TWI505828B - 新穎醫藥組成物 - Google Patents

新穎醫藥組成物 Download PDF

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Publication number
TWI505828B
TWI505828B TW100146692A TW100146692A TWI505828B TW I505828 B TWI505828 B TW I505828B TW 100146692 A TW100146692 A TW 100146692A TW 100146692 A TW100146692 A TW 100146692A TW I505828 B TWI505828 B TW I505828B
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TW
Taiwan
Prior art keywords
tablet
lozenge
drug
pharmaceutical
dimethyl
Prior art date
Application number
TW100146692A
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English (en)
Chinese (zh)
Other versions
TW201249441A (en
Inventor
道格拉斯 狄馬林
諾迪普 李
法蘭斯科 軒歷基斯
王立弘
Original Assignee
葛蘭素史克智慧財產(第二)有限公司
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46314827&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI505828(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 葛蘭素史克智慧財產(第二)有限公司 filed Critical 葛蘭素史克智慧財產(第二)有限公司
Publication of TW201249441A publication Critical patent/TW201249441A/zh
Application granted granted Critical
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2813Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW100146692A 2010-12-20 2011-12-16 新穎醫藥組成物 TWI505828B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201061424967P 2010-12-20 2010-12-20

Publications (2)

Publication Number Publication Date
TW201249441A TW201249441A (en) 2012-12-16
TWI505828B true TWI505828B (zh) 2015-11-01

Family

ID=46314827

Family Applications (1)

Application Number Title Priority Date Filing Date
TW100146692A TWI505828B (zh) 2010-12-20 2011-12-16 新穎醫藥組成物

Country Status (38)

Country Link
US (5) US20130266649A1 (enExample)
EP (4) EP2654736B1 (enExample)
JP (2) JP6126014B2 (enExample)
KR (1) KR101911109B1 (enExample)
CN (1) CN103998041B (enExample)
AR (2) AR084102A1 (enExample)
AU (1) AU2011349422B2 (enExample)
BR (1) BR112013015602B1 (enExample)
CA (1) CA2822701C (enExample)
CL (1) CL2013001779A1 (enExample)
CR (1) CR20130352A (enExample)
CY (1) CY1123376T1 (enExample)
DK (3) DK4159205T3 (enExample)
DO (1) DOP2013000138A (enExample)
EA (1) EA025198B1 (enExample)
ES (3) ES2985024T3 (enExample)
FI (2) FI4159205T3 (enExample)
HR (3) HRP20240563T1 (enExample)
HU (3) HUE066526T2 (enExample)
IL (1) IL226855A (enExample)
JO (1) JO3594B1 (enExample)
LT (3) LT4159204T (enExample)
MA (1) MA34883B1 (enExample)
MX (1) MX2013007073A (enExample)
MY (1) MY170501A (enExample)
NZ (1) NZ612157A (enExample)
PE (1) PE20140040A1 (enExample)
PH (1) PH12013501209A1 (enExample)
PL (3) PL4159205T3 (enExample)
PT (3) PT4159204T (enExample)
RS (2) RS65497B1 (enExample)
SG (1) SG191054A1 (enExample)
SI (3) SI4159205T1 (enExample)
TW (1) TWI505828B (enExample)
UA (1) UA113158C2 (enExample)
UY (1) UY33818A (enExample)
WO (1) WO2012088033A2 (enExample)
ZA (1) ZA201304189B (enExample)

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TWI505828B (zh) 2010-12-20 2015-11-01 葛蘭素史克智慧財產(第二)有限公司 新穎醫藥組成物
BR112015003418A2 (pt) 2012-08-17 2017-07-04 Hoffmann La Roche produto farmacêutico, conjunto, métodos para estender a duração da resposta ao tratamento, de retardar ou prevenir o desenvolvimento de resistência ao tratamento, para a seleção de uma terapia e para otimizar a eficácia terapêutica.
AU2013352369B2 (en) * 2012-11-30 2016-07-28 Novartis Ag. Novel pharmaceutical composition
WO2015019125A1 (en) * 2013-08-05 2015-02-12 Societe De Developpement Et De Recherche Industrielle Molecular targets for the treatment of wounds, in particular chronic wounds
CN103819471A (zh) * 2013-11-25 2014-05-28 镇江圣安医药有限公司 吡啶并(4,3-d)嘧啶-1(2H)-基苯基乙酰胺的衍生物及其应用
WO2015081566A1 (zh) * 2013-12-06 2015-06-11 杭州普晒医药科技有限公司 曲美替尼及其溶剂化物的晶型、其制备方法、含有它们的药物组合物及其用途
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TW201818936A (zh) 2016-11-25 2018-06-01 大陸商江蘇恆瑞醫藥股份有限公司 一種吡啶酮類衍生物醫藥組成物及其製備方法
US11266653B2 (en) 2017-05-02 2022-03-08 Novartis Ag Combination therapy
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JP2022540253A (ja) * 2019-07-11 2022-09-14 プラクシス プレシジョン メディシンズ, インコーポレイテッド T型カルシウムチャネル調節因子の製剤およびその使用方法
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RU2749719C1 (ru) * 2020-10-08 2021-06-16 Нестерук Владимир Викторович Препарат для лечения анемии, связанной с хроническим заболеванием почек, и способ его получения
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WO2024171019A1 (en) * 2023-02-13 2024-08-22 Alembic Pharmaceuticals Limited Pharmaceutical composition of trametinib and process of preparation thereof
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US20080254131A1 (en) * 2006-10-13 2008-10-16 Sunil Vandse Controlled-release galantamine formulations

