TWI455941B - 純化十字孢靈素之方法 - Google Patents
純化十字孢靈素之方法 Download PDFInfo
- Publication number
- TWI455941B TWI455941B TW101122882A TW101122882A TWI455941B TW I455941 B TWI455941 B TW I455941B TW 101122882 A TW101122882 A TW 101122882A TW 101122882 A TW101122882 A TW 101122882A TW I455941 B TWI455941 B TW I455941B
- Authority
- TW
- Taiwan
- Prior art keywords
- staurosporine
- purifying
- alcohol solvent
- suspension
- purifying staurosporine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 title claims 2
- HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title claims 2
- CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 title claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Extraction Or Liquid Replacement (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62534304P | 2004-11-05 | 2004-11-05 | |
| US64213105P | 2005-01-07 | 2005-01-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201247681A TW201247681A (en) | 2012-12-01 |
| TWI455941B true TWI455941B (zh) | 2014-10-11 |
Family
ID=35501294
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101122880A TWI530500B (zh) | 2004-11-05 | 2005-11-04 | 非晶形ｎ-苄醯基-十字孢靈素、其製備方法及其用途 |
| TW094138677A TWI433852B (zh) | 2004-11-05 | 2005-11-04 | N－苄醯基－十字孢靈素之結晶形、其製備方法及其用途 |
| TW103130302A TWI530501B (zh) | 2004-11-05 | 2005-11-04 | 純化十字孢靈素之方法 |
| TW101122882A TWI455941B (zh) | 2004-11-05 | 2005-11-04 | 純化十字孢靈素之方法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101122880A TWI530500B (zh) | 2004-11-05 | 2005-11-04 | 非晶形ｎ-苄醯基-十字孢靈素、其製備方法及其用途 |
| TW094138677A TWI433852B (zh) | 2004-11-05 | 2005-11-04 | N－苄醯基－十字孢靈素之結晶形、其製備方法及其用途 |
| TW103130302A TWI530501B (zh) | 2004-11-05 | 2005-11-04 | 純化十字孢靈素之方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US8198435B2 (enExample) |
| EP (3) | EP1812448B1 (enExample) |
| JP (4) | JP5057986B2 (enExample) |
| KR (3) | KR101289998B1 (enExample) |
| CN (2) | CN102993213A (enExample) |
| AR (1) | AR052322A1 (enExample) |
| AU (2) | AU2005300693B2 (enExample) |
| BR (1) | BRPI0517689A (enExample) |
| CA (1) | CA2584911C (enExample) |
| CY (1) | CY1113059T1 (enExample) |
| DK (1) | DK1812448T3 (enExample) |
| EC (1) | ECSP12007431A (enExample) |
| ES (1) | ES2388142T3 (enExample) |
| GT (1) | GT200500311A (enExample) |
| HK (1) | HK1211587A1 (enExample) |
| HR (1) | HRP20120652T1 (enExample) |
| IL (3) | IL182691A (enExample) |
| JO (1) | JO2897B1 (enExample) |
| MA (1) | MA29033B1 (enExample) |
| MX (2) | MX2007005429A (enExample) |
| MY (2) | MY154878A (enExample) |
| NO (2) | NO338960B1 (enExample) |
| NZ (3) | NZ599033A (enExample) |
| PE (3) | PE20060947A1 (enExample) |
| PL (1) | PL1812448T3 (enExample) |
| PT (1) | PT1812448E (enExample) |
| RU (2) | RU2394038C2 (enExample) |
| SI (1) | SI1812448T1 (enExample) |
| TN (1) | TNSN07165A1 (enExample) |
| TW (4) | TWI530500B (enExample) |
| WO (1) | WO2006048296A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008021347A2 (en) * | 2006-08-16 | 2008-02-21 | Novartis Ag | Method for making solid dispersions of highly crystalline therapeutic compounds |
| EP2327706A1 (en) * | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
| KR20160008267A (ko) | 2014-07-14 | 2016-01-22 | 주식회사 윈스 | 네트워크 기반 영상감시체계에서의 사용자 행위 분석 시스템 |
| WO2018165071A1 (en) | 2017-03-06 | 2018-09-13 | Teva Pharmaceutical Works Ltd. | Solid state forms of midostaurin |
