TWI482766B

TWI482766B - As a spiro compound for hepatitis C virus inhibitors

As a spiro compound for hepatitis C virus inhibitors Download PDF

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Publication number: TWI482766B
Authority: TW; Taiwan
Prior art keywords: alkyl; independently; aliphatic; aryl; group
Prior art date: 2011-07-09

Application number

TW101124685A

Other languages

English (en)

Chinese (zh)

Other versions

TW201302731A (zh

Original Assignee

Sunshine Lake Pharma Co Ltd

Priority date

2011-07-09

Filing date

2012-07-09

Publication date

2015-05-01

2012-07-09 Application filed by Sunshine Lake Pharma Co Ltd filed Critical Sunshine Lake Pharma Co Ltd

2013-01-16 Publication of TW201302731A publication Critical patent/TW201302731A/zh

2015-05-01 Application granted granted Critical

2015-05-01 Publication of TWI482766B publication Critical patent/TWI482766B/zh

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239000003112 inhibitor Substances 0.000 title claims description 7
241000711549 Hepacivirus C Species 0.000 title description 75
150000003413 spiro compounds Chemical class 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 468
125000001931 aliphatic group Chemical group 0.000 claims description 296
-1 hydroxy, amino Chemical group 0.000 claims description 238
125000000217 alkyl group Chemical group 0.000 claims description 223
125000000623 heterocyclic group Chemical group 0.000 claims description 185
125000003118 aryl group Chemical group 0.000 claims description 172
125000003545 alkoxy group Chemical group 0.000 claims description 160
229910052727 yttrium Inorganic materials 0.000 claims description 150
125000001072 heteroaryl group Chemical group 0.000 claims description 147
229910052801 chlorine Inorganic materials 0.000 claims description 67
229910052731 fluorine Inorganic materials 0.000 claims description 67
229910052799 carbon Inorganic materials 0.000 claims description 64
229910052739 hydrogen Inorganic materials 0.000 claims description 64
229910052717 sulfur Inorganic materials 0.000 claims description 60
229910052794 bromium Inorganic materials 0.000 claims description 59
229910052760 oxygen Inorganic materials 0.000 claims description 58
229910052757 nitrogen Inorganic materials 0.000 claims description 57
125000004104 aryloxy group Chemical group 0.000 claims description 56
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 56
125000004093 cyano group Chemical group *C#N 0.000 claims description 52
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 51
125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims description 49
229910052740 iodine Inorganic materials 0.000 claims description 47
125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 46
125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims description 46
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125000004433 nitrogen atom Chemical group N* 0.000 claims description 40
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125000003710 aryl alkyl group Chemical group 0.000 claims description 35
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 35
150000003839 salts Chemical class 0.000 claims description 35
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 32
238000000034 method Methods 0.000 claims description 32
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125000000304 alkynyl group Chemical group 0.000 claims description 23
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PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 21
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125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 8
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