Also Published As

Publication number Publication date
LT4159205T (lt) 2024-05-10
LT2654736T (lt) 2020-09-25
UY33818A (es) 2012-07-31
CN103998041A (zh) 2014-08-20
KR101911109B1 (ko) 2018-10-23
WO2012088033A3 (en) 2014-03-13
PT4159204T (pt) 2024-05-07
FI4159205T3 (fi) 2024-04-23
CN103998041B (zh) 2016-08-17
US8580304B2 (en) 2013-11-12
HRP20201409T1 (hr) 2020-11-27
BR112013015602A2 (pt) 2017-02-21
SG191054A1 (en) 2013-08-30
DK2654736T3 (da) 2020-09-14
EA201390913A1 (ru) 2014-04-30
HRP20240564T1 (hr) 2024-09-27
JO3594B1 (ar) 2020-07-05
BR112013015602B1 (pt) 2022-03-03
US9399021B2 (en) 2016-07-26
FI4159204T3 (fi) 2024-04-22
DK4159205T3 (da) 2024-05-13
IL226855A (en) 2017-04-30
DOP2013000138A (es) 2013-11-30
HUE050788T2 (hu) 2021-01-28
LT4159204T (lt) 2024-05-10
CA2822701C (en) 2018-10-23
US20120183613A1 (en) 2012-07-19
RS65497B1 (sr) 2024-06-28
HUE066526T2 (hu) 2024-08-28
HUE066525T2 (hu) 2024-08-28
EP4159205B1 (en) 2024-02-14
NZ612157A (en) 2015-05-29
US20140154316A1 (en) 2014-06-05
ES2982775T3 (es) 2024-10-17
ES2985024T3 (es) 2024-11-04
UA113158C2 (xx) 2016-12-26
EP2654736A4 (en) 2015-04-22
PT2654736T (pt) 2020-09-24
PL4159205T3 (pl) 2024-06-24
JP6126014B2 (ja) 2017-05-10
HRP20240563T1 (hr) 2024-08-16
CA2822701A1 (en) 2012-06-28
PE20140040A1 (es) 2014-02-26
MY170501A (en) 2019-08-08
WO2012088033A2 (en) 2012-06-28
SI4159204T1 (sl) 2024-06-28
EA025198B1 (ru) 2016-11-30
CL2013001779A1 (es) 2014-06-27
ZA201304189B (en) 2014-02-26
MA34883B1 (fr) 2014-02-01
US20140099365A1 (en) 2014-04-10
SI4159205T1 (sl) 2024-06-28
EP4159204B1 (en) 2024-02-14
AU2011349422B2 (en) 2015-12-10
EP4159205A1 (en) 2023-04-05
EP3808343A1 (en) 2021-04-21
PT4159205T (pt) 2024-05-08
DK4159204T3 (da) 2024-05-21
EP2654736B1 (en) 2020-07-01
KR20130130028A (ko) 2013-11-29
US9271941B2 (en) 2016-03-01
AU2011349422A1 (en) 2013-05-02
CY1123376T1 (el) 2021-12-31
SI2654736T1 (sl) 2020-10-30
US9155706B2 (en) 2015-10-13
US20130266649A1 (en) 2013-10-10
US20140037726A1 (en) 2014-02-06
ES2820536T3 (es) 2021-04-21
JP2014510704A (ja) 2014-05-01
PL2654736T3 (pl) 2020-12-14
CR20130352A (es) 2013-12-18
MX2013007073A (es) 2013-09-26
JP2017137299A (ja) 2017-08-10
EP2654736A2 (en) 2013-10-30
AR084102A1 (es) 2013-04-24
PL4159204T3 (pl) 2024-07-01
AR122185A2 (es) 2022-08-24
RS65496B1 (sr) 2024-06-28
PH12013501209A1 (en) 2013-07-29
EP4159204A1 (en) 2023-04-05
TW201249441A (en) 2012-12-16

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