JP2011516041A5 - - Google Patents
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- JP2011516041A5 JP2011516041A5 JP2010550830A JP2010550830A JP2011516041A5 JP 2011516041 A5 JP2011516041 A5 JP 2011516041A5 JP 2010550830 A JP2010550830 A JP 2010550830A JP 2010550830 A JP2010550830 A JP 2010550830A JP 2011516041 A5 JP2011516041 A5 JP 2011516041A5
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- antibody
- antibodies
- seq
- tyrp1
- human
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6919908P | 2008-03-12 | 2008-03-12 | |
| US61/069,199 | 2008-03-12 | ||
| PCT/US2009/036739 WO2009114585A1 (en) | 2008-03-12 | 2009-03-11 | Anti-tyrp1 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011516041A JP2011516041A (ja) | 2011-05-26 |
| JP2011516041A5 true JP2011516041A5 (enExample) | 2014-03-06 |
Family
ID=40790741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010550830A Pending JP2011516041A (ja) | 2008-03-12 | 2009-03-11 | 抗ｔｙｒｐ１抗体 |
Country Status (19)
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Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2167540B1 (en) * | 2007-06-29 | 2018-02-14 | F. Hoffmann-La Roche AG | Heavy chain mutant leading to improved immunoglobulin production |
| MX2016010177A (es) | 2014-02-07 | 2017-01-09 | Dong Wha Pharm Co Ltd | Composicion adyuvante anticancerosa que contiene promotor de la expresion de rip3 como principio activo, metodo para la deteccion de adyuvante anticanceroso que potencia la sensibilidad al farmaco anticanceroso mediante la estimulacion de la expresion de rip3 y metodo para controlar la sensibilidad del farmaco anticanceroso. |
| DK3233907T3 (da) | 2014-12-19 | 2021-06-07 | Genmab As | Bispecifikke heterodimeriske proteiner hos gnavere |
| RU2630647C1 (ru) * | 2016-05-27 | 2017-09-11 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К КОНФОРМАЦИОННОМУ ЭПИТОПУ С3 КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА, ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), И ШТАММ КЛЕТОК ЯИЧНИКОВ КИТАЙСКОГО ХОМЯЧКА CHO-humC34-ПРОДУЦЕНТ ДАННОГО ГУМАНИЗИРОВАННОГО АНТИТЕЛА |
| GB201613167D0 (en) | 2016-07-29 | 2016-09-14 | Univ Southampton | Cancer and b-cell related disease therapy |
| WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
| MX2019015053A (es) * | 2017-06-14 | 2020-02-13 | Adicet Bio Inc | Anticuerpos capaces de unirse a hla-a2/tyrd de forma restringida por hla y usos de estos. |
| RU2687609C1 (ru) * | 2018-05-30 | 2019-05-15 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Гуманизированное антитело к конформационному эпитопу сз компонента комплемента человека |
| EP3856775B9 (en) | 2018-09-27 | 2025-01-22 | Autolus Limited | Chimeric antigen receptor |
| EP3876988A4 (en) * | 2018-11-09 | 2022-11-09 | Beth Israel Deaconess Medical Center | THERAPIES TARGETED AGAINST CDCP1 |
| TWI881476B (zh) * | 2018-12-21 | 2025-04-21 | 瑞士商赫孚孟拉羅股份公司 | 結合cd3之抗體 |
| CN114765980A (zh) * | 2019-09-06 | 2022-07-19 | 加利福尼亚大学董事会 | 用于治疗癌症的嵌合抗原受体及相关方法和组合物 |
| WO2023094569A1 (en) * | 2021-11-26 | 2023-06-01 | F. Hoffmann-La Roche Ag | Combination therapy of anti-tyrp1/anti-cd3 bispecific antibodies and tyrp1-specific antibodies |
| WO2025104289A1 (en) | 2023-11-17 | 2025-05-22 | Medincell S.A. | Antineoplastic combinations |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4798790A (en) | 1985-07-18 | 1989-01-17 | Sloan-Kettering Institute | Monoclonal antibody specific for a pigmentation associated antigen |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3853515T3 (de) | 1987-05-21 | 2005-08-25 | Micromet Ag | Multifunktionelle proteine mit vorbestimmter zielsetzung. |
| IL89489A0 (en) | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
