BR0215149A - Uso de nanopartìculas inorgânicas para modificar a viscosidade e outras propriedades fìsicas de composições farmacêuticas e óticas - Google Patents

Uso de nanopartìculas inorgânicas para modificar a viscosidade e outras propriedades fìsicas de composições farmacêuticas e óticas

Info

Publication number
BR0215149A
BR0215149A BR0215149-9A BR0215149A BR0215149A BR 0215149 A BR0215149 A BR 0215149A BR 0215149 A BR0215149 A BR 0215149A BR 0215149 A BR0215149 A BR 0215149A
Authority
BR
Brazil
Prior art keywords
compositions
pharmaceutical
physical properties
viscosity
nanoparticles
Prior art date
Application number
BR0215149-9A
Other languages
English (en)
Inventor
Howard Allen Ketelson
David L Meadows
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of BR0215149A publication Critical patent/BR0215149A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"USO DE NANOPARTìCULAS INORGâNICAS PARA MODIFICAR A VISCOSIDADE E OUTRAS PROPRIEDADES FìSICAS DE COMPOSIçõES FARMACêUTICAS E óTICAS". A presente invenção refere-se ao uso de nanopartículas de materiais inorgânicos (por exemplo, argilas sintéticas de esmectita) em composições farmacêuticas oftálmicas e óticas. As nanopartículas são utilizadas para modificar as propriedades reológicas das composições, de modo a aumentar a viscosidade, as características de fluxo, a lubricidade ou outras características das composições. A invenção é particularmente dirigida ao fornecimento de composições lubrificantes para os olhos e ouvidos e para aumento da viscosidade, afinamento por cisalhamento e lubricidade das composições de lágrimas artificiais.
BR0215149-9A 2001-12-21 2002-12-20 Uso de nanopartìculas inorgânicas para modificar a viscosidade e outras propriedades fìsicas de composições farmacêuticas e óticas BR0215149A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34296401P 2001-12-21 2001-12-21
PCT/US2002/041249 WO2003059263A2 (en) 2001-12-21 2002-12-20 Inorganic nanoparticles to modify the viscosity and physical properties of ophthalmic and otic compositions.

Publications (1)

Publication Number Publication Date
BR0215149A true BR0215149A (pt) 2004-10-19

Family

ID=23344065

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215149-9A BR0215149A (pt) 2001-12-21 2002-12-20 Uso de nanopartìculas inorgânicas para modificar a viscosidade e outras propriedades fìsicas de composições farmacêuticas e óticas

Country Status (9)

