TWI375571B - Ophthalmic devices for sustained delivery of active compounds - Google Patents
Ophthalmic devices for sustained delivery of active compounds Download PDFInfo
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- TWI375571B TWI375571B TW095115677A TW95115677A TWI375571B TW I375571 B TWI375571 B TW I375571B TW 095115677 A TW095115677 A TW 095115677A TW 95115677 A TW95115677 A TW 95115677A TW I375571 B TWI375571 B TW I375571B
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- prepolymer
- vinyl
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- poly
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Classifications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00865—Applying coatings; tinting; colouring
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
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- Manufacturing & Machinery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Eyeglasses (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| CA2824301C (en) | 2005-11-25 | 2016-01-12 | Novartis Ag | F, g, h, i and k crystal forms of imatinib mesylate |
| BRPI0718543A2 (pt) * | 2006-11-06 | 2013-11-12 | Novartis Ag | Dispositivos oculares e métodos de fabricação e uso dos mesmos |
| US20080152540A1 (en) * | 2006-12-22 | 2008-06-26 | Bausch & Lomb Incorporated | Packaging solutions |
| JP5643092B2 (ja) | 2007-08-31 | 2014-12-17 | ノバルティス アーゲー | コンタクトレンズのパッケージング溶液 |
| TWI551305B (zh) | 2007-08-31 | 2016-10-01 | 諾華公司 | 相對黏稠封裝溶液之用途 |
| US20090182068A1 (en) * | 2008-01-14 | 2009-07-16 | Yuwen Liu | Polymerizable Contact Lens Formulations and Contact Lenses Obtained Therefrom |
| JP4869274B2 (ja) * | 2008-03-21 | 2012-02-08 | 株式会社メニコン | ソフトコンタクトレンズ包装製品及びソフトコンタクトレンズの包装方法 |
| EP2307189B1 (en) | 2008-07-21 | 2014-06-04 | Novartis AG | Silicone hydrogel contact lenses with convertible comfort agents |
| US20100106128A1 (en) * | 2008-10-23 | 2010-04-29 | Shane Mao | Contact lens cases for delivery of ophthalmic agents |
| TWI506333B (zh) * | 2008-12-05 | 2015-11-01 | Novartis Ag | 用以傳遞疏水性舒適劑之眼用裝置及其製造方法 |
| AU2012268828B2 (en) * | 2008-12-05 | 2013-09-05 | Alcon Inc. | Ophthalmic devices for delivery of hydrophobic comfort agents |
| EP2962682B1 (en) * | 2008-12-11 | 2018-03-28 | Massachusetts Institute Of Technology | Method of making a contact lens drug delivery device |
| CA2753106C (en) * | 2009-02-20 | 2016-09-13 | Seed Co., Ltd. | Hydrogel contact lens for sustained drug release and drug release method using hydrogel contact lens for sustained drug release |
| ES2634551T3 (es) * | 2010-04-03 | 2017-09-28 | Praful Doshi | Métodos para revestir una lente de contacto |
| SG187082A1 (en) | 2010-07-30 | 2013-02-28 | Coopervision Int Holding Co Lp | Ophthalmic device molds formed from vinyl alcohol copolymer, ophthalmic devices molded therein, and related methods |
| SG194955A1 (en) | 2011-06-09 | 2013-12-30 | Novartis Ag | Silicone hydrogel lenses with nano-textured surfaces |
| EP2793851B1 (en) | 2011-12-21 | 2016-04-27 | Novartis AG | Contact lenses containing carotenoid and method for making same |
| US9351827B2 (en) * | 2012-04-03 | 2016-05-31 | Johnson & Johnson Vision Care, Inc. | Lens driver for variable-optic electronic ophthalmic lens |
| US9827250B2 (en) * | 2012-07-31 | 2017-11-28 | Johnson & Johnson Vision Care, Inc. | Lens incorporating myopia control optics and muscarinic agents |
| EP3233450B1 (en) | 2014-12-17 | 2019-01-30 | Novartis AG | Reusable lens molds and methods of use thereof |
| WO2016100457A1 (en) | 2014-12-17 | 2016-06-23 | Novartis Ag | Reusable lens molds and methods of use thereof |
| MY186090A (en) | 2015-12-03 | 2021-06-21 | Alcon Inc | Contact lens packaging solutions |