| WO2019215759A1 (en) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | An improved process for preparation of midostaurin |
| IT201900004729A1 (it) | 2019-03-29 | 2020-09-29 | Procos Spa | Processo per la preparazione di midostaurina ad elevato grado di purezza |
| US20220242880A1 (en) * | 2019-06-24 | 2022-08-04 | Dr. Reddy?s Laboratories Limited | Process for preparation of midostaurin |
| IT201900014346A1 (it) * | 2019-08-08 | 2021-02-08 | Procos Spa | Processo per la preparazione di midostaurina amorfa con un basso contenuto di solvente organico residuo |
| IT202000004291A1 (it) | 2020-03-02 | 2021-09-02 | Indena Spa | Processo per la purificazione di alcaloidi indolo carbazolici |
| CN111393454A (zh) * | 2020-05-07 | 2020-07-10 | 奥锐特药业(天津)有限公司 | 米哚妥林的新晶型及其制备方法 |
| CN115124551B (zh) * | 2021-03-24 | 2024-04-30 | 奥锐特药业(天津)有限公司 | 一种高纯度米哚妥林的制备方法 |
| WO2023205504A1 (en) * | 2022-04-22 | 2023-10-26 | Rutgers, The State University Of New Jersey | Formulations and methods for treating epidermolysis bullosa simplex and related conditions |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107297A (en) * | 1976-12-11 | 1978-08-15 | The Kitasato Institute | Antibiotic compound |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60185719A (ja) | 1984-03-06 | 1985-09-21 | Ajinomoto Co Inc | 抗腫瘍剤 |
| IL86632A0 (en) * | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| US5073633A (en) | 1989-03-23 | 1991-12-17 | Bristol-Myers Company | BMY-41950 antitumor antibiotic |
| US5096330A (en) * | 1990-06-21 | 1992-03-17 | M-B-W Inc. | Pitch control mechanism for a surface finishing machine |
| JPH05247055A (ja) * | 1992-03-03 | 1993-09-24 | Meiji Seika Kaisha Ltd | スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤 |
| JPH05247955A (ja) | 1992-03-06 | 1993-09-24 | Taisei Corp | 擁壁の施工方法 |
| DE69326388T2 (de) | 1992-06-22 | 1999-12-30 | Kyowa Hakko Kogyo Co., Ltd. | Verfahren zur Herstellung von Staurosporin-Derivaten |
| AU2565895A (en) * | 1994-06-01 | 1995-12-21 | Ciba-Geigy Ag | Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents |
| JP4070810B2 (ja) | 1995-12-11 | 2008-04-02 | セファロン・インコーポレイテッド | タンパク質キナーゼｃの阻害剤としての縮合イソインドロン |
| CA2382931C (en) * | 1999-08-30 | 2011-01-25 | Polyphor Ag | Synthesis of template-fixed .beta.-hairpin loop mimetics |
| BR0208306A (pt) | 2001-03-26 | 2004-03-09 | Novartis Ag | Composições farmacêuticas |
| KR100407758B1 (ko) | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
| US7608420B2 (en) | 2003-04-22 | 2009-10-27 | Lonza Ag | Process for the recovery of staurosporine from a fermentation broth |
-
2005
- 2005-10-26 JO JO2005162A patent/JO2897B1/en active
- 2005-10-28 MY MYPI20091911A patent/MY154878A/en unknown
- 2005-10-28 MY MYPI20055091A patent/MY147404A/en unknown
- 2005-10-28 GT GT200500311A patent/GT200500311A/es unknown
- 2005-11-03 EP EP05803350A patent/EP1812448B1/en not_active Expired - Lifetime
- 2005-11-03 KR KR1020127022584A patent/KR101289998B1/ko not_active Expired - Lifetime
- 2005-11-03 EP EP10173464.8A patent/EP2272850B1/en not_active Expired - Lifetime
- 2005-11-03 EP EP15171908.5A patent/EP2955186A1/en not_active Withdrawn
- 2005-11-03 JP JP2007539535A patent/JP5057986B2/ja not_active Expired - Lifetime
- 2005-11-03 NZ NZ599033A patent/NZ599033A/xx not_active IP Right Cessation
- 2005-11-03 CA CA2584911A patent/CA2584911C/en not_active Expired - Lifetime