Country Link
US (1) US20050002970A1 (pt)
EP (1) EP1471925A2 (pt)
JP (1) JP2005514433A (pt)
KR (1) KR20040073503A (pt)
AU (1) AU2002367030B2 (pt)
BR (1) BR0215149A (pt)
CA (1) CA2467764A1 (pt)
MX (1) MXPA04004915A (pt)
WO (1) WO2003059263A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL211494B1 (pl) 2001-12-21 2012-05-31 Alcon Zastosowanie syntetycznych, nieorganicznych nanocząstek jako nośników dla leków i kompozycja farmaceutyczna do oczu lub uszu
MXPA04005227A (es) 2001-12-21 2004-10-11 Alcon Inc Uso de nanoparticulas como portadores para biocidas en composiciones oftalmicas.
WO2004085998A2 (en) * 2003-03-28 2004-10-07 The Children's Hospital Of Philadelphia Biomimetic hierarchies using functionalized nanoparticles as building blocks
US20040242729A1 (en) * 2003-05-30 2004-12-02 3M Innovative Properties Company Stabilized particle dispersions containing surface-modified inorganic nanoparticles
FR2867386B1 (fr) * 2004-03-09 2008-01-18 Armand Neumann Collyre constitue d'une eau argileuse filtree et purifiee de ses particules utilise, pour le traitement des glaucomes
WO2006122543A1 (de) * 2005-05-18 2006-11-23 Tihomir Lelas Mikronisierte mineralische materialien und deren herstellung
EP1973998B1 (en) 2006-01-12 2022-06-08 The Board Of Trustees Of The University Of Arkansas Nanoparticle compositions and methods for making and using the same
US10100266B2 (en) 2006-01-12 2018-10-16 The Board Of Trustees Of The University Of Arkansas Dielectric nanolubricant compositions
US7959949B2 (en) 2006-04-27 2011-06-14 University Of Central Florida Research Foundation, Inc. Functionalized nanoceria composition for ophthalmic treatment
WO2008030805A1 (en) * 2006-09-05 2008-03-13 Cerion Technology, Inc. Cerium dioxide nanoparticle-containing fuel additive
WO2008036855A2 (en) * 2006-09-21 2008-03-27 Alcon Research, Ltd. Self-preserved aqueous pharmaceutical compositions
US9119391B1 (en) 2007-07-16 2015-09-01 University Of Central Florida Research Foundation, Inc. Polymer coated ceria nanoparticles for selective cytoprotection
MX2010004840A (es) * 2007-10-30 2010-10-20 Unilever Nv Metodo para construir viscosidad y viscoelasticidad en soluciones surfactantes al adicionar nanoparticulas y composiciones de las mismas.
AU2009240470B8 (en) * 2008-04-25 2015-02-05 The Board Of Regents Of The University Of Oklahoma Inhibition of neovascularization by cerium oxide nanoparticles
US8916199B1 (en) 2008-04-25 2014-12-23 University of Central Florida Research Foundation, Ind. Inhibition of angiogenesis associated with ovarian cancer by nanoparticles of cerium oxide
US9127202B1 (en) 2008-07-18 2015-09-08 University Of Central Florida Research Foundation, Inc. Biocompatible nano rare earth oxide upconverters for imaging and therapeutics
EP2151466A1 (en) * 2008-08-01 2010-02-10 SiNatur GmbH Biologically active silicic acid
CN105671124A (zh) * 2008-12-31 2016-06-15 3M创新有限公司 大肠菌检测方法以及其中使用的试剂盒
US8883519B1 (en) 2009-03-17 2014-11-11 University Of Central Florida Research Foundation, Inc. Oxidase activity of polymeric coated cerium oxide nanoparticles
US9585840B1 (en) 2009-07-10 2017-03-07 University Of Central Florida Research Foundation, Inc. Redox active cerium oxide nanoparticles and associated methods
US8795731B1 (en) 2009-10-12 2014-08-05 University Of Central Florida Research Foundation, Inc. Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation
US8877207B2 (en) 2010-09-17 2014-11-04 University Of Central Florida Research Foundation, Inc. Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of Alzheimer's disease and associated methods
US8951539B1 (en) 2011-06-07 2015-02-10 University Of Central Florida Research Foundation, Inc. Methods of promoting angiogenesis using cerium oxide nanoparticles
US9161950B2 (en) 2011-09-21 2015-10-20 University Of Central Florida Foundation, Inc. Neuronal protection by cerium oxide nanoparticles
WO2013151698A1 (en) 2012-04-04 2013-10-10 Duke University Methods for using cerium oxide nanoparticles to mitigate or protect against radiation injury
US8476206B1 (en) 2012-07-02 2013-07-02 Ajay P. Malshe Nanoparticle macro-compositions
US8486870B1 (en) 2012-07-02 2013-07-16 Ajay P. Malshe Textured surfaces to enhance nano-lubrication
US9463437B2 (en) 2013-02-14 2016-10-11 University Of Central Florida Research Foundation, Inc. Methods for scavenging nitric oxide using cerium oxide nanoparticles
US20140268028A1 (en) * 2013-03-15 2014-09-18 Johnson & Johnson Vision Care, Inc. Silicone-containing contact lens having clay treatment applied thereto
US20190054185A1 (en) * 2017-08-18 2019-02-21 King Fahd University Of Petroleum And Minerals Use of nano-sized clay crystallites to restore adhesion among tumor and aging stem cells

