017-03-02 University Of Cincinnati Methods and compositions for the detection of fc receptor binding activity of antibodies
WO2017044895A2 (en) 2015-09-10 2017-03-16 City Of Hope MVA-gH/gL-PC VACCINE DERIVED ANTIBODIES NEUTRALIZING HUMAN CYTOMEGALOVIRUS INFECTIVITY AND METHODS THEREOF
TWI747936B (zh) * 2015-12-18 2021-12-01 日商中外製藥股份有限公司 抗c5抗體及使用方法
TWI605057B (zh) * 2015-12-18 2017-11-11 中外製藥股份有限公司 抗肌抑素抗體、含變異fc區之多肽及使用方法
JP7141336B2 (ja) 2015-12-25 2022-09-22 中外製薬株式会社 抗ミオスタチン抗体および使用方法
MX392624B (es) 2016-03-08 2025-03-24 Univ Zuerich Conformeros abiertos hla-b57
CA3029197A1 (en) 2016-06-24 2017-12-28 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof
TW202300168A (zh) 2016-08-05 2023-01-01 日商中外製藥股份有限公司 Il-8相關疾病之治療用或預防用組成物
CN109562171B (zh) 2016-08-10 2023-10-17 苏黎世大学 MHC Ia类开放型构象异构体
JP7191833B2 (ja) 2017-01-30 2022-12-19 中外製薬株式会社 抗スクレロスチン抗体およびその使用
KR20190133718A (ko) * 2017-03-31 2019-12-03 알마 바이오 테라퓨틱스 Hla-b27 관련 염증성 질환의 치료 방법 및 이와 관련된 조성물
WO2018237022A1 (en) 2017-06-21 2018-12-27 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof
CN111556895B (zh) 2017-11-14 2024-09-13 中外制药株式会社 抗-c1s抗体及使用方法
CN108486226B (zh) * 2018-04-01 2022-04-12 广东辉锦创兴生物医学科技有限公司 Hla-b27等位基因的检测试剂盒及其应用
SG10202106830VA (en) 2018-08-10 2021-08-30 Chugai Pharmaceutical Co Ltd Anti-cd137 antigen-binding molecule and utilization thereof
EP3941489A4 (en) * 2019-03-21 2022-12-28 Gamida-Cell Ltd. EXTENDED NK CELL FRACTIONS SUITABLE FOR POLYTHERAPY TRANSPLANTATION
US12473353B2 (en) 2019-05-15 2025-11-18 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule, a pharmaceutical composition, and a method
CN111175490A (zh) * 2020-01-19 2020-05-19 泛肽生物科技(浙江)有限公司 一种定性检测hla-b27的试剂盒及其检测方法
AU2022256043A1 (en) * 2021-04-07 2023-10-12 Regeneron Pharmaceuticals, Inc. A composition for use in treating mhc-1-opathies
WO2023064850A1 (en) * 2021-10-14 2023-04-20 Regeneron Pharmaceuticals, Inc. Treatment of uveitis with endoplasmic reticulum aminopeptidase 1 (erap1) inhibitors
US20250302956A1 (en) * 2022-05-13 2025-10-02 Memorial Sloan-Kettering Cancer Center Compositions and methods for modulating tcr specificity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369010A (en) 1985-08-16 1994-11-29 Genetic Systems Corporation Monoclonal antibody to polymorphic HLA determinant -B27
DE3650327T2 (de) * 1985-08-16 1996-01-04 Genetic Systems Corp Monoklonaler Antikörper gegen die polymorphe Determinante B27 des HLA.
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
US5734023A (en) * 1991-11-19 1998-03-31 Anergen Inc. MHC class II β chain/peptide complexes useful in ameliorating deleterious immune responses
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JP5848861B2 (ja) 2004-04-20 2016-01-27 ジェンマブ エー/エスGenmab A/S Cd20に対するヒトモノクローナル抗体
NZ573557A (en) 2006-06-02 2010-08-27 Regeneron Pharma High affinity antibodies to human il-6 receptor
US20130315933A1 (en) 2010-10-06 2013-11-28 Christoph Renner Antibodies Directed Against HLA-B27 Homodimers and Methods and Uses Thereof in Diagnosis and Therapy
TWI619729B (zh) 2012-04-02 2018-04-01 再生元醫藥公司 抗-hla-b*27抗體及其用途

