TWI360655B - Apparatus and methods for detecting nucleic acid i - Google Patents
Apparatus and methods for detecting nucleic acid i Download PDFInfo
- Publication number
- TWI360655B TWI360655B TW093131325A TW93131325A TWI360655B TW I360655 B TWI360655 B TW I360655B TW 093131325 A TW093131325 A TW 093131325A TW 93131325 A TW93131325 A TW 93131325A TW I360655 B TWI360655 B TW I360655B
- Authority
- TW
- Taiwan
- Prior art keywords
- layer
- dielectric material
- dielectric
- rti
- electrode
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 49
- 150000007523 nucleic acids Chemical class 0.000 title claims description 24
- 108020004707 nucleic acids Proteins 0.000 title claims description 13
- 102000039446 nucleic acids Human genes 0.000 title claims description 13
- 239000000523 sample Substances 0.000 claims description 52
- 239000003989 dielectric material Substances 0.000 claims description 47
- 229910052751 metal Inorganic materials 0.000 claims description 33
- 239000002184 metal Substances 0.000 claims description 33
- 238000006243 chemical reaction Methods 0.000 claims description 31
- 238000009396 hybridization Methods 0.000 claims description 26
- 239000000463 material Substances 0.000 claims description 23
- 229910052782 aluminium Inorganic materials 0.000 claims description 13
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 13
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 11
- 230000005684 electric field Effects 0.000 claims description 11
- 238000000151 deposition Methods 0.000 claims description 10
- 239000000758 substrate Substances 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 9
- 229920002120 photoresistant polymer Polymers 0.000 claims description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 229910052681 coesite Inorganic materials 0.000 claims description 4
- 229910052906 cristobalite Inorganic materials 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 229910052682 stishovite Inorganic materials 0.000 claims description 4
- 229910052905 tridymite Inorganic materials 0.000 claims description 4
- 239000012620 biological material Substances 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000001846 repelling effect Effects 0.000 claims description 3
- 230000005611 electricity Effects 0.000 claims description 2
- 239000011810 insulating material Substances 0.000 claims description 2
- 238000000059 patterning Methods 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000027756 respiratory electron transport chain Effects 0.000 claims 7
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- 229910052797 bismuth Inorganic materials 0.000 claims 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims 1
- 239000002001 electrolyte material Substances 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 235000012431 wafers Nutrition 0.000 description 9
- 239000012472 biological sample Substances 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 7
- 239000012634 fragment Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000010804 cDNA synthesis Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000003487 electrochemical reaction Methods 0.000 description 2
- 238000005868 electrolysis reaction Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 238000007899 nucleic acid hybridization Methods 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002351 wastewater Substances 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010291 electrical method Methods 0.000 description 1
- 238000005566 electron beam evaporation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000012212 insulator Substances 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000000623 plasma-assisted chemical vapour deposition Methods 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/686,252 US7390622B2 (en) | 2003-10-16 | 2003-10-16 | Apparatus and methods for detecting nucleic acid in biological samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200517656A TW200517656A (en) | 2005-06-01 |
| TWI360655B true TWI360655B (en) | 2012-03-21 |
Family
ID=34465492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093131325A TWI360655B (en) | 2003-10-16 | 2004-10-15 | Apparatus and methods for detecting nucleic acid i |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7390622B2 (enExample) |
| EP (2) | EP1673476B1 (enExample) |
| JP (2) | JP5248017B2 (enExample) |