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947573A (en) * 1969-12-01 1976-03-30 Burton, Parsons And Company, Inc. Opthalmic solution
US3884826A (en) * 1973-07-20 1975-05-20 Barnes Hind Pharm Inc Thixotropic cleaning agent for hard contact lenses
US3974125A (en) * 1974-09-27 1976-08-10 Exxon Research And Engineering Company Higher dialkyl dimethyl ammonium clay gelling agents for unsaturated polyester compositions
US4127423A (en) * 1977-09-13 1978-11-28 Burton, Parsons And Company, Inc. Contact lens cleaning solution
US4120949A (en) * 1977-10-05 1978-10-17 Cooper Laboratories, Inc. Ophthalmic solution
US4271143A (en) * 1978-01-25 1981-06-02 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
US4394179A (en) * 1979-06-25 1983-07-19 Polymer Technology Corporation Abrasive-containing contact lens cleaning materials
US4374745A (en) * 1981-08-13 1983-02-22 Barnes-Hind Pharmaceuticals, Inc. Cleaning compositions
GB8401965D0 (en) * 1984-01-25 1984-02-29 Beecham Group Plc Composition
EP0217440A1 (en) * 1985-09-27 1987-04-08 The Procter & Gamble Company Stable aqueous pharmaceutical suspensions
US4804539A (en) * 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
IL80298A (en) * 1986-10-14 1993-01-31 Res & Dev Co Ltd Eye drops
WO1988004168A1 (en) * 1986-12-08 1988-06-16 Arseco, Inc. A storage stable topical composition
US4891043A (en) * 1987-05-28 1990-01-02 Board Of Trustees Of The University Of Illinois System for selective release of liposome encapsulated material via laser radiation
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
US5037647A (en) * 1988-09-15 1991-08-06 Alcon Laboratories, Inc. Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride
US5674504A (en) * 1989-07-12 1997-10-07 L'oreal Cosmetic composition in the form of an aqueous gel containing in suspension spheroids of a non-hydrophilic, lipoidal substance
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
JP2536806B2 (ja) * 1991-03-27 1996-09-25 アルコン ラボラトリーズ インコーポレイテッド ゲル化多糖類と微粉砕された薬剤担体とを組み合わせた局部眼科用組成物
EP0546728A3 (en) * 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
US5139782A (en) * 1991-12-23 1992-08-18 Uop Facial cleansing mineral compositions
US5394179A (en) * 1992-03-20 1995-02-28 Scitex Digital Printing, Inc. Stimulator for continous ink print head
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
ATE365530T1 (de) * 1992-07-13 2007-07-15 Shiseido Co Ltd Retinolthaltiges, stabilisiertes hautpflegemittel zur äusserlichen anwendung
US5532224A (en) * 1993-12-22 1996-07-02 Alcon Laboratories, Inc. Contact lens cleaning composition containing polyalklene oxide modified siloxanes
WO1996003158A1 (en) * 1994-07-22 1996-02-08 Alcon Laboratories, Inc. Use of low molecular weight amino acids in ophthalmic compositions
US5585108A (en) * 1994-12-30 1996-12-17 Nanosystems L.L.C. Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays
CN1155383C (zh) * 1995-12-21 2004-06-30 阿尔康实验室公司 某些异喹啉磺酰基化合物治疗青光眼及眼局部缺血的用途
US6015816A (en) * 1996-02-29 2000-01-18 The Research Foundation Of State University Of New York Antimicrobial compositions
ES2161473T3 (es) * 1996-09-20 2001-12-01 Bausch & Lomb Metodo y composicion para rehumedecer lentes de contacto y aliviar la sequedad ocular.
US5811580A (en) * 1996-12-04 1998-09-22 The Lubrizol Corporation Process for the preparation of N-hydrocarbyl-substituted amides via the ritter reaction using solid clay catalysts
DE69713388T2 (de) * 1996-12-13 2002-10-31 Alcon Lab Inc Verwendung von niedermolekularen aminoalkoholen in ophthalmologischen präparaten
US5858346A (en) * 1997-05-09 1999-01-12 Allergan Compositions and methods for enhancing contact lens wearability
CA2296080C (en) * 1997-07-29 2005-02-01 Alcon Laboratories, Inc. Ophthalmic compositions containing galactomannan polymers and borate
JPH11281937A (ja) * 1998-03-27 1999-10-15 Menicon Co Ltd コンタクトレンズ用剤
JP2001240547A (ja) * 2000-02-29 2001-09-04 Lion Corp 花粉症抑制剤
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
PL211494B1 (pl) * 2001-12-21 2012-05-31 Alcon Zastosowanie syntetycznych, nieorganicznych nanocząstek jako nośników dla leków i kompozycja farmaceutyczna do oczu lub uszu

