TWI583698B - 人類gdnf之變異體 - Google Patents

人類gdnf之變異體 Download PDF

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Publication number
TWI583698B
TWI583698B TW101110653A TW101110653A TWI583698B TW I583698 B TWI583698 B TW I583698B TW 101110653 A TW101110653 A TW 101110653A TW 101110653 A TW101110653 A TW 101110653A TW I583698 B TWI583698 B TW I583698B
Authority
TW
Taiwan
Prior art keywords
gdnf
seq
variant
human
xaa
Prior art date
Application number
TW101110653A
Other languages
English (en)
Chinese (zh)
Other versions
TW201245220A (en
Inventor
東米安 東 姆 梁
盧基榮
可帕那 馬哈須 默卷
馬摩 甘南
琳達 毛琳 歐布萊恩
羅莎夢 卡蘿 史密斯
Original Assignee
美國禮來大藥廠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美國禮來大藥廠 filed Critical 美國禮來大藥廠
Publication of TW201245220A publication Critical patent/TW201245220A/zh
Application granted granted Critical
Publication of TWI583698B publication Critical patent/TWI583698B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • External Artificial Organs (AREA)
TW101110653A 2011-04-11 2012-03-27 人類gdnf之變異體 TWI583698B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161474024P 2011-04-11 2011-04-11

Publications (2)

Publication Number Publication Date
TW201245220A TW201245220A (en) 2012-11-16
TWI583698B true TWI583698B (zh) 2017-05-21

Family

ID=45932578

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101110653A TWI583698B (zh) 2011-04-11 2012-03-27 人類gdnf之變異體

Country Status (28)

Country Link
US (1) US9243046B2 (enExample)
EP (1) EP2696889B1 (enExample)
JP (1) JP6093345B2 (enExample)
KR (1) KR101554799B1 (enExample)
CN (1) CN103635201B (enExample)
AU (1) AU2012243178B2 (enExample)
BR (1) BR112013026004B1 (enExample)
CA (1) CA2833158C (enExample)
CY (1) CY1119750T1 (enExample)
DK (1) DK2696889T3 (enExample)
EA (1) EA025129B1 (enExample)
ES (1) ES2656020T3 (enExample)
HR (1) HRP20171993T1 (enExample)
HU (1) HUE036239T2 (enExample)
IL (1) IL228102A (enExample)
LT (1) LT2696889T (enExample)
ME (1) ME02849B (enExample)
MX (1) MX337206B (enExample)
NO (1) NO2696889T3 (enExample)
PL (1) PL2696889T3 (enExample)
PT (1) PT2696889T (enExample)
RS (1) RS56639B1 (enExample)
SG (1) SG193483A1 (enExample)
SI (1) SI2696889T1 (enExample)
TW (1) TWI583698B (enExample)
UA (1) UA112981C2 (enExample)
WO (1) WO2012141936A1 (enExample)
ZA (1) ZA201306556B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3454886A1 (en) 2016-05-13 2019-03-20 Instituto de Medicina Molecular Methods of treating diseases associated with ilc3 cells
US20230022970A1 (en) * 2019-12-19 2023-01-26 Transfert Plus, Société En Commandite Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies
EP4347645A1 (en) 2021-06-03 2024-04-10 Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud Foundation Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit
CN116606365A (zh) * 2023-02-24 2023-08-18 肇庆医学高等专科学校 一种gdnf新型变体及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127419A1 (en) * 1995-09-28 2004-07-01 Amgen Methods of using truncated glial cell line-derived neurotrophic factor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006116A1 (en) 1991-09-20 1993-04-01 Syntex-Synergen Neuroscience Joint Venture Glial derived neurotrophic factor
US6042579A (en) 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
DE19816186A1 (de) 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
FI20070808A0 (fi) 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
CN101775072B (zh) * 2008-05-21 2012-09-05 王尚武 一种融合穿透肽的神经细胞营养因子gdnf
WO2010090523A1 (en) * 2009-02-06 2010-08-12 Pepscan Systems B.V. Truncated cystine-knot proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127419A1 (en) * 1995-09-28 2004-07-01 Amgen Methods of using truncated glial cell line-derived neurotrophic factor

Also Published As

Publication number Publication date
JP2014512369A (ja) 2014-05-22
NZ614325A (en) 2015-07-31
CN103635201B (zh) 2016-11-09
AU2012243178B2 (en) 2016-09-29
SI2696889T1 (en) 2018-01-31
EP2696889B1 (en) 2017-11-15
EP2696889A1 (en) 2014-02-19
CY1119750T1 (el) 2018-06-27
JP6093345B2 (ja) 2017-03-08
CN103635201A (zh) 2014-03-12
US9243046B2 (en) 2016-01-26
BR112013026004A2 (pt) 2016-11-29
DK2696889T3 (en) 2018-01-22
KR101554799B1 (ko) 2015-09-21
PL2696889T3 (pl) 2018-04-30
US20130324474A1 (en) 2013-12-05
MX2013011919A (es) 2014-03-27
CA2833158A1 (en) 2012-10-18
ZA201306556B (en) 2015-03-25
IL228102A (en) 2017-04-30
ES2656020T3 (es) 2018-02-22
HUE036239T2 (hu) 2018-06-28
TW201245220A (en) 2012-11-16
ME02849B (me) 2018-01-20
HRP20171993T1 (hr) 2018-02-09
UA112981C2 (uk) 2016-11-25
BR112013026004B1 (pt) 2020-09-29
PT2696889T (pt) 2018-02-05
LT2696889T (lt) 2018-02-12
KR20130131470A (ko) 2013-12-03
EA201370204A1 (ru) 2014-02-28
MX337206B (es) 2016-02-17
SG193483A1 (en) 2013-10-30
WO2012141936A1 (en) 2012-10-18
IL228102A0 (en) 2013-09-30
NO2696889T3 (enExample) 2018-04-14
AU2012243178A1 (en) 2013-09-05
RS56639B1 (sr) 2018-03-30
EA025129B1 (ru) 2016-11-30
CA2833158C (en) 2018-07-17

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