HK1225960A1 - 含有rip3表達促進劑作為活性成分的抗癌輔劑組合物、篩選通過促進rip3表達增强抗癌藥物的敏感性的抗癌輔劑的方法和監測抗癌藥物的敏感性的方法 - Google Patents

含有rip3表達促進劑作為活性成分的抗癌輔劑組合物、篩選通過促進rip3表達增强抗癌藥物的敏感性的抗癌輔劑的方法和監測抗癌藥物的敏感性的方法

Info

Publication number
HK1225960A1
HK1225960A1 HK16114238A HK16114238A HK1225960A1 HK 1225960 A1 HK1225960 A1 HK 1225960A1 HK 16114238 A HK16114238 A HK 16114238A HK 16114238 A HK16114238 A HK 16114238A HK 1225960 A1 HK1225960 A1 HK 1225960A1
Authority
HK
Hong Kong
Prior art keywords
anticancer
sensitivity
rip3 expression
anticancer drug
screening
Prior art date
Application number
HK16114238A
Other languages
English (en)
Inventor
You Sun Kim
Gi Bang Koo
Jung Ho Yun
Woo Jung Kim
Yu Na Jo
Original Assignee
Dong Wha Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020140164963A external-priority patent/KR101721407B1/ko
Application filed by Dong Wha Pharm Co Ltd filed Critical Dong Wha Pharm Co Ltd
Publication of HK1225960A1 publication Critical patent/HK1225960A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
HK16114238A 2014-02-07 2016-12-14 含有rip3表達促進劑作為活性成分的抗癌輔劑組合物、篩選通過促進rip3表達增强抗癌藥物的敏感性的抗癌輔劑的方法和監測抗癌藥物的敏感性的方法 HK1225960A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20140014242 2014-02-07
KR20140014243 2014-02-07
KR1020140164963A KR101721407B1 (ko) 2014-02-07 2014-11-25 Rip3 발현을 촉진하여 항암제 감수성을 증진시키는 항암 보조제 스크리닝 방법 및 항암제 감수성 모니터링 방법

Publications (1)

Publication Number Publication Date
HK1225960A1 true HK1225960A1 (zh) 2017-09-22

Family

ID=56684818

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16114238A HK1225960A1 (zh) 2014-02-07 2016-12-14 含有rip3表達促進劑作為活性成分的抗癌輔劑組合物、篩選通過促進rip3表達增强抗癌藥物的敏感性的抗癌輔劑的方法和監測抗癌藥物的敏感性的方法

Country Status (14)

Country Link
US (1) US10391115B2 (zh)
EP (1) EP3103475B1 (zh)
JP (1) JP6464436B2 (zh)
CN (1) CN106132435B (zh)
AU (1) AU2014382143B2 (zh)
CA (1) CA2938821A1 (zh)
CL (1) CL2016001965A1 (zh)
HK (1) HK1225960A1 (zh)
IL (1) IL247120A0 (zh)
MX (1) MX2016010177A (zh)
NZ (1) NZ723237A (zh)
PH (1) PH12016501554A1 (zh)
RU (1) RU2016135933A (zh)
SG (1) SG11201606439VA (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3529268A1 (en) 2016-10-19 2019-08-28 The Scripps Research Institute Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof
CN107164411A (zh) * 2017-06-29 2017-09-15 中国农业科学院兰州兽医研究所 一种程序性坏死诱导系统的建立方法
CN111154807B (zh) * 2020-01-17 2023-03-24 山东农业大学 一种分泌型的崂山奶山羊乳腺上皮细胞系的构建方法
CN113122538A (zh) * 2021-04-15 2021-07-16 遵义医科大学附属医院 一种靶向敲减Rip3基因表达的shRNA、重组载体及其应用
CN113834937B (zh) * 2021-08-24 2022-06-03 中日友好医院(中日友好临床医学研究所) 一组区分特发性炎性肌病的诊断标记物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10013029A1 (de) 2000-03-17 2001-09-20 Roehm Gmbh Mehrschichtige Arzneiform für die Colonfreigabe
US6613753B2 (en) 2001-02-21 2003-09-02 Supergen, Inc. Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation
EP1762575A1 (en) 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identification of tumor-associated antigens for diagnosis and therapy
CA2647671A1 (en) 2006-03-31 2007-11-01 Massachusetts Institute Of Technology Treatment of tumors expressing mutant egf receptors
EP1961825A1 (en) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Method for predicting the occurrence of metastasis in breast cancer patients
AU2008226283A1 (en) * 2007-03-09 2008-09-18 The University Of British Columbia Assessing chemotherapy resistance of colorectal tumors by determining sparc hypermethylation
US20090162434A1 (en) 2007-12-21 2009-06-25 Disphar International Bv Mesalazine tablet
WO2009096196A1 (ja) 2008-01-31 2009-08-06 Keio University 抗がん剤感受性の判定方法
US7951370B2 (en) 2008-03-12 2011-05-31 Imclone Llc Anti-TYRP1 antibodies
US7622106B1 (en) 2009-03-06 2009-11-24 Board Of Regents, The University Of Texas System Necrosis assay
US20110042247A1 (en) 2009-06-25 2011-02-24 Chandrasekhar Kocherlakota Formulations of azacitidine and its derivatives
WO2011028660A1 (en) * 2009-09-01 2011-03-10 Trustees Of Dartmouth College Compositions for inhibiting growth of cancer stem cells
US20130237445A1 (en) * 2010-09-14 2013-09-12 The University Of North Carolina At Chapel Hill Methods and kits for detecting melanoma
KR20130124961A (ko) 2010-12-09 2013-11-15 에프. 호프만-라 로슈 아게 베바시주맙 병용 치료를 위한 마커로서의 agtr1
CN102319218B (zh) 2011-09-22 2014-10-01 贝沃特医药技术(上海)有限公司 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法
US9822170B2 (en) 2012-02-22 2017-11-21 Alethia Biotherapeutics Inc. Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer
CN103417982A (zh) * 2012-05-16 2013-12-04 上海市肿瘤研究所 人源性长寿保障基因2在制备提高乳腺癌细胞对抗癌药物的敏感性的药物中的用途

