TWI384997B - 抗酪胺酸酶相關蛋白-１（ｔｙｒｐ１）抗體 - Google Patents

抗酪胺酸酶相關蛋白-１（ｔｙｒｐ１）抗體 Download PDF

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Publication number
TWI384997B
TWI384997B TW098107909A TW98107909A TWI384997B TW I384997 B TWI384997 B TW I384997B TW 098107909 A TW098107909 A TW 098107909A TW 98107909 A TW98107909 A TW 98107909A TW I384997 B TWI384997 B TW I384997B
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Taiwan
Prior art keywords
antibody
antigen
seq
binding fragment
antibodies
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TW098107909A
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English (en)
Chinese (zh)
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TW200944232A (en
Inventor
Xiaoqiang Kang
Paul J Balderes
Original Assignee
Imclone Llc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40790741&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI384997(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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Publication of TW200944232A publication Critical patent/TW200944232A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW098107909A 2008-03-12 2009-03-11 抗酪胺酸酶相關蛋白-１（ｔｙｒｐ１）抗體 TWI384997B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6919908P 2008-03-12 2008-03-12

Publications (2)

Publication Number Publication Date
TW200944232A TW200944232A (en) 2009-11-01
TWI384997B true TWI384997B (zh) 2013-02-11

Family

ID=40790741

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098107909A TWI384997B (zh) 2008-03-12 2009-03-11 抗酪胺酸酶相關蛋白-１（ｔｙｒｐ１）抗體

Country Status (19)

Country Link
US (1) US7951370B2 (enExample)
EP (1) EP2268672A1 (enExample)
JP (1) JP2011516041A (enExample)
KR (1) KR101203777B1 (enExample)
CN (1) CN101970500B (enExample)
AR (1) AR070821A1 (enExample)
AU (1) AU2009222998B2 (enExample)
BR (1) BRPI0909633A2 (enExample)
CA (1) CA2718289A1 (enExample)
CL (1) CL2009000567A1 (enExample)
EA (1) EA019517B1 (enExample)
IL (1) IL207581A0 (enExample)
MX (1) MX2010010021A (enExample)
NZ (1) NZ587305A (enExample)
PE (1) PE20091679A1 (enExample)
TW (1) TWI384997B (enExample)
UA (1) UA99339C2 (enExample)
WO (1) WO2009114585A1 (enExample)
ZA (1) ZA201006099B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
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KR101163295B1 (ko) * 2007-06-29 2012-07-05 에프. 호프만-라 로슈 아게 향상된 면역글로불린을 생산하는 중쇄 돌연변이체
JP6464436B2 (ja) 2014-02-07 2019-02-06 アジュ ユニバーシティー インダストリー−アカデミック コーオペレイション ファウンデーションＡｊｏｕ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎｄｕｓｔｒｙ−Ａｃａｄｅｍｉｃ Ｃｏｏｐｅｒａｔｉｏｎ Ｆｏｕｎｄａｔｉｏｎ 受容体共役タンパク質キナーゼ−３（ｒｉｐ３）発現促進剤を有効成分として含む抗癌補助用組成物、受容体共役タンパク質キナーゼ−３（ｒｉｐ３）の発現を促して抗癌剤感受性を増進させる抗癌補助剤のスクリーニング方法及び抗癌剤感受性のモニターリング方法
EP3233907B1 (en) 2014-12-19 2021-03-03 Genmab A/S Rodent bispecific heterodimeric proteins
RU2630647C1 (ru) * 2016-05-27 2017-09-11 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К КОНФОРМАЦИОННОМУ ЭПИТОПУ С3 КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА, ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), И ШТАММ КЛЕТОК ЯИЧНИКОВ КИТАЙСКОГО ХОМЯЧКА CHO-humC34-ПРОДУЦЕНТ ДАННОГО ГУМАНИЗИРОВАННОГО АНТИТЕЛА
GB201613167D0 (en) 2016-07-29 2016-09-14 Univ Southampton Cancer and b-cell related disease therapy
WO2018075586A1 (en) * 2016-10-18 2018-04-26 Memorial Sloan-Kettering Cancer Center Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof
KR20200021074A (ko) * 2017-06-14 2020-02-27 아디셋 바이오, 인크. Hla 제한된 방식으로 hla-a2/tyrd를 결합할 수 있는 항체 및 이의 용도
RU2687609C1 (ru) * 2018-05-30 2019-05-15 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства Гуманизированное антитело к конформационному эпитопу сз компонента комплемента человека
SG11202102781UA (en) 2018-09-27 2021-04-29 Autolus Ltd Chimeric antigen receptor
JP7440509B2 (ja) 2018-11-09 2024-02-28 ベス イスラエル デアコネス メディカル センター Ｃｄｃｐ１－標的化療法
SG11202102859TA (en) 2018-12-21 2021-04-29 Hoffmann La Roche Antibodies binding to cd3
US20230049954A1 (en) * 2019-09-06 2023-02-16 The Regents Of The University Of California Chimeric antigen receptors and related methods and compositions for the treatment of cancer
EP4121454A1 (en) * 2020-03-19 2023-01-25 Imperial College Innovations Limited Coronavirus antibody
CN118284625A (zh) * 2021-11-26 2024-07-02 豪夫迈·罗氏有限公司 抗tyrp1/抗cd3双特异性抗体与tyrp1特异性抗体的组合疗法
AU2024381207A1 (en) 2023-11-17 2026-05-14 Institut National de la Santé et de la Recherche Médicale Antineoplastic combinations
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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Also Published As

Publication number Publication date
TW200944232A (en) 2009-11-01
US7951370B2 (en) 2011-05-31
PE20091679A1 (es) 2009-11-04
AU2009222998A1 (en) 2009-09-17
AU2009222998B2 (en) 2013-05-23
JP2011516041A (ja) 2011-05-26
IL207581A0 (en) 2010-12-30
WO2009114585A1 (en) 2009-09-17
CN101970500A (zh) 2011-02-09
AR070821A1 (es) 2010-05-05
EP2268672A1 (en) 2011-01-05
KR20100113631A (ko) 2010-10-21
ZA201006099B (en) 2012-01-25
KR101203777B1 (ko) 2012-11-21
NZ587305A (en) 2012-05-25
CL2009000567A1 (es) 2010-02-26
MX2010010021A (es) 2011-02-15
BRPI0909633A2 (pt) 2015-09-22
EA019517B1 (ru) 2014-04-30
US20090232823A1 (en) 2009-09-17
CA2718289A1 (en) 2009-09-17
UA99339C2 (ru) 2012-08-10
CN101970500B (zh) 2013-08-14
EA201071068A1 (ru) 2011-04-29

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