TWI483744B - Containers of water systems - Google Patents
Containers of water systems Download PDFInfo
- Publication number
- TWI483744B TWI483744B TW100118517A TW100118517A TWI483744B TW I483744 B TWI483744 B TW I483744B TW 100118517 A TW100118517 A TW 100118517A TW 100118517 A TW100118517 A TW 100118517A TW I483744 B TWI483744 B TW I483744B
- Authority
- TW
- Taiwan
- Prior art keywords
- water
- polyoxyethylene
- component
- group
- based composition
- Prior art date
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 102
- -1 polyoxyethylene Polymers 0.000 claims description 194
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 119
- 239000000203 mixture Substances 0.000 claims description 105
- 125000000217 alkyl group Chemical group 0.000 claims description 39
- 239000004359 castor oil Substances 0.000 claims description 39
- 235000019438 castor oil Nutrition 0.000 claims description 39
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 39
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 28
- 150000005215 alkyl ethers Chemical class 0.000 claims description 26
- 239000003112 inhibitor Substances 0.000 claims description 26
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 25
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 24
- 239000000194 fatty acid Substances 0.000 claims description 24
- 229930195729 fatty acid Natural products 0.000 claims description 24
- 125000003342 alkenyl group Chemical group 0.000 claims description 21
- 239000002736 nonionic surfactant Substances 0.000 claims description 20
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 19
- 229910052799 carbon Inorganic materials 0.000 claims description 19
- 229920003169 water-soluble polymer Polymers 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 17
- 125000000466 oxiranyl group Chemical group 0.000 claims description 16
- 229910052751 metal Inorganic materials 0.000 claims description 12
- 239000002184 metal Substances 0.000 claims description 12
- 229920001577 copolymer Polymers 0.000 claims description 11
- 239000008346 aqueous phase Substances 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 10
- 239000012071 phase Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 9
- 239000011734 sodium Substances 0.000 claims description 9
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 8
- 230000000737 periodic effect Effects 0.000 claims description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 239000011591 potassium Substances 0.000 claims description 7
- 229910052700 potassium Inorganic materials 0.000 claims description 7
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 6
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 5