| HUE063934T2 (hu) | 2015-12-17 | 2024-02-28 | Alcon Inc | Újrahasználható lencseszerszámok, valamint eljárások azok használatára |
| US20180092776A1 (en) | 2016-09-30 | 2018-04-05 | Sara Heikali | Method and device for treating and managing diseased ocular tissue |
| AU2018314280B2 (en) | 2017-08-11 | 2023-07-20 | Rsem, Société En Commandite | Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells |
| JP7518773B2 (ja) * | 2019-02-12 | 2024-07-18 | 株式会社クラレ | ポリマー組成物、ゲル、フィルムおよび粒子 |
| JP7704740B2 (ja) | 2019-09-16 | 2025-07-08 | アムジエン・インコーポレーテツド | 薬物送達デバイスの外部滅菌の方法 |
| KR20220034199A (ko) * | 2019-09-18 | 2022-03-17 | 알콘 인코포레이티드 | 습식-패킹 소프트 하이드로겔 안구 삽입물 |
| JP7564197B2 (ja) | 2019-11-04 | 2024-10-08 | アルコン インク． | 異なる柔軟性を有する表面を有するコンタクトレンズ |
| CN111116798B (zh) * | 2019-12-24 | 2021-07-23 | 中国科学院广州能源研究所 | 一种改性的天然气水合物动力学抑制剂 |
| US12358247B2 (en) | 2020-07-28 | 2025-07-15 | Alcon Inc. | Contact lenses with softer lens surfaces |
| US20240092043A1 (en) | 2022-08-17 | 2024-03-21 | Alcon Inc. | Contact lens with a hydrogel coating thereon |
Family Cites Families (62)
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| JPS5590928A (en) * | 1978-12-29 | 1980-07-10 | Olympus Optical Co Ltd | Endoscope objective lens which performs changing of magnification and focusing simultaneously |
| US4312575A (en) | 1979-09-18 | 1982-01-26 | Peyman Gholam A | Soft corneal contact lens with tightly cross-linked polymer coating and method of making same |
| US4444711A (en) | 1981-12-21 | 1984-04-24 | Husky Injection Molding Systems Ltd. | Method of operating a two-shot injection-molding machine |
| US4460534A (en) | 1982-09-07 | 1984-07-17 | International Business Machines Corporation | Two-shot injection molding |
| US4625007A (en) | 1982-09-30 | 1986-11-25 | Polymer Technology Corporation | Silicone-containing contact lens material and contact lenses made thereof |
| US5266563A (en) * | 1984-06-11 | 1993-11-30 | Biomatrix, Inc. | Hyakyribate-poly (ethylene oxide) mixtures |
| US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4883658A (en) | 1986-04-28 | 1989-11-28 | Holly Frank J | Ophthalmic solution for treatment of dry-eye syndrome |
| US4744980A (en) | 1986-04-28 | 1988-05-17 | Holly Frank J | Ophthalmic solution for treatment of dry eye syndrome |
| US4910277A (en) | 1988-02-09 | 1990-03-20 | Bambury Ronald E | Hydrophilic oxygen permeable polymers |
| US4810764A (en) | 1988-02-09 | 1989-03-07 | Bausch & Lomb Incorporated | Polymeric materials with high oxygen permeability and low protein substantivity |
| US5177165A (en) | 1990-11-27 | 1993-01-05 | Bausch & Lomb Incorporated | Surface-active macromonomers |
| EP0603268B1 (en) | 1991-09-12 | 1996-12-18 | BAUSCH & LOMB INCORPORATED | Wettable silicone hydrogel compositions and methods |
| US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| AU5092493A (en) | 1992-09-08 | 1994-03-29 | Allergan, Inc. | Sustained release of ophthalmic drugs from a soluble polymer drug delivery vehicle |
| US6800225B1 (en) | 1994-07-14 | 2004-10-05 | Novartis Ag | Process and device for the manufacture of mouldings and mouldings manufactured in accordance with that process |
| EP0637491B1 (de) | 1993-07-29 | 1997-11-05 | Novartis AG | Verfahren und Vorrichtung zur Herstellung von Formkörpern |
| TW272976B (enExample) * | 1993-08-06 | 1996-03-21 | Ciba Geigy Ag | |
| EP0655470B1 (de) | 1993-11-26 | 1999-05-12 | Novartis AG | Vernetzbare Copolymere und Hydrogele |
| US5712356A (en) | 1993-11-26 | 1998-01-27 | Ciba Vision Corporation | Cross-linkable copolymers and hydrogels |