Also Published As

Publication number Publication date
EP1471925A2 (en) 2004-11-03
AU2002367030B2 (en) 2008-10-16
AU2002367030A1 (en) 2003-07-30
JP2005514433A (ja) 2005-05-19
CA2467764A1 (en) 2003-07-24
KR20040073503A (ko) 2004-08-19
MXPA04004915A (es) 2004-08-11
WO2003059263A2 (en) 2003-07-24
US20050002970A1 (en) 2005-01-06
WO2003059263A3 (en) 2003-12-04

Similar Documents

Publication Publication Date Title
BR0215149A (pt) Uso de nanopartìculas inorgânicas para modificar a viscosidade e outras propriedades fìsicas de composições farmacêuticas e óticas
BR0215238A (pt) Uso de nanopartìculas inor ânicas sintéticas como veìculos para drogas oftálmicas e óticas
BR9714270A (pt) Composição lìquida de limpeza de pele
JP5788412B2 (ja) 添加物を含む安定ヒドロゲル組成物
BR0314242B8 (pt) polímero, processo para a preparação do mesmo, emulsão polimérica, composição, composição formulada, emulsão polimérica aquosa, composição para o cuidado dos cabelos, e, composição para o cuidado da pele
BR0307962A (pt) Preparação cosmética
BR0116773A (pt) Composição na forma de uma dispersão aquosa
FR2827513B1 (fr) Composition a usage cosmetique ou dermatologique contenant un polymere triblocs
ATE129411T1 (de) Natriumhyaluronat-zusammensetzung.
BRPI0506874A (pt) composições de xampu condicionante
DE60030542D1 (de) Nicht stechendes überzugsmittel
EP1568755A3 (en) Base oil
BR0207484A (pt) Composições viscoelásticas
BR0204056B1 (pt) mÉtodo de aumento da viscosidade de baixa taxa de cisalhamento e Índice de reduÇço de cisalhamento de fluidos contendo cÁtion divalente e os fluidos obtidos desse modo.
BR9913617A (pt) Composições de reologia modificada e seus processos
ATE233083T1 (de) Synthetisches viskoseelastisches material für physiologische anwendungen wie für ophtalmologische anwendungen
BR9714162A (pt) Métodos de fabricação de composições antitranspirantes em bastão de gel sólido com baixa formação residual
WO2003013612A1 (en) Polysaccharide-containing compositions and use thereof
BR9715014A (pt) Composições antitranspirantes em bastão de gel sólido
BR0300096A (pt) Polìmero, processo de preparação de polìmeros, uso de pelo menos um polìmero e composição
ES2149035T3 (es) Emulsion agua en aceite que comprende silice pirogenica y un alquileter de polisacarido
DE60233691D1 (de) Kosmetische Zusammensetzung mit einem Blockcopolymer
BRPI0411954A (pt) nanopartìculas de derivados poli-oxietilenados e respectivo método de preparação
BR0115154A (pt) material viscoelástico transicional não-aspirante para uso em cirurgia
KR930018017A (ko) 화장 비누 조성물

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA:INT.CI. A61K 33/22, A61K 47/02, A61K 9/00, A61K 9/06, A61K 9/08, A61P 27/02, A61P 27/16, A61P31/04, A61P 31/10, A61K 33/22, A61K 47/02, A61K 9/00, A61K 9/06, A61K 9/08, A61P 27/00, A61P 31/00

Ipc: A61K 33/22 (2011.01), A61K 47/02 (2011.01), A61K 9

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.