TWI583698B - 人類gdnf之變異體 - Google Patents

人類gdnf之變異體 Download PDF

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Publication number
TWI583698B
TWI583698B TW101110653A TW101110653A TWI583698B TW I583698 B TWI583698 B TW I583698B TW 101110653 A TW101110653 A TW 101110653A TW 101110653 A TW101110653 A TW 101110653A TW I583698 B TWI583698 B TW I583698B
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TW
Taiwan
Prior art keywords
gdnf
seq
variant
human
xaa
Prior art date
Application number
TW101110653A
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English (en)
Chinese (zh)
Other versions
TW201245220A (en
Inventor
東米安 東 姆 梁
盧基榮
可帕那 馬哈須 默卷
馬摩 甘南
琳達 毛琳 歐布萊恩
羅莎夢 卡蘿 史密斯
Original Assignee
美國禮來大藥廠
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Application filed by 美國禮來大藥廠 filed Critical 美國禮來大藥廠
Publication of TW201245220A publication Critical patent/TW201245220A/zh
Application granted granted Critical
Publication of TWI583698B publication Critical patent/TWI583698B/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW101110653A 2011-04-11 2012-03-27 人類gdnf之變異體 TWI583698B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161474024P 2011-04-11 2011-04-11

Publications (2)

Publication Number Publication Date
TW201245220A TW201245220A (en) 2012-11-16
TWI583698B true TWI583698B (zh) 2017-05-21

Family

ID=45932578

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101110653A TWI583698B (zh) 2011-04-11 2012-03-27 人類gdnf之變異體

Country Status (28)

Country Link
US (1) US9243046B2 (enExample)
EP (1) EP2696889B1 (enExample)
JP (1) JP6093345B2 (enExample)
KR (1) KR101554799B1 (enExample)
CN (1) CN103635201B (enExample)
AU (1) AU2012243178B2 (enExample)
BR (1) BR112013026004B1 (enExample)
CA (1) CA2833158C (enExample)
CY (1) CY1119750T1 (enExample)
DK (1) DK2696889T3 (enExample)
EA (1) EA025129B1 (enExample)
ES (1) ES2656020T3 (enExample)
HR (1) HRP20171993T1 (enExample)
HU (1) HUE036239T2 (enExample)
IL (1) IL228102A (enExample)
LT (1) LT2696889T (enExample)
ME (1) ME02849B (enExample)
MX (1) MX337206B (enExample)
NO (1) NO2696889T3 (enExample)
PL (1) PL2696889T3 (enExample)
PT (1) PT2696889T (enExample)
RS (1) RS56639B1 (enExample)
SG (1) SG193483A1 (enExample)
SI (1) SI2696889T1 (enExample)
TW (1) TWI583698B (enExample)
UA (1) UA112981C2 (enExample)
WO (1) WO2012141936A1 (enExample)
ZA (1) ZA201306556B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7000349B2 (ja) 2016-05-13 2022-02-04 インスティテュート デ メディシナ モレキュラー ジョアオ ロボ アントゥネス Ilc3細胞に関連する疾患を処置する方法
ES3036928T3 (en) * 2019-12-19 2025-09-25 Transfert Plus Soc En Commandite Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies
JP2024522938A (ja) 2021-06-03 2024-06-21 フンダサン デー.アンナ ジ ソーメル チャンパリマウド エー ドクトル カルロス モンテス チャンパリマウド 脳-脂肪回路を介してilc2および肥満度を制御する神経-間葉単位

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127419A1 (en) * 1995-09-28 2004-07-01 Amgen Methods of using truncated glial cell line-derived neurotrophic factor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9205293A (es) 1991-09-20 1993-05-01 Syntex Sinergen Neuroscience J Factores neurotrofico derivado del glial
US6042579A (en) 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
FI20070808A0 (fi) * 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
CN101775072B (zh) * 2008-05-21 2012-09-05 王尚武 一种融合穿透肽的神经细胞营养因子gdnf
AU2010211438B2 (en) * 2009-02-06 2016-04-14 Academisch Ziekenhuis Maastricht Truncated cystine-knot proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127419A1 (en) * 1995-09-28 2004-07-01 Amgen Methods of using truncated glial cell line-derived neurotrophic factor

Also Published As

Publication number Publication date
UA112981C2 (uk) 2016-11-25
HRP20171993T1 (hr) 2018-02-09
WO2012141936A1 (en) 2012-10-18
JP6093345B2 (ja) 2017-03-08
DK2696889T3 (en) 2018-01-22
KR101554799B1 (ko) 2015-09-21
TW201245220A (en) 2012-11-16
MX337206B (es) 2016-02-17
EA025129B1 (ru) 2016-11-30
LT2696889T (lt) 2018-02-12
KR20130131470A (ko) 2013-12-03
NZ614325A (en) 2015-07-31
RS56639B1 (sr) 2018-03-30
CA2833158A1 (en) 2012-10-18
US20130324474A1 (en) 2013-12-05
EP2696889B1 (en) 2017-11-15
EA201370204A1 (ru) 2014-02-28
MX2013011919A (es) 2014-03-27
BR112013026004A2 (pt) 2016-11-29
CN103635201A (zh) 2014-03-12
SI2696889T1 (en) 2018-01-31
IL228102A (en) 2017-04-30
JP2014512369A (ja) 2014-05-22
BR112013026004B1 (pt) 2020-09-29
CY1119750T1 (el) 2018-06-27
CA2833158C (en) 2018-07-17
NO2696889T3 (enExample) 2018-04-14
CN103635201B (zh) 2016-11-09
ES2656020T3 (es) 2018-02-22
HUE036239T2 (hu) 2018-06-28
PT2696889T (pt) 2018-02-05
EP2696889A1 (en) 2014-02-19
SG193483A1 (en) 2013-10-30
PL2696889T3 (pl) 2018-04-30
IL228102A0 (en) 2013-09-30
ZA201306556B (en) 2015-03-25
AU2012243178A1 (en) 2013-09-05
ME02849B (me) 2018-01-20
AU2012243178B2 (en) 2016-09-29
US9243046B2 (en) 2016-01-26

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