JP5057986B2 - 有機化合物 - Google Patents

有機化合物 Download PDF

Info

Publication number
JP5057986B2
JP5057986B2 JP2007539535A JP2007539535A JP5057986B2 JP 5057986 B2 JP5057986 B2 JP 5057986B2 JP 2007539535 A JP2007539535 A JP 2007539535A JP 2007539535 A JP2007539535 A JP 2007539535A JP 5057986 B2 JP5057986 B2 JP 5057986B2
Authority
JP
Japan
Prior art keywords
staurosporine
benzoyl
crystalline form
compound
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2007539535A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008518995A (ja
JP2008518995A5 (enExample
Inventor
パスカル・オアン
ベルント・コッホ
ミヒャエル・ムッツ
Original Assignee
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35501294&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5057986(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2008518995A publication Critical patent/JP2008518995A/ja
Publication of JP2008518995A5 publication Critical patent/JP2008518995A5/ja
Application granted granted Critical
Publication of JP5057986B2 publication Critical patent/JP5057986B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2007539535A 2004-11-05 2005-11-03 有機化合物 Expired - Lifetime JP5057986B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62534304P 2004-11-05 2004-11-05
US60/625,343 2004-11-05
US64213105P 2005-01-07 2005-01-07
US60/642,131 2005-01-07
PCT/EP2005/011789 WO2006048296A1 (en) 2004-11-05 2005-11-03 Organic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012109447A Division JP5701246B2 (ja) 2004-11-05 2012-05-11 有機化合物

Publications (3)

Publication Number Publication Date
JP2008518995A JP2008518995A (ja) 2008-06-05
JP2008518995A5 JP2008518995A5 (enExample) 2008-12-25
JP5057986B2 true JP5057986B2 (ja) 2012-10-24

Family

ID=35501294

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007539535A Expired - Lifetime JP5057986B2 (ja) 2004-11-05 2005-11-03 有機化合物
JP2012109447A Expired - Lifetime JP5701246B2 (ja) 2004-11-05 2012-05-11 有機化合物
JP2015003634A Withdrawn JP2015063569A (ja) 2004-11-05 2015-01-09 有機化合物
JP2017004320A Pending JP2017061578A (ja) 2004-11-05 2017-01-13 有機化合物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2012109447A Expired - Lifetime JP5701246B2 (ja) 2004-11-05 2012-05-11 有機化合物
JP2015003634A Withdrawn JP2015063569A (ja) 2004-11-05 2015-01-09 有機化合物
JP2017004320A Pending JP2017061578A (ja) 2004-11-05 2017-01-13 有機化合物

Country Status (31)

Country Link
US (2) US8198435B2 (enExample)
EP (3) EP1812448B1 (enExample)
JP (4) JP5057986B2 (enExample)
KR (3) KR101333851B1 (enExample)
CN (2) CN102993213A (enExample)
AR (1) AR052322A1 (enExample)
AU (2) AU2005300693B2 (enExample)
BR (1) BRPI0517689A (enExample)
CA (1) CA2584911C (enExample)
CY (1) CY1113059T1 (enExample)
DK (1) DK1812448T3 (enExample)
EC (1) ECSP12007431A (enExample)
ES (1) ES2388142T3 (enExample)
GT (1) GT200500311A (enExample)
HK (1) HK1211587A1 (enExample)
HR (1) HRP20120652T1 (enExample)
IL (3) IL182691A (enExample)
JO (1) JO2897B1 (enExample)
MA (1) MA29033B1 (enExample)
MX (2) MX346525B (enExample)
MY (2) MY147404A (enExample)
NO (2) NO338960B1 (enExample)
NZ (3) NZ599033A (enExample)
PE (3) PE20130377A1 (enExample)
PL (1) PL1812448T3 (enExample)
PT (1) PT1812448E (enExample)
RU (2) RU2394038C2 (enExample)
SI (1) SI1812448T1 (enExample)
TN (1) TNSN07165A1 (enExample)
TW (4) TWI530500B (enExample)
WO (1) WO2006048296A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101462693B1 (ko) * 2006-08-16 2014-11-17 노파르티스 아게 고도 결정질 치료용 화합물의 고체 분산체 제조 방법
EP2327706A1 (en) * 2009-11-30 2011-06-01 Novartis AG Polymorphous forms III and IV of N-benzoyl-staurosporine
KR20160008267A (ko) 2014-07-14 2016-01-22 주식회사 윈스 네트워크 기반 영상감시체계에서의 사용자 행위 분석 시스템
EP3592749A1 (en) * 2017-03-06 2020-01-15 Teva Pharmaceutical Works Ltd. Solid state forms of midostaurin
WO2019215759A1 (en) * 2018-05-09 2019-11-14 Alaparthi Lakshmi Prasad An improved process for preparation of midostaurin
IT201900004729A1 (it) 2019-03-29 2020-09-29 Procos Spa Processo per la preparazione di midostaurina ad elevato grado di purezza
US20220242880A1 (en) * 2019-06-24 2022-08-04 Dr. Reddy?s Laboratories Limited Process for preparation of midostaurin
IT201900014346A1 (it) * 2019-08-08 2021-02-08 Procos Spa Processo per la preparazione di midostaurina amorfa con un basso contenuto di solvente organico residuo
IT202000004291A1 (it) 2020-03-02 2021-09-02 Indena Spa Processo per la purificazione di alcaloidi indolo carbazolici
CN111393454A (zh) * 2020-05-07 2020-07-10 奥锐特药业(天津)有限公司 米哚妥林的新晶型及其制备方法
CN115124551B (zh) * 2021-03-24 2024-04-30 奥锐特药业(天津)有限公司 一种高纯度米哚妥林的制备方法
WO2023205504A1 (en) * 2022-04-22 2023-10-26 Rutgers, The State University Of New Jersey Formulations and methods for treating epidermolysis bullosa simplex and related conditions

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5373501A (en) * 1976-12-11 1978-06-30 Kitasato Inst Novel antibiotics amm2282 and process for preparing same
JPS60185719A (ja) 1984-03-06 1985-09-21 Ajinomoto Co Inc 抗腫瘍剤
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
IL86632A0 (en) * 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
US5073633A (en) * 1989-03-23 1991-12-17 Bristol-Myers Company BMY-41950 antitumor antibiotic
US5096330A (en) * 1990-06-21 1992-03-17 M-B-W Inc. Pitch control mechanism for a surface finishing machine
JPH05247055A (ja) * 1992-03-03 1993-09-24 Meiji Seika Kaisha Ltd スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤
JPH05247955A (ja) 1992-03-06 1993-09-24 Taisei Corp 擁壁の施工方法
US5344926A (en) 1992-06-22 1994-09-06 Kyowa Hakko Kogyo Co., Ltd. Process for producing staurosporine derivatives
WO1995032975A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents
RU2191175C2 (ru) * 1995-12-11 2002-10-20 Сефалон, Инкорпорейтед Конденсированные изоиндолоны в качестве ингибиторов протеинкиназы с
BR9917475B1 (pt) * 1999-08-30 2013-07-23 processo para a manufatura de compostos, e, modificação do processo.
CA2439097C (en) 2001-03-26 2010-10-12 Novartis Ag Pharmaceutical compositions
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
WO2004094645A1 (en) * 2003-04-22 2004-11-04 Lonza Ag Process for the recovery of staurosporine from a fermentation broth

Also Published As

Publication number Publication date
RU2467012C2 (ru) 2012-11-20
TW201247680A (en) 2012-12-01
PL1812448T3 (pl) 2012-10-31
GT200500311A (es) 2006-05-22
JP2012149099A (ja) 2012-08-09
IL207702A0 (en) 2010-12-30
JP5701246B2 (ja) 2015-04-15
TNSN07165A1 (en) 2008-11-21
US8198435B2 (en) 2012-06-12
PE20130377A1 (es) 2013-04-03
IL182691A0 (en) 2007-09-20
PE20090433A1 (es) 2009-05-05
US20090137552A1 (en) 2009-05-28
JP2008518995A (ja) 2008-06-05
RU2009137788A (ru) 2011-04-20
TWI530501B (zh) 2016-04-21
MY147404A (en) 2012-11-30
TWI530500B (zh) 2016-04-21
RU2007120695A (ru) 2008-12-10
EP2955186A1 (en) 2015-12-16
WO2006048296A1 (en) 2006-05-11
NO340404B1 (no) 2017-04-18
MY154878A (en) 2015-08-14
MX346525B (es) 2017-03-23
PT1812448E (pt) 2012-08-24
EP2272850A3 (en) 2011-09-21
AU2009245817A1 (en) 2009-12-24
BRPI0517689A (pt) 2008-10-14
US8710216B2 (en) 2014-04-29
JP2015063569A (ja) 2015-04-09
EP1812448B1 (en) 2012-05-23
TWI433852B (zh) 2014-04-11
NO20072290L (no) 2007-05-30
HRP20120652T1 (hr) 2012-09-30
EP1812448A1 (en) 2007-08-01
NO20161152A1 (no) 2007-05-30
US20120322789A1 (en) 2012-12-20
IL217571A (en) 2017-07-31
AR052322A1 (es) 2007-03-14
PE20060947A1 (es) 2006-10-30
JP2017061578A (ja) 2017-03-30
KR20070083979A (ko) 2007-08-24
KR101289998B1 (ko) 2013-07-30
CN102993213A (zh) 2013-03-27
AU2005300693B2 (en) 2010-08-19
NO338960B1 (no) 2016-11-07
HK1211587A1 (en) 2016-05-27
SI1812448T1 (sl) 2012-09-28
TW200628474A (en) 2006-08-16
JO2897B1 (en) 2015-09-15
TW201446773A (zh) 2014-12-16
AU2005300693A1 (en) 2006-05-11
MA29033B1 (fr) 2007-11-01
EP2272850A2 (en) 2011-01-12
NZ599033A (en) 2012-09-28
DK1812448T3 (da) 2012-08-27
NZ588025A (en) 2012-04-27
KR101333851B1 (ko) 2013-11-27
IL182691A (en) 2013-02-28
ECSP12007431A (es) 2012-06-29
TW201247681A (en) 2012-12-01
TWI455941B (zh) 2014-10-11
KR20120101600A (ko) 2012-09-13
CN102627658A (zh) 2012-08-08
AU2009245817B2 (en) 2013-02-21
CA2584911A1 (en) 2006-05-11
KR101265850B1 (ko) 2013-05-20
EP2272850B1 (en) 2017-05-10
HK1108881A1 (en) 2008-05-23
CY1113059T1 (el) 2016-04-13
CA2584911C (en) 2017-10-24
KR20120101601A (ko) 2012-09-13
RU2394038C2 (ru) 2010-07-10
NZ554653A (en) 2010-10-29
MX2007005429A (es) 2007-05-18
ES2388142T3 (es) 2012-10-09
IL207702A (en) 2016-09-29

Similar Documents

Publication Publication Date Title
JP5701246B2 (ja) 有機化合物
WO2006083682A2 (en) Polymorphic forms of a gabaa agonist
HK1149754A (en) Process for purifying staurosporine
HK1108881B (en) Organic compounds
CN101048416A (zh) 有机化合物
JP2009523768A (ja) ピロロピリミジン誘導体の固体形態および抗腫瘍剤としてのそれらの使用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081024

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20081024

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120214

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120511

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120612

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120614

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120710

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120731

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150810

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5057986

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250