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 239000011777 magnesium Substances 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 229940047670 sodium acrylate Drugs 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
- 125000005037 alkyl phenyl group Chemical group 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 235000013305 food Nutrition 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
- 150000002739 metals Chemical class 0.000 claims description 3
- 229920005862 polyol Polymers 0.000 claims description 3
- 150000003077 polyols Chemical class 0.000 claims description 3
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 229940104261 taurate Drugs 0.000 claims description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 2
- MHZGKXUYDGKKIU-UHFFFAOYSA-N Decylamine Chemical compound CCCCCCCCCCN MHZGKXUYDGKKIU-UHFFFAOYSA-N 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 150000002429 hydrazines Chemical class 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 239000002594 sorbent Substances 0.000 claims 1
- 230000005068 transpiration Effects 0.000 description 28
- 230000000694 effects Effects 0.000 description 25
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 12
- 230000002401 inhibitory effect Effects 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 10
- 235000002639 sodium chloride Nutrition 0.000 description 10
- JPPRXACMNPYJNK-UHFFFAOYSA-N 1-docosoxydocosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCCCCCC JPPRXACMNPYJNK-UHFFFAOYSA-N 0.000 description 9
- 229910052783 alkali metal Inorganic materials 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 229920006317 cationic polymer Polymers 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000008020 evaporation Effects 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 6
- 229960003975 potassium Drugs 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- XSFDAOSPLREHPH-UHFFFAOYSA-N 1-tetracosoxytetracosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCCCCCCCC XSFDAOSPLREHPH-UHFFFAOYSA-N 0.000 description 5
- 229940075507 glyceryl monostearate Drugs 0.000 description 5
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 5
- 230000001629 suppression Effects 0.000 description 5
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 5
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- 229920000856 Amylose Polymers 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 2
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229920006318 anionic polymer Polymers 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229920003086 cellulose ether Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- HOWGUJZVBDQJKV-UHFFFAOYSA-N docosane Chemical compound CCCCCCCCCCCCCCCCCCCCCC HOWGUJZVBDQJKV-UHFFFAOYSA-N 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229940074774 glycyrrhizinate Drugs 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 2
