TWI546078B - 於腦脊髓膜內遞送乙醯肝素ｎ－硫酸酯酶之方法及組合物 - Google Patents

於腦脊髓膜內遞送乙醯肝素ｎ－硫酸酯酶之方法及組合物 Download PDF

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TWI546078B
TWI546078B TW100122532A TW100122532A TWI546078B TW I546078 B TWI546078 B TW I546078B TW 100122532 A TW100122532 A TW 100122532A TW 100122532 A TW100122532 A TW 100122532A TW I546078 B TWI546078 B TW I546078B
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concentration
formulation
hns
polysorbate
rhhns
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TW100122532A
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TW201204385A (en
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法拉 納托里
朱高忠
珍妮佛 帖略
江原
捷米 宗
札赫拉 夏若克
布萊恩 維納格利亞
潘金
理查 菲佛
柏里克斯 加萊斯
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舒爾人類基因療法公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
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    • C12Y310/00—Hydrolases acting on sulfur-nitrogen bonds (3.10)
    • C12Y310/01—Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
    • C12Y310/01001—N-Sulfoglucosamine sulfohydrolase (3.10.1.1)
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TW100122532A 2010-06-25 2011-06-27 於腦脊髓膜內遞送乙醯肝素ｎ－硫酸酯酶之方法及組合物 TWI546078B (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US35885710P 2010-06-25 2010-06-25
US36078610P 2010-07-01 2010-07-01
US38786210P 2010-09-29 2010-09-29
US201161435710P 2011-01-24 2011-01-24
US201161442115P 2011-02-11 2011-02-11
US201161476210P 2011-04-15 2011-04-15
US201161495268P 2011-06-09 2011-06-09
PCT/US2011/041922 WO2011163647A2 (en) 2010-06-25 2011-06-25 Methods and compositions for cns delivery of heparan n-sulfatase

Publications (2)

Publication Number Publication Date
TW201204385A TW201204385A (en) 2012-02-01
TWI546078B true TWI546078B (zh) 2016-08-21

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TW100122532A TWI546078B (zh) 2010-06-25 2011-06-27 於腦脊髓膜內遞送乙醯肝素ｎ－硫酸酯酶之方法及組合物

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US (1) US9320711B2 (https=)
EP (1) EP2588131B1 (https=)
JP (1) JP6073783B2 (https=)
KR (1) KR20140005842A (https=)
CN (1) CN103260637B (https=)
AU (2) AU2011270667B2 (https=)
BR (1) BR112012033197A2 (https=)
CA (1) CA2805413A1 (https=)
MX (1) MX2013000320A (https=)
NZ (1) NZ605874A (https=)
RU (1) RU2012154576A (https=)
TW (1) TWI546078B (https=)
WO (1) WO2011163647A2 (https=)

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MX2013000320A (es) 2013-06-05
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EP2588131B1 (en) 2019-08-14
NZ605874A (en) 2015-02-27
JP2013530988A (ja) 2013-08-01
CN103260637A (zh) 2013-08-21
TW201204385A (en) 2012-02-01
BR112012033197A2 (pt) 2017-06-06
CA2805413A1 (en) 2011-12-29
US20120014936A1 (en) 2012-01-19
KR20140005842A (ko) 2014-01-15
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