Also Published As

Publication number Publication date
JP6464436B2 (ja) 2019-02-06
AU2014382143B2 (en) 2018-02-08
CN106132435B (zh) 2021-08-27
EP3103475B1 (en) 2020-08-12
PH12016501554A1 (en) 2016-09-14
SG11201606439VA (en) 2016-09-29
IL247120A0 (en) 2016-09-29
AU2014382143A1 (en) 2016-09-01
MX2016010177A (es) 2017-01-09
RU2016135933A3 (zh) 2018-03-15
JP2017511812A (ja) 2017-04-27
US10391115B2 (en) 2019-08-27
CA2938821A1 (en) 2015-08-13
EP3103475A4 (en) 2017-07-12
EP3103475A1 (en) 2016-12-14
NZ723237A (en) 2018-02-23
CL2016001965A1 (es) 2017-03-17
CN106132435A (zh) 2016-11-16
US20160346307A1 (en) 2016-12-01
RU2016135933A (ru) 2018-03-15

Similar Documents

Publication Publication Date Title
HK1244803A1 (zh) 作為抗癌藥物的取代的2-氫-吡唑衍生物
IL247062A0 (en) Heterocyclic compounds, their preparation and pharmaceutical preparations containing them
HK1232229A1 (zh) '- '-硫代核苷的新型化合物及其製備方法、藥物組合物和應用
HK1225960A1 (zh) 含有rip3表達促進劑作為活性成分的抗癌輔劑組合物、篩選通過促進rip3表達增强抗癌藥物的敏感性的抗癌輔劑的方法和監測抗癌藥物的敏感性的方法
ZA201703112B (en) Substituted benzothiophenyl derivatives as gpr40 agonists for the treatment of type ii diabetes
HUE048569T2 (hu) Hatóanyagként donepezilt tartalmazó transzdermális készítmény
ZA201608442B (en) Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
SG11201705194XA (en) Pharmaceutical composition for treating diabetes
EP3229791A4 (en) Novel polymorphs of ivacaftor, process for its preparation and pharmaceutical composition thereof
SG11201610636VA (en) Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor
IL251456A0 (en) Substances with agonist activity for gpr119, processes for their preparation and preparations containing them
PL3110249T3 (pl) Sposób wytwarzania mikrokapsułek biobójczych
ZA201700278B (en) Pharmaceutical composition containing docetaxel
EP3275881A4 (en) Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heterooxy, preparation method thereof and pharmaceutical use thereof
EP3096879A4 (en) Method of preparing epoxidation catalysts
GB2564185B (en) Process for the preparation of derivatives of benzodioxole
EP3159336A4 (en) Crystal of allisartan isoproxil, preparation method therefor and pharmaceutical composition containing same
EP3145507A4 (en) Aza-ellipticine analogs, methods of synthesis and methods of treatment
EP3175851A4 (en) Use of butenylphthalide, usage method thereof and method for preparing same into pharmaceutical composition
EP3150710A4 (en) Method for preparing biobased homoserine lactone hydrochloride and biobased organic acid from microorganism-derived o-acyl homoserine
ZA201701714B (en) Anthostema senegalense-based composition, for use as an anti-aids drug
FI20146104A (fi) Prosessi spirosyklisten substituoitujen bentsofurokinolitsiinien valmistamiseksi
HUE051014T2 (hu) Taxán vegyületet tartalmazó tumorellenes gyógyszer és tumorellenes hatáserõsítõ
IL253055A0 (en) A method for the preparation of certain tetrazoles converted in positions 1 and 5
HUP1500377A2 (hu) A 4-(furan-2-yl)hepta-1,6-dien-4-ol vegyület, mint rákellenes gyógyszer