- 239000000347 magnesium hydroxide Substances 0.000 description 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000000346 nonvolatile oil Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 229940093932 potassium hydroxide Drugs 0.000 description 2
- 235000011118 potassium hydroxide Nutrition 0.000 description 2
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- HANWHVWXFQSQGJ-UHFFFAOYSA-N 1-tetradecoxytetradecane Chemical compound CCCCCCCCCCCCCCOCCCCCCCCCCCCCC HANWHVWXFQSQGJ-UHFFFAOYSA-N 0.000 description 1
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- ZKYCLDTVJCJYIB-UHFFFAOYSA-N 2-methylidenedecanamide Chemical compound CCCCCCCCC(=C)C(N)=O ZKYCLDTVJCJYIB-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 240000008564 Boehmeria nivea Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 description 1
- QZKRHPLGUJDVAR-UHFFFAOYSA-K EDTA trisodium salt Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O QZKRHPLGUJDVAR-UHFFFAOYSA-K 0.000 description 1
- 229920000896 Ethulose Polymers 0.000 description 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- IQUXMWPPVALPOM-UHFFFAOYSA-M P(=O)(OCCO)OP(=O)[O-].[K+] Chemical compound P(=O)(OCCO)OP(=O)[O-].[K+] IQUXMWPPVALPOM-UHFFFAOYSA-M 0.000 description 1
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- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- WRZYGPIFICWRCG-OOFFSTKBSA-M sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trih Chemical compound [Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O WRZYGPIFICWRCG-OOFFSTKBSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- JZBRFIUYUGTUGG-UHFFFAOYSA-J tetrapotassium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [K+].[K+].[K+].[K+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O JZBRFIUYUGTUGG-UHFFFAOYSA-J 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- FYZXEMANQYHCFX-UHFFFAOYSA-K tripotassium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxymethyl)amino]acetate Chemical compound [K+].[K+].[K+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O FYZXEMANQYHCFX-UHFFFAOYSA-K 0.000 description 1
- 229960005066 trisodium edetate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000008307 w/o/w-emulsion Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Description
本發明係關於一種抑制水分自水相蒸散之穩定性良好的容器裝之水系組合物。
於化妝料、醫藥品、准藥品、食品等領域，存在大量含有水作為基劑之組合物，此種水系組合物為了防止水自組合物中蒸發，多將組合物保存於密閉容器中。然而，存在因日常使用之開蓋等而導致水自水系組合物中緩慢蒸發，從而產生物性變化或變色之情況。又，噴霧式容器、泵式容器等由於所噴出之內容物會殘留於噴出口並於噴出口附近乾燥，故而存在附著於噴出口之內容物產生變色、變臭而令使用感惡化之問題。進而，亦存在內容物乾燥固化而產生堵塞，有時無法噴出之問題。
為抑制上述內容物之固化，防止噴出容器之堵塞，而提出有對選自於25℃以下為固體狀之物質及/或皮膜形成高分子中之1種以上，以特定比率調配非揮發性液狀油(參照專利文獻1)。然而，為抑制內容物之固化，必需調配大量非揮發性油劑且劑形有限制。又，即便以特定比率調配非揮發性油劑，亦會產生內容物之固化，抑制堵塞之效果不充分。
另一方面，有人提出有藉由將環氧乙烷之平均加成數為5以上之聚氧乙烯二十二烷基醚調配至乳化組合物中，而提昇調配高濃度醇時之乳化系的經時穩定性(參照專利文獻2、3)，但其係用以防止乳化系之硬度或黏度之下降者，對水之作用完全不為人知。
[專利文獻1]日本專利特開2003-321321號公報
