MX337206B - Variantes de factor neurotrófico derivado de celulas gliales humanas. - Google Patents

Variantes de factor neurotrófico derivado de celulas gliales humanas.

Info

Publication number
MX337206B
MX337206B MX2013011919A MX2013011919A MX337206B MX 337206 B MX337206 B MX 337206B MX 2013011919 A MX2013011919 A MX 2013011919A MX 2013011919 A MX2013011919 A MX 2013011919A MX 337206 B MX337206 B MX 337206B
Authority
MX
Mexico
Prior art keywords
variants
human gdnf
gdnf
human
methods
Prior art date
Application number
MX2013011919A
Other languages
English (en)
Other versions
MX2013011919A (es
Inventor
Donmienne Doen Mun Leung
Kalpana Mahesh Merchant
Mahmoud Ghanem
Linda Maureen O Bryan
Rosamund Carol Smith
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2013011919A publication Critical patent/MX2013011919A/es
Publication of MX337206B publication Critical patent/MX337206B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • External Artificial Organs (AREA)

Abstract

La presente invención se refiere a una nueva variante de GDNF truncada de dominio GDNF humano maduro que carece de los primeros 31 aminoácidos en el N-término ("GDNF truncado de ?31-N-término"), con ciertas sustituciones de aminoácidos introducidas para proporcionar variantes de GDNF, adecuadamente potentes, estables, que ofrecen propiedades de bio-distribución deseable y un perfil de inmunogenicidad farmacéuticamente aceptable. La presente invención proporciona ciertas variantes de GDNF humano que imparten una o más ventajas sobre el GDNF de tipo nativo humano maduro que incluye variantes que tienen estabilidad farmacéutica mejorada, así como también bio-distribución mejorada, enlace de heparina reducido, desamidación reducida susceptibilidad reducida para formación de succinimida, y potencial de inmunogenicidad reducida comparado con el GDNF de tipo nativo humano. Ciertas nuevas variantes del GDNF pueden ser una opción de nuevo tratamiento útil para pacientes con enfermedad de Parkinson.
MX2013011919A 2011-04-11 2012-04-03 Variantes de factor neurotrófico derivado de celulas gliales humanas. MX337206B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161474024P 2011-04-11 2011-04-11
PCT/US2012/031927 WO2012141936A1 (en) 2011-04-11 2012-04-03 Variants of human gdnf

Publications (2)

Publication Number Publication Date
MX2013011919A MX2013011919A (es) 2014-03-27
MX337206B true MX337206B (es) 2016-02-17

Family

ID=45932578

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013011919A MX337206B (es) 2011-04-11 2012-04-03 Variantes de factor neurotrófico derivado de celulas gliales humanas.

Country Status (28)

Country Link
US (1) US9243046B2 (es)
EP (1) EP2696889B1 (es)
JP (1) JP6093345B2 (es)
KR (1) KR101554799B1 (es)
CN (1) CN103635201B (es)
AU (1) AU2012243178B2 (es)
BR (1) BR112013026004B1 (es)
CA (1) CA2833158C (es)
CY (1) CY1119750T1 (es)
DK (1) DK2696889T3 (es)
EA (1) EA025129B1 (es)
ES (1) ES2656020T3 (es)
HR (1) HRP20171993T1 (es)
HU (1) HUE036239T2 (es)
IL (1) IL228102A (es)
LT (1) LT2696889T (es)
ME (1) ME02849B (es)
MX (1) MX337206B (es)
NO (1) NO2696889T3 (es)
PL (1) PL2696889T3 (es)
PT (1) PT2696889T (es)
RS (1) RS56639B1 (es)
SG (1) SG193483A1 (es)
SI (1) SI2696889T1 (es)
TW (1) TWI583698B (es)
UA (1) UA112981C2 (es)
WO (1) WO2012141936A1 (es)
ZA (1) ZA201306556B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018013885A (es) 2016-05-13 2019-08-16 Inst De Medicina Molecular Joaeo Lobo Antunes Métodos de tratamiento de enfermedades asociadas con células linfoides innatas del grupo 3 (cli3).
CA3162011A1 (en) * 2019-12-19 2021-06-24 Rodolphe SORET Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies
JP2024522938A (ja) 2021-06-03 2024-06-21 フンダサン デー．アンナ ジ ソーメル チャンパリマウド エー ドクトル カルロス モンテス チャンパリマウド 脳－脂肪回路を介してｉｌｃ２および肥満度を制御する神経－間葉単位

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2119463C (en) 1991-09-20 2003-09-16 Leu-Fen H. Lin Glial cell line-derived neutrophic factor
US6184200B1 (en) * 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US6042579A (en) 1997-04-30 2000-03-28 Medtronic, Inc. Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
FI20070808A0 (fi) * 2007-10-25 2007-10-25 Mart Saarma GDNF:n silmukointivariantit ja niiden käytöt
CN101775072B (zh) * 2008-05-21 2012-09-05 王尚武 一种融合穿透肽的神经细胞营养因子gdnf
CA2751445C (en) * 2009-02-06 2018-06-19 Pepscan Systems B.V. Truncated cystine-knot proteins

Also Published As

Publication number Publication date
CY1119750T1 (el) 2018-06-27
KR20130131470A (ko) 2013-12-03
ES2656020T3 (es) 2018-02-22
UA112981C2 (uk) 2016-11-25
HUE036239T2 (hu) 2018-06-28
KR101554799B1 (ko) 2015-09-21
PL2696889T3 (pl) 2018-04-30
RS56639B1 (sr) 2018-03-30
SI2696889T1 (en) 2018-01-31
EP2696889A1 (en) 2014-02-19
US20130324474A1 (en) 2013-12-05
ME02849B (me) 2018-01-20
CA2833158A1 (en) 2012-10-18
EA025129B1 (ru) 2016-11-30
AU2012243178B2 (en) 2016-09-29
US9243046B2 (en) 2016-01-26
JP6093345B2 (ja) 2017-03-08
CN103635201B (zh) 2016-11-09
BR112013026004A2 (pt) 2016-11-29
BR112013026004B1 (pt) 2020-09-29
IL228102A0 (en) 2013-09-30
LT2696889T (lt) 2018-02-12
AU2012243178A1 (en) 2013-09-05
JP2014512369A (ja) 2014-05-22
HRP20171993T1 (hr) 2018-02-09
NO2696889T3 (es) 2018-04-14
DK2696889T3 (en) 2018-01-22
IL228102A (en) 2017-04-30
SG193483A1 (en) 2013-10-30
EP2696889B1 (en) 2017-11-15
EA201370204A1 (ru) 2014-02-28
ZA201306556B (en) 2015-03-25
CA2833158C (en) 2018-07-17
NZ614325A (en) 2015-07-31
WO2012141936A1 (en) 2012-10-18
CN103635201A (zh) 2014-03-12
TW201245220A (en) 2012-11-16
TWI583698B (zh) 2017-05-21
MX2013011919A (es) 2014-03-27
PT2696889T (pt) 2018-02-05

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