| CN (1) | CN1867681B (enExample) |
| AU (1) | AU2004282235B2 (enExample) |
| BR (1) | BRPI0415342A (enExample) |
| CA (1) | CA2542518C (enExample) |
| MX (1) | MXPA06004205A (enExample) |
| MY (2) | MY144038A (enExample) |
| RU (1) | RU2359038C2 (enExample) |
| SG (1) | SG147452A1 (enExample) |
| TW (1) | TWI360655B (enExample) |
| WO (1) | WO2005038048A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7390622B2 (en) * | 2003-10-16 | 2008-06-24 | Hai Kang Life Corporation Limited | Apparatus and methods for detecting nucleic acid in biological samples |
| US8906609B1 (en) | 2005-09-26 | 2014-12-09 | Arrowhead Center, Inc. | Label-free biomolecule sensor based on surface charge modulated ionic conductance |
| KR100723427B1 (ko) * | 2006-05-12 | 2007-05-30 | 삼성전자주식회사 | 기판상에 생체분자 액적을 프린팅하는 장치 및 방법 |
| US20080221805A1 (en) * | 2007-03-09 | 2008-09-11 | David Richard Andrews | Multi-channel lock-in amplifier system and method |
| ES2307430B1 (es) * | 2007-05-09 | 2009-10-20 | Consejo Superior De Investigaciones Cientificas | Biosensor y sus aplicaciones. |
| BRPI0813718A2 (pt) | 2007-07-13 | 2014-12-30 | Univ Leland Stanford Junior | Método e aparelho que utilizam um campo elétrico para ensaios biológicos aperfeiçoados |
| KR100969671B1 (ko) * | 2008-03-28 | 2010-07-14 | 디지탈 지노믹스(주) | 고감도 바이오 센서 및 이를 포함하는 바이오 칩 그리고이를 제조하는 방법 |
| WO2011108540A1 (ja) | 2010-03-03 | 2011-09-09 | 国立大学法人大阪大学 | ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置 |
| JP5781256B2 (ja) | 2012-06-28 | 2015-09-16 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | リーダー装置および信号増幅方法 |
| BR112015018674A2 (pt) * | 2013-02-07 | 2017-07-18 | Koninklijke Philips Nv | aparelho para o processamento de sequências de nucleotídeos, método para o processamento de sequências de nucleotídeos, e, uso do aparelho |
| US9151759B2 (en) * | 2013-05-06 | 2015-10-06 | Research Foundation Of The City University Of New York | Method for detecting cells with elastic cell membranes |
| CN106104274B (zh) | 2013-09-18 | 2018-05-22 | 量子生物有限公司 | 生物分子测序装置、系统和方法 |
| JP2015077652A (ja) | 2013-10-16 | 2015-04-23 | クオンタムバイオシステムズ株式会社 | ナノギャップ電極およびその製造方法 |
| US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
| WO2015170782A1 (en) | 2014-05-08 | 2015-11-12 | Osaka University | Devices, systems and methods for linearization of polymers |
| CN106536710B (zh) | 2014-08-08 | 2018-07-06 | 应用材料公司 | 用于生物医用器件的液膜的图案化沉积 |
| US10379101B2 (en) * | 2015-11-23 | 2019-08-13 | Hai Kang Life Corporation Limited | Apparatus for detection of biomolecules and its fabrication |
| US10640822B2 (en) | 2016-02-29 | 2020-05-05 | Iridia, Inc. | Systems and methods for writing, reading, and controlling data stored in a polymer |
| RU2022101599A (ru) * | 2016-02-29 | 2022-02-25 | Айридия, Инк. | Способы, композиции и устройства для хранения информации |
| CN115595360A (zh) | 2016-04-27 | 2023-01-13 | 因美纳剑桥有限公司（Gb） | 用于生物分子的测量和测序的系统和方法 |
| CN108130273B (zh) * | 2016-12-01 | 2021-10-12 | 京东方科技集团股份有限公司 | 检测基板及其制作方法、检测核酸的方法 |
| EP3732302A4 (en) * | 2017-12-28 | 2021-09-15 | Ador Diagnostics S.r.l. | METHOD FOR RAPID DETECTION OF THE PRESENCE OF TARGET MOLECULES OF NUCLEIC ACID |
| US11837302B1 (en) | 2020-08-07 | 2023-12-05 | Iridia, Inc. | Systems and methods for writing and reading data stored in a polymer using nano-channels |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1337173C (en) * | 1989-04-28 | 1995-10-03 | Westaim Biomedical Corp. | Thin film diagnostic device |
| RU2032908C1 (ru) * | 1991-04-26 | 1995-04-10 | Институт геохимии и аналитической химии им.В.И.Вернадского РАН | Устройство для определения биологически активных соединений в биологических жидкостях и способ изготовления чувствительного элемента |
| US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| US6017696A (en) * | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
| US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
| US6306348B1 (en) * | 1993-11-01 | 2001-10-23 | Nanogen, Inc. | Inorganic permeation layer for micro-electric device |
| JPH08154656A (ja) * | 1994-12-05 | 1996-06-18 | Nikon Corp | 核酸ハイブリダイゼーション試験の方法、核酸ハイブリダイゼーション試験用基材および核酸ハイブリダイゼーション試験用装置 |
| US5605622A (en) * | 1995-07-18 | 1997-02-25 | Ferraro; Michael J. | Swimming pool vacuum system |
| AU745126B2 (en) * | 1997-04-16 | 2002-03-14 | Applied Biosystems, Llc | Nucleic acid archiving |