[專利文獻2]日本專利特開平1-266844號公報
[專利文獻3]日本專利特表平11-508253號公報
本發明提供一種容器裝之水系組合物，其含有如下成分(A)~(D)：(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)、及(D)水。
又，本發明提供一種自水系組合物之水分蒸散抑制劑，其以如下成分(A)~(C)作為有效成分：(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、及(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)。
進而，本發明提供一種自水系組合物之水分蒸散抑制方法，其特徵在於：使水系組合物中含有(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、以及(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)。
本發明者為了開發藉由抑制容器裝之水系組合物之水分蒸散而抑制內容物之固化或性狀變化，經時穩定性優異，即便用於噴霧式容器、泵式容器時，亦可抑制附著於噴出口之內容物之乾燥而防止堵塞的容器裝之水系組合物，進行了各種研究，結果發現：於組合使用水溶性高分子與聚氧乙烯烷基或烯基醚之情形時，可顯著抑制自水系組合物之水分蒸散，該效果於使用烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4者作為聚氧乙烯烷基或烯基醚之情形時尤其優異。
另外，為了將該水系組合物用於化妝料、准藥品、醫藥品等，而對各種具有生理作用或藥理作用等之水溶性成分的調配進行研究，從而判明：於調配各種鹼金屬鹽等後，會產生上述水分蒸散抑制效果顯著下降之問題。
因此，本發明之課題在於提供一種容器裝之水系組合物，其即便於前述容器裝之水系組合物中調配有鹼金屬鹽等之情形時，亦可維持優異之水分蒸散抑制效果，且經時穩定性優異。
因此，本發明者為了解決上述課題而進行研究，結果發現：於水系組合物中，除調配水溶性高分子與上述聚氧乙烯烷基或烯基醚以外，亦調配具有環氧乙烷基之非離子性界面活性劑，藉此即便於調配有鹼金屬鹽等阻礙水分蒸散抑制之物質之情形時，亦可獲得優異之水分蒸散抑制效果，從而完成本發明。
本發明提供一種水系組合物，其即便於調配有鹼金屬鹽等阻礙水分蒸散抑制之物質之情形時，水分蒸散抑制效果亦較高，即便長時間保存亦可抑制分離等外觀上之變化，且經時穩定性優異。又，藉由添加少量之上述(A)成分(以下亦稱為聚氧乙烯烷基醚(A)、POE烷基醚)、具有環氧乙烷基之非離子性界面活性劑，可表現、維持較高之水分蒸散抑制效果，因此無劑形之限制，對使用感亦無影響。
本發明之組合物之較佳態樣例如如下所述。
[1]一種容器裝之水系組合物，其含有如下成分(A)~(D)：(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)、及(D)水。
[2]一種自水系組合物之水分蒸散抑制劑，其以如下成分(A)~(C)作為有效成分：(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、及(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)。
[3]一種自水系組合物之水分蒸散抑制方法，其特徵在於：使水系組合物中含有(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、以及(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)。
[4]如上述[1]之容器裝之水系組合物、[2]之水分蒸散抑制劑或者[3]之水分蒸散抑制方法，其中成分(A)為烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~3的聚氧乙烯烷基或烯基醚。
[5]如上述[1]或[4]之容器裝之水系組合物、[2]或[4]之水分蒸散抑制劑或者[3]或[4]之水分蒸散抑制方法，其中成分(A)為烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~2.5的聚氧乙烯烷基或烯基醚。
[6]如上述[1]、[4]、[5]中任一項之容器裝之水系組合物、[2]、[4]、[5]中任一項之水分蒸散抑制劑或者[3]、[4]、[5]中任一項之水分蒸散抑制方法，其中成分(A)為選自聚氧乙烯(2)二十烷基醚、聚氧乙烯(3)二十烷基醚、聚氧乙烯(4)二十烷基醚、聚氧乙烯(2)二十二烷基醚、聚氧乙烯(3)二十二烷基醚、聚氧乙烯(4)二十二烷基醚、聚氧乙烯(2)二十四烷基醚、聚氧乙烯(3)二十四烷基醚及聚氧乙烯(4)二十四烷基醚中者。
[7]如上述[1]、[4]至[6]中任一項之容器裝之水系組合物、[2]、[4]至[6]中任一項之水分蒸散抑制劑或者[3]、[4]至[6]中任一項之水分蒸散抑制方法，其中成分(A)為烷基或烯基之碳數為21~23且環氧乙烷之平均加成莫耳數為1.5~4的聚氧乙烯烷基或烯基醚。
[8]如上述[1]、[4]至[7]中任一項之容器裝之水系組合物、[2]、[4]至[7]中任一項之水分蒸散抑制劑或者[3]、[4]至[7]中任一項之水分蒸散抑制方法，其中成分(A)為烷基或烯基之碳數為21~23且環氧乙烷之平均加成莫耳數為1.5~3的聚氧乙烯烷基或烯基醚。
[9]如上述[1]、[4]至[8]中任一項之容器裝之水系組合物、[2]、[4]至[8]中任一項之水分蒸散抑制劑或者[3]、[4]至[8]中任一項之水分蒸散抑制方法，其中成分(A)為烷基或烯基之碳數為21~23且環氧乙烷之平均加成莫耳數為1.5~2.5的聚氧乙烯烷基或烯基醚。
[10]如上述[1]、[4]至[9]中任一項之容器裝之水系組合物、[2]、[4]至[9]中任一項之水分蒸散抑制劑或者[3]、[4]至[9]中任一項之水分蒸散抑制方法，其中成分(A)為聚氧乙烯(2)二十二烷基醚。
[11]如上述[1]、[4]至[10]中任一項之容器裝之水系組合物、[2]、[4]至[10]中任一項之水分蒸散抑制劑或者[3]、[4]至[10]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.05~20質量%之成分(A)。
[12]如上述[1]、[4]至[11]中任一項之容器裝之水系組合物、[2]、[4]至[11]中任一項之水分蒸散抑制劑或者[3]、[4]至[11]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.1~20質量%之成分(A)。
[13]如上述[1]、[4]至[12]中任一項之容器裝之水系組合物、[2]、[4]至[12]中任一項之水分蒸散抑制劑或者[3]、[4]至[12]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.1~10質量%之成分(A)。
[14]如上述[1]、[4]至[13]中任一項之容器裝之水系組合物、[2]、[4]至[13]中任一項之水分蒸散抑制劑或者[3]、[4]至[13]中任一項之水分蒸散抑制方法，其中成分(B)為選自由羧乙烯聚合物、丙烯酸-甲基丙烯酸烷基酯共聚物、三仙膠、羥丙基甲基纖維素、聚丙烯醯胺及(丙烯酸鈉/丙烯醯基二甲基牛磺酸鈉)共聚物所組成之群中之1種或2種以上。
[15]如上述[1]、[4]至[14]中任一項之容器裝之水系組合物、[2]、[4]至[14]中任一項之水分蒸散抑制劑或者[3]、[4]至[14]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.01~5質量%之成分(B)。
[16]如上述[1]、[4]至[15]中任一項之容器裝之水系組合物、[2]、[4]至[15]中任一項之水分蒸散抑制劑或者[3]、[4]至[15]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.05~3質量%之成分(B)。
[17]如上述[1]、[4]至[15]中任一項之容器裝之水系組合物、[2]、[4]至[15]中任一項之水分蒸散抑制劑或者[3]、[4]至[15]中任一項之水分蒸散抑制方法，其中成分(C)非離子性界面活性劑之環氧乙烷之平均加成莫耳數為10以上。
[18]如上述[1]、[4]至[16]中任一項之容器裝之水系組合物、[2]、[4]至[16]中任一項之水分蒸散抑制劑或者[3]、[4]至[16]中任一項之水分蒸散抑制方法，其中成分(C)非離子性界面活性劑之環氧乙烷之平均加成莫耳數為10~200。
[19]如上述[1]、[4]至[18]中任一項之容器裝之水系組合物、[2]、[4]至[18]中任一項之水分蒸散抑制劑或者[3]、[4]至[18]中任一項之水分蒸散抑制方法，其中成分(C)為選自聚氧乙烯烷基醚、聚氧乙烯烷基苯醚、聚氧乙烯聚氧丙烯烷基醚、聚氧乙烯脂肪酸酯、聚氧乙烯甘油脂肪酸酯、聚氧乙烯去水山梨醇脂肪酸酯、聚氧乙烯蓖麻油、聚氧乙烯氫化蓖麻油、聚氧伸烷基氫化蓖麻油脂肪酸酯及聚氧乙烯山梨醇中之1種或2種以上。
[20]如上述[1]、[4]至[19]中任一項之容器裝之水系組合物、[2]、[4]至[19]中任一項之水分蒸散抑制劑或者[3]、[4]至[19]中任一項之水分蒸散抑制方法，其中成分(C)為選自聚氧乙烯甘油脂肪酸酯、聚氧乙烯去水山梨醇脂肪酸酯、聚氧乙烯蓖麻油、聚氧乙烯氫化蓖麻油及聚氧伸烷基氫化蓖麻油脂肪醃酯中之1種或2種以上。
[21]如上述[1)、[4]至[20]中任一項之容器裝之水系組合物、[2]、[4]至[20]中任一項之水分蒸散抑制劑或者[3]、[4]至[20]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.001~15質量%之成分(C)。
[22]如上述[1]、[4]至[21]中任一項之容器裝之水系組合物、[2]、[4]至[21]中任一項之水分蒸散抑制劑或者[3]、[4]至[21]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.005~10質量%之成分(C)。
[23]如上述[1]、[4]至[22]中任一項之容器裝之水系組合物、[2]、[4]至[22]中任一項之水分蒸散抑制劑或者[3]、[4]至[22]中任一項之水分蒸散抑制方法，其中相對於組合物總量而含有0.01~5質量%之成分(C)。
[24]如上述[1]、[4]至[23]中任一項之容器裝之水系組合物、[2]、[4]至[23]中任一項之水分蒸散抑制劑或者[3]、[4]至[23]中任一項之水分蒸散抑制方法，其進而含有多元醇。
[25]如上述[1]、[4]至[24]中任一項之容器裝之水系組合物、[2]、[4]至[24]中任一項之水分蒸散抑制劑或者[3]、[4]至[24]中任一項之水分蒸散抑制方法，其進而含有(E)選自週期表第1族之金屬、週期表第2族之金屬、及該等金屬之水溶性化合物中之1種或2種以上之化合物。
[26]如上述[25]之容器裝之水系組合物、水分蒸散抑制劑或者水分蒸散抑制方法，其中上述成分(E)為選自鈉、鉀、鎂、鈣及該等之水溶性化合物中之1種或2種以上。
[27]如上述[1]、[4]至[26]中任一項之容器裝之水系組合物，其形態為水溶液、或連續相為水相之乳化系。
[28]如上述[1]、[4]至[27]中任一項之容器裝之水系組合物，其係化妝料、醫藥品、准藥品或食品用水系組合物。
本發明中所謂水系組合物係指水相為連續相之組合物，包括含有水溶性成分之水溶液組合物、連續相中含有水之水包油型乳化組合物、W/O/W(水包油包水，Water in oil in water)型乳化組合物。
本發明中所謂水相係指含有水之相。
本發明中所謂阻礙水分蒸散抑制之物質係指藉由添加至含有聚氧乙烯烷基醚(A)、水溶性高分子、水之水系組合物中會導致水分蒸散速度大幅度提昇的物質。例如，若為於實施例所記載之試驗方法(試驗1)中，使表1之組合物之水分蒸散速度相對於未添加試驗物質之表1之組合物之水分蒸散速度而提高10 mg/h以上的物質，則可稱為本發明中之阻礙水分蒸散抑制之物質。
尤其是關於週期表第1族之金屬(鹼金屬)、週期表第2族之金屬及該等金屬之水溶性化合物，藉由添加至含有聚氧乙烯烷基醚(A)及水溶性高分子之水系組合物中，可見水分蒸散抑制效果明顯下降之現象。
尤其是於醫藥品、化妝品領域，若考慮對人體之適應性，則尤其是鈉、鉀、鎂、鈣及該等之水溶性化合物對水分蒸散抑制之阻礙之影響較為重要。具體而言，可列舉：水溶性有機酸鈉鹽、水溶性無機酸鈉鹽、鹵化鈉、氫氧化鈉、水溶性有機酸鉀鹽、水溶性無機酸鉀鹽、鹵化鉀、氫氧化鉀、水溶性有機酸鎂鹽、水溶性無機酸鎂鹽、鹵化鎂、氫氧化鎂、水溶性有機酸鈣鹽、水溶性無機酸鈣鹽、鹵化鈣、氫氧化鈣等。
