BR112022002467A2 - Insertos oculares de hidrogel suave embalados a úmido - Google Patents
Insertos oculares de hidrogel suave embalados a úmidoInfo
- Publication number
- BR112022002467A2 BR112022002467A2 BR112022002467A BR112022002467A BR112022002467A2 BR 112022002467 A2 BR112022002467 A2 BR 112022002467A2 BR 112022002467 A BR112022002467 A BR 112022002467A BR 112022002467 A BR112022002467 A BR 112022002467A BR 112022002467 A2 BR112022002467 A2 BR 112022002467A2
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogel
- eye
- soft hydrogel
- hydrogel eye
- mucoadhesive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Abstract
INSERTOS OCULARES DE HIDROGEL SUAVE EMBALADOS A ÚMIDO. A presente invenção refere-se, em geral, a um inserto ocular de hidrogel suave que é composto de pelo menos um material de hidrogel no estado totalmente hidratado e pode ser confortável para uso. O material de hidrogel compreende cadeias poliméricas, que são derivadas de pelo menos um copolímero hidrofílico contendo arilborono e pelo menos um polímero mucoadesivo, e reticulações de éster borônico cíclico para reticular essas cadeias de polímero mucoadesivo e cadeias de copolímero hidrofílico contendo arilborono para formar uma rede polimérica tridimensional. Essas reticulações de éster borônico cíclico podem ser lentamente hidrolisadas na lágrima dos olhos de um paciente, resultando na desintegração (dissolução) da rede polimérica tridimensional e fornecendo, desse modo, polímeros mucoadesivos e opcionalmente fármacos impregnados no inserto ocular de hidrogel de uma maneira controlada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962901967P | 2019-09-18 | 2019-09-18 | |
PCT/IB2020/058689 WO2021053586A1 (en) | 2019-09-18 | 2020-09-17 | Wet-packed soft hydrogel ocular inserts |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022002467A2 true BR112022002467A2 (pt) | 2022-07-19 |
Family
ID=72659825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022002467A BR112022002467A2 (pt) | 2019-09-18 | 2020-09-17 | Insertos oculares de hidrogel suave embalados a úmido |
Country Status (11)
Country | Link |
---|---|
US (1) | US11931454B2 (pt) |
EP (1) | EP4017478A1 (pt) |
JP (1) | JP7419499B2 (pt) |
KR (1) | KR20220034199A (pt) |
CN (1) | CN114727954A (pt) |
AU (1) | AU2020347951B2 (pt) |
BR (1) | BR112022002467A2 (pt) |
CA (1) | CA3153384C (pt) |
MX (1) | MX2022003324A (pt) |
TW (1) | TWI812881B (pt) |
WO (1) | WO2021053586A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114891239A (zh) * | 2022-03-23 | 2022-08-12 | 武汉理工大学 | 一种硼氮内配位硼酸酯水凝胶及其制备方法 |
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US3961628A (en) | 1974-04-10 | 1976-06-08 | Alza Corporation | Ocular drug dispensing system |
US4402695A (en) | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
US4281654A (en) | 1980-04-07 | 1981-08-04 | Alza Corporation | Drug delivery system for controlled ocular therapy |
US5229128A (en) | 1986-06-11 | 1993-07-20 | Haddad Heskel M | Drug delivery ophthalmic insert and method of preparing same |
US4910015A (en) | 1987-10-19 | 1990-03-20 | Massachusetts Institute Of Technology | Surface-active polysiloxanes and drug releasing materials thereof |
US5609885A (en) | 1992-09-15 | 1997-03-11 | Alza Corporation | Osmotic membrane and delivery device |
US5707643A (en) | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
US5607696A (en) | 1995-02-10 | 1997-03-04 | Alza Corporation | Osmotic membrane and delivery device |
CN1229110C (zh) | 1997-07-29 | 2005-11-30 | 阿尔康实验室公司 | 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物 |
EP1438022A1 (en) | 2001-08-07 | 2004-07-21 | Vista Scientific LLC | Drug release system for controlled therapy |
US20060166879A1 (en) | 2002-12-20 | 2006-07-27 | Chakshu Research Inc | Treatment of conditions associated with the presence of macromolecular aggregates, particularly ophthalmic disorders |
EP1696878A1 (en) | 2003-12-11 | 2006-09-06 | Alcon, Inc. | Ophthalmic compositions containing a polysaccharide/borate gelling system |
US20050129770A1 (en) | 2003-12-11 | 2005-06-16 | Alcon, Inc. | Ophthalmic compositions containing a PVA/borate gelling system |
US9804295B2 (en) * | 2005-05-05 | 2017-10-31 | Novartis Ag | Ophthalmic devices for sustained delivery of active compounds |