| EP0362371A4 (en) | 1988-04-15 | 1990-10-24 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
| ATE119198T1 (de) | 1988-04-16 | 1995-03-15 | Celltech Ltd | Verfahren zur herstellung von proteinen mittels rekombinanter dna. |
| IE910820A1 (en) | 1990-03-22 | 1991-09-25 | Sloan Kettering Inst Cancer | Gp75 as a tumor vaccine for melanoma |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
| AU6171196A (en) * | 1995-06-07 | 1996-12-30 | Sloan-Kettering Institute For Cancer Research | Therapeutic uses of ta99 |
| US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
| BR9815289A (pt) * | 1997-11-14 | 2001-12-26 | Euro Celtique Sa | Imunoglobulina modificada, molécula, ácidonucleico isolado, célula contendo o mesmo, animalnão-humano recombinante, composiçãofarmacêutica, composição de vacina, processospara identificar ou medir ou detectar um antìgenode câncer, um antìgeno de um agente de doençainfecciosa, um ligante, e um receptor em umaamostra a ser testada, kits para detecção de umantìgeno de câncer, de um antìgeno de um agentede doença infecciosa, de um receptor celular paraum agente de doença infecciosa, de um ligante, e deum antìgeno de câncer, processos de diagnósticoou de exame para a presença de ou umapredisposição para desenvolvimento de um câncertipificado pela presença aumentada de umantìgeno de câncer, e para a presença de umagente de doença infecciosa, processos detratamento ou de prevenção de um câncertipificado pela presença de um antìgeno de câncer,de uma doença infecciosa tipificada pela presençade um antìgeno de agente de doença infecciosa, ede uma doença causada por um agente de doençainfecciosa que se liga em um receptor celular,processos para modulação de atividade de umprimeiro membro de um par de ligação, processo deprodução de uma imunoglobulina modificada,processo de produção de um ácido nucleicocodificador de imunoglobulina modificada, e, ácidonucleico isolado |
| NZ522847A (en) * | 2000-05-16 | 2004-11-26 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| WO2006047340A2 (en) * | 2004-10-22 | 2006-05-04 | Amgen Inc. | Methods for refolding of recombinant antibodies |
-
2009
- 2009-03-11 NZ NZ587305A patent/NZ587305A/en not_active IP Right Cessation
- 2009-03-11 KR KR1020107020296A patent/KR101203777B1/ko not_active Expired - Fee Related
- 2009-03-11 PE PE2009000356A patent/PE20091679A1/es not_active Application Discontinuation
- 2009-03-11 MX MX2010010021A patent/MX2010010021A/es active IP Right Grant
- 2009-03-11 CL CL2009000567A patent/CL2009000567A1/es unknown
- 2009-03-11 JP JP2010550830A patent/JP2011516041A/ja active Pending
- 2009-03-11 BR BRPI0909633A patent/BRPI0909633A2/pt not_active IP Right Cessation
- 2009-03-11 WO PCT/US2009/036739 patent/WO2009114585A1/en not_active Ceased
- 2009-03-11 CN CN2009801085150A patent/CN101970500B/zh not_active Expired - Fee Related
- 2009-03-11 UA UAA201010912A patent/UA99339C2/ru unknown
- 2009-03-11 AU AU2009222998A patent/AU2009222998B2/en not_active Ceased
- 2009-03-11 CA CA2718289A patent/CA2718289A1/en not_active Abandoned
- 2009-03-11 TW TW098107909A patent/TWI384997B/zh not_active IP Right Cessation
- 2009-03-11 US US12/401,800 patent/US7951370B2/en not_active Expired - Fee Related
- 2009-03-11 AR ARP090100858A patent/AR070821A1/es not_active Application Discontinuation
- 2009-03-11 EA EA201071068A patent/EA019517B1/ru not_active IP Right Cessation
- 2009-03-11 EP EP09719438A patent/EP2268672A1/en not_active Withdrawn
-
2010
- 2010-08-12 IL IL207581A patent/IL207581A0/en unknown
- 2010-08-26 ZA ZA2010/06099A patent/ZA201006099B/en unknown
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