| US20040053290A1 (en) * | 2000-01-11 | 2004-03-18 | Terbrueggen Robert Henry | Devices and methods for biochip multiplexing |
| US20020177135A1 (en) * | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| WO2001043870A2 (en) * | 1999-12-15 | 2001-06-21 | Motorola Inc. | Column and row addressable high density biochip array |
| US20020090649A1 (en) * | 1999-12-15 | 2002-07-11 | Tony Chan | High density column and row addressable electrode arrays |
| US6458000B2 (en) * | 1999-12-30 | 2002-10-01 | Thomas & Betts International, Inc. | Power connector ground polarization insert and connector used therewith |
| AU2001252973A1 (en) * | 2000-04-17 | 2001-10-30 | Purdue Research Foundation | Biosensor and related method |
| US7306924B2 (en) * | 2000-04-17 | 2007-12-11 | Purdue Research Foundation | Biosensor and related method |
| WO2002031463A2 (en) * | 2000-08-31 | 2002-04-18 | Motorola, Inc. | High density column and row addressable electrode arrays |
| JP4193345B2 (ja) * | 2000-09-07 | 2008-12-10 | 横河電機株式会社 | 生体高分子の遺伝子配列を計測するための測定装置 |
| EP1331999A2 (en) * | 2000-11-03 | 2003-08-06 | Clinical Micro Sensors, Inc. | Devices and methods for biochip multiplexing |
| JP3758183B2 (ja) * | 2001-11-08 | 2006-03-22 | 横河電機株式会社 | バイオチップおよびそれを用いた遺伝子配列測定装置 |
| US7153687B2 (en) * | 2002-08-13 | 2006-12-26 | Hong Kong Dna Chips Limited | Apparatus and methods for detecting DNA in biological samples |
| CN1186627C (zh) | 2003-02-28 | 2005-01-26 | 北京青鸟元芯微系统科技有限责任公司 | 低功耗化学气体传感器芯片及其制备方法 |
| JP4482856B2 (ja) * | 2003-08-29 | 2010-06-16 | セイコーエプソン株式会社 | 試料中の標的物質の検出方法、センサ基体、及び検出キット |
| JP4281479B2 (ja) * | 2003-09-05 | 2009-06-17 | ソニー株式会社 | 電極ユニットと該電極ユニットを用いる物質間の相互作用検出のためのバイオアッセイ用基板 |
| JP4403376B2 (ja) * | 2003-10-09 | 2010-01-27 | ソニー株式会社 | 物質間の相互作用検出部と該検出部を備えるバイオアッセイ用基板及び該検出部への水溶液供給方法 |
| US7390622B2 (en) * | 2003-10-16 | 2008-06-24 | Hai Kang Life Corporation Limited | Apparatus and methods for detecting nucleic acid in biological samples |
-
2003
- 2003-10-16 US US10/686,252 patent/US7390622B2/en not_active Expired - Lifetime
-
2004
- 2004-10-15 MY MYPI20083009A patent/MY144038A/en unknown
- 2004-10-15 MY MYPI20044310A patent/MY139466A/en unknown
- 2004-10-15 TW TW093131325A patent/TWI360655B/zh not_active IP Right Cessation
- 2004-10-18 SG SG200807795-0A patent/SG147452A1/en unknown
- 2004-10-18 AU AU2004282235A patent/AU2004282235B2/en not_active Ceased
- 2004-10-18 WO PCT/CN2004/001180 patent/WO2005038048A1/en not_active Ceased
- 2004-10-18 CA CA2542518A patent/CA2542518C/en not_active Expired - Fee Related
- 2004-10-18 MX MXPA06004205A patent/MXPA06004205A/es active IP Right Grant
- 2004-10-18 EP EP04789841.6A patent/EP1673476B1/en not_active Expired - Lifetime
- 2004-10-18 RU RU2006111450/13A patent/RU2359038C2/ru not_active IP Right Cessation
- 2004-10-18 EP EP12190679A patent/EP2554683A1/en not_active Withdrawn
- 2004-10-18 CN CN2004800302044A patent/CN1867681B/zh not_active Expired - Fee Related
- 2004-10-18 JP JP2006534560A patent/JP5248017B2/ja not_active Expired - Lifetime
- 2004-10-18 BR BRPI0415342-1A patent/BRPI0415342A/pt not_active IP Right Cessation
-
2008
- 2008-05-01 US US12/113,392 patent/US7888109B2/en not_active Expired - Fee Related
-
2011
- 2011-02-14 US US13/026,620 patent/US20120010093A1/en not_active Abandoned
-
2013
- 2013-02-15 JP JP2013028093A patent/JP2013140168A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2542518A1 (en) | 2005-04-28 |
| JP2013140168A (ja) | 2013-07-18 |
| WO2005038048A1 (en) | 2005-04-28 |
| HK1098177A1 (en) | 2007-07-13 |
| US20050084865A1 (en) | 2005-04-21 |
| RU2006111450A (ru) | 2007-10-20 |
| BRPI0415342A (pt) | 2006-12-05 |
| TW200517656A (en) | 2005-06-01 |
| US20080242562A1 (en) | 2008-10-02 |
| SG147452A1 (en) | 2008-11-28 |
| CA2542518C (en) | 2012-05-29 |
| EP1673476A1 (en) | 2006-06-28 |
| EP1673476A4 (en) | 2010-01-06 |
| US7390622B2 (en) | 2008-06-24 |
| US7888109B2 (en) | 2011-02-15 |
| MY139466A (en) | 2009-10-30 |
| AU2004282235B2 (en) | 2011-09-08 |
| JP5248017B2 (ja) | 2013-07-31 |
| MXPA06004205A (es) | 2007-02-16 |
| AU2004282235A1 (en) | 2005-04-28 |
| RU2359038C2 (ru) | 2009-06-20 |
| CN1867681A (zh) | 2006-11-22 |
| JP2007508554A (ja) | 2007-04-05 |
| US20120010093A1 (en) | 2012-01-12 |
| MY144038A (en) | 2011-07-29 |
| EP2554683A1 (en) | 2013-02-06 |
| CN1867681B (zh) | 2010-12-08 |
| EP1673476B1 (en) | 2013-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |