BR112013015602A2 - nova composição farmacèutica - Google Patents

nova composição farmacèutica

Info

Publication number
BR112013015602A2
BR112013015602A2 BR112013015602A BR112013015602A BR112013015602A2 BR 112013015602 A2 BR112013015602 A2 BR 112013015602A2 BR 112013015602 A BR112013015602 A BR 112013015602A BR 112013015602 A BR112013015602 A BR 112013015602A BR 112013015602 A2 BR112013015602 A2 BR 112013015602A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
new pharmaceutical
new
composition
pharmaceutical
Prior art date
Application number
BR112013015602A
Other languages
English (en)
Other versions
BR112013015602B1 (pt
Inventor
J Demarini Douglas
Henriquez Francisco
Wang Lihong
T Le Ngocdiep
Original Assignee
Glaxosmithkline Intellectual Property (No 2) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46314827&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013015602(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Intellectual Property (No 2) Ltd filed Critical Glaxosmithkline Intellectual Property (No 2) Ltd
Publication of BR112013015602A2 publication Critical patent/BR112013015602A2/pt
Publication of BR112013015602B1 publication Critical patent/BR112013015602B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2813Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112013015602-3A 2010-12-20 2011-12-20 Comprimido farmacêutico compreendendo solvato de dimetil sulfóxido de n-{3-[3- ciclopropil-5-(2-fluoro-4-iodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenil}acetamida, e seu processo de preparação BR112013015602B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201061424967P 2010-12-20 2010-12-20
US61/424,967 2010-12-20
PCT/US2011/066021 WO2012088033A2 (en) 2010-12-20 2011-12-20 Novel pharmaceutical composition

Publications (2)

Publication Number Publication Date
BR112013015602A2 true BR112013015602A2 (pt) 2017-02-21
BR112013015602B1 BR112013015602B1 (pt) 2022-03-03

Family

ID=46314827

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013015602-3A BR112013015602B1 (pt) 2010-12-20 2011-12-20 Comprimido farmacêutico compreendendo solvato de dimetil sulfóxido de n-{3-[3- ciclopropil-5-(2-fluoro-4-iodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2h-pirido[4,3-d]pirimidin-1-il]fenil}acetamida, e seu processo de preparação

Country Status (37)

Country Link
US (5) US20130266649A1 (pt)
EP (4) EP2654736B1 (pt)
JP (2) JP6126014B2 (pt)
KR (1) KR101911109B1 (pt)
CN (1) CN103998041B (pt)
AR (2) AR084102A1 (pt)
AU (1) AU2011349422B2 (pt)
BR (1) BR112013015602B1 (pt)
CA (1) CA2822701C (pt)
CL (1) CL2013001779A1 (pt)
CR (1) CR20130352A (pt)
CY (1) CY1123376T1 (pt)
DK (3) DK4159205T3 (pt)
DO (1) DOP2013000138A (pt)
EA (1) EA025198B1 (pt)
ES (1) ES2820536T3 (pt)
FI (2) FI4159205T3 (pt)
HR (1) HRP20201409T1 (pt)
HU (1) HUE050788T2 (pt)
IL (1) IL226855A (pt)
JO (1) JO3594B1 (pt)
LT (3) LT2654736T (pt)
MA (1) MA34883B1 (pt)
MX (1) MX2013007073A (pt)
MY (1) MY170501A (pt)
NZ (1) NZ612157A (pt)
PE (1) PE20140040A1 (pt)
PL (2) PL2654736T3 (pt)
PT (3) PT4159204T (pt)
RS (2) RS65496B1 (pt)
SG (1) SG191054A1 (pt)
SI (3) SI4159204T1 (pt)
TW (1) TWI505828B (pt)
UA (1) UA113158C2 (pt)
UY (1) UY33818A (pt)
WO (1) WO2012088033A2 (pt)
ZA (1) ZA201304189B (pt)