Also Published As

Publication number Publication date
AR090585A1 (es) 2014-11-26
AU2013243644B2 (en) 2018-02-08
KR20150003256A (ko) 2015-01-08
AU2013243644C1 (en) 2018-05-10
US9790273B2 (en) 2017-10-17
TW201343675A (zh) 2013-11-01
AU2013243644A1 (en) 2014-10-23
EP2834272B1 (en) 2020-06-24
MY171180A (en) 2019-09-30
HK1207092A1 (en) 2016-01-22
SG11201405759UA (en) 2014-11-27
MX365690B (es) 2019-06-11
WO2013152001A3 (en) 2013-12-27
TWI619729B (zh) 2018-04-01
UY34721A (es) 2013-10-31
BR112014024622A2 (pt) 2017-08-08
CA2868907C (en) 2022-01-04
WO2013152001A2 (en) 2013-10-10
NZ700650A (en) 2017-02-24
IL256716A (en) 2018-03-29
CA2868907A1 (en) 2013-10-10
JP2015514110A (ja) 2015-05-18
EA201491827A1 (ru) 2015-03-31
EP2834272A2 (en) 2015-02-11
CL2014002631A1 (es) 2015-01-16
CN104169302A (zh) 2014-11-26
MX2014011898A (es) 2014-11-12
SG10201608136SA (en) 2016-11-29
PH12014502184A1 (en) 2014-12-10
JP6320993B2 (ja) 2018-05-09
US20130259876A1 (en) 2013-10-03
IL234707A0 (en) 2014-11-30

Similar Documents

Publication Publication Date Title
CO7121320A2 (es) Anticuerpos anti-hla-b*27 y usos de estos
IL290613A (en) Humanized or chimeric cd3 antibodies
UY34876A (es) Anticuerpos anti-egfr y usos de los mismos
TWD180147S (zh) 淨水器
CL2015001321A1 (es) Anticuerpos anti-ceacam5 y usos de éstos
CO7151521A2 (es) Anticuerpos anti-fcrn
CO7020877A2 (es) Anticuerpos anti-asic1 y usos de los mismos
EA201491357A1 (ru) Анти-lrp5 антитела и способы их применения
EP2864479A4 (en) MODULATION OF THE UBE3A ATS EXPRESSION
UY34680A (es) Anticuerpos humanos anti-cd27, métodos, y usos
EA201590993A1 (ru) Гетеродимерные иммуноглобулины
CL2016001212A1 (es) Moduladores de aplnr y usos de estos
UY34782A (es) Anticuerpos humanos para fel d1 y métodos para usarlos.
BR112014026926A2 (pt) uso terapêutico de produtos de semente de chardonnay
EP2970511A4 (en) INSULIN CONJUGATES incretin
UY34602A (es) ?Derivados de bencimidazolil- e imidazopiridinil-metilamina?
EP2839005A4 (en) MIRNA MODULATORS OF THERMOGENESIS
SI3513806T1 (sl) Sestava imunogena
EP2870180C0 (en) ANTI-BIOTIN ANTIBODIES AND METHODS OF USE
CO7151499A2 (es) Formulación inyectable
EP2776564A4 (en) MODULATION OF TMPRSS6.EXPRESSION
PL4066849T3 (pl) Preparaty daptomycyny i ich zastosowania
HUE045668T2 (hu) Oldat készítmények módosított anti-IL-23p19 antitestekbõl
UY34702A (es) Composiciones y métodos agrícolas u hortícolas
CO7151478A2 (es) Formulaciones estabilizadas que contienen anticuerpos anti-dll4