更具體而言，作為阻礙水分蒸散抑制之物質，可列舉含有1種或2種以上之如下物質者：抗壞血酸鈉、抗壞血酸硫酸酯二鈉、海藻酸鈉、苯甲酸鈉、乙二胺四乙酸二鈉、乙二胺四乙酸三鈉、乙二胺四乙酸四鈉、乙二胺四乙酸二鈉鈣、氯化鈉、檸檬酸鈉、檸檬酸二鈉、甘草酸鈉、甘草次酸二鈉、麩胺酸鈉、琥珀酸二鈉、氫氧化鈉、山梨酸鈉、碳酸氫鈉、碳酸鈉、去氫乙酸鈉、偏矽酸鈉、偏磷酸鈉、羥基伸乙基二膦酸四鈉、焦磷酸鈉、焦亞硫酸鈉、六偏磷酸鈉、多磷酸鈉、硫酸鈉、亞硫酸鈉、亞硫酸氫鈉、磷酸一鈉、磷酸二氫鈉、磷酸氫二鈉、磷酸三鈉、抗壞血酸鉀、抗壞血酸硫酸酯二鉀、海藻酸鉀、苯甲酸鉀、乙二胺四乙酸二鉀、乙二胺四乙酸三鉀、乙二胺四乙酸四鉀、乙二胺四乙酸二鉀鈣、氯化鉀、檸檬酸鉀、檸檬酸二鉀、甘草酸鉀、甘草次酸二鉀、麩胺酸鉀、琥珀酸二鉀、氫氧化鉀、山梨酸鉀、碳酸氫鉀、碳酸鉀、去氫乙酸鉀、偏矽酸鉀、偏磷酸鉀、羥基伸乙基二膦酸四鉀、焦磷酸鉀、焦亞硫酸鉀、六偏磷酸鉀、多磷酸鉀、硫酸鉀、亞硫酸鉀、亞硫酸氫鉀、磷酸一鉀、磷酸二氫鉀、磷酸氫二鉀、磷酸三鉀、氯化鈣、氫氧化鈣、乙酸鈣、碳酸鈣、硫乙醇酸鈣、硫酸鎂、氯化鎂、氫氧化鎂、乙酸鎂、碳酸鎂、硫乙醇酸鎂、硫酸鎂等。
該等阻礙水分蒸散抑制之物質於水系組合物中之含量並無特別限定，若考慮各種藥效、作用，則含有0.0001質量%以上即可，較佳為含有0.0001~10質量%，藉此可獲得充分之各種藥效、作用。
本發明所使用之聚氧乙烯烷基醚(A)係烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4者。
聚氧乙烯烷基醚(A)之烷基或烯基可為直鏈，亦可為支鏈，其構造並無限定，較佳為直鏈或支鏈之烷基，更佳為直鏈之烷基。烷基或烯基之碳數為20~24，較佳之碳數為21~23，最佳為碳數為22之二十二烷基。於烷基或烯基之碳數未達20之情形時，水分蒸散抑制效果較低，故而欠佳。又，於烷基或烯基之碳數超過24之情形時，變得難溶於水相，故而於製劑方面欠佳。
聚氧乙烯烷基醚(A)之環氧乙烷之平均加成莫耳數為1.5~4之範圍，較佳為1.5~3，更佳為1.5~2.5。於平均加成莫耳數未達1.5之情形時，結晶性較高，難溶於水相，故而欠佳。又，於平均加成莫耳數超過4之情形時，水分蒸散抑制效果明顯下降，故而欠佳。通常可獲得之聚氧乙烯烷基醚(A)係環氧乙烷之加成莫耳數以所需之聚合度為中心極其廣泛地分佈之混合物，但平均加成莫耳數於上述範圍內對於本發明較為重要。
作為本發明之聚氧乙烯烷基醚(A)，主要可列舉：聚氧乙烯(2)二十烷基醚、聚氧乙烯(3)二十烷基醚、聚氧乙烯(4)二十烷基醚、聚氧乙烯(2)二十二烷基醚、聚氧乙烯(3)二十二烷基醚、聚氧乙烯(4)二十二烷基醚、聚氧乙烯(2)二十四烷基醚、聚氧乙烯(3)二十四烷基醚、聚氧乙烯(4)二十四烷基醚等，較佳可列舉聚氧乙烯(2)二十二烷基醚、聚氧乙烯(3)二十二烷基醚、聚氧乙烯(4)二十二烷基醚。再者，若所使用之聚氧乙烯烷基醚之平均加成莫耳數在上述範圍內，則亦可併用該等所列舉之聚氧乙烯烷基醚以外者。
本發明之水系組合物中之聚氧乙烯烷基醚(A)之含量相對於組合物總量，較佳為0.05~20質量%，更佳為0.1~20質量%，尤佳為0.1~10質量%。若於該範圍內，則水分蒸散抑制效果較高，可容易地調配於水相中，故而較佳。
本發明之水系組合物中使用(B)水溶性高分子。水溶性高分子使(A)聚氧乙烯烷基醚穩定地分散保持於水相中，有助於水分蒸散抑制效果。作為本發明所使用之水溶性高分子，可列舉：水溶性之陽離子性高分子、陰離子性高分子、非離子性高分子及兩性高分子或雙極性高分子等。
作為陽離子性高分子，具體可列舉：聚(二甲基二烯丙基鹵化銨)型陽離子性聚合物，二甲基二烯丙基鹵化銨與丙烯醯胺之共聚物陽離子性聚合物，含有四級氮之纖維素醚，或由聚乙二醇、表氯醇、丙烯胺及牛脂脂肪酸所獲得之牛脂醯胺之縮合產物，或者乙烯吡咯烷酮-甲基丙烯酸二甲基胺基乙酯共聚物陽離子化物等，作為聚(二甲基二烯丙基鹵化銨)型陽離子性高分子，可列舉：以Merquat 100之商品名，由美國默克公司(Merck & Co.Inc.)銷售者等。作為二甲基二烯丙基鹵化銨與丙烯醯胺之共聚物型陽離子性聚合物，可列舉：Merquat 550[美國默克公司(Merquat & Co.,Inc.)]等。作為聚乙二醇、表氯醇、丙烯胺及牛脂醯胺或椰油醯胺之縮合產物之例，可列舉：以Polyquat H之商品名，由西德Henkel公司(Henkel International Co.)銷售者等。含有四級氮之纖維素為以Polymer JR-400、Polymer JR-125、Polymer JR-30M之商品名，由美國聯合碳化物公司(Union Carbide Corp.)銷售者等。乙烯吡咯烷酮-甲基丙烯酸二甲基胺基乙酯共聚物陽離子化物為以Gafquat 755、Gafquat 734之商品名，由美國GAF公司(GAF Corp.)銷售者等。
作為陰離子性高分子，具體可列舉：羧乙烯聚合物、羧甲基纖維素、卡拉膠(carrageenan)、三仙膠、聚苯乙烯磺酸鹽、瓊脂、甘地膠、刺捂桐樹膠、果膠、海藻酸鹽(alginate)、以及聚(丙烯酸)及丙烯酸、甲基丙烯酸之鹼金屬及銨鹽等丙烯酸或甲基丙烯酸衍生物。
作為非離子性高分子，具體可列舉：纖維素醚(羥丁基甲基纖維素、羥丙基纖維素、羥丙基甲基纖維素、乙基羥乙基纖維素、羥乙基纖維素等)、丙二醇海藻酸酯、聚丙烯醯胺、(丙烯酸鈉/丙烯醯基二甲基牛磺酸鈉)共聚物、聚(環氧乙烷)、聚乙烯醇、聚乙烯吡咯烷酮、羥丙基瓜爾膠、刺槐豆膠、直鏈澱粉、羥乙基直鏈澱粉、玻尿酸及其鹼金屬鹽、澱粉及澱粉衍生物、及該等之混合物等。
作為兩性高分子或雙極性高分子，具體可列舉：辛基丙烯醯胺/丙烯酸酯/甲基丙烯酸丁胺基乙酯共聚物、聚四級銨鹽-47、聚四級銨鹽-43等。
該等水溶性高分子可使用1種，或適當組合使用2種以上。就易以各種劑形使用而言，較佳為可列舉：羧乙烯聚合物、丙烯酸-甲基丙烯酸烷基酯共聚物、三仙膠、羥丙基甲基纖維素、聚丙烯醯胺、(丙烯酸鈉/丙烯醯基二甲基牛磺酸鈉)共聚物、玻尿酸及其鹼金屬鹽。
本發明所使用之水溶性高分子之含量相對於組合物總量，較佳為0.01~5質量%，更佳為0.05~3質量%。若於該範圍內，則可保持製劑之穩定性，可獲得優異之水分蒸散抑制效果，故而較佳。
作為本發明所使用之(C)具有環氧乙烷基之非離子性界面活性劑(其中，除聚氧乙烯烷基醚(A)以外)，可列舉醚型與酯型，醚型可列舉聚氧乙烯烷基醚、聚氧乙烯烷基苯醚、聚氧乙烯聚氧丙烯烷基醚，作為酯型，可列舉聚氧乙烯脂肪酸酯、聚氧乙烯甘油脂肪酸酯、聚氧乙烯去水山梨醇脂肪酸酯、聚氧乙烯蓖麻油、聚氧乙烯氫化蓖麻油、聚氧伸烷基氫化蓖麻油脂肪酸酯、聚氧乙烯山梨醇。該等中，就使用感、安全性方面而言，較佳為酯型，尤佳為聚氧乙烯甘油脂肪酸酯、聚氧乙烯去水山梨醇脂肪酸酯、聚氧乙烯蓖麻油、聚氧乙烯氫化蓖麻油、聚氧伸烷基氫化蓖麻油脂肪酸酯。
