TWI487535B - 類鐸受體3(toll like receptor3)拮抗劑,方法及用途 - Google Patents
類鐸受體3(toll like receptor3)拮抗劑,方法及用途 Download PDFInfo
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- TWI487535B TWI487535B TW094141961A TW94141961A TWI487535B TW I487535 B TWI487535 B TW I487535B TW 094141961 A TW094141961 A TW 094141961A TW 94141961 A TW94141961 A TW 94141961A TW I487535 B TWI487535 B TW I487535B
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- seq
- amino acid
- xaa
- antibody
- tlr3
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- C07K—PEPTIDES
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- C07K—PEPTIDES
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Rheumatology (AREA)
- Biochemistry (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63181504P | 2004-11-30 | 2004-11-30 | |
| US63639904P | 2004-12-15 | 2004-12-15 | |
| US64187705P | 2005-01-06 | 2005-01-06 | |
| US71319505P | 2005-08-31 | 2005-08-31 | |
| US72761005P | 2005-10-18 | 2005-10-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200631594A TW200631594A (en) | 2006-09-16 |
| TWI487535B true TWI487535B (zh) | 2015-06-11 |
Family
ID=36565702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094141961A TWI487535B (zh) | 2004-11-30 | 2005-11-29 | 類鐸受體3(toll like receptor3)拮抗劑,方法及用途 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8153583B2 (https=) |
| EP (2) | EP1824514B1 (https=) |
| JP (2) | JP5039560B2 (https=) |
| KR (1) | KR101317264B1 (https=) |
| AR (1) | AR051836A1 (https=) |
| AU (1) | AU2005311894A1 (https=) |
| BR (1) | BRPI0518664A2 (https=) |
| CA (1) | CA2589636C (https=) |
| EA (1) | EA200701192A1 (https=) |
| IL (1) | IL183541A (https=) |
| MX (1) | MX2007006442A (https=) |
| NO (1) | NO20073293L (https=) |
| NZ (1) | NZ555475A (https=) |
| TW (1) | TWI487535B (https=) |
| WO (1) | WO2006060513A2 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| DK1945820T3 (da) * | 2005-10-27 | 2013-11-11 | Janssen Biotech Inc | Toll-lignende receptor-3-modulatorer, fremgangsmåder og anvendelser |
| US8066981B2 (en) * | 2006-11-14 | 2011-11-29 | The Texas A & M University System | Compositions and methods related to toll-like receptor-3 |
| EP2155889A4 (en) * | 2007-05-25 | 2010-06-16 | Centocor Ortho Biotech Inc | TOLL RECEPTOR 3 MODULATORS AND USES THEREOF |
| EP2796466B1 (en) | 2007-12-07 | 2017-11-22 | ZymoGenetics, Inc. | Humanized antibody molecules specific for IL-31 |
| EP2238155A4 (en) * | 2007-12-26 | 2011-07-06 | Centocor Ortho Biotech Inc | CYNOMOLGUS TYPE TOLL 3 RECEIVER |
| US20100105875A1 (en) * | 2008-06-09 | 2010-04-29 | Maria Scarselli | Antibodies against neisserial factor H binding protein |
| ES2360334T3 (es) * | 2008-06-27 | 2011-06-03 | Theranor Sprl | Composiciones farmacéuticas de anticuerpos para enfermedades causadas por virus. |
| WO2010040054A2 (en) * | 2008-10-02 | 2010-04-08 | Centocor Ortho Biotech Inc. | Methods for suppressing toll-like receptor activity |
| PE20110808A1 (es) * | 2008-10-31 | 2011-10-31 | Janssen Biotech Inc | Anticuerpos contra el receptor 3 de tipo toll |
| US8460659B2 (en) | 2008-10-31 | 2013-06-11 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases |
| US20100136094A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100135983A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100137247A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100136095A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100136097A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100136096A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100137246A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| EA021512B1 (ru) * | 2009-04-29 | 2015-07-30 | Янссен Байотек Инк. | Антагонисты толл-подобного рецептора 3 |
| ES2543095T3 (es) | 2009-07-10 | 2015-08-14 | Innate Pharma | Agentes de unión a TLR3 |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| WO2012095432A2 (en) | 2011-01-12 | 2012-07-19 | Innate Pharma | Tlr3 binding agents |
