TWI384997B - 抗酪胺酸酶相關蛋白-１（ｔｙｒｐ１）抗體 - Google Patents
抗酪胺酸酶相關蛋白-１（ｔｙｒｐ１）抗體 Download PDFInfo
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- TWI384997B TWI384997B TW098107909A TW98107909A TWI384997B TW I384997 B TWI384997 B TW I384997B TW 098107909 A TW098107909 A TW 098107909A TW 98107909 A TW98107909 A TW 98107909A TW I384997 B TWI384997 B TW I384997B
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
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- Mycology (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
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| US6919908P | 2008-03-12 | 2008-03-12 |
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| TW200944232A TW200944232A (en) | 2009-11-01 |
| TWI384997B true TWI384997B (zh) | 2013-02-11 |
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| TW098107909A TWI384997B (zh) | 2008-03-12 | 2009-03-11 | 抗酪胺酸酶相關蛋白-１（ｔｙｒｐ１）抗體 |
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| EP (1) | EP2268672A1 (enExample) |
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| BR (1) | BRPI0909633A2 (enExample) |
| CA (1) | CA2718289A1 (enExample) |
| CL (1) | CL2009000567A1 (enExample) |
| EA (1) | EA019517B1 (enExample) |
| IL (1) | IL207581A0 (enExample) |
| MX (1) | MX2010010021A (enExample) |
| NZ (1) | NZ587305A (enExample) |
| PE (1) | PE20091679A1 (enExample) |
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| EP2167540B1 (en) * | 2007-06-29 | 2018-02-14 | F. Hoffmann-La Roche AG | Heavy chain mutant leading to improved immunoglobulin production |
| MX2016010177A (es) | 2014-02-07 | 2017-01-09 | Dong Wha Pharm Co Ltd | Composicion adyuvante anticancerosa que contiene promotor de la expresion de rip3 como principio activo, metodo para la deteccion de adyuvante anticanceroso que potencia la sensibilidad al farmaco anticanceroso mediante la estimulacion de la expresion de rip3 y metodo para controlar la sensibilidad del farmaco anticanceroso. |
| DK3233907T3 (da) | 2014-12-19 | 2021-06-07 | Genmab As | Bispecifikke heterodimeriske proteiner hos gnavere |
| RU2630647C1 (ru) * | 2016-05-27 | 2017-09-11 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К КОНФОРМАЦИОННОМУ ЭПИТОПУ С3 КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА, ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), И ШТАММ КЛЕТОК ЯИЧНИКОВ КИТАЙСКОГО ХОМЯЧКА CHO-humC34-ПРОДУЦЕНТ ДАННОГО ГУМАНИЗИРОВАННОГО АНТИТЕЛА |
| GB201613167D0 (en) | 2016-07-29 | 2016-09-14 | Univ Southampton | Cancer and b-cell related disease therapy |
| WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
| MX2019015053A (es) * | 2017-06-14 | 2020-02-13 | Adicet Bio Inc | Anticuerpos capaces de unirse a hla-a2/tyrd de forma restringida por hla y usos de estos. |
| RU2687609C1 (ru) * | 2018-05-30 | 2019-05-15 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Гуманизированное антитело к конформационному эпитопу сз компонента комплемента человека |
| EP3856775B9 (en) | 2018-09-27 | 2025-01-22 | Autolus Limited | Chimeric antigen receptor |
| EP3876988A4 (en) * | 2018-11-09 | 2022-11-09 | Beth Israel Deaconess Medical Center | THERAPIES TARGETED AGAINST CDCP1 |
| TWI881476B (zh) * | 2018-12-21 | 2025-04-21 | 瑞士商赫孚孟拉羅股份公司 | 結合cd3之抗體 |
| CN114765980A (zh) * | 2019-09-06 | 2022-07-19 | 加利福尼亚大学董事会 | 用于治疗癌症的嵌合抗原受体及相关方法和组合物 |
| WO2023094569A1 (en) * | 2021-11-26 | 2023-06-01 | F. Hoffmann-La Roche Ag | Combination therapy of anti-tyrp1/anti-cd3 bispecific antibodies and tyrp1-specific antibodies |
| WO2025104289A1 (en) | 2023-11-17 | 2025-05-22 | Medincell S.A. | Antineoplastic combinations |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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|---|---|
| CL2009000567A1 (es) | 2010-02-26 |
| KR20100113631A (ko) | 2010-10-21 |
| UA99339C2 (ru) | 2012-08-10 |
| CN101970500A (zh) | 2011-02-09 |
| AU2009222998B2 (en) | 2013-05-23 |
| KR101203777B1 (ko) | 2012-11-21 |
| AR070821A1 (es) | 2010-05-05 |
| NZ587305A (en) | 2012-05-25 |
| EA019517B1 (ru) | 2014-04-30 |
| EP2268672A1 (en) | 2011-01-05 |
| AU2009222998A1 (en) | 2009-09-17 |
| IL207581A0 (en) | 2010-12-30 |
| MX2010010021A (es) | 2011-02-15 |
| US7951370B2 (en) | 2011-05-31 |
| CN101970500B (zh) | 2013-08-14 |
| US20090232823A1 (en) | 2009-09-17 |
| JP2011516041A (ja) | 2011-05-26 |
| CA2718289A1 (en) | 2009-09-17 |
| EA201071068A1 (ru) | 2011-04-29 |
| BRPI0909633A2 (pt) | 2015-09-22 |
| PE20091679A1 (es) | 2009-11-04 |
| WO2009114585A1 (en) | 2009-09-17 |
| TW200944232A (en) | 2009-11-01 |
| ZA201006099B (en) | 2012-01-25 |
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