TWI504748B - 於異源性生物體中使用多不飽和脂肪酸(pufa)聚酮合成酶系統來製造多不飽和脂肪酸之技術(一) - Google Patents

於異源性生物體中使用多不飽和脂肪酸(pufa)聚酮合成酶系統來製造多不飽和脂肪酸之技術(一) Download PDF

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TWI504748B
TWI504748B TW096108936A TW96108936A TWI504748B TW I504748 B TWI504748 B TW I504748B TW 096108936 A TW096108936 A TW 096108936A TW 96108936 A TW96108936 A TW 96108936A TW I504748 B TWI504748 B TW I504748B
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pufa
organism
seq
plant
microorganism
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TW200806792A (en
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James G Metz
Jerry M Kuner
James Casey Lippmeier
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Dsm Ip Assets Bv
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TW096108936A 2006-03-15 2007-03-15 於異源性生物體中使用多不飽和脂肪酸(pufa)聚酮合成酶系統來製造多不飽和脂肪酸之技術(一) TWI504748B (zh)

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US78320506P 2006-03-15 2006-03-15
US78461606P 2006-03-21 2006-03-21

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TW200806792A TW200806792A (en) 2008-02-01
TWI504748B true TWI504748B (zh) 2015-10-21

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TW096108936A TWI504748B (zh) 2006-03-15 2007-03-15 於異源性生物體中使用多不飽和脂肪酸(pufa)聚酮合成酶系統來製造多不飽和脂肪酸之技術(一)
TW096108937A TW200813222A (en) 2006-03-15 2007-03-15 Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems

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Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US20070244192A1 (en) * 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US8003772B2 (en) 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
ES2529572T3 (es) 2004-04-22 2015-02-23 Commonwealth Scientific And Industrial Research Organisation Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes
EP2357243B1 (en) 2004-04-22 2018-12-12 Commonwealth Scientific and Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
US7759548B2 (en) * 2006-03-15 2010-07-20 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems
RU2009111266A (ru) 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Синтез жирных кислот
EP2126042A4 (en) * 2007-01-12 2010-08-04 Univ Colorado Regents COMPOSITIONS AND METHODS FOR INCREASING TOLERANCE FOR THE PRODUCTION BY MICRO-ORGANISMS OF PRODUCED ORGANIC CHEMICALS
BRPI0811967B1 (pt) 2007-06-01 2023-01-17 Terravia Holdings, Inc Microalga chlorella ou prototheca e método para produção de lipídios microbianos
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
WO2009097331A1 (en) * 2008-01-28 2009-08-06 The Board Of Regents Of The University Of Oklahoma Very long chain polyunsaturated fatty acids, methods of production, and uses
WO2010019813A2 (en) * 2008-08-13 2010-02-18 Sapphire Energy, Inc. Production of fatty actds by genetically modified photosynthetic organisms
WO2010033921A2 (en) * 2008-09-19 2010-03-25 President And Fellows Of Harvard College Photoautotrophic adipogenesis technology (phat)
WO2010057246A1 (en) 2008-11-18 2010-05-27 Commonwealth Scientific Industrial Research Organisation Enzymes and methods for producing omega-3 fatty acids
CA2745129C (en) 2008-11-28 2019-05-07 Solazyme, Inc. Production of tailored oils in heterotrophic microorganisms
EP2379703A4 (en) * 2008-12-19 2013-01-23 Alpha J Res Ltd Partnership OPTIMIZED PREPARATION OF ALGAE PRODUCTS BY DECONTROLLING CELL PROLIFERATION AND PRODUCTION OF ALGAE PRODUCT
TW201028472A (en) * 2009-01-13 2010-08-01 Alpha J Res Ltd Partnership Use of plant growth regulators to enhance algae growth for the production of added value products
AU2010225930B2 (en) * 2009-03-16 2017-01-12 Dsm Ip Assets B.V. Protein production in microorganisms of the phylum Labyrinthulomycota
US8940884B2 (en) 2009-03-19 2015-01-27 Dsm Ip Assets B.V. Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof
US8993841B2 (en) 2009-06-08 2015-03-31 Basf Plant Science Company Gmbh Fatty acid elongation components and uses thereof
AU2010266458A1 (en) * 2009-06-30 2011-11-03 Solae, Llc Omega-3 fatty acid enriched baked foods and bar compositions
GB2487866A (en) 2009-09-27 2012-08-08 Opx Biotechnologies Inc Method for producing 3-Hydroxypropionic acid and other products
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
JP5838473B2 (ja) * 2009-12-28 2016-01-06 サノフィ ワクチン テクノロジーズ エス.エー.エス. 微細藻類におけるヘマグルチニン−ノイラミニダーゼタンパク質の産生方法
CA3028175C (en) * 2009-12-28 2022-05-24 Sanofi Vaccine Technologies, S.A.S. Methods of producing heterologous viral neuraminidase proteins in microalgae
JP5872483B2 (ja) 2009-12-30 2016-03-01 ビーエイエスエフ ファーマ(コーラニッシュ)リミテッド 擬似移動床式クロマトグラフ分離方法
UY33171A (es) * 2010-01-07 2011-07-29 Basf Agro B V Arnhem Nl Plantas tolerantes a herbicidas
GB2492256A (en) * 2010-01-27 2012-12-26 Opx Biotechnologies Inc Microorganism production of high-valve chemical products, and related compositions, methods and systems
CN104388438A (zh) * 2010-02-01 2015-03-04 三得利控股株式会社 编码酰基-CoA合成酶同源物的多核苷酸及其用途
US8372465B2 (en) * 2010-02-17 2013-02-12 Bunge Oils, Inc. Oil compositions of stearidonic acid
US11236351B2 (en) 2010-05-17 2022-02-01 Dow Agrosciences Llc Production of DHA and other LC PUFAs in plants
TW201144442A (en) * 2010-05-17 2011-12-16 Dow Agrosciences Llc Production of DHA and other LC-PUFAs in plants
CA3039432A1 (en) 2010-05-28 2011-12-01 Corbion Biotech, Inc. Tailored oils produced from recombinant heterotrophic microorganisms
CA2804925A1 (en) * 2010-06-25 2011-12-29 Basf Plant Science Company Gmbh Acyltransferases from thraustochytrium species and uses thereof in fatty acid production
AU2013202057B2 (en) * 2010-06-25 2016-01-28 Basf Plant Science Company Gmbh Acyltransferases and uses therof in fatty acid production
US9066527B2 (en) 2010-11-03 2015-06-30 Solazyme, Inc. Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods
EP2670855B1 (en) 2011-02-02 2019-08-21 Corbion Biotech, Inc. Tailored oils produced from recombinant oleaginous microorganisms
CN102250864B (zh) * 2011-05-03 2013-03-20 中国农业大学 亚油酸异构酶在脱氢和异构方面的双重用途
WO2012154626A1 (en) 2011-05-06 2012-11-15 Solazyme, Inc. Genetically engineered microorganisms that metabolize xylose
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
TW201307553A (zh) 2011-07-26 2013-02-16 Dow Agrosciences Llc 在植物中生產二十二碳六烯酸(dha)及其他長鏈多元不飽和脂肪酸(lc-pufa)之技術
WO2013018879A1 (ja) * 2011-08-04 2013-02-07 サントリーホールディングス株式会社 脂肪酸鎖長延長促進活性を有するタンパク質、これをコードする遺伝子及びその用途
CA2856485A1 (en) * 2011-11-25 2013-05-30 National Institute Of Agrobiological Sciences Plant transformant, transformation method for plant, and vector used in said method
