MX2016010177A - Composicion adyuvante anticancerosa que contiene promotor de la expresion de rip3 como principio activo, metodo para la deteccion de adyuvante anticanceroso que potencia la sensibilidad al farmaco anticanceroso mediante la estimulacion de la expresion de rip3 y metodo para controlar la sensibilidad del farmaco anticanceroso. - Google Patents
Composicion adyuvante anticancerosa que contiene promotor de la expresion de rip3 como principio activo, metodo para la deteccion de adyuvante anticanceroso que potencia la sensibilidad al farmaco anticanceroso mediante la estimulacion de la expresion de rip3 y metodo para controlar la sensibilidad del farmaco anticanceroso.Info
- Publication number
- MX2016010177A MX2016010177A MX2016010177A MX2016010177A MX2016010177A MX 2016010177 A MX2016010177 A MX 2016010177A MX 2016010177 A MX2016010177 A MX 2016010177A MX 2016010177 A MX2016010177 A MX 2016010177A MX 2016010177 A MX2016010177 A MX 2016010177A
- Authority
- MX
- Mexico
- Prior art keywords
- rip3
- sensitivity
- anticancer drug
- anticancer
- expression
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
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- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
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Abstract
La presente invención se refiere a una composición farmacéutica para un adyuvante anticanceroso que contiene, como principio activo, un agente inductor o un activador de la expresión de la proteína quinasa 3 de interacción con receptor (RIP3). La presente invención también proporciona un método para potenciar la muerte de células cancerosas un agente inductor o un activador de la expresión de RIP3 en combinación con un fármaco anticanceroso. Adicionalmente, la presente invención se refiere a un método para detectar un adyuvante anticanceroso que potencia la sensibilidad al fármaco anticanceroso mediante la estimulación de la expresión de RIP3 y a un método de seguimiento de la sensibilidad a fármacos anticancerosos basado en la expresión de RIP3. Por lo tanto, en el caso de los pacientes que carecen de expresión de RIP3, el uso de un agente quimioterapéutico convencional después de la inducción de la expresión de RIP3 mediante tratamiento previo con un agente de desmetilación puede ser una estrategia terapéutica eficaz. Asimismo, cabe esperar que el seguimiento de la sensibilidad al fármaco anticanceroso y la detección de un adyuvante anticanceroso que potencia la sensibilidad al fármaco anticanceroso en la terapia contra el cáncer puede ser una estrategia eficaz.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20140014242 | 2014-02-07 | ||
KR20140014243 | 2014-02-07 | ||
KR1020140164963A KR101721407B1 (ko) | 2014-02-07 | 2014-11-25 | Rip3 발현을 촉진하여 항암제 감수성을 증진시키는 항암 보조제 스크리닝 방법 및 항암제 감수성 모니터링 방법 |
PCT/KR2014/011376 WO2015119362A1 (ko) | 2014-02-07 | 2014-11-25 | Rip3 발현촉진제를 유효성분으로 포함하는 항암보조용 조성물, rip3 발현을 촉진하여 항암제 감수성을 증진시키는 항암 보조제 스크리닝 방법 및 항암제 감수성 모니터링 방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016010177A true MX2016010177A (es) | 2017-01-09 |
Family
ID=56684818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016010177A MX2016010177A (es) | 2014-02-07 | 2014-11-25 | Composicion adyuvante anticancerosa que contiene promotor de la expresion de rip3 como principio activo, metodo para la deteccion de adyuvante anticanceroso que potencia la sensibilidad al farmaco anticanceroso mediante la estimulacion de la expresion de rip3 y metodo para controlar la sensibilidad del farmaco anticanceroso. |
Country Status (14)
Country | Link |
---|---|
US (1) | US10391115B2 (es) |
EP (1) | EP3103475B1 (es) |
JP (1) | JP6464436B2 (es) |
CN (1) | CN106132435B (es) |
AU (1) | AU2014382143B2 (es) |
CA (1) | CA2938821A1 (es) |
CL (1) | CL2016001965A1 (es) |
HK (1) | HK1225960A1 (es) |
IL (1) | IL247120A0 (es) |
MX (1) | MX2016010177A (es) |
NZ (1) | NZ723237A (es) |
PH (1) | PH12016501554A1 (es) |
RU (1) | RU2016135933A (es) |
SG (1) | SG11201606439VA (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3529268A1 (en) | 2016-10-19 | 2019-08-28 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
CN107164411A (zh) * | 2017-06-29 | 2017-09-15 | 中国农业科学院兰州兽医研究所 | 一种程序性坏死诱导系统的建立方法 |