AR058707A1 (es) | 2005-12-22 | 2008-02-20 | Glaxosmithkline Biolog Sa | Vacuna, procedimiento para fabricarla y su uso |
US20080171072A1 (en) | 2006-08-11 | 2008-07-17 | Frank Burczynski | Ocular inserts containing apomorphine |
US20090131303A1 (en) | 2007-11-16 | 2009-05-21 | Bor-Shyue Hong | Methods and compositions for treating dry eye |
US20110059176A1 (en) | 2007-11-22 | 2011-03-10 | The University Of Tokyo | Material for preventing tissue adhesion and material for preventing joint contracture |
US7837934B2 (en) * | 2008-01-09 | 2010-11-23 | Bausch & Lomb Incorporated | Packaging solutions |
TWI526213B (zh) | 2008-04-26 | 2016-03-21 | 愛爾康研究有限公司 | 聚合性人工淚液系統 |
JP2009296909A (ja) | 2008-06-11 | 2009-12-24 | Sumitomo Bakelite Co Ltd | 三次元架橋体の溶解方法 |
US20100168851A1 (en) * | 2008-12-30 | 2010-07-01 | David Paul Vanderbilt | Surface Modified Biomedical Devices |
US8534031B2 (en) | 2008-12-30 | 2013-09-17 | Bausch & Lomb Incorporated | Packaging solutions |
EP4108216A1 (en) | 2009-06-03 | 2022-12-28 | Forsight Vision5, Inc. | Anterior segment drug delivery |
US8410190B2 (en) * | 2009-09-22 | 2013-04-02 | Coopervision International Holding Company, Lp | Wettable hydrogel materials for use in ophthalmic applications and methods |
US8939948B2 (en) | 2010-06-01 | 2015-01-27 | Forsight Vision5, Inc. | Ocular insert apparatus and methods |
US20120213840A1 (en) | 2011-02-18 | 2012-08-23 | Valeant International (Barbados) Srl | Ocular strips |
US20120215184A1 (en) | 2011-02-18 | 2012-08-23 | Valeant International (Barbados) Srl | Cylindrical ocular inserts |
SG11201407394TA (en) * | 2012-05-25 | 2014-12-30 | Johnson & Johnson Vision Care | Polymers and nanogel materials and methods for making and using the same |
US9597227B2 (en) | 2013-03-15 | 2017-03-21 | Abbott Medical Optics Inc. | Trans-sclera portal for delivery of therapeutic agents |
JP5671183B1 (ja) | 2014-08-28 | 2015-02-18 | 株式会社ユニバーサルビュー | 眼瞼内装用具 |
US10683379B2 (en) | 2015-03-23 | 2020-06-16 | Massachusetts Institute Of Technology | Polymers, hydrogels, and uses thereof |
US20160296532A1 (en) | 2015-04-13 | 2016-10-13 | Forsight Vision5, Inc. | Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent |
CN115919996A (zh) | 2015-05-01 | 2023-04-07 | 雅利斯塔制药公司 | 用于治疗眼科疾病的脂联素拟肽 |
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JP6703408B2 (ja) | 2016-01-30 | 2020-06-03 | 国立大学法人 筑波大学 | ポリイオンコンプレックスを有効成分とするドライアイ処置用組成物 |
PT109154B (pt) | 2016-02-12 | 2019-11-05 | Univ De Coimbra | Tecnologia não-invasiva de inserto ocular para libertação controlada de fármacos |
EP3619222A4 (en) | 2017-05-05 | 2021-02-17 | Nino Sorgente | METHODS AND COMPOSITIONS FOR IMPROVING EYE HEALTH |
CN110831991B (zh) * | 2017-07-18 | 2022-05-24 | 爱尔康公司 | 含有磷酰胆碱的基于聚(甲基)丙烯酰胺的共聚物 |
CN117270235A (zh) * | 2018-01-30 | 2023-12-22 | 爱尔康公司 | 在其上具有润滑涂层的隐形眼镜 |
US11061169B2 (en) * | 2018-11-15 | 2021-07-13 | Alcon Inc. | Contact lens with phosphorylcholine-modified polyvinylalcohols therein |
-
2020
- 2020-09-17 AU AU2020347951A patent/AU2020347951B2/en active Active
- 2020-09-17 JP JP2022512726A patent/JP7419499B2/ja active Active
- 2020-09-17 EP EP20781083.9A patent/EP4017478A1/en active Pending
- 2020-09-17 CN CN202080064286.3A patent/CN114727954A/zh active Pending
- 2020-09-17 BR BR112022002467A patent/BR112022002467A2/pt unknown
- 2020-09-17 CA CA3153384A patent/CA3153384C/en active Active
- 2020-09-17 KR KR1020227004556A patent/KR20220034199A/ko unknown
- 2020-09-17 WO PCT/IB2020/058689 patent/WO2021053586A1/en unknown
- 2020-09-17 US US17/024,268 patent/US11931454B2/en active Active
- 2020-09-17 MX MX2022003324A patent/MX2022003324A/es unknown
- 2020-09-18 TW TW109132230A patent/TWI812881B/zh active
Also Published As
Publication number | Publication date |
---|---|
JP7419499B2 (ja) | 2024-01-22 |
AU2020347951B2 (en) | 2023-11-02 |
CA3153384C (en) | 2024-02-13 |
US20210077385A1 (en) | 2021-03-18 |
AU2020347951A1 (en) | 2022-05-05 |
EP4017478A1 (en) | 2022-06-29 |
CN114727954A (zh) | 2022-07-08 |
MX2022003324A (es) | 2022-04-18 |
TW202114636A (zh) | 2021-04-16 |
TWI812881B (zh) | 2023-08-21 |
WO2021053586A1 (en) | 2021-03-25 |
JP2022545693A (ja) | 2022-10-28 |
CA3153384A1 (en) | 2021-03-25 |
US11931454B2 (en) | 2024-03-19 |
KR20220034199A (ko) | 2022-03-17 |
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