具有環氧乙烷基之非離子性界面活性劑之環氧乙烷的平均加成莫耳數較佳為10以上，更佳為10~200，更佳為20~200，更佳為30~140，尤佳為40~120。若於該範圍內，則皮膚刺激性較小，可獲得優異之水分蒸散抑制效果，經時穩定性亦較高，故而較佳。
作為較佳之具有環氧乙烷基之非離子性界面活性劑，例如可列舉：聚氧乙烯(40)甘油三油酸酯、聚氧乙烯(50)甘油三油酸酯、聚氧乙烯(60)甘油三油酸酯、聚氧乙烯(45)甘油單硬脂酸酯、聚氧乙烯(50)甘油單硬脂酸酯、聚氧乙烯(75)甘油單硬脂酸酯、聚氧乙烯(90)甘油單硬脂酸酯、聚氧乙烯(100)甘油單硬脂酸酯、聚氧乙烯(120)甘油單硬脂酸酯、聚氧乙烯(40)甘油單異硬脂酸酯、聚氧乙烯(40)甘油三異硬脂酸酯、聚氧乙烯(50)甘油三異硬脂酸酯、聚氧乙烯(60)甘油三異硬脂酸酯、聚氧乙烯(120)三硬脂酸去水山梨醇、聚氧乙烯(40)蓖麻油、聚氧乙烯(50)蓖麻油、聚氧乙烯(60)蓖麻油、聚氧乙烯(75)蓖麻油、聚氧乙烯(100)蓖麻油、聚氧乙烯(40)氫化蓖麻油、聚氧乙烯(50)氫化蓖麻油、聚氧乙烯(60)氫化蓖麻油、聚氧乙烯(80)氫化蓖麻油、聚氧乙烯(100)氫化蓖麻油、聚氧乙烯(40)氫化蓖麻油單月桂酸酯、聚氧乙烯(50)氫化蓖麻油單月桂酸酯、聚氧乙烯(60)氫化蓖麻油單月桂酸酯、聚氧乙烯(40)氫化蓖麻油單硬脂酸酯、聚氧乙烯(50)氫化蓖麻油單硬脂酸酯、聚氧乙烯(40)氫化蓖麻油單異硬脂酸酯、聚氧乙烯(50)氫化蓖麻油單異硬脂酸酯、聚氧乙烯(60)氫化蓖麻油單異硬脂酸酯、聚氧乙烯(40)氫化蓖麻油三硬脂酸酯、聚氧乙烯(50)氫化蓖麻油三硬脂酸酯、聚氧乙烯(60)氫化蓖麻油三硬脂酸酯等；該等可使用1種，或者可組合使用2種以上。
本發明所使用之(C)具有環氧乙烷基之非離子性界面活性劑的含量相對於組合物總量較佳為0.001~15質量%，更佳為0.005~10質量%，尤佳為0.01~5質量%。若於該範圍內，則皮膚刺激性較低，可獲得良好之水分蒸散抑制效果，故而較佳。
具有環氧乙烷基之非離子性界面活性劑與阻礙水分蒸散抑制之物質的含有質量比較佳為1：20~50：1，更佳為1：12~20：1，尤佳為1：4~15：1。若於該範圍內，則可獲得良好之水分蒸散抑制效果，故而較佳。
於本發明之組合物中，為了提高聚氧乙烯烷基醚(A)於水相中之溶解性，較佳為進而併用多元醇。作為較佳之多元醇，可列舉：乙二醇、二乙二醇、三乙二醇、聚乙二醇(平均分子量未達1000)、丙二醇、二丙二醇、聚丙二醇(平均分子量未達1000)、異戊二醇、1,3-丁二醇等二醇類；甘油、二甘油、聚甘油等。
多元醇之含量相對於聚氧乙烯烷基醚(A)之含量，以質量比計較佳為併用0.5~50倍，更佳為1~35倍，尤佳為1~20倍。若於該範圍內，則聚氧乙烯烷基醚(A)之溶解性良好，可獲得良好之水分蒸散抑制效果，故而較佳。
於本發明之組合物中，除上述必須成分以外，亦可於無損本發明之目的之範圍內，調配高級醇類、脂肪酸類、酯類、固醇類、固醇脂肪酸酯類、烴類、油脂類、聚矽氧油、保濕劑、植物萃取物、維生素類、抗氧化劑、殺菌防腐劑、消炎劑、驅蟲劑、生理活性成分、鹽類、螯合劑、中和劑、pH調整劑、香料等。
本發明之水系組合物中之含水量只要為可形成水溶液或連續相為水相之O/W系或W/O/W系之乳化系的量即可，較佳為10質量%以上，更佳為15質量%以上，尤佳為20質量%以上。
本發明之水系組合物只要可保持製劑之穩定性，則即便為黏度(25℃)為100 mPa．s以下之低黏度的液狀，亦可獲得較高之水分蒸散抑制效果。
本發明之水系組合物之劑形只要水相為連續相，則無特別限定，可採用乳液、凝膠狀、噴霧狀、慕絲狀等。
作為本發明之水系組合物之用途，並無特別限定，較佳可列舉化妝料、醫藥品、准藥品、食品(包括健康食品)等。具體而言，適宜用作洗髮精、潤絲精、護髮素等毛髮化妝料，洗面乳、清潔化妝料、防曬化妝料、面膜、按摩化妝料等皮膚化妝料。
本發明所使用之容器係具有某種程度之密閉性的容器，只要為附蓋瓶、廣口瓶、管體、噴霧容器、泵式容器、泵式發泡容器等用於上述適宜用途的容器，則無特別限定。可於該等容器中填充上述水系組合物而使用。
尤其於噴霧容器、泵式容器、泵式發泡容器等噴出容器中使用本發明之水系組合物之情形時，即便含有易固化之固體脂質或粉末，亦可防止噴出口之變質(變色、變臭)或堵塞，可較佳地利用。
以下，列舉實施例及比較例對本發明進行更具體地說明，但本發明並不限定於下述實施例。再者，各成分之量為質量%。
將5 g下述表2所示之成分之試樣1~14添加至開口面積13.85 cm2
之培養皿中，測定於濕度30%、溫度30℃下經過1、3、5、7、12、18、24小時後之試樣之重量變化。將藉由最小平方法由上述重量變化之斜率算出之(nX+m；X為時間h)之n設為水分蒸散速度(單位：mg/h)，取絕對值並作圖。求出各試樣合計3次之平均值。再者，水分蒸散速度越小則越抑制蒸散。
根據試驗1可知：對於以平均加成莫耳數為5之聚氧乙烯二十二烷基醚為代表之其他聚氧乙烯烷基醚，平均加成莫耳數為1.5~4、尤其為2之聚氧乙烯二十二烷基醚顯示出優異之水分蒸散性。
以與試驗1相同之方式對下述表4及5所示之成分之實施例1~5、比較例1~7及對照例測定水分蒸散速度。又，如下述般定義相對於對照例(表5之對照例)之水分蒸散抑制率。
水分蒸散抑制率(%)={1-(實施例或比較例之水分蒸散速度)/(對照例之水分蒸散速度)}×100
A.將成分(1)、(2)與成分(14)均勻地混合。
B.於成分A中緩慢地添加成分(3)~(13)、(15)，並均勻地混合。
根據試驗2可知：藉由併用聚氧乙烯烷基醚(A)及水溶性高分子(比較例7)，而與對照例(122 mg/h)相比進一步抑制水分蒸散(41 mg/h)。相對於此，藉由添加鹼金屬鹽等，會使其水分蒸散抑制效果下降(比較例1~6)。可知：相對於此，藉由含有具有環氧乙烷基之非離子界面活性劑，可將由阻礙水分蒸散抑制之物質所引起之水分蒸散抑制效果之下降改善至不含阻礙水分蒸散抑制之物質之水平。
以與試驗1及2相同條件對下述表6所示之實施例6~11、比較例8、9測定試樣之重量變化，求出水分蒸散速度、水分蒸散抑制率。
A.將成分(1)與成分(6)均勻地混合。
B.於成分A中緩慢地添加成分(2)~(5)、(7)、(8)，並均勻地混合。
根據試驗3可知：若以作為阻礙水分蒸散抑制之物質之甘草酸鉀之十分之一左右的調配量含有具有環氧乙烷基之POE氫化蓖麻油，則可提高水分蒸散抑制效果，若以五分之一左右的調配量含有具有環氧乙烷基之POE氫化蓖麻油，則可將水分蒸散抑制效果改善至不含阻礙水分蒸散抑制之物質之水平。
Claims (16)