- 2005-11-03 MX MX2007005429A patent/MX2007005429A/es active IP Right Grant
- 2005-11-03 ES ES05803350T patent/ES2388142T3/es not_active Expired - Lifetime
- 2005-11-03 SI SI200531555T patent/SI1812448T1/sl unknown
- 2005-11-03 HR HRP20120652TT patent/HRP20120652T1/hr unknown
- 2005-11-03 US US11/718,029 patent/US8198435B2/en active Active
- 2005-11-03 AU AU2005300693A patent/AU2005300693B2/en not_active Expired
- 2005-11-03 NZ NZ554653A patent/NZ554653A/en not_active IP Right Cessation
- 2005-11-03 RU RU2007120695/04A patent/RU2394038C2/ru active
- 2005-11-03 PL PL05803350T patent/PL1812448T3/pl unknown
- 2005-11-03 NZ NZ588025A patent/NZ588025A/en not_active IP Right Cessation
- 2005-11-03 CN CN2012104320940A patent/CN102993213A/zh active Pending
- 2005-11-03 CN CN2012101018747A patent/CN102627658A/zh active Pending
- 2005-11-03 PT PT05803350T patent/PT1812448E/pt unknown
- 2005-11-03 WO PCT/EP2005/011789 patent/WO2006048296A1/en not_active Ceased
- 2005-11-03 DK DK05803350.7T patent/DK1812448T3/da active
- 2005-11-03 KR KR1020127022582A patent/KR101265850B1/ko not_active Expired - Lifetime
- 2005-11-03 BR BRPI0517689-1A patent/BRPI0517689A/pt not_active IP Right Cessation
- 2005-11-03 KR KR1020077010191A patent/KR101333851B1/ko not_active Expired - Lifetime
- 2005-11-03 MX MX2011007303A patent/MX346525B/es unknown
- 2005-11-04 TW TW101122880A patent/TWI530500B/zh not_active IP Right Cessation
- 2005-11-04 TW TW094138677A patent/TWI433852B/zh not_active IP Right Cessation
- 2005-11-04 PE PE2005001297A patent/PE20060947A1/es not_active Application Discontinuation
- 2005-11-04 TW TW103130302A patent/TWI530501B/zh not_active IP Right Cessation
- 2005-11-04 TW TW101122882A patent/TWI455941B/zh not_active IP Right Cessation
- 2005-11-04 PE PE2012002519A patent/PE20130377A1/es not_active Application Discontinuation
- 2005-11-04 PE PE2009000199A patent/PE20090433A1/es not_active Application Discontinuation
- 2005-11-04 AR ARP050104637A patent/AR052322A1/es not_active Application Discontinuation
-
2007
- 2007-04-19 IL IL182691A patent/IL182691A/en active IP Right Grant
- 2007-05-02 NO NO20072290A patent/NO338960B1/no unknown
- 2007-05-04 TN TNP2007000165A patent/TNSN07165A1/fr unknown
- 2007-05-22 MA MA29924A patent/MA29033B1/fr unknown
- 2007-12-19 HK HK15112508.3A patent/HK1211587A1/en unknown
-
2009
- 2009-10-13 RU RU2009137788/04A patent/RU2467012C2/ru active
- 2009-12-07 AU AU2009245817A patent/AU2009245817B2/en not_active Expired
-
2010
- 2010-08-19 IL IL207702A patent/IL207702A/en active IP Right Grant
-
2012
- 2012-01-16 IL IL217571A patent/IL217571A/en active IP Right Grant
- 2012-03-12 EC ECSP12007431 patent/ECSP12007431A/es unknown
- 2012-05-11 JP JP2012109447A patent/JP5701246B2/ja not_active Expired - Lifetime
- 2012-05-15 US US13/472,130 patent/US8710216B2/en not_active Expired - Lifetime
- 2012-08-21 CY CY20121100747T patent/CY1113059T1/el unknown
-
2015
- 2015-01-09 JP JP2015003634A patent/JP2015063569A/ja not_active Withdrawn
-
2016
- 2016-07-12 NO NO20161152A patent/NO340404B1/no unknown
-
2017
- 2017-01-13 JP JP2017004320A patent/JP2017061578A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107297A (en) * | 1976-12-11 | 1978-08-15 | The Kitasato Institute | Antibiotic compound |
| US5093330A (en) * | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |