TWI377209B - Novel n-glucoside derivatives having a sglt inhibitory activity - Google Patents
Novel n-glucoside derivatives having a sglt inhibitory activity Download PDFInfo
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- TWI377209B TWI377209B TW093122844A TW93122844A TWI377209B TW I377209 B TWI377209 B TW I377209B TW 093122844 A TW093122844 A TW 093122844A TW 93122844 A TW93122844 A TW 93122844A TW I377209 B TWI377209 B TW I377209B
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- 125000000217 alkyl group Chemical group 0.000 claims description 114
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Classifications
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
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- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
Landscapes
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- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49152303P | 2003-08-01 | 2003-08-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200510440A TW200510440A (en) | 2005-03-16 |
| TWI377209B true TWI377209B (en) | 2012-11-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093122844A TWI377209B (en) | 2003-08-01 | 2004-07-30 | Novel n-glucoside derivatives having a sglt inhibitory activity |
Country Status (18)
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| EP (1) | EP1654269B1 (enExample) |
| JP (1) | JP4717811B2 (enExample) |
| KR (1) | KR101101500B1 (enExample) |
| CN (2) | CN1829728A (enExample) |
| AU (1) | AU2004260760B2 (enExample) |
| BR (1) | BRPI0413233A (enExample) |
| CA (1) | CA2534022C (enExample) |
| EA (1) | EA011025B1 (enExample) |
| ES (1) | ES2527053T3 (enExample) |
| IL (1) | IL173051A (enExample) |
| MX (1) | MXPA06001273A (enExample) |
| NO (1) | NO333679B1 (enExample) |
| NZ (1) | NZ545305A (enExample) |
| TW (1) | TWI377209B (enExample) |
| UA (5) | UA86042C2 (enExample) |
| WO (1) | WO2005012321A1 (enExample) |
| ZA (2) | ZA200601686B (enExample) |
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| KR100942622B1 (ko) * | 2003-08-01 | 2010-02-17 | 미쓰비시 타나베 파마 코퍼레이션 | 나트륨-의존성 수송체에 대해 저해 활성을 갖는 신규화합물 |
| US8785403B2 (en) | 2003-08-01 | 2014-07-22 | Mitsubishi Tanabe Pharma Corporation | Glucopyranoside compound |
| TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
| AR053329A1 (es) * | 2005-01-31 | 2007-05-02 | Tanabe Seiyaku Co | Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt) |
| TWI365186B (en) | 2005-01-31 | 2012-06-01 | Mitsubishi Tanabe Pharma Corp | Indole derivatives |
| JP5073948B2 (ja) * | 2005-01-31 | 2012-11-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
| TWI418556B (zh) * | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
| TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法 |
| AU2007329490B2 (en) * | 2006-12-04 | 2012-05-17 | Janssen Pharmaceutica N.V. | Thienyl-containing glycopyranosyl derivatives as antidiabetics |
| UY30730A1 (es) * | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
| WO2008109591A1 (en) * | 2007-03-08 | 2008-09-12 | Lexicon Pharmaceuticals, Inc. | Phlorizin analogs as inhibitors of sodium glucose co-transporter 2 |
| WO2009035969A1 (en) | 2007-09-10 | 2009-03-19 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of sglt |
| CL2008003653A1 (es) | 2008-01-17 | 2010-03-05 | Mitsubishi Tanabe Pharma Corp | Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica. |
| EP2668953A1 (en) | 2008-05-22 | 2013-12-04 | Bristol-Myers Squibb Company | Pharmaceutical compositions comprising an SGLT2 inhibitor with a supply of carbohydrate and/or an inhibitor of uric acid synthesis |
