MX337206B - Variantes de factor neurotrófico derivado de celulas gliales humanas. - Google Patents
Variantes de factor neurotrófico derivado de celulas gliales humanas.Info
- Publication number
- MX337206B MX337206B MX2013011919A MX2013011919A MX337206B MX 337206 B MX337206 B MX 337206B MX 2013011919 A MX2013011919 A MX 2013011919A MX 2013011919 A MX2013011919 A MX 2013011919A MX 337206 B MX337206 B MX 337206B
- Authority
- MX
- Mexico
- Prior art keywords
- variants
- human gdnf
- gdnf
- human
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- External Artificial Organs (AREA)
Abstract
La presente invención se refiere a una nueva variante de GDNF truncada de dominio GDNF humano maduro que carece de los primeros 31 aminoácidos en el N-término ("GDNF truncado de ?31-N-término"), con ciertas sustituciones de aminoácidos introducidas para proporcionar variantes de GDNF, adecuadamente potentes, estables, que ofrecen propiedades de bio-distribución deseable y un perfil de inmunogenicidad farmacéuticamente aceptable. La presente invención proporciona ciertas variantes de GDNF humano que imparten una o más ventajas sobre el GDNF de tipo nativo humano maduro que incluye variantes que tienen estabilidad farmacéutica mejorada, así como también bio-distribución mejorada, enlace de heparina reducido, desamidación reducida susceptibilidad reducida para formación de succinimida, y potencial de inmunogenicidad reducida comparado con el GDNF de tipo nativo humano. Ciertas nuevas variantes del GDNF pueden ser una opción de nuevo tratamiento útil para pacientes con enfermedad de Parkinson.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161474024P | 2011-04-11 | 2011-04-11 | |
PCT/US2012/031927 WO2012141936A1 (en) | 2011-04-11 | 2012-04-03 | Variants of human gdnf |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013011919A MX2013011919A (es) | 2014-03-27 |
MX337206B true MX337206B (es) | 2016-02-17 |
Family
ID=45932578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013011919A MX337206B (es) | 2011-04-11 | 2012-04-03 | Variantes de factor neurotrófico derivado de celulas gliales humanas. |
Country Status (28)
Country | Link |
---|---|
US (1) | US9243046B2 (es) |
EP (1) | EP2696889B1 (es) |
JP (1) | JP6093345B2 (es) |
KR (1) | KR101554799B1 (es) |
CN (1) | CN103635201B (es) |
AU (1) | AU2012243178B2 (es) |
BR (1) | BR112013026004B1 (es) |
CA (1) | CA2833158C (es) |
CY (1) | CY1119750T1 (es) |
DK (1) | DK2696889T3 (es) |
EA (1) | EA025129B1 (es) |
ES (1) | ES2656020T3 (es) |
HR (1) | HRP20171993T1 (es) |
HU (1) | HUE036239T2 (es) |
IL (1) | IL228102A (es) |
LT (1) | LT2696889T (es) |
ME (1) | ME02849B (es) |
MX (1) | MX337206B (es) |
NO (1) | NO2696889T3 (es) |
PL (1) | PL2696889T3 (es) |
PT (1) | PT2696889T (es) |
RS (1) | RS56639B1 (es) |
SG (1) | SG193483A1 (es) |
SI (1) | SI2696889T1 (es) |
TW (1) | TWI583698B (es) |
UA (1) | UA112981C2 (es) |
WO (1) | WO2012141936A1 (es) |
ZA (1) | ZA201306556B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018013885A (es) | 2016-05-13 | 2019-08-16 | Inst De Medicina Molecular Joaeo Lobo Antunes | Métodos de tratamiento de enfermedades asociadas con células linfoides innatas del grupo 3 (cli3). |
EP4076499A4 (en) * | 2019-12-19 | 2023-11-01 | Transfert Plus Societe en Commandite | USE OF GLIAL CELL-DERIVED NEUROTROPHIC FACTOR (GDNF) FOR THE TREATMENT OF ENTERIC NEUROPATHIES |
IL309027A (en) | 2021-06-03 | 2024-02-01 | Fundac?O D Anna De Sommer Champalimaud E Dr Carlos Montez Champalimaud | Neuro-messenger units that control ILC2 and obesity in brain fat cell circuit findings |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2119463C (en) | 1991-09-20 | 2003-09-16 | Leu-Fen H. Lin | Glial cell line-derived neutrophic factor |
US6184200B1 (en) * | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
US6042579A (en) | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
DE19816186A1 (de) * | 1998-04-14 | 1999-10-21 | Univ Muenchen L Maximilians | GDNF-kodierende DNA, Teile davon und GDNF-Varianten |
US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
FI20070808A0 (fi) * | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
CN101775072B (zh) * | 2008-05-21 | 2012-09-05 | 王尚武 | 一种融合穿透肽的神经细胞营养因子gdnf |
NZ594481A (en) * | 2009-02-06 | 2012-09-28 | Pepscan Systems Bv | Truncated cystine-knot proteins |
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2012
- 2012-03-04 UA UAA201311714A patent/UA112981C2/uk unknown
- 2012-03-27 TW TW101110653A patent/TWI583698B/zh active
- 2012-04-03 DK DK12712874.2T patent/DK2696889T3/en active
- 2012-04-03 PT PT127128742T patent/PT2696889T/pt unknown
- 2012-04-03 CN CN201280018010.7A patent/CN103635201B/zh active Active
- 2012-04-03 ME MEP-2017-276A patent/ME02849B/me unknown
- 2012-04-03 AU AU2012243178A patent/AU2012243178B2/en not_active Ceased
- 2012-04-03 LT LTEP12712874.2T patent/LT2696889T/lt unknown
- 2012-04-03 SI SI201231134T patent/SI2696889T1/en unknown
- 2012-04-03 MX MX2013011919A patent/MX337206B/es active IP Right Grant
- 2012-04-03 WO PCT/US2012/031927 patent/WO2012141936A1/en active Application Filing
- 2012-04-03 ES ES12712874.2T patent/ES2656020T3/es active Active
- 2012-04-03 JP JP2014505179A patent/JP6093345B2/ja active Active
- 2012-04-03 CA CA2833158A patent/CA2833158C/en not_active Expired - Fee Related
- 2012-04-03 EP EP12712874.2A patent/EP2696889B1/en active Active
- 2012-04-03 EA EA201370204A patent/EA025129B1/ru not_active IP Right Cessation
- 2012-04-03 HU HUE12712874A patent/HUE036239T2/hu unknown
- 2012-04-03 PL PL12712874T patent/PL2696889T3/pl unknown
- 2012-04-03 BR BR112013026004-1A patent/BR112013026004B1/pt not_active IP Right Cessation
- 2012-04-03 SG SG2013069554A patent/SG193483A1/en unknown
- 2012-04-03 RS RS20171274A patent/RS56639B1/sr unknown
- 2012-04-03 KR KR1020137026366A patent/KR101554799B1/ko active IP Right Grant
- 2012-04-03 US US14/000,704 patent/US9243046B2/en active Active
- 2012-04-03 NO NO12712874A patent/NO2696889T3/no unknown
-
2013
- 2013-08-22 IL IL228102A patent/IL228102A/en active IP Right Grant
- 2013-08-30 ZA ZA2013/06556A patent/ZA201306556B/en unknown
-
2017
- 2017-12-21 HR HRP20171993TT patent/HRP20171993T1/hr unknown
-
2018
- 2018-01-09 CY CY20181100021T patent/CY1119750T1/el unknown
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Legal Events
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FG | Grant or registration |