| US5894002A (en) | 1993-12-13 | 1999-04-13 | Ciba Vision Corporation | Process and apparatus for the manufacture of a contact lens |
| US5843346A (en) | 1994-06-30 | 1998-12-01 | Polymer Technology Corporation | Method of cast molding contact lenses |
| US6407145B1 (en) | 1994-08-04 | 2002-06-18 | Novartis Ag | Photocrosslinkable materials and applications |
| US5665840A (en) | 1994-11-18 | 1997-09-09 | Novartis Corporation | Polymeric networks from water-soluble prepolymers |
| EP0712867B1 (de) | 1994-11-18 | 1999-07-14 | Novartis AG | Polymere Netzwerke aus wasserlöslichen Präpolymeren |
| MX9705867A (es) | 1995-02-03 | 1997-12-31 | Novartis Ag | Polimeros reticulados que contienen fotoiniciadores. |
| TW349967B (en) | 1995-02-03 | 1999-01-11 | Novartis Ag | Process for producing contact lenses and a cross-linkable polyvinylalcohol used therefor |
| AU4438696A (en) | 1995-02-03 | 1996-08-21 | Novartis Ag | Crosslinked polymers |
| WO1996024075A1 (en) | 1995-02-03 | 1996-08-08 | Novartis Ag | Crosslinked polymers containing ester or amide groups |
| US5583463A (en) | 1995-05-30 | 1996-12-10 | Micron Technology, Inc. | Redundant row fuse bank circuit |
| DE69625658T2 (de) * | 1995-09-13 | 2003-07-17 | Seikagaku Kogyo K.K.(Seikagaku Corp.), Tokio/Tokyo | Kontaktlinse auf Basis photogehärteter Hyaluronsäure |
| WO1998017704A1 (en) | 1996-10-21 | 1998-04-30 | Novartis Ag | Crosslinkable polymers |
| EP0867456A1 (de) | 1997-02-04 | 1998-09-30 | Novartis AG | Ophthalmischer Formkörper |
| TW425403B (en) | 1997-02-04 | 2001-03-11 | Novartis Ag | Branched polyurethane (meth)acrylate prepolymers, opthal-mic mouldings derived therefrom and processes for their manufacture |
| ES2175698T3 (es) | 1997-02-21 | 2002-11-16 | Novartis Ag | Articulos de moldeo oftalmicos. |
| GB9711818D0 (en) | 1997-06-06 | 1997-08-06 | Bausch & Lomb | Contact lens packing solutions and methods for improving the comfort of disposable contact lenses |
| WO1999011692A1 (en) | 1997-09-03 | 1999-03-11 | The Regents Of The University Of California | Novel biomimetic hydrogel materials |
| JP4616473B2 (ja) | 1997-09-16 | 2011-01-19 | ノバルティス アーゲー | 架橋結合可能なポリ尿素ポリマー類 |
| TW429327B (en) | 1997-10-21 | 2001-04-11 | Novartis Ag | Single mould alignment |
| US6367929B1 (en) | 1998-03-02 | 2002-04-09 | Johnson & Johnson Vision Care, Inc. | Hydrogel with internal wetting agent |
| US6943203B2 (en) | 1998-03-02 | 2005-09-13 | Johnson & Johnson Vision Care, Inc. | Soft contact lenses |
| US6822016B2 (en) | 2001-09-10 | 2004-11-23 | Johnson & Johnson Vision Care, Inc. | Biomedical devices containing internal wetting agents |
| US7052131B2 (en) | 2001-09-10 | 2006-05-30 | J&J Vision Care, Inc. | Biomedical devices containing internal wetting agents |
| US6039913A (en) | 1998-08-27 | 2000-03-21 | Novartis Ag | Process for the manufacture of an ophthalmic molding |
| EP1002807A1 (en) | 1998-11-20 | 2000-05-24 | Novartis AG | Functionalized resin derived from polyallylamine |
| JP5242876B2 (ja) | 2000-03-24 | 2013-07-24 | ノバルティス アーゲー | 架橋結合性または重合性プレポリマー |
| US6811805B2 (en) | 2001-05-30 | 2004-11-02 | Novatis Ag | Method for applying a coating |
| JP2003033454A (ja) | 2001-07-23 | 2003-02-04 | Endo Mfg Co Ltd | ゴルフクラブヘッドの製造方法 |
| TWI255224B (en) * | 2002-01-09 | 2006-05-21 | Novartis Ag | Polymeric articles having a lubricious coating and method for making the same |
| WO2004016671A1 (en) | 2002-08-14 | 2004-02-26 | Novartis Ag | Radiation-curable prepolymers |
| US7235195B2 (en) * | 2002-09-06 | 2007-06-26 | Novartis Ag | Method for making opthalmic devices |
| US20040116564A1 (en) | 2002-11-27 | 2004-06-17 | Devlin Brian Gerrard | Stabilization of poly(oxyalkylene) containing polymeric materials |