- 一種容器裝之水系組合物，其含有如下成分(A)~(E)：(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)、(D)水及(E)選自週期表第1族之金屬、週期表第2族之金屬、及該等金屬之水溶性化合物中之1種或2種以上之阻礙水分蒸散抑制之物質，成分(C)與成分(E)之含有比例為1：20~50：1。
- 如請求項1之容器裝之水系組合物，其中成分(A)為烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~3之聚氧乙烯烷基或烯基醚。
- 如請求項1之容器裝之水系組合物，其中相對於組合物總量而含有0.05~20質量%之成分(A)。
- 如請求項1之容器裝之水系組合物，其中成分(B)為選自由羧乙烯聚合物、丙烯酸-甲基丙烯酸烷基酯共聚物、三仙膠、羥丙基甲基纖維素、聚丙烯醯胺及(丙烯酸鈉/丙烯醯基二甲基牛磺酸鈉)共聚物所組成之群中之1種或2種以上。
- 如請求項1之容器裝之水系組合物，其中相對於組合物總量而含有0.01~5質量%之成分(B)。
- 如請求項1之容器裝之水系組合物，其中成分(C)非離子性界面活性劑之環氧乙烷之平均加成莫耳數為10以上。
- 如請求項1之容器裝之水系組合物，其中成分(C)非離子性界面活性劑之環氧乙烷之平均加成莫耳數為10~200。
- 如請求項1之容器裝之水系組合物，其中成分(C)為選自聚氧乙烯烷基醚、聚氧乙烯烷基苯醚、聚氧乙烯聚氧丙烯烷基醚、聚氧乙烯脂肪酸酯、聚氧乙烯甘油脂肪酸酯、聚氧乙烯去水山梨醇脂肪酸酯、聚氧乙烯蓖麻油、聚氧乙烯氫化蓖麻油、聚氧申烷基氫化蓖麻油脂肪酸酯及聚氧乙烯山梨醇中之1種或2種以上。
- 如請求項1之容器裝之水系組合物，其中成分(C)為選自聚氧乙烯甘油脂肪酸酯、聚氧乙烯去水山梨醇脂肪酸酯、聚氧乙烯蓖麻油、聚氧乙烯氫化蓖麻油及聚氧伸烷基氫化蓖麻油脂肪酸酯中之1種或2種以上。
- 如請求項1之容器裝之水系組合物，其中相對於組合物總量而含有0.001~15質量%之成分(C)。
- 如請求項1之容器裝之水系組合物，其進而含有多元醇。
- 如請求項1之容器裝之水系組合物，其中上述成分(E)為選自鈉、鉀、鎂、鈣、及該等之水溶性化合物中之1種或2種以上。
- 如請求項1之容器裝之水系組合物，其形態為水溶液、或連續相為水相之乳化系。
- 如請求項1之容器裝之水系組合物，其係化妝料、醫藥 品、准藥品或食品用水系組合物。
- 一種水分蒸散抑制劑，其含有如請求項1之水系組合物。
- 一種自水系組合物之水分蒸散抑制方法，其特徵在於：對於含有下述之成分(D)、成分(E)之水系組合物，以成分(C)對於成分(E)為1/20~50(質量比)之方式含有成分(A)~成分(C)作為有效成分，(A)烷基或烯基之碳數為20~24且環氧乙烷之平均加成莫耳數為1.5~4之聚氧乙烯烷基或烯基醚、(B)水溶性高分子、(C)具有環氧乙烷基之非離子性界面活性劑(其中，(A)成分除外)、(D)水及(E)選自週期表第1族之金屬、週期表第2族之金屬、及該等金屬之水溶性化合物中之1種或2種以上之阻礙水分蒸散抑制之物質。
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| JP5689288B2 (ja) | 2010-05-17 | 2015-03-25 | 花王株式会社 | 皮膚外用剤 |
| JP5695339B2 (ja) | 2010-04-27 | 2015-04-01 | 花王株式会社 | 容器入り水系組成物 |
| JP5584524B2 (ja) | 2010-06-07 | 2014-09-03 | 花王株式会社 | 水中油型乳化組成物及びその製造方法 |
-
2010
- 2010-05-27 JP JP2010121631A patent/JP5581115B2/ja active Active
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2011
- 2011-05-26 US US13/700,322 patent/US8710066B2/en active Active
- 2011-05-26 KR KR1020127030774A patent/KR101536043B1/ko active IP Right Grant
- 2011-05-26 TW TW100118517A patent/TWI483744B/zh not_active IP Right Cessation
- 2011-05-26 WO PCT/JP2011/062062 patent/WO2011149006A1/ja active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3146059A (en) * | 1957-11-20 | 1964-08-25 | Nikken Chemicals Co Ltd | Evaporation-suppressing agents and method of their production |
| TW200501893A (en) * | 2002-12-19 | 2005-01-16 | Hayashibara Biochem Lab | Method of inhibiting water content variation of composition and use thereof |
| JP2008081472A (ja) * | 2006-09-28 | 2008-04-10 | Kao Corp | 皮膚外用剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011246398A (ja) | 2011-12-08 |
| KR101536043B1 (ko) | 2015-07-10 |
| TW201143812A (en) | 2011-12-16 |
| WO2011149006A1 (ja) | 2011-12-01 |
| JP5581115B2 (ja) | 2014-08-27 |
| US20130096205A1 (en) | 2013-04-18 |
| KR20130109934A (ko) | 2013-10-08 |
| US8710066B2 (en) | 2014-04-29 |
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