| MY169358A (en) * | 2011-08-23 | 2019-03-26 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| WO2013026837A1 (en) * | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| CA2855955A1 (en) * | 2011-09-12 | 2013-03-21 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists |
| EP2855527B1 (en) * | 2012-05-31 | 2018-08-01 | Innate Pharma | Tlr3 binding agents |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| MX375359B (es) | 2013-02-26 | 2025-03-06 | Roche Glycart Ag | Moléculas biespecíficas de unión a antígeno activadoras de células t. |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| RS60739B1 (sr) | 2014-11-17 | 2020-09-30 | Regeneron Pharma | Postupci za lečenje tumora upotrebom cd3xcd20 bispecifičnog antitela |
| CA2981312C (en) | 2015-03-30 | 2023-09-26 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| LT3353212T (lt) | 2015-09-23 | 2021-12-27 | Regeneron Pharmaceuticals, Inc. | Optimizuoti anti-cd3 bispecifiniai antikūnai ir jų naudojimas |
| EP3356410B1 (en) | 2015-10-02 | 2021-10-20 | F. Hoffmann-La Roche AG | Bispecific anti-ceaxcd3 t cell activating antigen binding molecules |
| EP4026848A1 (en) | 2015-12-09 | 2022-07-13 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody for reducing the cytokine release syndrome |
| JP6949030B2 (ja) | 2016-01-08 | 2021-10-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Pd−1軸結合アンタゴニスト及び抗cea/抗cd3二重特異性抗体を用いたcea陽性がんの治療方法 |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| US12227565B2 (en) | 2018-06-20 | 2025-02-18 | Biora Therapeutics, Inc. | Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine |
| RS66543B1 (sr) | 2018-08-31 | 2025-03-31 | Regeneron Pharma | Strategija doziranja koja ublažava sindrom oslobađanja citokina za cd3/cd20 bispecifična antitela |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003106499A1 (ja) * | 2002-06-12 | 2003-12-24 | 科学技術振興事業団 | 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US20030032090A1 (en) * | 1997-05-07 | 2003-02-13 | Schering Corporation, A New Jersey Corporation | Human receptor proteins; related reagents and methods |
| ATE458053T1 (de) | 1997-05-07 | 2010-03-15 | Schering Corp | Menschliche toll-like-rezeptorproteine, zugehörige reagenzien und verfahren |
| ATE365043T1 (de) | 1999-03-09 | 2007-07-15 | Anker Stefan | Endotoxinhemmern zur behandlung von kachexie |
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US7709451B2 (en) * | 2001-09-07 | 2010-05-04 | Trustees Of Boston University | Method and composition for treating immune complex associated disorders |
| WO2003031573A2 (en) | 2001-10-05 | 2003-04-17 | Coley Pharmaceutical Gmbh | Toll-like receptor 3 signaling agonists and antagonists |
| EP1495756A4 (en) | 2002-04-08 | 2009-10-28 | Takeda Pharmaceutical | THERAPEUTIC AGENT FOR SEVERE SEPTIC STATE PREVENTION |
| BRPI0411514A (pt) * | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | antagonistas de receptor toll-like de molécula pequena |
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| WO2003106499A1 (ja) * | 2002-06-12 | 2003-12-24 | 科学技術振興事業団 | 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット |
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| AU2005311894A1 (en) | 2006-06-08 |
| EP2481425A1 (en) | 2012-08-01 |
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| NZ555475A (en) | 2010-12-24 |
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| CA2589636A1 (en) | 2006-06-08 |
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| JP5039560B2 (ja) | 2012-10-03 |
| EP1824514A2 (en) | 2007-08-29 |
| TW200631594A (en) | 2006-09-16 |
| KR101317264B1 (ko) | 2013-10-15 |
| NO20073293L (no) | 2007-08-17 |
| KR20070090969A (ko) | 2007-09-06 |
| HK1131744A1 (en) | 2010-02-05 |
| WO2006060513A2 (en) | 2006-06-08 |
| MX2007006442A (es) | 2007-10-23 |
| BRPI0518664A2 (pt) | 2008-12-02 |
| EP1824514A4 (en) | 2009-11-18 |
| US20060115475A1 (en) | 2006-06-01 |
| US8153583B2 (en) | 2012-04-10 |
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