| US20040115270A1 (en) | 2002-12-13 | 2004-06-17 | Dharmendra Jani | Absorption and controlled release of polyethers from hydrogel biomaterials |
| US7387759B2 (en) | 2002-12-17 | 2008-06-17 | Novartis Ag | System and method for curing polymeric moldings having a masking collar |
| US7384590B2 (en) | 2002-12-17 | 2008-06-10 | Novartis Ag | System and method for curing polymeric moldings |
| US20040119176A1 (en) | 2002-12-23 | 2004-06-24 | Bausch & Lomb Incorporated | Method for manufacturing lenses |
| US20040214914A1 (en) | 2003-04-24 | 2004-10-28 | Ocular Sciences, Inc. | Hydrogel contact lenses and package systems and production methods for same |
| US7977430B2 (en) | 2003-11-25 | 2011-07-12 | Novartis Ag | Crosslinkable polyurea prepolymers |
| US7786185B2 (en) | 2004-03-05 | 2010-08-31 | Johnson & Johnson Vision Care, Inc. | Wettable hydrogels comprising acyclic polyamides |
| US7249848B2 (en) | 2004-09-30 | 2007-07-31 | Johnson & Johnson Vision Care, Inc. | Wettable hydrogels comprising reactive, hydrophilic, polymeric internal wetting agents |
-
2006
- 2006-05-02 US US11/416,260 patent/US9804295B2/en active Active
- 2006-05-03 AR ARP060101787A patent/AR055931A1/es active IP Right Grant
- 2006-05-03 TW TW095115677A patent/TWI375571B/zh active
- 2006-05-04 WO PCT/EP2006/004193 patent/WO2006117228A2/en not_active Ceased
- 2006-05-04 PL PL06742806T patent/PL1886169T5/pl unknown
- 2006-05-04 ES ES06742806.0T patent/ES2357623T5/es active Active
- 2006-05-04 AU AU2006243345A patent/AU2006243345B2/en active Active
- 2006-05-04 DK DK06742806.0T patent/DK1886169T4/en active
- 2006-05-04 EP EP06742806.0A patent/EP1886169B2/en active Active
- 2006-05-04 CA CA2606073A patent/CA2606073C/en active Active
- 2006-05-04 CN CN2006800152347A patent/CN101171531B/zh active Active
- 2006-05-04 DE DE602006019234T patent/DE602006019234D1/de active Active
- 2006-05-04 AT AT06742806T patent/ATE493679T2/de active
- 2006-05-04 MX MX2007013739A patent/MX2007013739A/es active IP Right Grant
- 2006-05-04 PT PT06742806T patent/PT1886169E/pt unknown
- 2006-05-04 BR BRPI0611434-2A patent/BRPI0611434A2/pt not_active Application Discontinuation
- 2006-05-04 JP JP2008509385A patent/JP5053261B2/ja active Active
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2007
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- 2007-12-04 NO NO20076252A patent/NO340948B1/no not_active IP Right Cessation
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0611434A2 (pt) | 2010-09-08 |
| CN101171531A (zh) | 2008-04-30 |
| CN101171531B (zh) | 2010-06-16 |
| MX2007013739A (es) | 2008-01-21 |
| DK1886169T4 (en) | 2016-03-14 |
| AR055931A1 (es) | 2007-09-12 |
| ZA200708953B (en) | 2008-06-25 |
| WO2006117228A2 (en) | 2006-11-09 |
| ES2357623T5 (es) | 2016-03-29 |
| PL1886169T3 (pl) | 2011-05-31 |
| EP1886169B2 (en) | 2015-12-09 |
| EP1886169B1 (en) | 2010-12-29 |
| US20060251696A1 (en) | 2006-11-09 |
| CA2606073C (en) | 2013-12-03 |
| AU2006243345A1 (en) | 2006-11-09 |
| AU2006243345B2 (en) | 2010-03-18 |
| DE602006019234D1 (de) | 2011-02-10 |
| TW200716201A (en) | 2007-05-01 |
| US9804295B2 (en) | 2017-10-31 |
| WO2006117228A3 (en) | 2007-02-01 |
| JP5053261B2 (ja) | 2012-10-17 |
| DK1886169T3 (da) | 2011-03-14 |
| JP2008539837A (ja) | 2008-11-20 |
| CA2606073A1 (en) | 2006-11-09 |
| ES2357623T3 (es) | 2011-04-28 |
| EP1886169A2 (en) | 2008-02-13 |
| PT1886169E (pt) | 2011-03-07 |
| NO340948B1 (no) | 2017-07-24 |
| PL1886169T5 (pl) | 2016-05-31 |
| US20170307780A1 (en) | 2017-10-26 |
| NO20076252L (no) | 2008-02-05 |
| ATE493679T2 (de) | 2011-01-15 |
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