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Publication number Priority date Publication date Assignee Title
CA2879252C (en) 2012-08-17 2017-10-10 F. Hoffmann-La Roche Ag Combination therapies for melanoma comprising administering cobimetinib and vemurafinib
ES2686730T3 (es) * 2012-11-30 2018-10-19 Novartis Ag Composición farmacéutica novedosa
WO2015019125A1 (en) * 2013-08-05 2015-02-12 Societe De Developpement Et De Recherche Industrielle Molecular targets for the treatment of wounds, in particular chronic wounds
CN103819471A (zh) * 2013-11-25 2014-05-28 镇江圣安医药有限公司 吡啶并(4,3-d)嘧啶-1(2H)-基苯基乙酰胺的衍生物及其应用
WO2015081566A1 (zh) * 2013-12-06 2015-06-11 杭州普晒医药科技有限公司 曲美替尼及其溶剂化物的晶型、其制备方法、含有它们的药物组合物及其用途
EP2913048A1 (en) * 2014-02-27 2015-09-02 ratiopharm GmbH Pharmaceutical composition comprising trametinib
KR101545268B1 (ko) 2015-02-05 2015-08-20 보령제약 주식회사 정제 및 이의 제조방법
WO2016126012A1 (en) * 2015-02-05 2016-08-11 Boryung Pharmaceutical Co., Ltd Tablet and method of preparing the same
US20170020880A1 (en) * 2015-07-22 2017-01-26 Hetero Research Foundation Pharmaceutical compositions of trametinib
JP6875501B2 (ja) 2016-08-10 2021-05-26 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Aktプロテインキナーゼ阻害剤を含む薬学的組成物
RU2627692C1 (ru) 2016-10-10 2017-08-10 Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") N-{ 3-[3-циклопропил-5-(2-фторо-4-иодофениламино)-6,8-диметил-2,4,7-триоксо-3,4,6,7-тетрагидро-2Н-пиридо[4,3-d]пиримидин-1-ил]-фенил} -циклопропанкарбоксамида диметилсульфоксида сольват в качестве ингибитора МЕК1/2
JP2019535696A (ja) 2016-11-25 2019-12-12 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. ピリドン誘導体の医薬組成物およびその製造方法
KR102641827B1 (ko) 2017-05-02 2024-03-04 노파르티스 아게 병용 요법
RU2749719C1 (ru) * 2020-10-08 2021-06-16 Нестерук Владимир Викторович Препарат для лечения анемии, связанной с хроническим заболеванием почек, и способ его получения
WO2023105286A1 (en) 2021-12-06 2023-06-15 My Personal Therapeutics Ltd A combination treatment for cancer

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US4727077A (en) 1985-02-20 1988-02-23 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compounds, process for their production, and antitumorous compositions containing them
JPS61205257A (ja) * 1985-03-08 1986-09-11 Ishihara Sangyo Kaisha Ltd ベンゾイルウレア系化合物、その製法及びそれを含有する抗ガン剤
US5559235A (en) 1991-10-29 1996-09-24 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
US5342947A (en) 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5491237A (en) 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
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US7378423B2 (en) * 2004-06-11 2008-05-27 Japan Tobacco Inc. Pyrimidine compound and medical use thereof
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JP5479337B2 (ja) * 2007-07-30 2014-04-23 アルディア バイオサイエンス,インク. Mek阻害剤およびrafキナーゼ阻害剤の組み合わせ、ならびにその使用
BRPI0817946A2 (pt) * 2007-09-25 2015-05-05 Teva Pharma Composições de imatinibe estável
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MX2012003546A (es) 2009-09-23 2012-09-07 Glaxosmithkline Llc Combinacion.
ES2527831T3 (es) 2009-09-23 2015-01-30 Glaxosmithkline Llc Combinación que comprende el inhibidor de MEK: N-{3-[3-ciclopropil-5-(2-fluoro-4-yodo-fenilamino)-6,8-dimetil-2,4,7-trioxo-3,4,6,7-tetrahidro-2H-pirido[4,3-d]pirimidin-1-il]fenil}acetamida y el inhibidor de Akt: N-{(1S)-2-amino-1-[(3-fluorofenil)metil]etil}-5-cloro-4-(4-cloro-1-metil-1H-pirazol-5-il)-2-tiofenocarboxamida
CA2775874A1 (en) 2009-09-28 2011-03-31 Glaxosmithkline Llc Combination
LT3560498T (lt) 2009-10-16 2022-11-25 Novartis Ag Derinys apimantis mek inhibitorių ir b-raf inhibitorių
AU2010322105B2 (en) 2009-11-17 2014-05-08 Novartis Ag Combination
US20130165456A1 (en) 2010-08-26 2013-06-27 Tona M. Gilmer Combination
US8977217B1 (en) 2013-02-20 2015-03-10 Triquint Semiconductor, Inc. Switching device with negative bias circuit