| CN102149717B (zh) | 2008-08-28 | 2014-05-14 | 辉瑞大药厂 | 二氧杂-双环[3.2.1]辛烷-2，3，4-三醇衍生物 |
| WO2010031813A1 (en) * | 2008-09-19 | 2010-03-25 | Novartis Ag | Glycoside derivatives and uses thereof |
| US9056850B2 (en) * | 2008-10-17 | 2015-06-16 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of SGLT |
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| EP2451797B1 (en) | 2009-07-10 | 2013-04-03 | Janssen Pharmaceutica, N.V. | CRYSTALLISATION PROCESS FOR 1-(ß-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-FLUOROPHENYL)-2-THIENYLMETHYL]BENZENE |
| WO2011047113A1 (en) * | 2009-10-14 | 2011-04-21 | Janssen Pharmaceutica Nv | Process for the preparation of compounds useful as inhibitors of sglt2 |
| WO2011051864A1 (en) | 2009-11-02 | 2011-05-05 | Pfizer Inc. | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| MY187718A (en) | 2010-05-11 | 2021-10-14 | Janssen Pharmaceutica Nv | Pharmaceutical formulations |
| CN103596944B (zh) | 2011-04-13 | 2017-02-22 | 詹森药业有限公司 | 可用作sglt2的抑制剂的化合物的制备方法 |
| US9035044B2 (en) | 2011-05-09 | 2015-05-19 | Janssen Pharmaceutica Nv | L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| CN105008379B (zh) * | 2013-02-26 | 2018-06-29 | 田边三菱制药株式会社 | α-卤代四酰基葡萄糖的制造方法 |
| CN103896930B (zh) * | 2014-04-02 | 2016-08-17 | 安徽联创生物医药股份有限公司 | 卡格列净半水合物药用晶型的制备方法 |
| US9695159B2 (en) | 2014-05-27 | 2017-07-04 | Glenmark Pharmaceuticals Limited | Process for preparation of canagliflozin |
| CN104045673B (zh) * | 2014-06-06 | 2017-01-18 | 安徽省食品药品检验研究院 | 双‑三氮唑缀合的假二糖衍生物及其制备方法 |
| CN104478968A (zh) * | 2015-01-14 | 2015-04-01 | 佛山市赛维斯医药科技有限公司 | 含噻唑基的o-半乳糖苷衍生物、其制备方法和用途 |
| CN106188022A (zh) * | 2015-04-30 | 2016-12-07 | 上海医药工业研究院 | 伊格列净的制备方法 |
| US20170071970A1 (en) | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
| MA51203A (fr) | 2017-11-30 | 2020-10-07 | Idorsia Pharmaceuticals Ltd | Combinaison d'un dérivé de 4-pyrimidinesulfamide avec un inhibiteur de sglt-2 pour le traitement de maladies liées à l'endothéline |
| MY210508A (en) | 2018-07-19 | 2025-09-28 | Astrazeneca Ab | Methods of treating hfpef employing dapagliflozin and compositions comprising the same |
| TW202220672A (zh) | 2020-07-27 | 2022-06-01 | 瑞典商阿斯特捷利康公司 | 用達格列淨治療慢性腎臟病之方法 |
| WO2022208172A1 (en) | 2021-04-01 | 2022-10-06 | Astrazeneca Uk Limited | Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition |
| WO2023144722A1 (en) | 2022-01-26 | 2023-08-03 | Astrazeneca Ab | Dapagliflozin for use in the treatment of prediabetes or reducing the risk of developing type 2 diabetes |
| WO2025125513A1 (en) | 2023-12-15 | 2025-06-19 | AstraZeneca Ireland Limited | Sglt2 inhibitors and baxdrostat for treating chronic kidney disease and hypertension |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE1075626B (de) * | 1960-02-18 | Farbwerke Hoechst Aktiengesellschaft vormals Meister Lucius &. Brunmg, Frankfurt/M | Verfahren zur Herstellung von wasserlöslichen chemotherapeutisch wirksamen Glykosiden | |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| HUP0300057A3 (en) | 2000-03-17 | 2003-09-29 | Kissei Pharmaceutical | Glucopyranosyloxy benzylbenzene derivatives, pharmaceutical compositions containing the same and intermediates for the preparation of the derivatives |
| US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| CN1293087C (zh) * | 2000-09-29 | 2007-01-03 | 橘生药品工业株式会社 | 吡喃葡糖氧基苄基苯衍生物及其药物组合物 |
| US7053060B2 (en) * | 2000-11-30 | 2006-05-30 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
