TWI312864B - Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody - Google Patents

Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody Download PDF

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Publication number
TWI312864B
TWI312864B TW095124248A TW95124248A TWI312864B TW I312864 B TWI312864 B TW I312864B TW 095124248 A TW095124248 A TW 095124248A TW 95124248 A TW95124248 A TW 95124248A TW I312864 B TWI312864 B TW I312864B
Authority
TW
Taiwan
Prior art keywords
absence
detection
target antigen
therapeutic antibody
corresponding therapeutic
Prior art date
Application number
TW095124248A
Other languages
English (en)
Chinese (zh)
Other versions
TW200741203A (en
Inventor
Helmut Lenz
Werner Scheuer
Martina Thier
Original Assignee
Hoffmann La Roche A F
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche A F filed Critical Hoffmann La Roche A F
Publication of TW200741203A publication Critical patent/TW200741203A/zh
Application granted granted Critical
Publication of TWI312864B publication Critical patent/TWI312864B/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW095124248A 2005-07-06 2006-07-04 Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody TWI312864B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05014618 2005-07-06
EP06004447 2006-03-06

Publications (2)

Publication Number Publication Date
TW200741203A TW200741203A (en) 2007-11-01
TWI312864B true TWI312864B (en) 2009-08-01

Family

ID=36922121

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095124248A TWI312864B (en) 2005-07-06 2006-07-04 Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody

Country Status (19)

Country Link
US (1) US20070009976A1 (enExample)
EP (2) EP2194380A3 (enExample)
JP (1) JP2008545145A (enExample)
KR (1) KR20080016939A (enExample)
AR (1) AR053948A1 (enExample)
AU (1) AU2006265275A1 (enExample)
BR (1) BRPI0612591A2 (enExample)
CA (1) CA2613187A1 (enExample)
CR (1) CR9635A (enExample)
EC (1) ECSP088081A (enExample)
IL (1) IL188317A0 (enExample)
MA (1) MA29730B1 (enExample)
MX (1) MX2008000277A (enExample)
MY (1) MY157955A (enExample)
NO (1) NO20076662L (enExample)
NZ (1) NZ564471A (enExample)
RU (1) RU2008103608A (enExample)
TW (1) TWI312864B (enExample)
WO (1) WO2007003420A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152656A0 (en) 2000-05-19 2003-06-24 Genentech Inc Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy
AU2005287404B2 (en) * 2004-07-22 2009-05-07 Genentech, Inc. HER2 antibody composition
EP1795004B1 (en) 2004-10-01 2015-02-25 The Board Of Trustees Of The Leland Stanford Junior University Imaging arrangement and method therefor
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
CN103251946A (zh) 2005-02-23 2013-08-21 健泰科生物技术公司 使用her二聚化抑制剂在癌症患者中延长病情进展前时间或存活
PE20070207A1 (es) * 2005-07-22 2007-03-09 Genentech Inc Tratamiento combinado de los tumores que expresan el her
WO2007092581A2 (en) 2006-02-07 2007-08-16 The Board Of Trustees Of The Leland Stanford Junior University Correction of optical aberrations
US8358354B2 (en) 2009-01-26 2013-01-22 The Board Of Trustees Of The Leland Stanford Junior University Correction of optical abberations
PE20090681A1 (es) 2007-03-02 2009-06-10 Genentech Inc Prediccion de respuesta a un inhibidor her
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
DK4403228T3 (da) 2011-10-14 2025-10-13 Hoffmann La Roche Anvendelser for og fremstillet artikel indbefattende HER2-dimeriseringshæmmeren pertuzumab
KR101327542B1 (ko) * 2012-03-15 2013-11-08 광주과학기술원 양자점 기반의 경쟁 면역분석법 및 다중 유세포 분석법을 이용한 시료 중 오염물질의 검출 방법
AU2012232949B2 (en) * 2012-09-28 2014-07-03 Willowtree Holdings Pty Ltd Temporary bulkhead
RU2737727C2 (ru) 2013-04-16 2020-12-02 Дженентек, Инк. Варианты пертузумаба и их аналитическая характеристика
RU2020120593A (ru) 2014-04-25 2020-09-01 Дженентек, Инк. Способы лечения раннего рака молочной железы трастузумабом-mcc-dm1 и пертузумабом
ES2984592T3 (es) 2015-05-30 2024-10-30 Hoffmann La Roche Procedimientos de tratamiento de cáncer de mama metastásico no tratado previamente positivo para HER2
WO2017087280A1 (en) 2015-11-16 2017-05-26 Genentech, Inc. Methods of treating her2-positive cancer
AU2017387909A1 (en) 2016-12-28 2019-06-27 Genentech, Inc. Treatment of advanced HER2 expressing cancer
TW202508629A (zh) 2017-01-17 2025-03-01 美商建南德克公司 皮下her2抗體調配物
KR20230144110A (ko) 2017-03-02 2023-10-13 제넨테크, 인크. Her2-양성 유방암 어쥬번트 치료
KR20190140952A (ko) 2017-04-24 2019-12-20 제넨테크, 인크. 막관통 및 인접막 도메인에서의 erbb2/her2 돌연변이
JP2023532122A (ja) 2020-06-29 2023-07-26 ジェネンテック， インコーポレイテッド ペルツズマブにトラスツズマブを加えた固定用量配合剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0590058B1 (en) * 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
WO1993021319A1 (en) 1992-04-08 1993-10-28 Cetus Oncology Corporation HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
JP2001504326A (ja) 1996-10-18 2001-04-03 ジェネンテック インコーポレーテッド 抗ＥｒｂＢ２抗体
JP4424987B2 (ja) * 2001-09-20 2010-03-03 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム Ｅｌｉｓａアッセイを用いた循環する治療抗体、抗原および抗原／抗体複合体の測定
EP2263691B1 (en) * 2002-07-15 2012-08-29 F.Hoffmann-La Roche Ag Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2C4 (rhuMAb 2C4)

Also Published As

Publication number Publication date
AR053948A1 (es) 2007-05-23
NZ564471A (en) 2010-04-30
EP2194380A2 (en) 2010-06-09
EP2194380A3 (en) 2010-07-14
TW200741203A (en) 2007-11-01
NO20076662L (no) 2008-04-03
RU2008103608A (ru) 2009-08-20
WO2007003420A1 (en) 2007-01-11
EP1902315A1 (en) 2008-03-26
CR9635A (es) 2008-02-20
KR20080016939A (ko) 2008-02-22
ECSP088081A (es) 2008-02-20
JP2008545145A (ja) 2008-12-11
BRPI0612591A2 (pt) 2010-11-23
CA2613187A1 (en) 2007-01-11
MX2008000277A (es) 2008-03-24
US20070009976A1 (en) 2007-01-11
MA29730B1 (fr) 2008-09-01
IL188317A0 (en) 2008-04-13
AU2006265275A1 (en) 2007-01-11
MY157955A (en) 2016-08-30

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