US9719114B2 (en) 2012-04-18 2017-08-01 Terravia Holdings, Inc. Tailored oils
AU2013249172C1 (en) 2012-04-18 2017-08-10 Corbion Biotech, Inc. Tailored oils
DE102012207921A1 (de) 2012-05-11 2013-11-14 Evonik Industries Ag Mehrstufiges Syntheseverfahren mit Synthesegas
HUE033766T2 (en) 2012-06-15 2018-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
CA2881666A1 (en) * 2012-08-10 2014-02-13 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
WO2014116754A1 (en) 2013-01-23 2014-07-31 Iowa State University Research Foundation, Inc. Materials and methods for characterizing and using kasiii for production of bi-functional fatty acids
US10184140B2 (en) 2013-01-23 2019-01-22 Iowa State University Research Foundation, Inc. Materials and methods for production of bi-functional fatty acids in recombinant bacteria
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
BR112015023583A2 (pt) 2013-03-15 2017-08-22 Dow Global Technologies Llc Método para vaporização 3-hp a partir de uma solução, vapor, solução 3-hp condensada, composição, produto químico à jusante, produto de consumo, sistema para purificação de 3-hp, método para produzir uma solução de 3-hp, método para decompor a amônia de 3-hp (a3-hp) e método para decompor a3-hp
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
BR112016001026A2 (pt) * 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
JP6517196B2 (ja) 2013-10-04 2019-05-22 テラヴィア ホールディングス, インコーポレイテッド 調整油
EP3063283A4 (en) 2013-11-01 2017-07-05 Conagen Inc. Methods of using acyl-coa synthetase for biosynthetic production of acyl-coas
TW201525136A (zh) * 2013-11-26 2015-07-01 Dow Agrosciences Llc 利用破囊壺菌PUFA合成酶於油籽作物中生成ω-3長鏈多不飽和脂肪酸
JP6553610B2 (ja) * 2013-12-05 2019-07-31 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 脂肪アミンの微生物生産方法
KR102386838B1 (ko) 2013-12-18 2022-04-15 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 장쇄 다중불포화 지방산을 포함하는 지질
EP3099782B1 (en) * 2014-01-28 2019-03-20 DSM IP Assets B.V. Factors for the production and accumulation of polyunsaturated fatty acids (pufas) derived from pufa synthases
KR102527795B1 (ko) 2014-06-27 2023-05-02 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 도코사펜타에노산을 포함하는 지질
ES2764273T3 (es) 2014-07-10 2020-06-02 Corbion Biotech Inc Nuevos genes de cetoacil ACP sintasa y uso de los mismos
WO2016014968A1 (en) 2014-07-24 2016-01-28 Solazyme, Inc. Variant thioesterases and methods of use
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
EP3194582A2 (en) 2014-09-18 2017-07-26 TerraVia Holdings, Inc. Acyl-acp thioesterases and mutants thereof
US10570427B2 (en) * 2014-10-31 2020-02-25 Lanzatech New Zealand Limited Fermentation process for the production of lipids
WO2016137897A1 (en) * 2015-02-24 2016-09-01 William Marsh Rice University Kasiii-free fa synthesis
ES2906721T3 (es) 2015-06-06 2022-04-20 Dsm Ip Assets Bv Producción de ácidos grasos poliinsaturados (PUFA) utilizando una nueva sintasa modular de ácido docosahexaenoico (DHA)
US20170191094A1 (en) * 2015-12-31 2017-07-06 Synthetic Genomics, Inc. Expression of type i fatty acid synthase genes in eukaryotic algae
EP3377057A4 (en) 2016-01-07 2018-12-05 Conagen Inc. Methods of making capsinoids by biosynthetic processes
DK3487986T3 (da) 2016-07-19 2021-07-26 Conagen Inc Fremgangsmåde til mikrobiel fremstilling af specifikke naturlige capsaicinoider
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
WO2019023524A2 (en) * 2017-07-27 2019-01-31 University Of Florida Research Foundation, Incorporated CYANOBACTERIAL HOSTS AND METHODS FOR PRODUCING CHEMICALS
KR102318983B1 (ko) * 2018-02-21 2021-11-01 경상북도 신규한 1-octen-3-ol을 생산하는 형질전환 효모 및 그 제조방법
WO2019164294A1 (ko) * 2018-02-21 2019-08-29 경상북도 신규한 1-octen-3-ol을 생산하는 형질전환 효모 및 그 제조방법
CN112661821B (zh) * 2021-01-21 2022-04-12 江南大学 一种柠檬酸转运蛋白及其在脂质合成中的应用
EP4423282A2 (en) * 2021-10-25 2024-09-04 Purdue Research Foundation Heterodimeric benzaldehyde synthase, methods of producing, and uses thereof
WO2023144707A1 (en) 2022-01-25 2023-08-03 Dsm Ip Assets B.V. Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production
WO2025238190A1 (en) 2024-05-15 2025-11-20 Dsm Ip Assets B.V. Spray-dried powders having high pufa content
CN119193346A (zh) * 2024-11-26 2024-12-27 南京师范大学 一种过表达溶血磷脂酸酰基转移酶基因的裂殖壶菌基因工程菌株及其构建方法和应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317248D0 (en) * 1983-06-24 1983-07-27 Wyeth John & Brother Ltd Fat compositions
US5246841A (en) 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5601860A (en) * 1990-11-30 1997-02-11 American Home Products Corporation Corandomized fat compositions for infant formulas
US5639790A (en) * 1991-05-21 1997-06-17 Calgene, Inc. Plant medium-chain thioesterases
AU675923B2 (en) * 1991-12-04 1997-02-27 E.I. Du Pont De Nemours And Company Fatty acid desaturase genes from plants
US5683898A (en) * 1992-05-15 1997-11-04 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
CA2113557A1 (en) 1992-05-15 1993-11-25 Kazunaga Yazawa Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid
US5798259A (en) 1992-05-15 1998-08-25 Sagami Chemical Research Center Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid
US5310242A (en) * 1992-09-28 1994-05-10 Golder Kimberly A Portable infant seat
US6372965B1 (en) * 1992-11-17 2002-04-16 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants
DE4323727A1 (de) 1993-07-15 1995-03-09 Boehringer Mannheim Gmbh Verfahren zur Identifizierung von menschlichen und tierischen Zellen mit der Fähigkeit zu unbegrenzter Proliferation oder zur Tumorbildung
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
EP0831149A4 (en) 1995-01-13 2000-12-06 Sagami Chem Res GENES CODING FOR THE GROUP OF ENZYMES FOR BIOSYNTHESIS OF EICOSAPENTIC ACID AND METHOD FOR PRODUCING EICOSAPENTIC ACID
DE69637953D1 (de) 1995-04-17 2009-07-30 Nat Inst Of Advanced Ind Scien Hoch ungesättigte fettsäurenproduzierende mikroorganismen und verfahren zur herstellung von hoch ungesättigten fettsäuren durch verwendung dieser mikroorganismen
ZA973565B (en) * 1996-04-26 1998-10-26 Du Pont Soybean oil having high oxidative stability
CA2259942A1 (en) 1996-07-10 1998-01-15 Sagami Chemical Research Center Process for producing icosapentaenoic acid by genetic recombination
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
SA98190002B1 (ar) * 1997-03-28 2006-06-20 ذي يونيفيرسيتي اوف تننيسي ريسيرش كوربوريشن استخدام أحماض دهنية تحتوي على عدة روابط غير مشبعة polyunsaturated fatty acids لتقليل حدوث الالتهاب المعوي القولوني الناخر incidence of necrotizing enterocolitis
US6432684B1 (en) * 1997-04-11 2002-08-13 Abbott Laboratories Human desaturase gene and uses thereof
US6051754A (en) * 1997-04-11 2000-04-18 Abbott Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants
PL336077A1 (en) 1997-04-11 2000-06-05 Calgene Llc Methods of and compositions for synthesising long-chain polyunsaturated fatty acids in plants
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
IN1998CH01219A (en) 1997-06-04 2005-03-04 Calgene Llc Production of polyunsaturated fatty acid by expression of polyketide-like synthesis genes in plants
US6013665A (en) * 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
US6677145B2 (en) 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US20070244192A1 (en) 1999-01-14 2007-10-18 Martek Biosciences Corporation Plant seed oils containing polyunsaturated fatty acids
US7271315B2 (en) 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US8003772B2 (en) * 1999-01-14 2011-08-23 Martek Biosciences Corporation Chimeric PUFA polyketide synthase systems and uses thereof
DE60122719T2 (de) 2000-06-08 2008-04-17 Miami University, Oxford Fettsäure-elongase-3-ketoacyl-coa-synthase-polypeptide
US20040010817A1 (en) 2000-07-21 2004-01-15 Washington State University Research Foundation Plant acyl-CoA synthetases
CN100567483C (zh) * 2000-09-28 2009-12-09 生物源食物及科学公司 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用
TWI324181B (en) 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
TWI426126B (zh) 2001-04-16 2014-02-11 Dsm Ip Assets Bv 多不飽和脂肪酸(pufa)聚乙醯合成酶系統及其用途(二)
EP1390507A2 (en) 2001-05-21 2004-02-25 Ecopia Biosciences Inc. Genes and proteins involved in the biosynthesis of enediyne ring structures
US20040005672A1 (en) 2002-02-22 2004-01-08 Santi Daniel V. Heterologous production of polyketides
GB2385852A (en) * 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
US7705202B2 (en) * 2002-03-16 2010-04-27 The University Of York Transgenic plants expressing enzymes involved in fatty acid biosynthesis
US20040172682A1 (en) 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
KR101234200B1 (ko) 2003-03-26 2013-02-19 마텍 바이오싸이언스스 코포레이션 Pufa 폴리케타이드 신타제 시스템 및 이의 용도
ES2421138T3 (es) 2003-03-31 2013-08-29 University Of Bristol Nuevas aciltransferasas vegetales específicas para ácidos grasos poliinsaturados de cadena larga
US7125672B2 (en) * 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7208590B2 (en) 2003-07-15 2007-04-24 Abbott Laboratories Genes involved in polyketide synthase pathways and uses thereof
DE102004017370A1 (de) * 2004-04-08 2005-10-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh PUFA-PKS Gene aus Ulkenia
DE102004060340A1 (de) 2004-07-16 2006-02-09 Basf Plant Science Gmbh Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen
EP2339007A1 (en) 2004-09-20 2011-06-29 BASF Plant Science GmbH Arabidopsis genes encoding proteins involved in sugar and lipid metabolism and methods of use
GB0421937D0 (en) * 2004-10-02 2004-11-03 Univ York Acyl CoA synthetases
WO2006135866A2 (en) * 2005-06-10 2006-12-21 Martek Biosciences Corporation Pufa polyketide synthase systems and uses thereof
US7759548B2 (en) * 2006-03-15 2010-07-20 Martek Biosciences Corporation Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems
FR2904328B1 (fr) * 2006-07-27 2008-10-24 St Microelectronics Sa Depot par adsorption sous un champ electrique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Tonon T et al., "Identification of a long-chain polyunsaturated fatty acid acyl-coenzyme a synthetase from the diatom Thalassiosira pseudonana", PLANT PHYSIOLOGY, vol.138, no.1, p.402-408, 2005/05 *

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