| JP4035052B2 (ja) | 2000-12-28 | 2008-01-16 | キッセイ薬品工業株式会社 | グルコピラノシルオキシピラゾール誘導体及びその医薬用途 |
| TWI255817B (en) * | 2001-02-14 | 2006-06-01 | Kissei Pharmaceutical | Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof |
| WO2003020737A1 (en) | 2001-09-05 | 2003-03-13 | Bristol-Myers Squibb Company | O-pyrazole glucoside sglt2 inhibitors and method of use |
| DE102004048388A1 (de) * | 2004-10-01 | 2006-04-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | D-Pyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
-
2004
- 2004-07-29 UA UAA200605348A patent/UA86042C2/ru unknown
- 2004-07-30 UA UAA200605347A patent/UA85569C2/ru unknown
- 2004-07-30 EP EP04771313.6A patent/EP1654269B1/en not_active Expired - Lifetime
- 2004-07-30 WO PCT/JP2004/011311 patent/WO2005012321A1/en not_active Ceased
- 2004-07-30 MX MXPA06001273A patent/MXPA06001273A/es active IP Right Grant
- 2004-07-30 UA UAA200605346A patent/UA87991C2/ru unknown
- 2004-07-30 CN CNA2004800220063A patent/CN1829728A/zh active Pending
- 2004-07-30 TW TW093122844A patent/TWI377209B/zh not_active IP Right Cessation
- 2004-07-30 NZ NZ545305A patent/NZ545305A/en not_active IP Right Cessation
- 2004-07-30 UA UAA200602256A patent/UA83377C2/uk unknown
- 2004-07-30 UA UAA200605349A patent/UA86599C2/ru unknown
- 2004-07-30 KR KR1020067002158A patent/KR101101500B1/ko not_active Expired - Fee Related
- 2004-07-30 CA CA2534022A patent/CA2534022C/en not_active Expired - Fee Related
- 2004-07-30 JP JP2006519250A patent/JP4717811B2/ja not_active Expired - Fee Related
- 2004-07-30 AU AU2004260760A patent/AU2004260760B2/en not_active Ceased
- 2004-07-30 US US10/566,585 patent/US7521430B2/en not_active Expired - Fee Related
- 2004-07-30 EA EA200600348A patent/EA011025B1/ru not_active IP Right Cessation
- 2004-07-30 BR BRPI0413233-5A patent/BRPI0413233A/pt not_active IP Right Cessation
- 2004-07-30 CN CN2010105463425A patent/CN102060888A/zh active Pending
- 2004-07-30 ES ES04771313.6T patent/ES2527053T3/es not_active Expired - Lifetime
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2006
- 2006-01-10 IL IL173051A patent/IL173051A/en not_active IP Right Cessation
- 2006-01-16 NO NO20060219A patent/NO333679B1/no not_active IP Right Cessation
- 2006-02-27 ZA ZA200601686A patent/ZA200601686B/en unknown
- 2006-05-15 ZA ZA200603880A patent/ZA200603880B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| UA86042C2 (en) | 2009-03-25 |
| UA85569C2 (ru) | 2009-02-10 |
| ZA200601686B (en) | 2007-05-30 |
| US20070060545A1 (en) | 2007-03-15 |
| KR20060132539A (ko) | 2006-12-21 |
| KR101101500B1 (ko) | 2012-01-03 |
| EP1654269A1 (en) | 2006-05-10 |
| IL173051A (en) | 2012-06-28 |
| UA87991C2 (en) | 2009-09-10 |
| CA2534022C (en) | 2012-10-02 |
| NO20060219L (no) | 2006-04-28 |
| ZA200603880B (en) | 2010-01-27 |
| EP1654269B1 (en) | 2014-10-15 |
| CA2534022A1 (en) | 2005-02-10 |
| US7521430B2 (en) | 2009-04-21 |
| BRPI0413233A (pt) | 2006-10-03 |
| JP4717811B2 (ja) | 2011-07-06 |
| IL173051A0 (en) | 2006-06-11 |
| NZ545305A (en) | 2008-11-28 |
| UA83377C2 (uk) | 2008-07-10 |
| WO2005012321A1 (en) | 2005-02-10 |
| EA200600348A1 (ru) | 2006-08-25 |
| CN102060888A (zh) | 2011-05-18 |
| NO333679B1 (no) | 2013-08-05 |
| JP2007518682A (ja) | 2007-07-12 |
| AU2004260760A1 (en) | 2005-02-10 |
| ES2527053T3 (es) | 2015-01-20 |
| CN1829728A (zh) | 2006-09-06 |
| TW200510440A (en) | 2005-03-16 |
| UA86599C2 (en) | 2009-05-12 |
| AU2004260760B2 (en) | 2009-08-13 |
| EA011025B1 (ru) | 2008-12-30 |
| MXPA06001273A (es) | 2006-04-11 |
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