CN111154807B (zh) * | 2020-01-17 | 2023-03-24 | 山东农业大学 | 一种分泌型的崂山奶山羊乳腺上皮细胞系的构建方法 |
CN113122538A (zh) * | 2021-04-15 | 2021-07-16 | 遵义医科大学附属医院 | 一种靶向敲减Rip3基因表达的shRNA、重组载体及其应用 |
CN113834937B (zh) * | 2021-08-24 | 2022-06-03 | 中日友好医院(中日友好临床医学研究所) | 一组区分特发性炎性肌病的诊断标记物 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10013029A1 (de) | 2000-03-17 | 2001-09-20 | Roehm Gmbh | Mehrschichtige Arzneiform für die Colonfreigabe |
US6613753B2 (en) * | 2001-02-21 | 2003-09-02 | Supergen, Inc. | Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation |
EP1762575A1 (en) | 2005-09-12 | 2007-03-14 | Ganymed Pharmaceuticals AG | Identification of tumor-associated antigens for diagnosis and therapy |
EP2163563A1 (en) | 2006-03-31 | 2010-03-17 | Massachusetts Institute of Technology | Treatment of tumors expressing mutant EGF receptors |
EP1961825A1 (en) * | 2007-02-26 | 2008-08-27 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Method for predicting the occurrence of metastasis in breast cancer patients |
CA2679497A1 (en) * | 2007-03-09 | 2008-09-18 | The University Of British Columbia | Diagnostic and therapeutic aspects of sparc promoter hypermethylation in colon cancer |
US20090162434A1 (en) | 2007-12-21 | 2009-06-25 | Disphar International Bv | Mesalazine tablet |
NZ586972A (en) * | 2008-01-31 | 2012-03-30 | Univ Keio | Method for determination of sensitivity to anti-cancer agent |
CA2718289A1 (en) | 2008-03-12 | 2009-09-17 | Imclone Llc | Anti-tyrp1 antibodies |
US7622106B1 (en) | 2009-03-06 | 2009-11-24 | Board Of Regents, The University Of Texas System | Necrosis assay |
US20110042247A1 (en) | 2009-06-25 | 2011-02-24 | Chandrasekhar Kocherlakota | Formulations of azacitidine and its derivatives |
WO2011028660A1 (en) * | 2009-09-01 | 2011-03-10 | Trustees Of Dartmouth College | Compositions for inhibiting growth of cancer stem cells |
US20130237445A1 (en) * | 2010-09-14 | 2013-09-12 | The University Of North Carolina At Chapel Hill | Methods and kits for detecting melanoma |
BR112013014195A2 (pt) | 2010-12-09 | 2017-08-15 | Hoffmann La Roche | Método para a identificação de um paciente, composição, uso de bevacizumabe para a preparação de uma composição farmacêutica, método para o tratamento de um distúrbio proliferativo e composição, uso ou método |
CN102319218B (zh) | 2011-09-22 | 2014-10-01 | 贝沃特医药技术(上海)有限公司 | 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法 |
CN104159611A (zh) | 2012-02-22 | 2014-11-19 | 阿莱斯亚生物疗法股份有限公司 | 共使用簇集蛋白抑制剂和egfr抑制剂以治疗癌症 |
CN103417982A (zh) | 2012-05-16 | 2013-12-04 | 上海市肿瘤研究所 | 人源性长寿保障基因2在制备提高乳腺癌细胞对抗癌药物的敏感性的药物中的用途 |
-
2014
- 2014-11-25 CA CA2938821A patent/CA2938821A1/en not_active Abandoned
- 2014-11-25 JP JP2016568771A patent/JP6464436B2/ja active Active
- 2014-11-25 NZ NZ723237A patent/NZ723237A/en not_active IP Right Cessation
- 2014-11-25 AU AU2014382143A patent/AU2014382143B2/en not_active Ceased
- 2014-11-25 RU RU2016135933A patent/RU2016135933A/ru not_active Application Discontinuation
- 2014-11-25 US US15/116,591 patent/US10391115B2/en active Active
- 2014-11-25 SG SG11201606439VA patent/SG11201606439VA/en unknown
- 2014-11-25 EP EP14882054.1A patent/EP3103475B1/en active Active
- 2014-11-25 CN CN201480077473.XA patent/CN106132435B/zh active Active
- 2014-11-25 MX MX2016010177A patent/MX2016010177A/es unknown
-
2016
- 2016-08-04 CL CL2016001965A patent/CL2016001965A1/es unknown
- 2016-08-04 IL IL247120A patent/IL247120A0/en unknown
- 2016-08-05 PH PH12016501554A patent/PH12016501554A1/en unknown
- 2016-12-14 HK HK16114238A patent/HK1225960A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN106132435B (zh) | 2021-08-27 |
AU2014382143A1 (en) | 2016-09-01 |
RU2016135933A (ru) | 2018-03-15 |
JP2017511812A (ja) | 2017-04-27 |
US20160346307A1 (en) | 2016-12-01 |
IL247120A0 (en) | 2016-09-29 |
AU2014382143B2 (en) | 2018-02-08 |
NZ723237A (en) | 2018-02-23 |
SG11201606439VA (en) | 2016-09-29 |
CA2938821A1 (en) | 2015-08-13 |
JP6464436B2 (ja) | 2019-02-06 |
CL2016001965A1 (es) | 2017-03-17 |
PH12016501554A1 (en) | 2016-09-14 |
HK1225960A1 (zh) | 2017-09-22 |
EP3103475A1 (en) | 2016-12-14 |
RU2016135933A3 (es) | 2018-03-15 |
CN106132435A (zh) | 2016-11-16 |
EP3103475B1 (en) | 2020-08-12 |
EP3103475A4 (en) | 2017-07-12 |
US10391115B2 (en) | 2019-08-27 |
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