Also Published As

Publication number Publication date
EP2654736A2 (en) 2013-10-30
WO2012088033A3 (en) 2014-03-13
FI4159205T3 (fi) 2024-04-23
UA113158C2 (xx) 2016-12-26
AU2011349422B2 (en) 2015-12-10
US9399021B2 (en) 2016-07-26
CA2822701A1 (en) 2012-06-28
RS65496B1 (sr) 2024-06-28
US20140099365A1 (en) 2014-04-10
KR101911109B1 (ko) 2018-10-23
AU2011349422A1 (en) 2013-05-02
SI4159204T1 (sl) 2024-06-28
ES2820536T3 (es) 2021-04-21
JP2014510704A (ja) 2014-05-01
CN103998041B (zh) 2016-08-17
CR20130352A (es) 2013-12-18
DK4159204T3 (da) 2024-05-21
EP2654736B1 (en) 2020-07-01
US9271941B2 (en) 2016-03-01
EA201390913A1 (ru) 2014-04-30
LT4159204T (lt) 2024-05-10
JP2017137299A (ja) 2017-08-10
SG191054A1 (en) 2013-08-30
EP4159204A1 (en) 2023-04-05
CA2822701C (en) 2018-10-23
KR20130130028A (ko) 2013-11-29
HRP20201409T1 (hr) 2020-11-27
JO3594B1 (ar) 2020-07-05
WO2012088033A2 (en) 2012-06-28
SI4159205T1 (sl) 2024-06-28
EP4159205A1 (en) 2023-04-05
MA34883B1 (fr) 2014-02-01
CN103998041A (zh) 2014-08-20
CL2013001779A1 (es) 2014-06-27
SI2654736T1 (sl) 2020-10-30
FI4159204T3 (fi) 2024-04-22
PT4159205T (pt) 2024-05-08
JP6126014B2 (ja) 2017-05-10
IL226855A (en) 2017-04-30
ZA201304189B (en) 2014-02-26
US9155706B2 (en) 2015-10-13
LT2654736T (lt) 2020-09-25
PT2654736T (pt) 2020-09-24
US20140154316A1 (en) 2014-06-05
MY170501A (en) 2019-08-08
PT4159204T (pt) 2024-05-07
UY33818A (es) 2012-07-31
PL2654736T3 (pl) 2020-12-14
EA025198B1 (ru) 2016-11-30
AR122185A2 (es) 2022-08-24
CY1123376T1 (el) 2021-12-31
LT4159205T (lt) 2024-05-10
EP4159205B1 (en) 2024-02-14
TW201249441A (en) 2012-12-16
US20120183613A1 (en) 2012-07-19
US20140037726A1 (en) 2014-02-06
DK4159205T3 (da) 2024-05-13
TWI505828B (zh) 2015-11-01
RS65497B1 (sr) 2024-06-28
PE20140040A1 (es) 2014-02-26
NZ612157A (en) 2015-05-29
DOP2013000138A (es) 2013-11-30
EP3808343A1 (en) 2021-04-21
US8580304B2 (en) 2013-11-12
BR112013015602B1 (pt) 2022-03-03
EP4159204B1 (en) 2024-02-14
DK2654736T3 (da) 2020-09-14
US20130266649A1 (en) 2013-10-10
MX2013007073A (es) 2013-09-26
HUE050788T2 (hu) 2021-01-28
AR084102A1 (es) 2013-04-24
PL4159205T3 (pl) 2024-06-24
EP2654736A4 (en) 2015-04-22

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25C Requirement related to requested transfer of rights

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMIT

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT

B25A Requested transfer of rights approved

Owner name: NOVARTIS PHARMA AG (CH)

B25A Requested transfer of rights approved

Owner name: NOVARTIS AG (CH)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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