HRP20171993T1 - Varijante ljudskog gdnf - Google Patents
Varijante ljudskog gdnf Download PDFInfo
- Publication number
- HRP20171993T1 HRP20171993T1 HRP20171993TT HRP20171993T HRP20171993T1 HR P20171993 T1 HRP20171993 T1 HR P20171993T1 HR P20171993T T HRP20171993T T HR P20171993TT HR P20171993 T HRP20171993 T HR P20171993T HR P20171993 T1 HRP20171993 T1 HR P20171993T1
- Authority
- HR
- Croatia
- Prior art keywords
- variant
- seq
- rgqrgkqrgcvltaihlnvtdlglgyetkeelifrycsgscdaaettyd
- human gdnf
- gdnf
- Prior art date
Links
- 101150082979 gdnf gene Proteins 0.000 title 1
- 101000997829 Homo sapiens Glial cell line-derived neurotrophic factor Proteins 0.000 claims 8
- 102000052654 human GDNF Human genes 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims 1
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013067 intermediate product Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (11)
1. Varijanta ljudskog GDNF, naznačena time što ima aminokiselinski slijed SEQ ID NO: 23:
RGQRGKQRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD
KILXaa84NLSXaa88NXaa90RLVSEKVGQACCRPIAFDDDLSFLDDNLVYHI
LRXaa125HSAKXaa130CGCI
gdje:
i) Xaa84 je K ili A;
ii) Xaa88 je R ili K;
iii) Xaa90 je R ili K;
iv) Xaa125 je K ili E; i
v) Xaa130 je R ili E.
2. Varijanta ljudskog GDNF u skladu s patentnim zahtjevom 1, naznačena time što se navedenu varijantu bira iz skupine koju čine
RGQRGKQRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD
KILKNLSRNRRLVSEKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAK
RCGCI (SEQ ID NO: 9),
RGQRGKQRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD
KILANLSKNKRLVSEKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAK
RCGCI (SEQ ID NO: 12),
i
RGQRGKQRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD
KILANLSKNKRLVSEKVGQACCRPIAFDDDLSFLDDNLVYHILREHSAK
ECGCI (SEQ ID NO: 15).
3. Varijanta ljudskog GDNF u skladu s patentnim zahtjevom 2, naznačena time što je navedena varijanta
RGQRGKQRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD
KILKNLSRNRRLVSEKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAK
RCGCI (SEQ. ID: 9).
4. Varijanta ljudskog GDNF u skladu s patentnim zahtjevom 2, naznačena time što je navedena varijanta
RGQRGKQRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD
KILANLSKNKRLVSEKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAK
RCGCI (SEQ ID NO: 12).
5. Varijanta ljudskog GDNF u skladu s patentnim zahtjevom 2, naznačena time što je navedena varijanta
RGQRGKQRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD
KILANLSKNKRLVSEKVGQACCRPIAFDDDLSFLDDNLVYHILREHSAK
ECGCI (SEQ ID NO: 15).
6. Međuprodukt , naznačen time što je namijenjen dobivanju Δ31-N-terminalne skraćene varijante GDNF koja sadrži aminokiselinski slijed koji se bira iz skupine koju čine
METDTLLLVVVLLLVVVPGSTGRGQRGKQRGCVLTAIHLNVTDLGLGYET
KEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSEKVGQACCRPIAFDD
DLSFLDDNL VYHILRKHSAKRCGCI (SEQ ID NO: 28);
i
MATGSRTSLLLAFGLLCLPWLQEGSARGQRGKQRGCVLTAIHLNVTDL
GLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSEKVGQACC
RPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI (SEQ ID NO: 35).
7. Međuprodukt u skladu s patentnim zahtjevom 6, naznačen time što je aminokiselinski slijed
MATGSRTSLLLAFGLLCLPWLQEGSARGQRGKQRGCVLTAIHLNVTDL
GLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRL VSEKVGQACC
RPIAFDDDLSFLDDNL VYHILRKHSAKRCGCI (SEQ ID NO: 35).
8. Farmaceutski pripravak, naznačen time što sadrži varijantu ljudskog GDNF u skladu s bilo kojim od patentnih zahtjeva 1 do 5, kao i jedan ili više farmaceutski prihvatljivih razrjeđivača, podloga ili pomoćnih tvari.
9. Farmaceutski pripravak u skladu s patentnim zahtjevom 8, naznačen time što je namijenjen upotrebi u liječenju Parkinsonove bolesti kod ljudskog pacijenta.
10. Varijanta ljudskog GDNF u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačena time što je namijenjena upotrebi kao medikament.
11. Varijanta ljudskog GDNF u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačena time što je namijenjena upotrebi u liječenju Parkinsonove bolesti.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474024P | 2011-04-11 | 2011-04-11 | |
| EP12712874.2A EP2696889B1 (en) | 2011-04-11 | 2012-04-03 | Variants of human gdnf |
| PCT/US2012/031927 WO2012141936A1 (en) | 2011-04-11 | 2012-04-03 | Variants of human gdnf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171993T1 true HRP20171993T1 (hr) | 2018-02-09 |
Family
ID=45932578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171993TT HRP20171993T1 (hr) | 2011-04-11 | 2017-12-21 | Varijante ljudskog gdnf |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US9243046B2 (hr) |
| EP (1) | EP2696889B1 (hr) |
| JP (1) | JP6093345B2 (hr) |
| KR (1) | KR101554799B1 (hr) |
| CN (1) | CN103635201B (hr) |
| AU (1) | AU2012243178B2 (hr) |
| BR (1) | BR112013026004B1 (hr) |
| CA (1) | CA2833158C (hr) |
| CY (1) | CY1119750T1 (hr) |
| DK (1) | DK2696889T3 (hr) |
| EA (1) | EA025129B1 (hr) |
| ES (1) | ES2656020T3 (hr) |
| HR (1) | HRP20171993T1 (hr) |
| HU (1) | HUE036239T2 (hr) |
| IL (1) | IL228102A (hr) |
| LT (1) | LT2696889T (hr) |
| ME (1) | ME02849B (hr) |
| MX (1) | MX337206B (hr) |
| NO (1) | NO2696889T3 (hr) |
| PL (1) | PL2696889T3 (hr) |
| PT (1) | PT2696889T (hr) |
| RS (1) | RS56639B1 (hr) |
| SG (1) | SG193483A1 (hr) |
| SI (1) | SI2696889T1 (hr) |
| TW (1) | TWI583698B (hr) |
| UA (1) | UA112981C2 (hr) |
| WO (1) | WO2012141936A1 (hr) |
| ZA (1) | ZA201306556B (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7000349B2 (ja) | 2016-05-13 | 2022-02-04 | インスティテュート デ メディシナ モレキュラー ジョアオ ロボ アントゥネス | Ｉｌｃ３細胞に関連する疾患を処置する方法 |
| JP2023515915A (ja) * | 2019-12-19 | 2023-04-17 | トランスフェルト・プラス・ソシエテ・アン・コマンディテ | 腸のニューロパチーを治療するためのグリア細胞株由来神経栄養因子（ｇｄｎｆ）の使用 |
| CA3222177A1 (en) | 2021-06-03 | 2022-12-08 | Fundacao D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2119463C (en) | 1991-09-20 | 2003-09-16 | Leu-Fen H. Lin | Glial cell line-derived neutrophic factor |
| US6184200B1 (en) * | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
| US6042579A (en) | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
| DE19816186A1 (de) | 1998-04-14 | 1999-10-21 | Univ Muenchen L Maximilians | GDNF-kodierende DNA, Teile davon und GDNF-Varianten |
| US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
| FI20070808A0 (fi) | 2007-10-25 | 2007-10-25 | Mart Saarma | GDNF:n silmukointivariantit ja niiden käytöt |
| CN101775072B (zh) * | 2008-05-21 | 2012-09-05 | 王尚武 | 一种融合穿透肽的神经细胞营养因子gdnf |
| EP2393832B1 (en) * | 2009-02-06 | 2015-07-08 | Pepscan Systems BV | Truncated cystine-knot proteins |
-
2012
- 2012-03-04 UA UAA201311714A patent/UA112981C2/uk unknown
- 2012-03-27 TW TW101110653A patent/TWI583698B/zh active
- 2012-04-03 MX MX2013011919A patent/MX337206B/es active IP Right Grant
- 2012-04-03 PT PT127128742T patent/PT2696889T/pt unknown
- 2012-04-03 EA EA201370204A patent/EA025129B1/ru not_active IP Right Cessation
- 2012-04-03 ME MEP-2017-276A patent/ME02849B/me unknown
- 2012-04-03 SI SI201231134T patent/SI2696889T1/en unknown
- 2012-04-03 JP JP2014505179A patent/JP6093345B2/ja active Active
- 2012-04-03 KR KR1020137026366A patent/KR101554799B1/ko active IP Right Grant
- 2012-04-03 CN CN201280018010.7A patent/CN103635201B/zh active Active
- 2012-04-03 NO NO12712874A patent/NO2696889T3/no unknown
- 2012-04-03 EP EP12712874.2A patent/EP2696889B1/en active Active
- 2012-04-03 RS RS20171274A patent/RS56639B1/sr unknown
- 2012-04-03 CA CA2833158A patent/CA2833158C/en not_active Expired - Fee Related
- 2012-04-03 SG SG2013069554A patent/SG193483A1/en unknown
- 2012-04-03 ES ES12712874.2T patent/ES2656020T3/es active Active
- 2012-04-03 PL PL12712874T patent/PL2696889T3/pl unknown
- 2012-04-03 LT LTEP12712874.2T patent/LT2696889T/lt unknown
- 2012-04-03 AU AU2012243178A patent/AU2012243178B2/en not_active Ceased
- 2012-04-03 HU HUE12712874A patent/HUE036239T2/hu unknown
- 2012-04-03 US US14/000,704 patent/US9243046B2/en active Active
- 2012-04-03 BR BR112013026004-1A patent/BR112013026004B1/pt not_active IP Right Cessation
- 2012-04-03 DK DK12712874.2T patent/DK2696889T3/en active
- 2012-04-03 WO PCT/US2012/031927 patent/WO2012141936A1/en active Application Filing
-
2013
- 2013-08-22 IL IL228102A patent/IL228102A/en active IP Right Grant
- 2013-08-30 ZA ZA2013/06556A patent/ZA201306556B/en unknown
-
2017
- 2017-12-21 HR HRP20171993TT patent/HRP20171993T1/hr unknown
-
2018
- 2018-01-09 CY CY20181100021T patent/CY1119750T1/el unknown
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